443 research outputs found
Postnatal DNA demethylation and its role in tissue maturation.
Development in mammals is accompanied by specific de novo and demethylation events that are thought to stabilize differentiated cell phenotypes. We demonstrate that a large percentage of the tissue-specific methylation pattern is generated postnatally. Demethylation in the liver is observed in thousands of enhancer-like sequences associated with genes that undergo activation during the first few weeks of life. Using. conditional gene ablation strategy we show that the removal of these methyl groups is stable and necessary for assuring proper hepatocyte gene expression and function through its effect on chromatin accessibility. These postnatal changes in methylation come about through exposure to hormone signaling. These results define the molecular rules of 5-methyl-cytosine regulation as an epigenetic mechanism underlying cellular responses to. changing environment
Manipulating the Tomonaga-Luttinger exponent by electric field modulation
We establish a theoretical framework for artificial control of the power-law
singularities in Tomonaga-Luttinger liquid states. The exponent governing the
power-law behaviors is found to increase significantly with an increase in the
amplitude of the periodic electric field modulation applied externally to the
system. This field-induced shift in the exponent indicates the tunability of
the transport properties of quasi-one-dimensional electron systems.Comment: 7 pages, 3 figure
Estimates of hadron azimuthal anisotropy from multiparton interactions in proton-proton collisions at sqrt(s) = 14 TeV
We estimate the amount of collective "elliptic flow" expected at mid-rapidity
in proton-proton (p-p) collisions at the CERN Large Hadron Collider (LHC),
assuming that any possible azimuthal anisotropy of the produced hadrons with
respect to the plane of the reaction follows the same overlap-eccentricity and
particle-density scalings as found in high-energy heavy ion collisions. Using a
Glauber eikonal model, we compute the p-p eccentricities, transverse areas and
particle-multiplicities for various phenomenological parametrisations of the
proton spatial density. For realistic proton transverse profiles, we find
integrated elliptic flow v2 parameters below 3% in p-p collisions at sqrt(s) =
14 TeV.Comment: 17 pages, 9 figures. Very minor mods. Version to appear in EPJ-
Survivability of copper projectiles during hypervelocity impacts in porous ice: A laboratory investigation of the survivability of projectiles impacting comets or other bodies
AbstractDuring hypervelocity impact (>a few kms−1) the resulting cratering and/or disruption of the target body often outweighs interest on the outcome of the projectile material, with the majority of projectiles assumed to be vaporised. However, on Earth, fragments, often metallic, have been recovered from impact sites, meaning that metallic projectile fragments may survive a hypervelocity impact and still exist within the wall, floor and/or ejecta of the impact crater post-impact. The discovery of the remnant impactor composition within the craters of asteroids, planets and comets could provide further information regarding the impact history of a body. Accordingly, we study in the laboratory the survivability of 1 and 2mm diameter copper projectiles fired onto ice at speeds between 1.00 and 7.05kms−1. The projectile was recovered intact at speeds up to 1.50kms−1, with no ductile deformation, but some surface pitting was observed. At 2.39kms−1, the projectile showed increasing ductile deformation and broke into two parts. Above velocities of 2.60kms−1 increasing numbers of projectile fragments were identified post impact, with the mean size of the fragments decreasing with increasing impact velocity. The decrease in size also corresponds with an increase in the number of projectile fragments recovered, as with increasing shock pressure the projectile material is more intensely disrupted, producing smaller and more numerous fragments. The damage to the projectile is divided into four classes with increasing speed and shock pressure: (1) minimal damage, (2) ductile deformation, start of break up, (3) increasing fragmentation, and (4) complete fragmentation. The implications of such behaviour is considered for specific examples of impacts of metallic impactors onto Solar System bodies, including LCROSS impacting the Moon, iron meteorites onto Mars and NASA’s “Deep Impact” mission where a spacecraft impacted a comet
Central Pb+Pb Collisions at 158 A GeV/c Studied by Pion-Pion Interferometry
Two-particle correlations have been measured for identified negative pions
from central 158 AGeV Pb+Pb collisions and fitted radii of about 7 fm in all
dimensions have been obtained. A multi-dimensional study of the radii as a
function of kT is presented, including a full correction for the resolution
effects of the apparatus. The cross term Rout-long of the standard fit in the
Longitudinally CoMoving System (LCMS) and the vl parameter of the generalised
Yano-Koonin fit are compatible with 0, suggesting that the source undergoes a
boost invariant expansion. The shapes of the correlation functions in Qinv and
Qspace have been analyzed in detail. They are not Gaussian but better
represented by exponentials. As a consequence, fitting Gaussians to these
correlation functions may produce different radii depending on the acceptance
of the experimental setup used for the measurement.Comment: 13 pages including 10 figure
Search for Disoriented Chiral Condensates in 158 AGeV Pb+Pb Collisions
The restoration of chiral symmetry and its subsequent breaking through a
phase transition has been predicted to create regions of Disoriented Chiral
Condensates (DCC). This phenomenon has been predicted to cause anomalous
fluctuations in the relative production of charged and neutral pions in
high-energy hadronic and nuclear collisions. The WA98 experiment has been used
to measure charged and photon multiplicities in the central region of 158 AGeV
Pb+Pb collisions at the CERN SPS. In a sample of 212646 events, no clear DCC
signal can be distinguished. Using a simple DCC model, we have set a 90% C.L.
upper limit on the maximum DCC production allowed by the data.Comment: 20 Pages, LaTeX, uses elsart.cls, 8 eps figures included, submitted
to Physics Letters
Proximity effect at superconducting Sn-Bi2Se3 interface
We have investigated the conductance spectra of Sn-Bi2Se3 interface junctions
down to 250 mK and in different magnetic fields. A number of conductance
anomalies were observed below the superconducting transition temperature of Sn,
including a small gap different from that of Sn, and a zero-bias conductance
peak growing up at lower temperatures. We discussed the possible origins of the
smaller gap and the zero-bias conductance peak. These phenomena support that a
proximity-effect-induced chiral superconducting phase is formed at the
interface between the superconducting Sn and the strong spin-orbit coupling
material Bi2Se3.Comment: 7 pages, 8 figure
Centrality Dependence of the High p_T Charged Hadron Suppression in Au+Au collisions at sqrt(s_NN) = 130 GeV
PHENIX has measured the centrality dependence of charged hadron p_T spectra
from central Au+Au collisions at sqrt(s_NN)=130 GeV. The truncated mean p_T
decreases with centrality for p_T > 2 GeV/c, indicating an apparent reduction
of the contribution from hard scattering to high p_T hadron production. For
central collisions the yield at high p_T is shown to be suppressed compared to
binary nucleon-nucleon collision scaling of p+p data. This suppression is
monotonically increasing with centrality, but most of the change occurs below
30% centrality, i.e. for collisions with less than about 140 participating
nucleons. The observed p_T and centrality dependence is consistent with the
particle production predicted by models including hard scattering and
subsequent energy loss of the scattered partons in the dense matter created in
the collisions.Comment: 7 pages text, LaTeX, 6 figures, 2 tables, 307 authors, resubmitted to
Phys. Lett. B. Revised to address referee concerns. Plain text data tables
for the points plotted in figures for this and previous PHENIX publications
are publicly available at
http://www.phenix.bnl.gov/phenix/WWW/run/phenix/papers.htm
Low Q^2 Jet Production at HERA and Virtual Photon Structure
The transition between photoproduction and deep-inelastic scattering is
investigated in jet production at the HERA ep collider, using data collected by
the H1 experiment. Measurements of the differential inclusive jet
cross-sections dsigep/dEt* and dsigmep/deta*, where Et* and eta* are the
transverse energy and the pseudorapidity of the jets in the virtual
photon-proton centre of mass frame, are presented for 0 < Q2 < 49 GeV2 and 0.3
< y < 0.6. The interpretation of the results in terms of the structure of the
virtual photon is discussed. The data are best described by QCD calculations
which include a partonic structure of the virtual photon that evolves with Q2.Comment: 20 pages, 5 Figure
Hadron Production in Diffractive Deep-Inelastic Scattering
Characteristics of hadron production in diffractive deep-inelastic
positron-proton scattering are studied using data collected in 1994 by the H1
experiment at HERA. The following distributions are measured in the
centre-of-mass frame of the photon dissociation system: the hadronic energy
flow, the Feynman-x (x_F) variable for charged particles, the squared
transverse momentum of charged particles (p_T^{*2}), and the mean p_T^{*2} as a
function of x_F. These distributions are compared with results in the gamma^* p
centre-of-mass frame from inclusive deep-inelastic scattering in the
fixed-target experiment EMC, and also with the predictions of several Monte
Carlo calculations. The data are consistent with a picture in which the
partonic structure of the diffractive exchange is dominated at low Q^2 by hard
gluons.Comment: 16 pages, 6 figures, submitted to Phys. Lett.
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