Methods which enhanced the representation of experiences of recovery and addiction in animation

This discussion considers qualitative and practice methodology as part of a PhD animation project on addiction recovery. This article outlines the data collection process, considers the analysis to production, and illustrate benefits of multi-method research in production. Collaborating with Aiséirí, a long-established addiction treatment service in Ireland, a qualitative study involving three focus groups with recoverees provided various Irish perspectives. The addition of arts-tools within these sessions provided supplementary insights, such as key journey points to recovery, representations of addiction, a cultural window to deeper understanding of the relationship to and perception of addiction and recovery, and visual research for animation development. The analysis worked in an iterative process with film development adapting a thematic analysis. Themes were then developed and created into two animated short films. This article uses examples from The Click (2021) which through its structure showcase 5 distinct journey points found from addiction to recovery

Serial Position Effects in Short-term Visual Memory: A SIMPLE Explanation?

A version of Sternberg’s (1966) short-term, visual memory recognition paradigm with pictures of unfamiliar faces as stimuli was used in three experiments to assess the applicability of the distinctiveness based SIMPLE model proposed by Brown, Neath & Chater (2002). Initial simulations indicated that the amount of recency predicted increased as the parameter measuring the psychological distinctiveness of the stimulus material (c) increased, and that the amount of primacy was dependent on the extent of proactive interference from previously presented stimuli. The data from experiment 1, which used memory lists of four and five faces varying in visual similarity confirmed the predicted, extended recency effect. However, changes in visual similarity were not found to produce changes in c. In Experiments 2 and 3, the conditions that influence the magnitude of c were explored. These revealed that both the familiarity of the stimulus class before testing, and changes in familiarity due to perceptual learning, influenced distinctiveness as indexed by the parameter c. Overall the empirical data from all three experiments were well-fit by SIMPLE

Spatial, temporal and functional molecular architecture of the munc18-syntaxin interaction

Regulation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors (SNARE) mediated exocytosis is dependent upon four key proteins; the vesicular SNARE synaptobrevin, target SNAREs SNAP-25 and syntaxin and the Sec1/Munc18 (SM) protein munc18-1. Despite the munc18-1-syntaxin interaction being central to regulated vesicle exocytosis the spatial and temporal pattern of their molecular distribution and interaction in neuroendocrine and neuronal cells remains undefined. Using in vitro and molecular approaches this thesis shows that disruption of the munc18- 1-syntaxin-N-terminal interaction results in significant changes in syntaxin localisation, membrane-proximal vesicle dynamics and fusion efficiency within neuroendocrine cells. Using the super-resolution techniques Ground State Depletion-Individual molecule return (GSDIM) Microscopy and Photoactivation Localisation Microscopy (PALM) this thesis has demonstrated that the spatial distribution of single munc18-1 molecules is non-random and that few munc18-1 molecules are required for exocytosis to proceed in neuroendocrine cells. Furthermore, targeted disruption of the N-terminal interaction resulted only in a reorganisation of interaction with syntaxin with no change in the molecular spatial pattern of secretory vesicles, syntaxin or munc18-1. Single molecule imaging PALM (sptPALM) enabled the investigation of the complex spatio-temporal behaviours of single munc18-1 molecules in living neuroendocrine cells. Spatially resolved maps of single munc18-1 molecules demonstrated that munc18-1 exhibits a caged motion within areas of the plasma membrane and were found to move between molecular storage depots distinct from vesicle docking sites. To explore the precise spatial and temporal sequence of interactions between syntaxin and munc18-1 in living neurons, super-resolution imaging techniques PALM and sptPALM were employed. Two kinetically and spatially distinct populations of munc18-1 molecules co-exist within a living neuron and munc18-1 requires syntaxin to traffic efficiently in axons but not for its retention in nerve terminals. Moreover, Fluorescence Correlation Spectroscopy (FCS) revealed that the majority of munc18-1 molecules do not interact with syntaxin in nerve terminals and the diffusion rate of syntaxin is significantly slowed down upon neuronal depolarisation

Creation of Dorothy Smith's standpoint epistemology : a feminist appropriation of male theorists / by Deirdre Mary Smyth.

One of Dorothy Smith's most important contributions to feminist theory was the development of her concept called'the standpoint of women' (Smith, 1979). This thesis traces the evolution of this concept In her work from her earliest intellectual beginnings to the present. It restricts the examination of Smith's writing to her work on ideology and the sociology of knowledge, giving attention to the male theorists that she has appropriated in her early writings and the emergence of a more autonomous framework In her recent publications. The thesis is constructed from a sociology of knowledge perspective, thus Smith's writings are contextualized in the socio-historical events that have shaped them, occurrences such as the Free Speech Movement and the Montreal Massacre. Data for the thesis includes Smith's original writing, secondary sources on her work and original interviews which I conducted with Smith about the intellectual development of her writing. In addition, the extent of Smith's Influence In Canadian sociology has been explored through: 1) A survey of several prominent Canadian feminist sociologists and the editors of a few feminist journals; and 2) A search of the Social Sciences Citation Index to discover where, how often and in what ways she has been cited. Chapter One introduces the predominant themes of the thesis. One of these themes is a method which begins inquiry from the personal, and another is the examination of epistemological autonomy in Smith's writing. Chapters 2 deals with the quantification of Smith's influence in sociology, through a the survey of feminist theorists and a citation analysis. Chapter 3 documents her intellectual beginnings at the London School of Economics and at the University of California at Berkeley. Marxist feminism and the domestic labour debate in feminist theory are the topic of Chapter 4. Chapter 5 traces the origin of the 'standpoint of women' and includes recent criticism. The Montreal Massacre and the possibility of an epistemological break in Smith's work are the subjects of Chapter 6. The thesis ends with an interpretation of how the male writers that Smith has chosen to appropriate have affected her work

Lipid oxidation in mayonnaise and the role of natural antioxidants: a review

Background Mayonnaise, a high-oil containing product, is susceptible to oxidation resulting in quality deterioration and the formation of undesirable components such as free radicals and reactive aldehydes. A better understanding of the factors affecting lipid oxidation and ways of retarding oxidation in mayonnaise is essential in order to improve the shelf-life of mayonnaise. Scope and approach This review presents up-to-date knowledge on the factors affecting lipid oxidation and strategies to retard lipid oxidation in mayonnaise, with an emphasis on natural antioxidants, and application to other similar emulsions. Eliminating possible factors, which will reduce the induction period and hasten rancidity, can increase the shelf life of mayonnaise but one of the most effective means of retarding lipid oxidation in mayonnaise is to incorporate antioxidants. Due to the negative effects and perceptions of synthetic antioxidants, there has been a growing interest in improving oxidative stability of food products with natural ingredients. Therefore, to provide a better base for food engineers to design an effective natural antioxidant system for mayonnaise, in this review the emphasis is given to using natural antioxidants in mayonnaise. Key findings and conclusion Recent studies showed that incorporation of natural antioxidants in mayonnaise could increase its oxidative stability. However, natural antioxidants may exert a negative effect on sensory properties and further studies are needed to identify, quantify and overcome this problem. Manipulating the interfacial layer of the oil droplet also shows promise for retarding oxidation; however, there is a lack of literature addressing this area

Big Data Matching Using the Identity Correlation Approach

[EN] The Identity Correlation Approach (ICA) is a statistical technique developed for matching big data where a unique identifier does not exist. This technique was developed to match the Irish Census 2011 dataset to Central Government Administrative Datasets in order to attach a unique identifier to each individual person in the Census dataset (McCormack & Smyth, 20151). The unique identifier attached is the PPS No. (Personal Public Service No.2). By attaching the PPS No. to the Census dataset, each individual can be linked to datasets held centrally by Public Sector Organisations. This expands the range of variables for statistical analysis at individual level. Statistical techniques developed here were undertaken for a major European Structure of Earnings Survey (SES) compiled by the CSO using administrative data only, and thus eliminating the need for an expensive business survey to be conducted (NES, 20073,4,5). A description of how the Identity Correlation Approach was developed is given in this paper. Data matching results and conclusions are presented here in relation to the Structure of Earnings Survey (SES)6 results for 2011.Smyth, M.; Mccormack, K. (2016). Big Data Matching Using the Identity Correlation Approach. En CARMA 2016: 1st International Conference on Advanced Research Methods in Analytics. Editorial Universitat Politècnica de València. 46-55. https://doi.org/10.4995/CARMA2016.2015.2991OCS465

Occupational therapy can flourish in the 21st century — a case for professional engagement with health economics

The view that the profession of occupational therapy will flourish in the 21st century was expressed before the banking system and financial market collapse in 2008. The profession now competes for scarce resources as austerity measures take effect. A summit meeting at the College of Occupational Therapists, in May 2013, discussed how to improve the profession's understanding and use of health economics. At this meeting, short-, medium-, and longer-term approaches were discussed, with the aim of improving the quality and quantity of publications on economic evaluations in occupational therapy. Despite an increasing number of publications on health economics across professions, occupational therapy lags behind. This focus is now vital for the profession

Optimization of parametric comb generation using interferometric wavelength selective switch

Poster: We propose and demonstrate frequency comb regeneration using parametric mixer dispersion managed by interferometric wavelength selective switch. The results show a good control over the bandwidth/flatness of the comb generated by the parametric process