What Faith Teaches Us: An Essay on Faith Adiele

Essay on the writer Faith Adiele and women\u27s bodies

Feeding Memories: A Conversation with Writers who Write About Food

Rochelle Spencer interviews Tara Christina, a writer and educator with degrees in holistic nutrition and is the founder and CEO of Tara’s Teas, an artisanal line of organic, loose leaf tea blends; Dera R. Williams whose work appears in several anthologies and you can find her food-related writing on her blog; and Shannon Holbrook, a writer and wine and food consultant who has organized prominent food-writing events throughout the Bay Area

Association of Adjuvant Tamoxifen and Aromatase Inhibitor Therapy With Contralateral Breast Cancer Risk Among US Women With Breast Cancer in a General Community Setting

Within ten years after breast cancer diagnosis, 5% of patients develop contralateral primary breast cancer (CBC). Randomized trials have found that tamoxifen and aromatase inhibitors (AIs) reduce CBC risk. However, little is known about the magnitude and duration of protective effects within the context of “real world” clinical management settings, where varying durations and gaps in treatment are common

Patterns and Drivers of UV Absorbing Chromophoric Dissolved Organic Matter in the Euphotic Layer of the Open Ocean

The global distribution of chromophoric dissolved organic matter (CDOM) in the euphotic layer of the Atlantic, Indian, and Pacific oceans (between 35 N and 40 S) was analyzed by absorption spectroscopy during the Malaspina 2010 circumnavigation. Absorption coefficients at 254 nm (a254) and 325 nm (a325), indices (a254/a365) and spectral slopes (between 275 and 295 nm, S275--295) were calculated from the dissolved fraction of the UV absorption spectra to describe the amount and quality of CDOM. Generalized Additive Models (GAMs) were applied to evaluate the relevance of physical and biogeochemical drivers for the variability of CDOM. Besides the low CDOM values, a first division of our data following the Longhurst’s biogeographic classification showed significant differences in CDOM levels among provinces. The lowest values of a254 and a325 were found in the oligotrophic gyres, particularly in the Indian Ocean, and the highest in the upwelling areas, particularly in the Equatorial Pacific. Opposite distributions were obtained for S275--295 and a254/a365, indicative of higher photobleaching in the gyres. The GAM analysis also shows that a254/a365 and S275--295 exhibited inverse relationships with solar radiation, indicating that the biological production of CDOM counteracts photodegradation as solar radiation increases. In summary, whereas photobleaching dictates the vertical distribution of CDOM, Chl a explains the CDOM differences among the photic layer of the tropical and subtropical ocean provinces visited during the circumnavigation.This study was funded by the Ingenio-Consolider project Malaspina 2010 Circumnavigation Expedition (MICINN CSD2008-00077). FI and JO were supported by a fellowship from the “Junta para la Ampliación de Estudios” (JAE-preDOC and JAE-postDOC programs 2011, respectively) from the CSIC

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

Clear cell renal carcinomas (ccRCCs) can display intratumor heterogeneity (ITH). We applied multiregion exome sequencing (M-seq) to resolve the genetic architecture and evolutionary histories of ten ccRCCs. Ultra-deep sequencing identified ITH in all cases. We found that 73–75% of identified ccRCC driver aberrations were subclonal, confounding estimates of driver mutation prevalence. ITH increased with the number of biopsies analyzed, without evidence of saturation in most tumors. Chromosome 3p loss and VHL aberrations were the only ubiquitous events. The proportion of C>T transitions at CpG sites increased during tumor progression. M-seq permits the temporal resolution of ccRCC evolution and refines mutational signatures occurring during tumor development

COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records

BACKGROUND: Updatable estimates of COVID-19 onset, progression, and trajectories underpin pandemic mitigation efforts. To identify and characterise disease trajectories, we aimed to define and validate ten COVID-19 phenotypes from nationwide linked electronic health records (EHR) using an extensible framework. METHODS: In this cohort study, we used eight linked National Health Service (NHS) datasets for people in England alive on Jan 23, 2020. Data on COVID-19 testing, vaccination, primary and secondary care records, and death registrations were collected until Nov 30, 2021. We defined ten COVID-19 phenotypes reflecting clinically relevant stages of disease severity and encompassing five categories: positive SARS-CoV-2 test, primary care diagnosis, hospital admission, ventilation modality (four phenotypes), and death (three phenotypes). We constructed patient trajectories illustrating transition frequency and duration between phenotypes. Analyses were stratified by pandemic waves and vaccination status. FINDINGS: Among 57 032 174 individuals included in the cohort, 13 990 423 COVID-19 events were identified in 7 244 925 individuals, equating to an infection rate of 12·7% during the study period. Of 7 244 925 individuals, 460 737 (6·4%) were admitted to hospital and 158 020 (2·2%) died. Of 460 737 individuals who were admitted to hospital, 48 847 (10·6%) were admitted to the intensive care unit (ICU), 69 090 (15·0%) received non-invasive ventilation, and 25 928 (5·6%) received invasive ventilation. Among 384 135 patients who were admitted to hospital but did not require ventilation, mortality was higher in wave 1 (23 485 [30·4%] of 77 202 patients) than wave 2 (44 220 [23·1%] of 191 528 patients), but remained unchanged for patients admitted to the ICU. Mortality was highest among patients who received ventilatory support outside of the ICU in wave 1 (2569 [50·7%] of 5063 patients). 15 486 (9·8%) of 158 020 COVID-19-related deaths occurred within 28 days of the first COVID-19 event without a COVID-19 diagnoses on the death certificate. 10 884 (6·9%) of 158 020 deaths were identified exclusively from mortality data with no previous COVID-19 phenotype recorded. We observed longer patient trajectories in wave 2 than wave 1. INTERPRETATION: Our analyses illustrate the wide spectrum of disease trajectories as shown by differences in incidence, survival, and clinical pathways. We have provided a modular analytical framework that can be used to monitor the impact of the pandemic and generate evidence of clinical and policy relevance using multiple EHR sources. FUNDING: British Heart Foundation Data Science Centre, led by Health Data Research UK

Afro-Surreal and Afro-Futuristic Visual Technologies in Junot Díaz’s The Brief Wondrous Life of Oscar Wao and Colson Whitehead’s Zone One

The recent explosion of interest in black speculative fiction necessitates study of these new, innovative texts. Afro-Surrealism, a form of black speculative fiction that began in the 1920s (First Wave Afro-Surrealism) and gained popularity in the 1960s (Second Wave Afro-Surrealism), has entered a Third Wave, one that closely mirrors its aesthetic cousin Afro- Futurism in its incorporation of technology into various texts. Both Afro-Surrealism and Afro-Futurism have sparked an outpouring of visual art, music, books, websites, and films, but more importantly, these movements have reinvigorated the novel by incorporating film’s storytelling techniques (jump cuts, montages). These narrative changes, when coupled with the frequent references to film, reveal how some black writers are rethinking technology.  For the Afro-Surrealist, borrowing from film’s visual technologies allows for a more meaningful retelling of history, while for the Afro-Futurist, cinematic writing represents people of color’s ability to work as technological innovators and creators. This paper positions Junot Díaz’s The Brief Wondrous Life of Oscar Wao as the representative Third Wave Afro-Surrealist text, and Colson Whitehead’s Zone One as the representative Afro-Futurist text. 

Unseen existences: Stories of life from Venembeli, Papua New Guinea

This article presents stories of life from Venembeli, a remote village in the hinterlands of Papua New Guinea. Caught up in a contentious mining development, villagers both long for and fear the development promised by global capitalism. But with a forty year development history, the proposed Wafi-Golpu mine has become the only lens through which the present or future is imagined and understood. We contend that this cultural hegemony has twisted the way stakeholders understand the mine's outcomes and impacts. Mindful of the power of language and dominant cultures, we adopt a refined version of the Melanesian tok stori methodology to capture stories that, together with illustrations and our own observations, make visible and amplify the stories from Venembeli. The stories illustrate a different reality to those presented in the usual western, technical and reductive impact assessments; offering insights into a complex human story that requires contemplation and empathy if the communities are to be valued, heard and respected. The outcome of telling these stories is uncertain, but this emancipatory participatory action research will help readers and stakeholders to better understand the community, and to prioritise their human flourishing to ensure positive, rather than negative mining legacies