1.2 GeV electron radiation spectra in thick tungsten single crystals and total radiation losses in tungsten, germanium and silicon single crystals

The experimental investigation of radiation energy losses of ultra relativistic electrons in aligned crystals of various atomic number are of great interest for several reasonye

Radiation Tolerance of Single-Sided Microstrip Detector with Si3N4Si_{3}N_{4} Insulator

The ALICE Collaboration is investigating the radiation tolerance and operation of silicon microstrip detectors for the inner tracking system. Detectors with and without an additional layer of Si3N4 insulator were made in one set, using the same thickness of SiO2 insulator. Measurements were made on both types of detectors after irradiation with 20 MeV electrons, using doses up to 2Mrad. The additional Si3N4 layer allows a coupling capacitor breakdown voltage larger than 100 V and capacitor yield larger than 99 percent. However, the leakage current for detectors with double layer insulator is about 20 nA per strip while the leakage current for the single layer SiO2 insulated detectors is only 0.5 nA. The 20 nA leakage current leads to 450 electrons noise when the ALICE 128C electronics with a peaking time of 1.4 microseconds is used. At a 1 nA leakage current the noise is 100 electrons. The ENC for an input capacitance of 5 pF is 300 electrons. Since all detectors show an increased leakage current after irradiation, the difference between the single and duoble layer insulation detectors becomes negligible when doses of the order of several hundreds of krad are applied

Вплив згодовування хелатних комплексів мікроелементів на середньодобовий баланс Cu, Zn та Мn в організмі корів у період роздою

The questions are considered about the effect of feeding of trace elements of different types and concentrations in premixes on the average daily balance of copper (Cu), zinc (Zn), manganese (Mn) in the organism of cows of Ukrainian black mottled dairy breed of the two months after calving. For the experiment, 40 cows were selected and formed four groups: one control and three experimental. The cows in the control group fed a premix of sulfate salts of copper, zinc and manganese in doses that are 100% covered their lack in a forage. Experimental animals from I, II and III groups were fed premixes with chelate complexes of Cu, Zn and Mn, which offset the deficiency of trace elements in the feed ration for 100, 50 and 25% (calculated on pure element), respectively. The diet was counted on a cow with an average live weight of 550 kg, with a daily milk yield of 20 kg 4% fat and balanced on the basis of the main nutrients in accordance with the norms. Іn the feeds, excrements, urine and milk of cows, the content of trace elements copper, zinc and manganese was determined by the standardized atomic absorption method on the spectrophotometer AAS-30 («SaglZeiss», Germany). Found a higher percentage of trace elements deposition in the body cows of feeding of chelates of copper, zinc, and manganese in the concentrations that cover their deficit in the diet in the 100% and 50% in the experimental I and II groups: Cu – 7.3% (P < 0.05) and 1.4%, Zn by 12.2% and 15.0% (P < 0.001), Mn by 13.2% (P < 0.01) and 9.0% (P < 0.05), respectively, in comparison with their sulfate salts in a 100 % dose. Based on the results of the balance study, the use in the feeding of cows during lactation of chelates of trace elements in concentrations intermediate to different experimental groups was proposed, namely – below normal their input in the form of sulfate salts on 25% for copper, 50% – zinc, and 65% – for manganese (calculated on pure element).Розглянуто питання щодо впливу згодовування мікроелементів різних типів і концентрацій у преміксах на середньодобовий баланс Купруму (Сu), Цинку (Zn), Мангану (Mn) в організмі корів української чорно-рябої молочної породи через два місяці після отелення. Встановлено вищий відсоток відкладання мікроелементів в організмі за згодовування коровам хелатів Cu, Zn і Mn у концентраціях, що покривають їхній дефіцит у раціоні на 100% та 50% в І і ІІ дослідних групах: Cu – на 7,3% (Р < 0,05) та 1,4%, для Zn – на 12,2% і 15,0% (Р < 0,001), Мn – на 13,2% (Р < 0,01) та 9,0% (Р < 0,05) відповідно, порівняно з їх сірчанокислими солями у 100 % дозі. На підставі результатів балансового досліду запропоновано використання в годівлі корів у період лактації хелатів мікроелементів у концентраціях, проміжних відносно різних дослідних груп, а саме – нижчих за норми їх введення у формі сірчанокислих солей на 25% для Cu, 50% – Zn, та 65% – для Мn (у розрахунку на чистий елемент)

Experimental Determination of the Characteristics of a Positron Source Using Channeling

Numerical simulations and `proof of principle' experiments showed clearly the interest of using crystals as photon generators dedicated to intense positron sources for linear colliders. An experimental investigation, using a 10 GeV secondary electron beam, of the SPS-CERN, impinging on an axially oriented thick tungsten crystal, has been prepared and operated between May and August 2000. After a short recall on the main features of positron sources using channeling in oriented crystals, the experimental set-up is described. A particular emphasis is put on the positron detector made of a drift chamber, partially immersed in a magnetic field. The enhancement in photon and positron production in the aligned crystal have been observed in the energy range 5 to 40 GeV, for the incident electrons, in crystals of 4 and 8 mm as in an hybrid target. The first results concerning this experiment are presented hereafter.Comment: 3 pages, 6 figures, submitted to Linac200

Analytical review of technical and tactical training of highly qualified athletes (men) who specialize in Sambo wrestling based on the results of the "2021 World Cup"

Пришва, О. Б. Аналітичний огляд техніко-тактичної підготовленості самбістів високої кваліфікації за підсумками «ЧС-2021» / Пришва О. Б., Драгунов Д. М., Голубничий М. В. та ін. // Науковий часопис НПУ імені М. П. Драгоманова. Серія 15: Науково-педагогічні проблеми фізичної культури (фізична культура і спорт). - 2022. - Вип. 3(148). - С. 109-115. - DOI: 10.31392/NPU-nc.series15.2022.3(148).24.Наведено аналітико-статистичний аналіз техніко-тактичної підготовленості висококваліфікованих самбістів, чемпіонів та призерів «ЧС – 2021». Рекомендовано провідним тренерам збірних команд областей України з боротьби самбо зосередити увагу на підвищенні показників активності та ефективності змагальних дій самбістів, а саме : удосконаленні техніко-тактичної підготовленості самбістів, а також покращенні їхніх показників підсистеми біологічного контролю.Taking into account the results of the analysis of scientific-methodical, special and reference literature, the members of the research group established, that the issue of analytical and statistical review of technical and tactical training of highly qualified athletes (Top 3 world rankings), who specialize in the sports section of Sambo wrestling as a result of their participation in the "World Cup – 2021" – insufficient number of specialized scientific and methodical works is devoted, which requires further research and emphasizes the relevance and practical component of the chosen field of study. The main purpose of the study is analytical and statistical analysis of technical and tactical training of highly qualified Sambo wrestlers (Top 3 world rankings, men), champions and winners of the 2021 World Cup (Tashkent, Uzbekistan). In the process of analytical and statistical work, the members of the research group used the following methods: abstraction, measurement, expert evaluation, survey, comparison, observation, etc. Leading coaches of the national teams of the regions of Ukraine in wrestling Sambo are recommended to focus on improving the activity and efficiency of competitive actions of Sambo wrestlers. Achieving the above indicators is possible under the following conditions: improving the technical and tactical training of Sambo wrestlers, as well as improving their performance subsystem biological control.Приведен аналитико-статистический анализ технико-тактической подготовленности высококвалифицированных самбистов, чемпионов и призеров «ЧМ-2021». Рекомендовано ведущим тренерам сборных команд областей Украины по борьбе самбо сосредоточить внимание на повышении показателей активности и эффективности соревновательных действий самбистов, а именно: усовершенствовании технико-тактической подготовленности самбистов, а также улучшении их показателей подсистемы биологического контроля

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.

1.2 GeV electron radiation spectra in thick tungsten single crystals and total radiation losses in tungsten, germanium and silicon single crystals

The experimental investigation of radiation energy losses of ultra relativistic electrons in aligned crystals of various atomic number are of great interest for several reaso

1.2 GeV electron radiation spectra in thick tungsten single crystals and total radiation losses in tungsten, germanium and silicon single crystals

yesThe experimental investigation of radiation energy losses of ultra relativistic electrons in aligned crystals of various atomic number are of great interest for several reaso