Statusbericht zum Stand der Tiergesundheit in der Ökologischen Tierhaltung - Schlussfolgerungen und Handlungsoptionen für die Agrarpolitik

Im Rahmen des Forschungsprojektes wurde anhand von Literaturrecherchen eine Metaanalyse zum Stand des Wissens über die Tiergesundheit in der Ökologischen Tierhaltung durchgeführt. Näher betrachtet wurden: Mastitis, Fruchtbarkeits-, Stoffwechsel- und Klauenerkrankungen bei Milchkühen, ausgewählte Erkrankungen bei Schweinen und Geflügel sowie Parasitosen. Die Ergebnisse der Literaturanalyse und die daraus zu ziehenden Schlussfolgerungen wurden mit einer Expertengruppe erörtert. Die Erhebungen führten zu dem Ergebnis, dass sich der Gesundheitsstatus der Nutztiere in der Ökologischen Tierhaltung nicht markant von der Situation in der herkömmlichen Tierproduktion abhebt. Die Erkrankungsraten weisen unabhängig von der Produktionsmethode ein hohes Niveau auf. Die Varianz diesbezüglich ist zwischen den Betrieben größer als zwischen den Wirtschaftsweisen. Maßgebliche Variationsursachen sind in einem unzureichenden Management begründet. Die Gesunderhaltung auf den Betrieben ist durch finanzielle und arbeitszeitliche Grenzen sowie strukturelle Probleme und Zielkonflikte erschwert. Verschiedene Initiativen zur Verbesserung dieser Situation konnten bisher keinen hinreichenden Erfolg verbuchen. Die Ökologische Tierhaltung könnte in dem Bemühen um einen hohen Gesundheitsstatus weiterhin eine Vorreiterrolle einnehmen. Aus der Gesamtschau der vielfältigen Aspekte wird allerdings geschlussfolgert, dass die gegenwärtige Situation nur dann nachhaltig verbessert werden kann, wenn ein grundlegender Wechsel von einer richtlinien- und maßnahmenorientierten zu einer ergebnisorientierten Herangehensweise erfolgt. Unter den gegenwärtigen Rahmenbedingungen ist ansonsten nur ein geringer Handlungsspielraum gegeben, das Anliegen „Tiergesundheit“ gegenüber anderen betrieblichen Zielgrößen wie Produktionskostensenkung, Arbeitszeiteinsparung und Leistungssteigerung zu behaupten. Dazu bedarf es der Unterstützung von agrarpolitischer Seite

Think globally, act locally - reducing environmental impacts of transport

This paper presents a pragmatic approach for reducing the environmental impacts of transport in the German Federal State Saxony. The aim is to use the potential of pricing measures for effectively reducing environmental impacts of transport. They are combined with less-effective but more accepted non-pricing measures in a policy package. The development of this approach starts with the calculation of the current external costs of transport in the case study area. Second, a policy package reducing these external costs is composed. Third, the development of the external costs is assessed and compared in two scenarios, a BAU-scenario and the policy scenario where measures reducing the environmental impacts of transport are implemented. Fourth, the public and political acceptability of this policy package are investigated. The results show that it is possible to develop a policy package that is effective for reducing the environmental impacts as well as acceptable to the public and politicians. Therefore, such a package approach is suitable to guide future political decisions and actions towards a more sustainable transport sector

How one small step for occupational health management leads to many steps for employees – an experimental field study of incentive designs in a gamified mHealth app

Physical inactivity has become one of the leading health risk factors in today\u27s work environment, and in response, companies show increasing interest in digital health interventions to promote employees\u27 well-being. Tools such as mHealth apps use promising approaches to encourage people to be more physically active, for example, through gamification elements combined with financial incentives. However, there is a lack of research on how these technologies and incentives need to be designed to affect employees\u27 health behaviour positively. Based on prospect theory, this study examines the effect of gamified loss-oriented vs gain-oriented financial incentive systems with identical economic value to promote physical activity of employees. Our experiment\u27s results showed an overall positive effect in increasing employees\u27 physical activity (mean daily step count); more specifically, the advantage of a loss-oriented versus a gain-oriented incentive strategy compared to the control group

Construction of the Views oN Infant Sleep (VNIS) Questionnaire

Parents' beliefs about infant sleep behaviour vary over time and across cultures. No validated instrument exists to understand parents' pre- and postnatal views on infant sleep behaviours, which may influence their caregiving decisions. The Views oN Infant Sleep Questionnaire (VNIS) will be a tool to assess parents' beliefs in order to facilitate tailored perinatal care, increase the reliability of postnatal self-report measures, allow for cross-cultural comparisons, and provide a baseline for researchers to use in longitudinal studies. We recruited an online sample of 971 female participants who were resident in the United Kingdom, at least 28 weeks pregnant, and at least 18 years of age. The initial questionnaire consisted of 31 questions about infant independence, night-waking, infant feeding, touch, and safety, and items were rated on a 5-point Likert scale. The item pool was reduced to 12 using principal component analysis and a structure was found for the three components “Closeness”, “Independence”, and “Night-waking”. Overall, these results suggest that the VNIS can provide a brief scale to measure different aspects of individuals' beliefs about infant sleep. In further research the VNIS needs to be validated with a confirmatory factor analysis in another sample, and to be tested as a cross-cultural instrument

Efficient Bioelectrochemical Conversion of Industrial Wastewater by Specific Strain Isolation and Community Adaptation

The aim of this study was the development of a specifically adapted microbial community for the removal of organic carbon from an industrial wastewater using a bioelectrochemical system. In a first step, ferric iron reducing microorganisms were isolated from the examined industrial wastewater. In a second step, it was tested to what extent these isolates or a cocultivation of the isolates with the exoelectrogenic model organism Geobacter sulfurreducens (G. sulfurreducens) were able to eliminate organic carbon from the wastewater. To establish a stable biofilm on the anode and to analyze the performance of the system, the experiments were conducted first under batch-mode conditions for 21 days. Since the removal of organic carbon was relatively low in the batch system, a similar experiment was conducted under continuous-mode conditions for 65 days, including a slow transition from synthetic medium to industrial wastewater as carbon and electron source and variations in the flow rate of the medium. The overall performance of the system was strongly increased in the continuous- compared to the batch-mode reactor and the highest average current density (1,368 mA/m2) and Coulombic efficiency (54.9%) was measured in the continuous-mode reactor inoculated with the coculture consisting of the new isolates and G. sulfurreducens. The equivalently inoculated batch-mode system produced only 82-fold lower current densities, which were accompanied by 42-fold lower Coulombic efficiencies

Simvastatin induces apoptosis in PTEN‑haploinsufficient lipoma cells

Adipose tissue tumors (lipomas) frequently develop in patients with heterozygous germ line phosphatase and tensin homolog (PTEN) mutations. simvastatin has been demonstrated to exhibit antitumor effects, and so the aim of the present study was to assess the effects of simvastatin on the growth of human PTEN haploinsufficient lipoma cells. Whether the effects of simvastatin in lipomas are mediated via PTEN upregulation was also assessed. The results of the present study revealed that simvastatin treatment reduced cell viability and induced apoptosis in human lipoma cells. Furthermore, it was demonstrated that the expression of cellular PTEN mRNA and protein was increased following simvastatin stimulation. In addition, the phosphorylation of protein kinase B and downstream targets of mammalian target of rapamycin and 4E‑binding protein (4E‑BP)‑1 was attenuated. It was also demonstrated that simvastatin induced PTEN transcriptional upregulation by increasing peroxisome proliferator‑activated receptor (PPAR)γ expression. The small interfering RNA‑mediated knockdown of PPARγ abrogated the stimulatory effect of simvastatin on the PTEN protein, but did not influence apoptosis. The results of the present study suggest that simvastatin may be beneficial for patients with inoperable PTEN haploinsufficient lipomas

Treatment with the calcineurin inhibitor and immunosuppressant cyclosporine A impairs sensorimotor gating in Dark Agouti rats

Rationale Calcineurin is a protein regulating cytokine expression in T lymphocytes and calcineurin inhibitors such as cyclosporine A (CsA) are widely used for immunosuppressive therapy. It also plays a functional role in distinct neuronal processes in the central nervous system. Disturbed information processing as seen in neuropsychiatric disorders is reflected by deficient sensorimotor gating, assessed as prepulse inhibition (PPI) of the acoustic startle response (ASR). Objective Patients who require treatment with immunosuppressive drugs frequently display neuropsychiatric alterations during treatment with calcineurin inhibitors. Importantly, knockout of calcineurin in the forebrain of mice is associated with cognitive impairments and symptoms of schizophrenia-like psychosis as seen after treatment with stimulants. Methods The present study investigated in rats effects of systemic acute and subchronic administration of CsA on sensorimotor gating. Following a single injection with effective doses of CsA, adult healthy male Dark Agouti rats were tested for PPI. For subchronic treatment, rats were injected daily with the same doses of CsA for 1 week before PPI was assessed. Since calcineurin works as a modulator of the dopamine pathway, activity of the enzyme tyrosine hydroxylase was measured in the prefrontal cortex and striatum after accomplishment of the study. Results Acute and subchronic treatment with the calcineurin inhibitor CsA disrupted PPI at a dose of 20 mg/kg. Concomitantly, following acute CsA treatment, tyrosine hydroxylase activity was reduced in the prefrontal cortex, which suggests that dopamine synthesis was downregulated, potentially reflecting a stimulatory impact of CsA on this neurotransmitter system. Conclusions The results support experimental and clinical evidence linking impaired calcineurin signaling in the central nervous system to the pathophysiology of neuropsychiatric symptoms. Moreover, these findings suggest that therapy with calcineurin inhibitors may be a risk factor for developing neurobehavioral alterations as observed after the abuse of psychomotor stimulant drugs

Near-normalization of glycaemic control with glucagon-like peptide-1 receptor agonist treatment combined with exercise in patients with type 2 diabetes

AIMS: To investigate the effects of exercise in combination with a glucagon‐like peptide‐1 receptor agonist (GLP‐1RA), liraglutide, or placebo for the treatment of type 2 diabetes. METHODS: Thirty‐three overweight, dysregulated and sedentary patients with type 2 diabetes were randomly allocated to 16 weeks of either exercise and liraglutide or exercise and placebo. Both groups had three supervised 60‐minute training sessions per week including spinning and resistance training. RESULTS: Glycated haemoglobin (HbA1c) levels dropped by a mean ± standard deviation of 2.0% ± 1.2% (from 8.2% ± 1.4%) in the exercise plus liraglutide group vs 0.3% ± 0.9% (from 8.0% ± 1.2%) in the exercise plus placebo group ( P < .001), and body weight was reduced more with liraglutide (−3.4 ± 2.9 kg vs −1.6 ± 2.3 kg; P < .001). Compared with baseline, similar reductions were seen in body fat (exercise plus liraglutide: −2.5% ± 1.4% [ P < .001]; exercise plus placebo: −2.2% ± 1.9% [ P < .001]) and similar increases were observed in maximum oxygen uptake (exercise plus liraglutide: 0.5 ± 0.5 L O(2)/min [ P < .001]; exercise plus placebo: 0.4 ± 0.4 L O(2)/min [ P = .002]). Greater reductions in fasting plasma glucose (−3.4 ± 2.3 mM vs −0.3 ± 2.6 mM, P < .001) and systolic blood pressure (−5.4 ± 7.4 mm Hg vs −0.6 ± 11.1 mm Hg, P < .01) were seen with exercise plus liraglutide vs exercise plus placebo. The two groups experienced similar increases in quality of life during the intervention. CONCLUSIONS: In obese patients with type 2 diabetes, exercise combined with GLP‐1RA treatment near‐normalized HbA1c levels and caused a robust weight loss when compared with placebo. These results suggest that a combination of exercise and GLP‐1RA treatment is effective in type 2 diabetes

The Grizzly, March 23, 1993

Ursinus Mourns The Loss of One of Our Own • Worst Storm of the Century • Danceteller Performs at Ursinus • Ursinus\u27s Own Ticketron • Consider Women\u27s Studies • Wismer Rolls Out the Red Carpet • College Needs Policy on Closing • No Class • The Right to Life • U.C. Baseball Heading in Right Direction • Softball Breaks Even in the Carolinas • Three Outstanding Jens • Gymnasts at Nationalshttps://digitalcommons.ursinus.edu/grizzlynews/1312/thumbnail.jp