960 research outputs found
Bases biomecánicas de las osteotomías tibiales
Peer Reviewe
Conceptos biomecánicos de los clavos «en cerrojo»
Se pasa revista a las propiedades mecánicas comparativas de
los diferentes montajes alcanzables con los distintos modelos y
concepciones de clavos «en cerrojo*. Es evidente que la rigidez
y resistencia de los clavos macizos y después de los clavos huecos
de sección cerrada es superior a los clavos convencionales
o de primera generación. Igualmente el bloqueo por tornillos o
pernos sobre cortical es mejor que el proporcionado por aletas
u otros artilugios a nivel de la esponjosa.
No cabe duda que los clavos «en cerrojo)) suponen un gran
avance y ventaja en el tratamiento de las fracturas complejas de
la extremidad inferior
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Efficient identification of hydrophobic MOFs: Application in the capture of toxic industrial chemicals
A novel and quick computational strategy is developed based on water Henry's constants to distinguish different levels of hydrophobicity among metal–organic frameworks. The technique is applied to a large database of MOFs to identify hydrophobic materials.We thank the Army Research Office (grant W911NF-12-1-0130) and the EPSRC IAA Partnership Development Award (RG/75759) for financial support. Computational work was partly supported by Northwestern University's shared computer system, Quest (project: P20261). D. F.-J. thanks the Royal Society for funding through a University Research Fellowship. We also thank Prof. Omar Yaghi and Dr Hiroyasu Furukawa for supplying the experimental water isotherms for some of the MOFs studied in this work. We thank Dr Pritha Ghosh and Dr Diego A. Gomez-Gualdron for fruitful discussions.This is the author accepted manuscript. The final version is available from the Royal Society of Chemistry via http://dx.doi.org/10.1039/c5ta06472
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Mechanically and chemically robust ZIF-8 monoliths with high volumetric adsorption capacity
The resultant monoliths are mechanically robust structures and present up to 3 times higher volumetric adsorption capacities than the conventional, powder MOF.This work was funded by the EPSRC IAA Partnership Development Award (RG/75759). D.F.-J. thanks the Royal Society for funding through a University Research Fellowship. T.D.B would like to thank Trinity Hall for funding and Professor Anthony Cheetham for use of lab facilities and equipmentThis is the accepted manuscript of a paper published in the Journal of Materials Chemistry A (Tian T, Velazquez-Garcia J, Bennett TD, Fairen-Jimenez D, Journal of Materials Chemistry A, 2015, 3, 2999-3005, doi:10.1039/c4ta05116e). The final version is available at http://dx.doi.org/10.1039/c4ta05116e
Tuning the endocytosis mechanism of Zr-based metal−organic frameworks through linker functionalization
A critical bottleneck for the use of metal-organic frameworks (MOFs) as drug delivery systems has been allowing them to reach their intracellular targets without being degraded in the acidic environment of the lysosomes. Cells take up particles by endocytosis through multiple biochemical pathways, and the fate of these particles depends on these routes of entry. Here, we show the effect of functional group incorporation into a series of Zr-based MOFs on their endocytosis mechanisms, allowing us to design an effi-cient drug delivery system. In particular, naphthalene-2,6-dicarboxylic acid and 4,4'-biphenyldicarboxylic acid ligands promote entry through the caveolin-pathway, allowing the particles to avoid lysosomal degradation and be delivered into the cytosol, en-hancing their therapeutic activity when loaded with drugs
On the design and implementation of flexible software platforms to facilitate the development of advanced graphics applications
This thesis presents the design and implementation of a software development platform (ATLAS) which offers some tools and methods to greatly simplify the construction of fairly sophisticated applications. It allows thus programmers to include advanced features in their applications with no or very little extra information and effort. These features include: the splitting of the application in distinct processes that may be distributed over a network; a powerful configuration and scripting language; several tools including an input system to easily construct reasonable interfaces; a flexible journaling mechanism --offering fault-tolerance to crashes of processes or communications--; and other features designed for graphics applications, like a global data identification- --addressing the problem of volatile references and giving support to processes of constraint solving--, and a uniform but flexible view of inputs allowing many different dialogue modes.These can be seen as related or overlapping with CORBA or other systems like Horus or Arjuna, but none of them addresses simultaneously all aspects included in ATLAS; more specifically none of them offers a standardized input model, a configuration and macro language, a journaling mechanism or gives support to processes of constraints solving and parametric design.The contributions of ATLAS are in showing how all these requirements can be addressed together; also in showing means by which this can be attained with little or no performance cost and without imposing on developers the need of mastering all these techniques. Finally, the design of the ATLAS journaling system is to our knowledge original in the simultaneous solution of all of its requirements
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Trinuclear Cage-Like Zn(II) Macrocyclic Complexes: Enantiomeric Recognition and Gas Adsorption Properties.
Three zinc(II) ions in combination with two units of enantiopure [3+3] triphenolic Schiff-base macrocycles 1, 2, 3, or 4 form cage-like chiral complexes. The formation of these complexes is accompanied by the enantioselective self-recognition of chiral macrocyclic units. The X-ray crystal structures of these trinuclear complexes show hollow metal-organic molecules. In some crystal forms, these barrel-shaped complexes are arranged in a window-to-window fashion, which results in the formation of 1D channels and a combination of both intrinsic and extrinsic porosity. The microporous nature of the [Zn3 12 ] complex is reflected in its N2 , Ar, H2 , and CO2 adsorption properties. The N2 and Ar adsorption isotherms show pressure-gating behavior, which is without precedent for any noncovalent porous material. A comparison of the structures of the [Zn3 12 ] and [Zn3 32 ] complexes with that of the free macrocycle H3 1 reveals a striking structural similarity. In H3 1, two macrocyclic units are stitched together by hydrogen bonds to form a cage very similar to that formed by two macrocyclic units stitched together by Zn(II) ions. This structural similarity is manifested also by the gas adsorption properties of the free H3 1 macrocycle. Recrystallization of [Zn3 12 ] in the presence of racemic 2-butanol resulted in the enantioselective binding of (S)-2-butanol inside the cage through the coordination to one of the Zn(II) ions.This work was supported by the NCN (NarodoweCentrumNauki, Poland) (grant 2011/03/B/ST5/01060).D.P.and J.L.thank the FNP Program“Mistrz” for financial support, and D.F.-J. thanks the Royal Society for funding through a University Research Fellowship.This is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1002/chem.20150347
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