Search for muon-neutrino emission from GeV and TeV gamma-ray flaring blazars using five years of data of the ANTARES telescope

The ANTARES telescope is well-suited for detecting astrophysical transient neutrino sources as it can observe a full hemisphere of the sky at all times with a high duty cycle. The background due to atmospheric particles can be drastically reduced, and the point-source sensitivity improved, by selecting a narrow time window around possible neutrino production periods. Blazars, being radio-loud active galactic nuclei with their jets pointing almost directly towards the observer, are particularly attractive potential neutrino point sources, since they are among the most likely sources of the very high-energy cosmic rays. Neutrinos and gamma rays may be produced in hadronic interactions with the surrounding medium. Moreover, blazars generally show high time variability in their light curves at different wavelengths and on various time scales. This paper presents a time-dependent analysis applied to a selection of flaring gamma-ray blazars observed by the FERMI/LAT experiment and by TeV Cherenkov telescopes using five years of ANTARES data taken from 2008 to 2012. The results are compatible with fluctuations of the background. Upper limits on the neutrino fluence have been produced and compared to the measured gamma-ray spectral energy distribution.Comment: 27 pages, 16 figure

Search for muon-neutrino emission from GeV and TeV gamma-ray flaring blazars using five years of data of the ANTARES telescope

The ANTARES telescope is well-suited for detecting astrophysical transient neutrino sources as it can observe a full hemisphere of the sky at all times with a high duty cycle. The background due to atmospheric particles can be drastically reduced, and the point-source sensitivity improved, by selecting a narrow time window around possible neutrino production periods. Blazars, being radio-loud active galactic nuclei with their jets pointing almost directly towards the observer, are particularly attractive potential neutrino point sources, since they are among the most likely sources of the very high-energy cosmic rays. Neutrinos and gamma rays may be produced in hadronic interactions with the surrounding medium. Moreover, blazars generally show high time variability in their light curves at different wavelengths and on various time scales. This paper presents a time-dependent analysis applied to a selection of flaring gamma-ray blazars observed by the FERMI/LAT experiment and by TeV Cherenkov telescopes using five years of ANTARES data taken from 2008 to 2012. The results are compatible with fluctuations of the background. Upper limits on the neutrino fluence have been produced and compared to the measured gamma-ray spectral energy distributionThe authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a l'energie atomique et aux energies alternatives (CEA), Commission Europeenne (FEDER fund and Marie Curie Program), Region Ile-de-France (DIM-ACAV) Region Alsace (contrat CPER), Region Provence-Alpes-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Stichting voor Fundamenteel Onderzoek der Materie (FOM), Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; National Authority for Scientific Research (ANCS), Romania; Ministerio de Economia y Competitividad (MINECO), Prometeo and Grisolia programs of Generalitat Valenciana and MultiDark, Spain; Agence de l'Oriental and CNRST, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities.Adrián Martínez, S.; Albert, A.; André, M.; Anton, G.; Ardid Ramírez, M.; Aubert, J.; Baret, B.... (2015). Search for muon-neutrino emission from GeV and TeV gamma-ray flaring blazars using five years of data of the ANTARES telescope. Journal of Cosmology and Astroparticle Physics. 12(14):1-26. https://doi.org/10.1088/1475-7516/2015/12/014S1261214Becker, J. K. (2008). High-energy neutrinos in the context of multimessenger astrophysics. Physics Reports, 458(4-5), 173-246. doi:10.1016/j.physrep.2007.10.006Bloom, S. D., & Marscher, A. P. (1996). An Analysis of the Synchrotron Self-Compton Model for the Multi--Wave Band Spectra of Blazars. The Astrophysical Journal, 461, 657. doi:10.1086/177092Maraschi, L., Ghisellini, G., & Celotti, A. (1992). A jet model for the gamma-ray emitting blazar 3C 279. The Astrophysical Journal, 397, L5. doi:10.1086/186531Dermer, C. D., & Schlickeiser, R. (1993). Model for the High-Energy Emission from Blazars. The Astrophysical Journal, 416, 458. doi:10.1086/173251Sikora, M., Begelman, M. C., & Rees, M. J. (1994). Comptonization of diffuse ambient radiation by a relativistic jet: The source of gamma rays from blazars? The Astrophysical Journal, 421, 153. doi:10.1086/173633Gaisser, T. K., Halzen, F., & Stanev, T. (1995). Particle astrophysics with high energy neutrinos. Physics Reports, 258(3), 173-236. doi:10.1016/0370-1573(95)00003-yLearned, J. G., & Mannheim, K. (2000). High-Energy Neutrino Astrophysics. Annual Review of Nuclear and Particle Science, 50(1), 679-749. doi:10.1146/annurev.nucl.50.1.679Urry, C. M., & Padovani, P. (1995). Unified Schemes for Radio-Loud Active Galactic Nuclei. Publications of the Astronomical Society of the Pacific, 107, 803. doi:10.1086/133630Halzen, F., & Hooper, D. (2002). High-energy neutrino astronomy: the cosmic ray connection. Reports on Progress in Physics, 65(7), 1025-1078. doi:10.1088/0034-4885/65/7/201Böttcher, M. (2007). Modeling the emission processes in blazars. Astrophysics and Space Science, 309(1-4), 95-104. doi:10.1007/s10509-007-9404-0Böttcher, M., Reimer, A., Sweeney, K., & Prakash, A. (2013). LEPTONIC AND HADRONIC MODELING OFFERMI-DETECTED BLAZARS. The Astrophysical Journal, 768(1), 54. doi:10.1088/0004-637x/768/1/54Reynoso, M. M., Romero, G. E., & Medina, M. C. (2012). A two-component model for the high-energy variability of blazars. Astronomy & Astrophysics, 545, A125. doi:10.1051/0004-6361/201219873Atoyan, A. ., & Dermer, C. . (2004). Neutrinos and γ-rays of hadronic origin from AGN jets. New Astronomy Reviews, 48(5-6), 381-386. doi:10.1016/j.newar.2003.12.046Neronov, A., & Ribordy, M. (2009). IceCube sensitivity for neutrino flux from Fermi blazars in quiescent states. Physical Review D, 80(8). doi:10.1103/physrevd.80.083008Mücke, A., & Protheroe, R. J. (2001). A proton synchrotron blazar model for flaring in Markarian 501. Astroparticle Physics, 15(1), 121-136. doi:10.1016/s0927-6505(00)00141-9Abdo, A. A., Ackermann, M., Ajello, M., Allafort, A., Antolini, E., Atwood, W. B., … Barbiellini, G. (2010). THE FIRST CATALOG OF ACTIVE GALACTIC NUCLEI DETECTED BY THEFERMILARGE AREA TELESCOPE. The Astrophysical Journal, 715(1), 429-457. doi:10.1088/0004-637x/715/1/429Ageron, M., Aguilar, J. A., Al Samarai, I., Albert, A., Ameli, F., André, M., … Ardid, M. (2011). ANTARES: The first undersea neutrino telescope. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 656(1), 11-38. doi:10.1016/j.nima.2011.06.103Aguilar, J. A., Samarai, I. A., Albert, A., André, M., Anghinolfi, M., Anton, G., … Astraatmadja, T. (2011). Search for a diffuse flux of high-energy νμ with the ANTARES neutrino telescope. Physics Letters B, 696(1-2), 16-22. doi:10.1016/j.physletb.2010.11.070Adrián-Martínez, S., Al Samarai, I., Albert, A., André, M., Anghinolfi, M., Anton, G., … Aubert, J.-J. (2012). SEARCH FOR COSMIC NEUTRINO POINT SOURCES WITH FOUR YEARS OF DATA FROM THE ANTARES TELESCOPE. The Astrophysical Journal, 760(1), 53. doi:10.1088/0004-637x/760/1/53Adrián-Martínez, S., Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., … Barrios, J. (2014). A search for time dependent neutrino emission from microquasars with the ANTARES telescope. Journal of High Energy Astrophysics, 3-4, 9-17. doi:10.1016/j.jheap.2014.06.002Adrián-Martínez, S., Albert, A., Al Samarai, I., André, M., Anghinolfi, M., Anton, G., … Aubert, J.-J. (2013). Search for muon neutrinos from gamma-ray bursts with the ANTARES neutrino telescope using 2008 to 2011 data. Astronomy & Astrophysics, 559, A9. doi:10.1051/0004-6361/201322169Abdo, A. A., Ackermann, M., Ajello, M., Antolini, E., Baldini, L., Ballet, J., … Bellazzini, R. (2010). GAMMA-RAY LIGHT CURVES AND VARIABILITY OF BRIGHTFERMI-DETECTED BLAZARS. The Astrophysical Journal, 722(1), 520-542. doi:10.1088/0004-637x/722/1/520Ackermann, M., Ajello, M., Allafort, A., Antolini, E., Atwood, W. B., Axelsson, M., … Bastieri, D. (2011). THE SECOND CATALOG OF ACTIVE GALACTIC NUCLEI DETECTED BY THEFERMILARGE AREA TELESCOPE. The Astrophysical Journal, 743(2), 171. doi:10.1088/0004-637x/743/2/171Hovatta, T., Pavlidou, V., King, O. G., Mahabal, A., Sesar, B., Dancikova, R., … Surace, J. (2014). Connection between optical and γ-ray variability in blazars. Monthly Notices of the Royal Astronomical Society, 439(1), 690-702. doi:10.1093/mnras/stt2494Adrián-Martínez, S., Al Samarai, I., Albert, A., André, M., Anghinolfi, M., Anton, G., … Aubert, J.-J. (2012). Search for neutrino emission from gamma-ray flaring blazars with the ANTARES telescope. Astroparticle Physics, 36(1), 204-210. doi:10.1016/j.astropartphys.2012.06.001Aguilar, J. A., Albert, A., Ameli, F., Amram, P., Anghinolfi, M., Anton, G., … Aubert, J.-J. (2005). Study of large hemispherical photomultiplier tubes for the ANTARES neutrino telescope. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 555(1-2), 132-141. doi:10.1016/j.nima.2005.09.035Amram, P., Anghinolfi, M., Anvar, S., Ardellier-Desages, F. ., Aslanides, E., Aubert, J.-J., … Battaglieri, M. (2002). The ANTARES optical module. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 484(1-3), 369-383. doi:10.1016/s0168-9002(01)02026-5Adrián-Martínez, S., Ageron, M., Aguilar, J. A., Samarai, I. A., Albert, A., André, M., … Ardid, M. (2012). The positioning system of the ANTARES Neutrino Telescope. Journal of Instrumentation, 7(08), T08002-T08002. doi:10.1088/1748-0221/7/08/t08002Aguilar, J. A., Albert, A., Ameli, F., Anghinolfi, M., Anton, G., Anvar, S., … Basa, S. (2007). The data acquisition system for the ANTARES neutrino telescope. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 570(1), 107-116. doi:10.1016/j.nima.2006.09.098Agrawal, V., Gaisser, T. K., Lipari, P., & Stanev, T. (1996). Atmospheric neutrino flux above 1 GeV. Physical Review D, 53(3), 1314-1323. doi:10.1103/physrevd.53.1314BECHERINI, Y., MARGIOTTA, A., SIOLI, M., & SPURIO, M. (2006). A parameterisation of single and multiple muons in the deep water or ice. Astroparticle Physics, 25(1), 1-13. doi:10.1016/j.astropartphys.2005.10.005Carminati, G., Bazzotti, M., Margiotta, A., & Spurio, M. (2008). Atmospheric MUons from PArametric formulas: a fast GEnerator for neutrino telescopes (MUPAGE). Computer Physics Communications, 179(12), 915-923. doi:10.1016/j.cpc.2008.07.014Margiotta, A. (2013). Common simulation tools for large volume neutrino detectors. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 725, 98-101. doi:10.1016/j.nima.2012.11.172Adrián-Martínez, S., Albert, A., Al Samarai, I., André, M., Anghinolfi, M., Anton, G., … Aubert, J.-J. (2013). Measurement of the atmospheric ν μ energy spectrum from 100 GeV to 200 TeV with the ANTARES telescope. The European Physical Journal C, 73(10). doi:10.1140/epjc/s10052-013-2606-4Abdo, A. A., Ajello, M., Allafort, A., Baldini, L., Ballet, J., Barbiellini, G., … Bellazzini, R. (2013). THE SECONDFERMILARGE AREA TELESCOPE CATALOG OF GAMMA-RAY PULSARS. The Astrophysical Journal Supplement Series, 208(2), 17. doi:10.1088/0067-0049/208/2/17Scargle, J. D. (1981). Studies in astronomical time series analysis. I - Modeling random processes in the time domain. The Astrophysical Journal Supplement Series, 45, 1. doi:10.1086/190706Scargle, J. D. (1998). Studies in Astronomical Time Series Analysis. V. Bayesian Blocks, a New Method to Analyze Structure in Photon Counting Data. The Astrophysical Journal, 504(1), 405-418. doi:10.1086/306064Scargle, J. D., Norris, J. P., Jackson, B., & Chiang, J. (2013). STUDIES IN ASTRONOMICAL TIME SERIES ANALYSIS. VI. BAYESIAN BLOCK REPRESENTATIONS. The Astrophysical Journal, 764(2), 167. doi:10.1088/0004-637x/764/2/167Neyman, J. (1937). Outline of a Theory of Statistical Estimation Based on the Classical Theory of Probability. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 236(767), 333-380. doi:10.1098/rsta.1937.0005Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., … Arguelles, C. (2015). SEARCHES FOR TIME-DEPENDENT NEUTRINO SOURCES WITH ICECUBE DATA FROM 2008 TO 2012. The Astrophysical Journal, 807(1), 46. doi:10.1088/0004-637x/807/1/46Kelner, S. R., Aharonian, F. A., & Bugayov, V. V. (2006). Energy spectra of gamma rays, electrons, and neutrinos produced at proton-proton interactions in the very high energy regime. Physical Review D, 74(3). doi:10.1103/physrevd.74.034018Kelner, S. R., & Aharonian, F. A. (2010). Erratum: Energy spectra of gamma rays, electrons, and neutrinos produced at interactions of relativistic protons with low energy radiation [Phys. Rev. D78, 034013 (2008)]. Physical Review D, 82(9). doi:10.1103/physrevd.82.099901Tchernin, C., Aguilar, J. A., Neronov, A., & Montaruli, T. (2013). Neutrino signal from extended Galactic sources in IceCube. Astronomy & Astrophysics, 560, A67. doi:10.1051/0004-6361/201321801Padovani, P., & Resconi, E. (2014). Are both BL Lacs and pulsar wind nebulae the astrophysical counterparts of IceCube neutrino events? Monthly Notices of the Royal Astronomical Society, 443(1), 474-484. doi:10.1093/mnras/stu1166Aleksić, J., Antonelli, L. A., Antoranz, P., Backes, M., Barrio, J. A., Bastieri, D., … Berger, K. (2011). MAGIC Observations and multiwavelength properties of the quasar 3C 279 in 2007 and 2009. Astronomy & Astrophysics, 530, A4. doi:10.1051/0004-6361/201116497Aleksić, J., Ansoldi, S., Antonelli, L. A., Antoranz, P., Babic, A., Bangale, P., … Bednarek, W. (2014). MAGIC observations and multifrequency properties of the flat spectrum radio quasar 3C 279 in 2011. Astronomy & Astrophysics, 567, A41. doi:10.1051/0004-6361/201323036Murase, K., Inoue, Y., & Dermer, C. D. (2014). Diffuse neutrino intensity from the inner jets of active galactic nuclei: Impacts of external photon fields and the blazar sequence. Physical Review D, 90(2). doi:10.1103/physrevd.90.023007Finke, J. D., & Becker, P. A. (2014). FOURIER ANALYSIS OF BLAZAR VARIABILITY. The Astrophysical Journal, 791(1), 21. doi:10.1088/0004-637x/791/1/21Tavecchio, F., Ghisellini, G., & Guetta, D. (2014). STRUCTURED JETS IN BL LAC OBJECTS: EFFICIENT PeV NEUTRINO FACTORIES? The Astrophysical Journal, 793(1), L18. doi:10.1088/2041-8205/793/1/l1

Oral anticoagulation in device-detected atrial fibrillation: effects of age, sex, cardiovascular comorbidities, and kidney function on outcomes in the NOAH-AFNET 6 trial.

Implanted pacemakers, defibrillators, and loop recorders detect short and rare episodes of device-detected atrial fibrillation [DDAF, previously also called atrial high-rate episodes or subclinical atrial fibrillation (AF)] in ∼30% of patients. Device-detected atrial fibrillation rarely has therapeutic consequences in patients with ECG-documented AF. Device-detected atrial fibrillation without ECG-documented AF can lead to consideration of oral anticoagulation in clinical practice, especially in older patients with multiple stroke risk factors and/or very long DDAF episodes, largely based on observational data. Two recent controlled trials, NOAH-AFNET 6 and ARTESiA, observed a low rate of ischaemic stroke without anticoagulation (1.1%–1.2%/patient-year) in patients with DDAF and stroke risk factors, including in patients with very long DDAF episodes in NOAH-AFNET 6. Current guidelines leave the decision to anticoagulate to clinical judgement, balancing the expected stroke risk, typically estimated by using stroke risk scores developed in patients with ECG-documented AF, and the stroke risk reduction induced by anticoagulation, with the increase in bleeding associated with anticoagulation therapy

Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference.

AIMS: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). METHODS AND RESULTS: Eighty-three international experts met in Münster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF. CONCLUSIONS: Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF