Prospects in Constraining the Dark Energy Potential

We generalize to non-flat geometries the formalism of Simon et al. (2005) to reconstruct the dark energy potential. This formalism makes use of quantities similar to the Horizon-flow parameters in inflation, can, in principle, be made non-parametric and is general enough to be applied outside the simple, single scalar field quintessence. Since presently available and forthcoming data do not allow a non-parametric and exact reconstruction of the potential, we consider a general parametric description in term of Chebyshev polynomials. We then consider present and future measurements of H(z), Baryon Acoustic Oscillations surveys and Supernovae type 1A surveys, and investigate their constraints on the dark energy potential. We find that, relaxing the flatness assumption increases the errors on the reconstructed dark energy evolution but does not open up significant degeneracies, provided that a modest prior on geometry is imposed. Direct measurements of H(z), such as those provided by BAO surveys, are crucially important to constrain the evolution of the dark energy potential and the dark energy equation of state, especially for non-trivial deviations from the standard LambdaCDM model.Comment: 22 pages, 7 figures. 2 references correcte

Anti-angiogenic and anti-proliferative graphene oxide nanosheets for tumor cell therapy

Graphene oxide (GO) is a bidimensional novel material that exhibits high biocompatibility and angiogenic properties, mostly related to the intracellular formation of reactive oxygen species (ROS). In this work, we set up an experimental methodology for the fabrication of GO@peptide hybrids by the immobilization, via irreversible physical adsorption, of the Ac-(GHHPH)4-NH2 peptide sequence, known to mimic the anti-angiogenic domain of the histidine-proline-rich glycoprotein (HPRG). The anti-proliferative capability of the graphene-peptide hybrids were tested in vitro by viability assays on prostate cancer cells (PC-3 line), human neuroblastoma (SH-SY5Y), and human retinal endothelial cells (primary HREC). The anti-angiogenic response of the two cellular models of angiogenesis, namely endothelial and prostate cancer cells, was scrutinized by prostaglandin E2 (PGE2) release and wound scratch assays, to correlate the activation of inflammatory response upon the cell treatments with the GO@peptide nanocomposites to the cell migration processes. Results showed that the GO@peptide nanoassemblies not only effectively induced toxicity in the prostate cancer cells, but also strongly blocked the cell migration and inhibited the prostaglandin-mediated inflammatory process both in PC-3 and in HRECs. Moreover, the cytotoxic mechanism and the internalization efficiency of the theranostic nanoplatforms, investigated by mitochondrial ROS production analyses and confocal microscopy imaging, unraveled a dose-dependent manifold mechanism of action performed by the hybrid nanoassemblies against the PC-3 cells, with the detection of the GO-characteristic cell wrapping and mitochondrial perturbation. The obtained results pointed out to the very promising potential of the synthetized graphene-based hybrids for cancer therapy

Observational signatures of Jordan-Brans-Dicke theories of gravity

We analyze the Jordan-Brans-Dicke model (JBD) of gravity, where deviations from General Relativity (GR) are described by a scalar field non-minimally coupled to gravity. The theory is characterized by a constant coupling parameter, $\omega_{\rm JBD}$; GR is recovered in the limit $\omega_{\rm JBD} \to \infty$. In such theories, gravity modifications manifest at early times, so that one cannot rely on the usual approach of looking for inconsistencies in the expansion history and perturbations growth in order to discriminate between JBD and GR. However, we show that a similar technique can be successfully applied to early and late times observables instead. Cosmological parameters inferred extrapolating early-time observations to the present will match those recovered from direct late-time observations only if the correct gravity theory is used. We use the primary CMB, as will be seen by the Planck satellite, as the early-time observable; and forthcoming and planned Supernov{\ae}, Baryonic Acoustic Oscillations and Weak Lensing experiments as late-time observables. We find that detection of values of $\omega_{\rm JBD}$ as large as 500 and 1000 is within reach of the upcoming (2010) and next-generation (2020) experiments, respectively.Comment: minor revision, references added, matching version published in JCA

First Year Wilkinson Microwave Anisotropy Probe (WMAP) Observations: Implications for Inflation

We confront predictions of inflationary scenarios with the WMAP data, in combination with complementary small-scale CMB measurements and large-scale structure data. The WMAP detection of a large-angle anti-correlation in the temperature--polarization cross-power spectrum is the signature of adiabatic superhorizon fluctuations at the time of decoupling. The WMAP data are described by pure adiabatic fluctuations: we place an upper limit on a correlated CDM isocurvature component. Using WMAP constraints on the shape of the scalar power spectrum and the amplitude of gravity waves, we explore the parameter space of inflationary models that is consistent with the data. We place limits on inflationary models; for example, a minimally-coupled lambda phi^4 is disfavored at more than 3-sigma using WMAP data in combination with smaller scale CMB and large scale structure survey data. The limits on the primordial parameters using WMAP data alone are: n_s(k_0=0.002 Mpc^{-1})=1.20_{-0.11}^{+0.12}, dn/dlnk=-0.077^{+0.050}_{- 0.052}, A(k_0=0.002 Mpc}^{-1})=0.71^{+0.10}_{-0.11} (68% CL), and r(k_0=0.002 Mpc^{-1})<1.28 (95% CL).Comment: Accepted by ApJ; 49 pages, 9 figures. V2: Gives constraints from WMAP data alone. Corrected approximation which made the constraints in Table 1 to shift slightly. Corrected the Inflation Flow following the revision to Kinney, astro-ph/0206032. No conclusions have been changed. For a detailed list of changes see http://www.astro.princeton.edu/~hiranya/README.ERRATA.tx

Neoadjuvant eribulin mesylate following anthracycline and taxane in triple negative breast cancer: Results from the HOPE study

Background Eribulin mesylate (E) is indicated for metastatic breast cancer patients previously treated with anthracycline and taxane. We argued that E could also benefit patients eligible for neoadjuvant chemotherapy. Methods Patients with primary triple negative breast cancer 2 cm received doxorubicin 60 mg/m2 and paclitaxel 200 mg/m2 x 4 cycles (AT) followed by E 1.4 mg/m2 x 4 cycles. Primary endpoint was pathological complete response (pCR) rate; secondary and explorative endpoints included clinical/metabolic response rates and safety, and biomarker analysis, respectively. Using a two-stage Simon design, 43 patients were to be included provided that 4 of 13 patients had achieved pCR in the first stage of the study. Results In stage I of the study 13 women were enrolled, median age 43 years, tumor size 2–5 cm in 9/13 (69%), positive nodal status in 8/13 (61%). Main grade 3 adverse event was neutropenia (related to AT and E in 4 and 2 cases, respectively). AT followed by E induced clinical complete + partial responses in 11/13 patients (85%), pCR in 3/13 (23%). Median measurements of maximum standardized uptake value (SUVmax) resulted 13, 3, and 1.9 at baseline, after AT and E, respectively. Complete metabolic response (CMR) occurred after AT and after E in 2 and 3 cases, respectively. Notably, 2 of the 5 (40%) patients with CMR achieved pCR at surgery. Immunostaining of paired pre-/post-treatment tumor specimens showed a reduction of β-catenin, CyclinD1, Zeb-1, and c-myc expression, in the absence of N-cadherin modulation. The study was interrupted at stage I due to the lack of the required patients with pCR. Conclusions Despite the early study closure, preoperative E following AT showed clinical and biological activity in triple negative breast cancer patients. Furthermore, the modulation of β-catenin pathway core proteins, supposedly outside the domain of epithelial–mesenchymal transition, claims for further investigation. Trial registration EU Clinical Trial Register, EudraCT number 2012-004956-12

First Year Wilkinson Microwave Anisotropy Probe (WMAP) Observations: Angular Power Spectrum

We present the angular power spectrum derived from the first-year Wilkinson Microwave Anisotropy Probe (WMAP) sky maps. We study a variety of power spectrum estimation methods and data combinations and demonstrate that the results are robust. The data are modestly contaminated by diffuse Galactic foreground emission, but we show that a simple Galactic template model is sufficient to remove the signal. Point sources produce a modest contamination in the low frequency data. After masking ~700 known bright sources from the maps, we estimate residual sources contribute ~3500 uK^2 at 41 GHz, and ~130 uK^2 at 94 GHz, to the power spectrum l*(l+1)*C_l/(2*pi) at l=1000. Systematic errors are negligible compared to the (modest) level of foreground emission. Our best estimate of the power spectrum is derived from 28 cross-power spectra of statistically independent channels. The final spectrum is essentially independent of the noise properties of an individual radiometer. The resulting spectrum provides a definitive measurement of the CMB power spectrum, with uncertainties limited by cosmic variance, up to l~350. The spectrum clearly exhibits a first acoustic peak at l=220 and a second acoustic peak at l~540 and it provides strong support for adiabatic initial conditions. Kogut et al. (2003) analyze the C_l^TE power spectrum, and present evidence for a relatively high optical depth, and an early period of cosmic reionization. Among other things, this implies that the temperature power spectrum has been suppressed by \~30% on degree angular scales, due to secondary scattering.Comment: One of thirteen companion papers on first-year WMAP results submitted to ApJ; 44 pages, 14 figures; a version with higher quality figures is also available at http://lambda.gsfc.nasa.gov/product/map/map_bibliography.htm

Cosmological Parameters Degeneracies and Non-Gaussian Halo Bias

We study the impact of the cosmological parameters uncertainties on the measurements of primordial non-Gaussianity through the large-scale non-Gaussian halo bias effect. While this is not expected to be an issue for the standard LCDM model, it may not be the case for more general models that modify the large-scale shape of the power spectrum. We consider the so-called local non-Gaussianity model and forecasts from planned surveys, alone and combined with a Planck CMB prior. In particular, we consider EUCLID- and LSST-like surveys and forecast the correlations among $f_{\rm NL}$ and the running of the spectral index $\alpha_s$, the dark energy equation of state $w$, the effective sound speed of dark energy perturbations $c^2_s$, the total mass of massive neutrinos $M_\nu=\sum m_\nu$, and the number of extra relativistic degrees of freedom $N_\nu^{rel}$. Neglecting CMB information on $f_{\rm NL}$ and scales $k > 0.03 h$/Mpc, we find that, if $N_\nu^{\rm rel}$ is assumed to be known, the uncertainty on cosmological parameters increases the error on $f_{\rm NL}$ by 10 to 30% depending on the survey. Thus the $f_{\rm NL}$ constraint is remarkable robust to cosmological model uncertainties. On the other hand, if $N_\nu^{\rm rel}$ is simultaneously constrained from the data, the $f_{\rm NL}$ error increases by $\sim 80$. Finally, future surveys which provide a large sample of galaxies or galaxy clusters over a volume comparable to the Hubble volume can measure primordial non-Gaussianity of the local form with a marginalized 1--$\sigma$ error of the order $\Delta f_{\rm NL} \sim 2-5$, after combination with CMB priors for the remaining cosmological parameters. These results are competitive with CMB bispectrum constraints achievable with an ideal CMB experiment.Comment: 17 pages, 1 figure added, typos corrected, comments added, matches the published versio

Is Adnexectomy Mandatory at the Time of Hysterectomy for Uterine Sarcomas? A Systematic Review and Meta-Analysis.

Background and Objectives: Uterine sarcomas represents only 3% of all the female genital tract ones. The tumoral stage is the most significant prognostic factor. The role of the bilateral salpingo-oophorectomy (BSO) in the surgical management of FIGO stage IA and IB appears still controversial. This review aims to investigate the impact of bilateral adnexectomy in the treatment of uterine sarcoma. Methods: Following the recommendations in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we systematically searched the PubMed, Scopus, Cochrane, Medline, and Medscape databases in February 2022. We applied no language or geographical restrictions, but we considered only English studies. We included the studies containing data about Recurrence Rate (RR), Disease-free Survival (DFS), and Overall Survival (OS). We used comparative studies for meta-analysis. Results: Seventeen studies fulfilled the inclusion criteria; 2 retrospective observational studies, and 15 retrospective comparative studies, And 14 out of the 15 comparative studies were enrolled in meta-analysis. A total of 3743 patients were analyzed concerning the use of adnexectomy with hysterectomy in patients with uterine sarcoma and compared with those who did not. Meta-analysis highlighted a non-significant worsening of the OS in the BSO group compared to the OP group and showed that adnexectomy does not improve the DFS (BSO OR 1.23 (95% CI 0.81–1.85) p = 0.34; I(2) = 24% p = 0.22). Conclusions: Most studies selected for our review showed that adnexectomy does not significantly affect the RR, OS, and PFS in treating FIGO stage I uterine sarcomas. Therefore, even if there is a unanimous consensus about bilateral adnexectomy in menopausal patients, preservation of ovarian tissue may be considered in premenopausal women. Nonetheless, there are not enough cases in the literature to recommend this procedure

The Void Abundance with Non-Gaussian Primordial Perturbations

We use a Press-Schechter-like calculation to study how the abundance of voids changes in models with non-Gaussian initial conditions. While a positive skewness increases the cluster abundance, a negative skewness does the same for the void abundance. We determine the dependence of the void abundance on the non-Gaussianity parameter fnl for the local-model bispectrum-which approximates the bispectrum in some multi-field inflation models-and for the equilateral bispectrum, which approximates the bispectrum in e.g. string-inspired DBI models of inflation. We show that the void abundance in large-scale-structure surveys currently being considered should probe values as small as fnl < 10 and fnl^eq < 30, over distance scales ~10 Mpc.Comment: Submitted to JCA