The Circumstellar Environment of High Mass Protostellar Objects. III Evidence of Infall?

The results are presented of a molecular line survey to search for the spectral signature of infall towards 77 850 micron continuum sources believed to be candidate high mass protostellar objects. Up to six different transitions, HCO+ 1-0, 3-2 and 4-3, H2CO 2_12-1_11, N2H+ and H13CO+ 3-2, were observed towards each source. Towards the peak of the 850 micron emission, N2H+ was typically strong, with a peak antenna temperature of ~1.5K, with a typical linewidth of ~2km/s. The good agreement between the velocity and velocity width of the N2H+ and H13CO+ emission suggests that both species are tracing similar material in the sources. With respect to the velocity of the N2H+, there is a statistically significant excess of blue asymmetric line profiles in both the HCO+ 1-0 and H2CO transitions. This excess reaches levels similar to that seen towards samples of low mass protostars, and suggests that the material around these high mass sources is infalling. We identify 22 promising candidate infall sources which show at least one blue asymmetric line profile and no red asymmetric profiles. The infall velocity is estimated to be in the range of 0.1 km/s to 1 km/s with an implied mass accretion rate of between 2x10^{-4} Msol/yr and 10^{-3}Msol/yr.Comment: Accepted for publication in Astronomy and Astrophysics. Higher resolution versions of Figures 1 and 2 are available from http://www.jb.man.ac.uk/~gaf/Papers.htm

Bright single-photon sources in bottom-up tailored nanowires

The ability to achieve near-unity light extraction efficiency is necessary for a truly deterministic single photon source. The most promising method to reach such high efficiencies is based on embedding single photon emitters in tapered photonic waveguides defined by top-down etching techniques. However, light extraction efficiencies in current top-down approaches are limited by fabrication imperfections and etching induced defects. The efficiency is further tempered by randomly positioned off-axis quantum emitters. Here, we present perfectly positioned single quantum dots on the axis of a tailored nanowire waveguide using bottom-up growth. In comparison to quantum dots in nanowires without waveguide, we demonstrate a 24-fold enhancement in the single photon flux, corresponding to a light extraction efficiency of 42 %. Such high efficiencies in one-dimensional nanowires are promising to transfer quantum information over large distances between remote stationary qubits using flying qubits within the same nanowire p-n junction.Comment: 19 pages, 6 figure

Dichotomy in the Dynamical Status of Massive Cores in Orion

To study the evolution of high mass cores, we have searched for evidence of collapse motions in a large sample of starless cores in the Orion molecular cloud. We used the Caltech Submillimeter Observatory telescope to obtain spectra of the optically thin (\H13CO+) and optically thick (\HCO+) high density tracer molecules in 27 cores with masses $>$ 1 \Ms. The red- and blue-asymmetries seen in the line profiles of the optically thick line with respect to the optically thin line indicate that 2/3 of these cores are not static. We detect evidence for infall (inward motions) in 9 cores and outward motions for 10 cores, suggesting a dichotomy in the kinematic state of the non-static cores in this sample. Our results provide an important observational constraint on the fraction of collapsing (inward motions) versus non-collapsing (re-expanding) cores for comparison with model simulations.Comment: 9 pages, 2 Figures. To appear in ApJ(Letters

Review: ‘Gimme five’: future challenges in multiple sclerosis. ECTRIMS Lecture 2009

This article is based on the ECTRIMS lecture given at the 25th ECTRIMS meeting which was held in Düsseldorf, Germany, from 9 to 12 September 2009. Five challenges have been identified: (1) safeguarding the principles of medical ethics; (2) optimizing the risk/benefit ratio; (3) bridging the gap between multiple sclerosis and experimental autoimmune encephalitis; (4) promoting neuroprotection and repair; and (5) tailoring multiple sclerosis therapy to the individual patient. Each of these challenges will be discussed and placed in the context of current research into the pathogenesis and treatment of multiple sclerosis

Test-meal palatability is associated with overconsumption but better represents preceding changes in appetite in non-obese males

Single course ad libitum meals are recommended for the assessment of energy intake within appetite research. This represents the first investigation of the comparative sensitivity of two single course ad libitum meals designed to differ in palatability. Two experiments were completed using a preload study design. All protocols were identical except for the energy content of the preloads (Experiment one: 579kJ and 1776kJ; Experiment two: 828kJ and 4188kJ). During each experiment, 10 healthy men completed four experimental trials constituting a low or high energy preload beverage, a 60 min intermeal interval, and consumption of a pasta-based or porridge-based ad libitum meal. Appetite ratings were measured throughout each trial and palatability was assessed after food consumption. Preload manipulation did not influence appetite (P=0.791) or energy intake (P=0.561) in experiment one. Palatability and energy intake were higher for the pasta meal than the porridge meal in both experiments (palatability P≤0.002; energy intake P≤0.001). In experiment two, consumption of the high energy preload decreased appetite (P=0.051) and energy intake (P=0.002). Energy compensation was not significantly different between pasta and porridge meals (P=0.172) but was more strongly correlated with preceding changes in appetite at the pasta meal (r=-0.758; P=0.011) than the porridge meal (r=-0.498; P=0.143). The provision of a highly palatable pasta-based meal produced energy intakes that were more representative of preceding appetite ratings but the moderately palatable porridge-based meal produced more ecologically valid energy intakes. Ad libitum meal selection and design may require a compromise between sensitivity and ecological validity

High quality factor GaAs microcavity with buried bullseye defects

The authors acknowledge financial support from the State of Bavaria, as well as from the DFG within the Project Schn1376/3.1: Polariton based single-photon sources, and from the Danish Research Council for Technology and Production (Sapere Aude LOQIT, DFF4005-00370).The development of high quality factor solid-state microcavities with low mode volumes has paved the way towards on-chip cavity quantum electrodynamics experiments and the development of high-performance nanophotonic devices. Here, we report on the implementation of a new kind of solid-state vertical microcavity, which allows for confinement of the electromagnetic field in the lateral direction without deep etching. The confinement originates from a local elongation of the cavity layer imprinted in a shallow etch and epitaxial overgrowth technique. We show that it is possible to improve the quality factor of such microcavities by a specific in-plane bullseye geometry consisting of a set of concentric rings with sub wavelength dimensions. This design results in a smooth effective lateral photonic potential and therefore in a reduction of lateral scattering losses, which makes it highly appealing for experiments in the framework of exciton-polariton physics demanding tight spatial confinement.PostprintPeer reviewe

Identification of a protein encoded in the EB-viral open reading frame BMRF2

Using monospecific rabbit sera against a peptide derived from a potential antigenic region of the Epstein-Barr viral amino acid sequence encoded in the open reading frame BMRF2 we could identify a protein-complex of 53/55 kDa in chemically induced B95-8, P3HR1 and Raji cell lines. This protein could be shown to be membrane-associated, as predicted by previous computer analysis of the secondary structure and hydrophilicity pattern, and may be a member of EBV-induced membrane proteins in lytically infected cells