Algebraic cubature on polygonal elements with a circular edge

We compute low-cardinality algebraic cubature formulas on convex or concave polygonal elements with a circular edge, by subdivision into circular quadrangles, blending formulas via subperiodic trigonometric Gaussian quadrature and final compression via Caratheodory\u2013Tchakaloff subsampling of discrete measures. We also discuss applications to the VEM (Virtual Element Method) in computational mechanics problems

5-th Dolomites Workshop on Constructive Approximation and Applications – Special Issue dedicated to Robert Schaback on the occasion of his 75th birthday

The guest editors discuss the highlights of the 5-th Dolomites Workshop on Constructive Approximation and Applications, and briefly introduce the papers included in this special issue

Evidence of very low metallicity and high ionization state in a strongly lensed, star-forming dwarf galaxy at z=3.417

We investigate the gas-phase metallicity and Lyman Continuum (LyC) escape fraction of a strongly gravitationally lensed, extreme emission-line galaxy at z=3.417, J1000+0221S, recently discovered by the CANDELS team. We derive ionization and metallicity sensitive emission-line ratios from H+K band LBT/LUCI medium resolution spectroscopy. J1000+0221S shows high ionization conditions, as evidenced by its enhanced [OIII]/[OII] and [OIII]/Hbeta ratios. Consistently, strong-line methods based on the available line ratios suggest that J1000+0221S is an extremely metal-poor galaxy, with a metallicity of 12+log(O/H) < 7.44 (< 5% solar), placing it among the most metal-poor star-forming galaxies at z > 3 discovered so far. In combination with its low stellar mass (2x10^8 Msun) and high star formation rate (5 Msun/yr), the metallicity of J1000+0221S is consistent with the extrapolation to low masses of the mass-metallicity relation traced by Lyman-break galaxies at z > 3, but it is 0.55 dex lower than predicted by the fundamental metallicity relation at z < 2.5. These observations suggest the picture of a rapidly growing galaxy, possibly fed by the massive accretion of pristine gas. Additionally, deep LBT/LBC in the UGR bands are used to derive a limit to the LyC escape fraction, thus allowing us to explore for the first time the regime of sub-L* galaxies at z > 3. We find a 1sigma upper limit to the escape fraction of 23%, which adds a new observational constraint to recent theoretical models predicting that sub-L* galaxies at high-z have high escape fractions and thus are the responsible for the reioization of the Universe.Comment: 5 pages, 3 figures and 1 table. Accepted for publication in ApJ Letter

S-ICD is effective in preventing sudden death in Arrhythmogenic Cardiomyopathy athletes during exercise

Here we describe the cases of two elite athletes, with a diagnosis of Arrhythmogenic Cardiomyopathy (ACM), in which a Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) has been implanted. Both patients experienced a ventricular tachycardia during exercise and received effective S-ICD shocks that interrupted arrhythmias. This report reveals for the first time that the S-ICD is effective in reverting arrhythmias in ACM patients, even during exercise. Moreover, these cases may confirm that competition/physical activity is associated with ICD shocks

Electron acceleration in a JET disruption simulation

Runaways are suprathermal electrons having sufficiently high energy to be continuously accelerated up to tens of MeV by a driving electric field [1]. Highly energetic runaway electron (RE) beams capable of damaging the tokamak first wall can be observed after a plasma disruption [2]. Therefore, it is of primary importance to fully understand their generation mechanisms in order to design mitigation systems able to guarantee safe tokamak operations. In a previous work, [3], a test particle tracker was introduced in the JOREK 3D non-linear MHD code and used for studying the electron confinement during a simulated JET-like disruption. It was found in [3] that relativistic electrons are not completely deconfined by the stochastic magnetic field taking place during the disruption thermal quench (TQ). This is due to the reformation of closed magnetic surfaces at the beginning of the current quench (CQ). This result was obtained neglecting the inductive electric field in order to avoid the unrealistic particle acceleration which otherwise would have happened due to the absence of collision effects. The present paper extends [3] analysing test electron dynamics in the same simulated JET-like disruption using the complete electric field. For doing so, a simplified collision model is introduced in the particle tracker guiding center equations. We show that electrons at thermal energies can become RE during or promptly after the TQ due to a combination of three phenomena: a first REs acceleration during the TQ due to the presence of a complex MHD-induced electric field, particle reconfinement caused by the fast reformation of closed magnetic surfaces after the TQ and a secondary acceleration induced by the CQ electric field

The Tunisian traditional rabbit breeding system versus the commercial system: an epidemiological perspective

[EN] Rabbit breeding is practiced in many hot climate countries and contributes in terms of agricultural activities to rural development. In Tunisia two different rabbit breeding systems can be identified - the "traditional" (an integrated free range and underground system) and the "commercial" (employing sheds and wire net cages) practice. 24 Tunisian rabbitries (10 traditional and 14 commercial) were included in an epidemiological study aimed at comparing the prevalence of pathogenic bacteria responsible for upper respiratory and digestive diseases in the two breeding systems. A total of 128 adult rabbits (mean age of 9.4 months) were tested using deep nasal and rectal swabs. Symptoms of nasal discharge and/or diarrhea were recorded. 281 bacterial strains were isolated in total, 138 in commercial and 143 in traditional farms. The bacteria most frequently isolated (61.2%) were Gram-positive strains, which included Streptococcus sp. (22.8%), coagulase negative Staphylococcus sp. (17.8%) and coagulase-positive Staphylococcus (17.4%) strains. Among the Gram-negative isolated bacteria, Escherichia coli was the most frequent (12.5%), followed by Proteus sp. (5.7%). The two Salmonella strains isolated were Salmonella bongori (found in the commercial system), and Salmonella typhimurium definitive phage-type (DT) 104 (found in the traditional farming system). The absence of Pasteurella multocida in the list of isolated bacteria may be directly correlated to the method of conserving the samples (storage at freezing temperature). The coagulase-positive Staphylococcus strains were frequently isolated (73.5%) from healthy rabbits, but seldom from rabbits with rhinitis (18.4%) or diarrhea (8.2%). Staphylococcus aureus strains were recovered at a higher rate in commercial farms (21%) in comparison with traditional (11.9%) farms. However, this difference was not statistically significant. Four Staphylococcus aureus strains, all belonging to commercial farms, proved positive when tested for enterotoxin production. The antimicrobial susceptibility of isolated Staphylococcus aureus strains was also investigated. Most of the antibiotics tested were very effective: the highest level of susceptibility was observed with enrofloxacin (100%). The low performance of Tunisian traditional rabbit rearing has been linked to the high mortality rate, which may possibly be due to the increased presence of pathogens at the rabbit flock level. However, this was not confirmed by the results of our study due to the fact that the bacterial contamination seems to be comparable in both the traditional and the commercial breeding systems.Belli, P.; Fontana, E.; Sommariva, M.; Scarpelli, L.; Ricci, C.; Luzi, F.; Haddad, B. (2008). The Tunisian traditional rabbit breeding system versus the commercial system: an epidemiological perspective. World Rabbit Science. 16(4). doi:10.4995/wrs.2008.617SWORD16

The lung microbiota: role in maintaining pulmonary immune homeostasis and its implications in cancer development and therapy

Like other body districts, lungs present a complex bacteria community. An emerging function of lung microbiota is to promote and maintain a state of immune tolerance, to prevent uncontrolled and not desirable inflammatory response caused by inhalation of harmless environmental stimuli. This effect is mediated by a continuous dialog between commensal bacteria and immune cells resident in lungs, which express a repertoire of sensors able to detect microorganisms. The same receptors are also involved in the recognition of pathogens and in mounting a proper immune response. Due to its important role in preserving lung homeostasis, the lung microbiota can be also considered a mirror of lung health status. Indeed, several studies indicate that lung bacterial composition drastically changes during the occurrence of pulmonary pathologies, such as lung cancer, and the available data suggest that the modifications of lung microbiota can be part of the etiology of tumors in lungs and can influence their progression and response to therapy. These results provide the scientific rationale to analyze lung microbiota composition as biomarker for lung cancer and to consider lung microbiota a new potential target for therapeutic intervention to reprogram the antitumor immune microenvironment. In the present review, we discussed about the role of lung microbiota in lung physiology and summarized the most relevant data about the relationship between lung microbiota and cancer

EXTENDING A MOBILE DEVICE WITH LOW-COST 3D MODELING AND BUILDING-SCALE MAPPING CAPABILITIES, FOR APPLICATION IN ARCHITECTURE AND ARCHAEOLOGY

One of the most challenging problem in architecture is the automated construction of 3D (and 4D) digital models of cultural objects with the aim of implementing open data repositories, scientifically authenticated and responding to well accepted standards of validation, evaluation, preservation, publication, updating and dissemination. The realization of such an ambitious objective requires the adoption of special technological instruments. In this paper we plan to use portable devices (i.e. smartphones, tablets or PDAs eventually extended to wearable ones), extended with a small plug-in, for automatically extracting 3D models of single objects and building-scale mapping of the surrounding environment. At the same time, the device will provide the capability of inserting notes and observations. Where the instrument cannot be directly applied, for example for exploring the top of a complex building, we consider mounting our device, or using equivalent existing equipment, on a drone, in a modular approach for obtaining data de-facto interchangeable. The approach based on the expansion packs has the advantage of anticipating (or even promoting) future extensions of new mobile devices, when the spectrum of possible applications justify the corresponding increased costs. In order to experiment and verify this approach we plan to test it in two specific scenarios of the cultural heritage domain in which such devices seem particularly promising: Strada Nuova in Genoa and Palazzo Ducale in Urbino, both located in Italy

Calcium as a key player in arrhythmogenic cardiomiopathy : adhesion disorder or intracellular alteration?

Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disease characterized by sudden death in young people and featured by fibro-adipose myocardium replacement, malignant arrhythmias, and heart failure. To date, no etiological therapies are available. Mutations in desmosomal genes cause abnormal mechanical coupling, trigger pro-apoptotic signaling pathways, and induce fibro-adipose replacement. Here, we discuss the hypothesis that the ACM causative mechanism involves a defect in the expression and/or activity of the cardiac Ca2+ handling machinery, focusing on the available data supporting this hypothesis. The Ca2+ toolkit is heavily remodeled in cardiomyocytes derived from a mouse model of ACM defective of the desmosomal protein plakophilin-2. Furthermore, ACM-related mutations were found in genes encoding for proteins involved in excitation\u2012contraction coupling, e.g., type 2 ryanodine receptor and phospholamban. As a consequence, the sarcoplasmic reticulum becomes more eager to release Ca2+, thereby inducing delayed afterdepolarizations and impairing cardiac contractility. These data are supported by preliminary observations from patient induced pluripotent stem-cell-derived cardiomyocytes. Assessing the involvement of Ca2+ signaling in the pathogenesis of ACM could be beneficial in the treatment of this life-threatening disease