10 research outputs found
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
- Author
- Abbas Jalal
- Abraham Sybil
- Ackert Jessica
- Adams Patricia
- Aggarwala Gaurav
- Aher Nutan
- Ahlqvist Jørn
- Ahn Chul Woo
- Akers Teresa
- Akhras Ronald
- Akhter Faiq
- Aksentyev Sergey
- Al Kawas Firas
- Alexander Karen
- Althouse Denise
- Altobelli Desma
- Alvarisqueta Andres
- Ambrosy Andrew
- Andersen James
- Andersen Ulla
- Anderson Michelle
- Anglade Moise
- Arbañil Hugo
- Arciszewska Malgorzata
- Argoud Georges
- Ariani Mehrdad
- Ashdji Reswan
- Avogaro Angelo
- Avramidis Iakovos
- Axthelm Christoph
- Aye Myint
- Babi Charleen
- Bachus Erasmus
- Baik Sei-Hyun
- Bailey Matt
- Bakhtari Ladan
- Baksi Arun
- Balasubramani Mathangi
- Baldovino Jorge
- Banach Marek
- Banerjee Subhash
- Bartlett Andrew
- Bartone Susan
- Baum Howard
- Bays Harold
- Bazhan Larysa
- Beasley Richard
- Beaudry Yves
- Beaulieu Gail
- Beboso Ronnie
- Bedard Jacques
- Beijerbacht Hugo Peter
- Belfort de Aguiar Renata
- Benjamin Sabrina
- Berger Dirk
- Berlingieri Joseph
- Berndtsson Blom Katarina
- Besada Diego
- Bethel M Angelyn
- Bhagwat Ravi
- Bhargava Anuj
- Bhosale Archana
- Bieler Tasso
- Bijata-Bronisz Renata
- Birkeland Kare
- Birkenfeld Andreas
- Blagden Mark
- Bloomfield Gerald
- Bode Bruce
- Boemi Massimo
- Bonadonna Riccardo
- Bondar Irina
- Bott Jochen
- Bousboulas Stavros
- Boye Alain
- Bratcher Christina
- Breneman Jody
- Briskin Toby
- Bristianou Magdalini
- Brockmyre Andrew
- Broughton Raymond
- Brown Judith
- Brown Kim
- Brychta Tomas
- Brønnum-Schou Jens
- Budhraja Madhusudan
- Bull Georgina
- Bundy Charles
- Burgess Lesley
- Busch Klaus
- Caca Karel
- Cadinot Didier
- Calderon Jorge
- Calella Pedro
- Califf Robert M
- Calvo Gómez Carlos
- Camacho Luis
- Cannon Kevin
- Cano Rodríguez Isidoro
- Cantero Maria Cecilia
- Carr Jewell
- Casson Ed
- Castaño Patricia
- Castro Conde Almudena
- Cathcart Harold
- Cavale Arvind
- Cech Vladimir
- Cequier Fillat Angel
- Cervantes-Escárcega Jose-Luis
- Cha Bong-Soo
- Chau Tuan
- Chaykin Louis
- Chehayeb Raja
- Chen David
- Chen Jung-Fu
- Chertkoff Alejandro
- Cheung Deanna
- Cheung Stephen
- Chevts Julia
- Chiang Chern-En
- Childress Richard
- Christian Tamra
- Chung Choon-Hee
- Coetzee Kathleen
- Cohen Allan
- Coker Rebecca
- Cole Joanna
- Collier Jeannie
- Condit Jonathan
- Consoli Agostino
- Conway James
- Cooksey Erin
- Cookson Tobias
- Cooper John
- Cooper Lauren
- Copland Allan
- Cornel Jan
- Cornett George Mitchell
- Crenier Laurent
- Cuadrado Jesus
- Cuatrecasas Cambra Guillem
- Cusson Jean
- D'Agostino Ralph B
- D'Agostino Ralph B.
- Daga Shruti
- Damyanova Velichka
- Dauber Ira
- Davila William
- Dawood Saleem
- De Armas Luis
- De Cosmo Salvatore
- De Loredo Luis
- De Teresa Parreño Luis
- de Álvaro Moreno Fernando
- Dean Julius
- Debroye Corinne
- Del Prato Stefano
- Del Prato Stefano
- Delgado Lista Javier
- Della Siega Anthony
- DeMets David
- Demidova Irina
- Derezinski Tadeusz
- Deshpande Sameer
- Detweiler Robert
- Devore Adam
- Di Bartolo Paolo
- Di Giovanna Michael
- Diaz Ernesto
- Dimitriadis Georgios
- Dimitrov Stefan
- Distiller Larry
- Dombrowski Keith
- Dominguez Andrea
- Domínguez Escribano José Ramón
- Donaldson Jill
- Donaubauer Torsten
- Dor Isaac
- Dotta Francesco
- Dreval Alexander
- Drummond Waymon
- Dumas Richard
- Dumbre Snehal
- Dungan Kathleen
- Durán García Santiago
- Duyck Francis
- Dvorakova Eva
- Dzongowski Peter
- Eagerton Donald
- Eapen Zubin
- Earl John
- Eaton Charles
- Ebo Geraldine
- Edelsberger Tomas
- Eliasson Bjorn
- Eliasson Ken
- Elisaf Moses
- Ellison Howard
- Elvira González Javier
- Emslie-Smith Alistair
- Endsley Patricia
- Enns Robert
- Erlinger Rudolf
- Ershova Olga
- Español Maria Vanesa
- Espinoza Augusto Dextre
- Farris Neil
- Ferguson Murdo
- Fernandez-Salazar Eva
- Fernández Rodríguez José María
- Fiel Thomas
- Finkelstein Hernan
- Firek Anthony
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- Fleming John
- Flota-Cervera Luis Fernando
- Forgosh Les
- Frechtel Gustavo
- French William
- Fretes Jose
- Friedman Daniel
- Frontoni Simona
- Funke Klaus
- Fushtey Ivan
- Gadzinski Waldemar
- Gajek Jacek
- Galatius Søren
- Galetta Marianna
- Galstyan Gagik
- Gambineri Alessandra
- Gandy Winston
- Garcia Ronald
- Garganeeva Alla
- Garrido Santos Natalia
- Garrido Elizabeth
- Garvey Louisa
- Gaudet Daniel
- Gazzaruso Carmine
- Gentry Tracy
- Giaccari Andrea
- Gill Santosh
- Giorgino Francesco
- Goday Arno Alberto
- Godse Rupali
- Gomez Huelgas Ricardo
- Gonzales Rolando Vargas
- Gonzalez Joaquin
- González Juanatey José Ramón
- González-González José Gerardo
- Goodman Shaun
- Gordon Murray
- Gouet Didier
- Grachova Mariya
- Granger Christopher B
- Granger Christopher B.
- Green Fiona
- Green Jennifer B
- Green Jennifer B
- Greene Deb
- Greene Stephen
- Grondin Francois
- Grosskopf Josef
- Groutars Reginald G.E.J.
- Guerci Bruno
- Guice Michael
- Guimaraes Patricia
- Gulseth Hanne
- Gummadi Siva
- Gunstone Anthony
- Gupta Anil
- Gupta Milan
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- Guttormsen Gaute
- Ha JuYoung
- Hackenyos Jonathan
- Haddock Trevorlyn
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- Haluzik Martin
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- Hartman Israel
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- Henry Patrick
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- Hernandez Adrian F
- Hernandez Adrian F.
- Hernandez-Cassis Carlos
- Heymer Peter
- Hidalgo Horacio
- Higgins Alexander
- Hoek Boudewijn A
- Holman Rury
- Hoogslag Pieter A.M.
- Houle Pierre-Alain
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- Jacobs Shahram
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- Janmohamed Salim
- Janmohamed Salim
- Jarosz Marie
- Jenkins Wendy
- Jensen Jan Skov
- Jerjes-Díaz Carlos Sánchez
- Jiménez Díaz Víctor Alfonso
- Jintapakorn Woravut
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- Johnson Andrew
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- Johnson Megan
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- Jones Nigel P
- Jones Nigel P
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- Kessler Laurence
- Khandelwal Chaitali
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- Khariouzov Andrei
- Khokhlov Aleksandr
- Kim Chong-Jin
- Kim Christopher
- Kim Ellen
- Kim Hye Soon
- Kim In Joo
- Kirby William
- Klausmann Gerhard
- Klein Christiane
- Kleinecke-Pohl Uwe
- Kleinertz Klaus
- Klodawska Katarzyna
- Knouse Albert
- Kobalava Zhanna
- Kober Lars
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- Kocsis Gyozo
- Kolls Brad
- Kong David
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- Kooy Adriaan
- Korpachev Vadym
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- Kosiborod Mikhail
- Koskinen Pekka
- Kosmacheva Elena
- Kostin Vladimir
- Kotsa Kalliopi
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- Kovacheva Snezhina
- Kovacs Christopher
- Koziolova Natalia
- Kragten Johannes A.
- Kravchun Nonna
- Kristiansen Ole Peter
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- Leiter Lawrence A
- Leiter Lawrence A.
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- McMurray John J.V.
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- Tews Dietrich
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- Thomas Betsy
- Thorpe Karl
- Thorpe Karl M
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- Tien Kai Jen
- Tinahones Madueno Francisco
- Tirador Louie
- Tonolo Giancarlo
- Torres-Colores Jose Juan
- Torstensson Ingemar
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- Tricoci Pierluigi
- Tripathy Devjit
- Trznadel-Morawska Iwona
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- Tschoepe Diethelm
- Tseng Shih-Ting
- Tu Shih-Te
- Tugwell Barna
- Tzatzagou Glykeria
- Ulied Armiñana Angels
- Ulla Maria
- Urbanek Robin
- Uwaifo Gabriel
- Van Gaal Luc
- Vandyne Beth
- Vaphare Ashok
- Vasilevskaya Olga
- Vass Viktor
- Vedere Amarnath
- Vemulapalli Sreekanth
- Venugopal Chandra
- Verbovaya Nelli
- Vercammen Chris
- Verra Fernando
- Vidrio-Velázquez Maricela
- Viergever Eric P.
- Villagordoa-Mesa Juan
- Vishneva Elena
- Vizel Saul
- Vlasenko Maryna
- Vo Anthony
- Voinot Christel
- Vorobyev Sergey
- Vorokhobina Natalya
- Vouillarmet Julien
- Vrkoc Jan
- Wang Chih-Yuan
- Wang Ji-Hung
- Watson Anthony
- Watson David
- Welch Michelle
- Welker James
- White Alexander
- Wilhelm Karl
- Willis John
- Wilson Matt
- Wilson Tim
- Witek Robert
- Wium Cecilie
- Womer Terese
- Woo Vincent
- Wraight Ella
- Wynne Alan
- Xing Weibing
- Yamwong Sukit
- Yazdani Shahram
- Ye June
- Yoo Soon Jib
- Yordanov Victor
- Yu Jaemyung
- Zabalua Silvina
- Zaidman Cesar
- Zang Eddie
- Zanozina Olga
- Zeller-Stefan Helga
- Zhdanova Elena
- Zlova Tetiana
- Zubiate Carlos
- Zykova Tatyana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background:
Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.
Methods:
We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515.
Findings:
Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group.
Interpretation:
In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes.
Funding:
GlaxoSmithKline
ATLAS Run 1 searches for direct pair production of third-generation squarks at the Large Hadron Collider
- Author
- Abbott Brad
- Abdallah Jalal
- Abdinov Ovsat
- Aben Rosemarie
- Abolins Maris
- AbouZeid Ossama
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby Sami
- Adamczyk Leszek
- Adams David
- Adelman Jahred
- Adomeit Stefanie
- Adye Tim
- Affolder Tony
- Agatonovic-Jovin Tatjana
- Agricola Johannes
- Aguilar-Saavedra Juan Anton
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akerstedt Henrik
- Akimov Andrei
- Alberghi Gian Luigi
- Albert Justin
- Albrand Solveig
- Alconada Verzini Maria Jose
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Alimonti Gianluca
- Alio Lion
- Alison John
- Alkire Steven Pat
- Allbrooke Benedict
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Altheimer Andrew Dav
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazi
- Amadio Brian Thom
- Amako Katsuya
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana Pat
- Amorim Antonio
- Amoroso Simone
- Amram Nir
- Amundsen Glenn
- Anastopoulos Christos
- Ancu Lucian Ste
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders Gabriel
- Anders John Kenne
- Anderson Kelby
- Andreazza Attilio
- Andrei George Vic
- Angelidakis Stylianos
- Angelozzi Ivan
- Anger Philipp
- Angerami Aaron
- Anghinolfi Francis
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antonelli Mario
- Antonov Alexey
- Antos Jaroslav
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan Pedro
- Arce Ayana
- Arduh Francisco
- Arguin Jean-Franc
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron Jame
- Arnaez Olivier
- Arnal Vanessa
- Arnold Hannah
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- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
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- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim Bora
- Auerbach Benjamin
- Augsten Kamil
- Aurousseau Mathieu
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad Ka
- Azuelos Georges
- Baak Max
- Baas Alessandra
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- Bachacou Henri
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- Backhaus Malte
- Bagiacchi Paolo
- Bagnaia Paolo
- Bai Yu
- Bain Travis
- Baines John
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- Baldin Evgenii
- Balek Petr
- Balestri Thomas
- Balli Fabrice
- Banas Elzbieta
- Banerjee Swagato
- Bannoura Arwa A E
- Bansil Hardeep Si
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- Bauer Florian
- Bawa Harinder S
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- Carquin Edson
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- Carter Janet
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- Chislett Rebecca Th
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- Clark Allan G
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- Cochran James H
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- de Asmundis Riccardo
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- Debbe Ramiro
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- Dedovich Dmitri
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- Dyndal Mateusz
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- Eckardt Christoph
- Ecker Katharina
- Edgar Ryan Chris
- Edson William
- Edwards Nicholas C
- Ehrenfeld Wolfgang
- Eifert Till
- Eigen Gerald
- Einsweiler Kevin
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- El Kacimi Mohamed
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- Ezhilov Alexey
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- Fincke-Keeler Margret
- Finelli Kevin Dani
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- Fusayasu Takahiro
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- Gadatsch Stefan
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- Gan KK
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- Garay Walls Francisca
- Garberson Ford
- Garcia-Sciveres Maurice
- García Navarro José Enri
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- Gardner Robert
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- Gaur Bakul
- Gauthier Lea
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- Gavrilenko Igor
- Gay Colin
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- Ge Peng
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- Gee Norman
- Geerts Daniël Al
- Geich-Gimbel Christoph
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- Gilles Geoffrey
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- Giorgi Filippo Ma
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- Giraud Pierre-Fra
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- Gkaitatzis Stamatios
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- Gladilin Leonid
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- Goddard Jack Rober
- Godlewski Jan
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- Golling Tobias
- Golubkov Dmitry
- Gomes Agostinho
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- Gonella Laura
- Gonzalez Parra Garoe
- Gonzalez-Sevilla Sergio
- González de la Hoz Santiago
- Gonçalo Ricardo
- Goossens Luc
- Gorbounov Petr Andre
- Gordon Howard
- Gorelov Igor
- Gorini Benedetto
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- Gorišek Andrej
- Gornicki Edward
- Goshaw Alfred
- Gostkin Mikhail Iv
- Goujdami Driss
- Goussiou Anna
- Govender Nicolin
- Gozani Eitan
- Grabas Herve Mari
- Graber Lars
- Grabowska-Bold Iwona
- Gradin Per Olov J
- Grafström Per
- Grahn Karl-Johan
- Gramling Johanna
- Gramstad Eirik
- Grancagnolo Sergio
- Grassi Valerio
- Gratchev Vadim
- Gray Heather
- Graziani Enrico
- Greenwood Zeno Dixon
- Gregersen Kristian
- Gregor Ingrid-Mar
- Grenier Philippe
- Griffiths Justin
- Grillo Alexander
- Grimm Kathryn
- Grinstein Sebastian
- Gris Philippe L
- Grivaz Jean-Franc
- Grohs Johannes P
- Grohsjean Alexander
- Gross Eilam
- Grosse-Knetter Joern
- Grossi Giulio Cor
- Grout Zara Jane
- Guan Liang
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- Guest Daniel
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- Guido Elisa
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- Gutierrez Ortiz Nicolas Gi
- Gutierrez Phillip
- Gutschow Christian
- Guyot Claude
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- Gössling Claus
- Haas Andy
- Haber Carl
- Hadavand Haleh Khan
- Haddad Nacim
- Haefner Petra
- Hageböck Stephan
- Hajduk Zbigniew
- Hakobyan Hrachya
- Haleem Mahsana
- Haley Joseph
- Hall David
- Halladjian Garabed
- Hallewell Gregory Da
- Hamacher Klaus
- Hamal Petr
- Hamano Kenji
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- Hamity Guillermo
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- Han Liang
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- Hanawa Keita
- Hance Michael
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- Hansen Jorn Dines
- Hansen Jørgen Be
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- Harkusha Siarhei
- Harrington Robert
- Harrison Paul Frase
- Hartjes Fred
- Hasegawa Makoto
- Hasegawa Satoshi
- Hasegawa Yoji
- Hasib A
- Hassani Samira
- Haug Sigve
- Hauser Reiner
- Hauswald Lorenz
- Havranek Miroslav
- Hawkes Christophe
- Hawkings Richard Jo
- Hawkins Anthony Da
- Hayashi Takayasu
- Hayden Daniel
- Hays Chris
- Hays Jonathan M
- Hayward Helen
- Haywood Stephen
- Head Simon
- Heck Tobias
- Hedberg Vincent
- Heelan Louise
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- Heim Timon
- Heinemann Beate
- Heinrich Lukas
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- Helary Louis
- Hellman Sten
- Hellmich Dennis
- Helsens Clement
- Henderson James
- Henderson Robert
- Heng Yang
- Hengler Christophe
- Henrichs Anna
- Henriques Correia Ana Maria
- Henrot-Versille Sophie
- Herbert Geoffrey H
- Hernández Jiménez Yesenia
- Herrberg-Schubert Ruth
- Herten Gregor
- Hertenberger Ralf
- Hervas Luis
- Hesketh Gavin Gran
- Hessey Nigel
- Hetherly Jeffrey Wa
- Hickling Robert
- Higón-Rodriguez Emilio
- Hill Ewan
- Hill John
- Hiller Karl Heinz
- Hillier Stephen
- Hinchliffe Ian
- Hines Elizabeth
- Hinman Rachel Rei
- Hirose Minoru
- Hirschbuehl Dominic
- Hobbs John
- Hod Noam
- Hodgkinson Mark
- Hodgson Paul
- Hoecker Andreas
- Hoeferkamp Martin
- Hoenig Friedrich
- Hohlfeld Marc
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- Holmes Tova Ray
- Homann Michael
- Hong Tae Min
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- Hopkins Walter
- Horii Yasuyuki
- Horton Arthur Jam
- Hostachy Jean-Yves
- Hou Suen
- Hoummada Abdeslam
- Howard Jacob
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- Hrynevich Aliaksei
- Hsu Catherine
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- Hubaut Fabrice
- Huegging Fabian
- Huffman Todd Brian
- Hughes Emlyn
- Hughes Gareth
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- Huseynov Nazim
- Huston Joey
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- Hülsing Tobias Ale
- Iacobucci Giuseppe
- Iakovidis Georgios
- Ibragimov Iskander
- Iconomidou-Fayard Lydia
- Ideal Emma
- Idrissi Zineb
- Iengo Paolo
- Igonkina Olga
- Iizawa Tomoya
- Ikegami Yoichi
- Ikematsu Katsumasa
- Ikeno Masahiro
- Ilchenko Iurii
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- Ilic Nikolina
- Ince Tayfun
- Introzzi Gianluca
- Ioannou Pavlos
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- Irles Quiles Adrian
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- Ishino Masaya
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- Istin Serhat
- Iturbe Ponce Julia Mari
- Iuppa Roberto
- Ivarsson Jenny
- Iwanski Wieslaw
- Iwasaki Hiroyuki
- Izen Joseph
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- Jabbar Samina
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- Jaekel Martin
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- Jennens David
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- Jeske Carl
- Ji Haoshuang
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- Jiggins Stephen
- Jimenez Pena Javier
- Jin Shan
- Jinaru Adam
- Jinnouchi Osamu
- Joergensen Morten Dam
- Johansson Per
- Johns Kenneth
- Jon-And Kerstin
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- Jovicevic Jelena
- Ju Xiangyang
- Jung Christian
- Jussel Patrick
- Juste Rozas Aurelio
- Jézéquel Stéphane
- Kaci Mohammed
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- Kagan Michael
- Kahn Sebastien
- Kajomovitz Enrique
- Kalderon Charles Wi
- Kama Sami
- Kamenshchikov Andrey
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- Sfiligoj Tina
- Sforza Federico
- Sfyrla Anna
- Shabalina Elizaveta
- Shamim Mansoora
- Shan Lianyou
- Shang Ruo-yu
- Shank James
- Shapiro Marjorie
- Shatalov Pavel
- Shaw Kate
- Shaw Savanna Ma
- Shcherbakova Anna
- Shehu Ciwake Yus
- Sherwood Peter
- Shi Liaoshan
- Shimizu Shima
- Shimmin Chase Owen
- Shimojima Makoto
- Shiyakova Mariya
- Shmeleva Alevtina
- Shoaleh Saadi Diane
- Shochet Mel
- Shojaii Seyedruhol
- Shrestha Suyog
- Shulga Evgeny
- Shupe Michael
- Shushkevich Stanislav
- Sicho Petr
- Sidebo Per Edvin
- Sidiropoulou Ourania
- Sidorov Dmitri
- Sidoti Antonio
- Siegert Frank
- Sijacki Djordje
- Silva José
- Silver Yiftah
- Silverstein Samuel
- Simak Vladislav
- Simard Olivier
- Simic Ljiljana
- Simion Stefan
- Simioni Eduard
- Simmons Brinick
- Simon Dorian
- Simoniello Rosa
- Sinervo Pekka
- Sinev Nikolai
- Sioli Maximilian
- Siragusa Giovanni
- Sisakyan Alexei
- Sivoklokov Serguei
- Sjursen Therese
- Sjölin Jörgen
- Skinner Malcolm Br
- Skottowe Hugh Phili
- Skubic Patrick
- Slater Mark
- Slavicek Tomas
- Slawinska Magdalena
- Sliwa Krzysztof
- Smakhtin Vladimir
- Smart Ben
- Smestad Lillian
- Smirnov Sergei
- Smirnov Yury
- Smirnova Lidia
- Smirnova Oxana
- Smith Matthew
- Smith Russell
- Smizanska Maria
- Smolek Karel
- Snesarev Andrei
- Snidero Giacomo
- Snyder Scott
- Sobie Randall
- Socher Felix
- Soffer Abner
- Soh Dart-yin
- Solans Carlos
- Solar Michael
- Solc Jaroslav
- Soldatov Evgeny
- Soldevila Urmila
- Solodkov Alexander
- Soloshenko Alexei
- Solovyanov Oleg
- Solovyev Victor
- Sommer Philip
- Song Hong Ye
- Soni Nitesh
- Sood Alexander
- Sopczak Andre
- Sopko Bruno
- Sopko Vit
- Sorin Veronica
- Sosa David
- Sosebee Mark
- Sotiropoulou Calliope L
- Soualah Rachik
- Soukharev Andrey
- South David
- Sowden Benjamin
- Spagnolo Stefania
- Spalla Margherita
- Spanò Francesco
- Spearman William Ro
- Sperlich Dennis
- Spettel Fabian
- Spighi Roberto
- Spigo Giancarlo
- Spiller Laurence A
- Spousta Martin
- Spreitzer Teresa
- St Denis Richard Da
- Staerz Steffen
- Stahlman Jonathan
- Stamen Rainer
- Stamm Soren
- Stanecka Ewa
- Stanescu Cristian
- Stanescu-Bellu Madalina
- Stanitzki Marcel Mic
- Stapnes Steinar
- Starchenko Evgeny
- Stark Jan
- Staroba Pavel
- Starovoitov Pavel
- Staszewski Rafal
- Stavina Pavel
- Steinberg Peter
- Stelzer Bernd
- Stelzer Harald Joe
- Stelzer-Chilton Oliver
- Stenzel Hasko
- Stewart Graeme
- Stillings Jan Andre
- Stockton Mark
- Stoebe Michael
- Stoicea Gabriel
- Stolte Philipp
- Stonjek Stefan
- Stradling Alden
- Straessner Arno
- Stramaglia Maria Elen
- Strandberg Jonas
- Strandberg Sara
- Strandlie Are
- Strauss Emanuel
- Strauss Michael
- Strizenec Pavol
- Strom David
- Stroynowski Ryszard
- Strubig Antonia
- Ströhmer Raimund
- Stucci Stefania A
- Stugu Bjarne
- Styles Nicholas A
- Su Dong
- Su Jun
- Subramaniam Rajivaloch
- Succurro Antonella
- Sugaya Yorihito
- Suhr Chad
- Suk Michal
- Sulin Vladimir
- Sultansoy Saleh
- Sumida Toshi
- Sun Siyuan
- Sun Xiaohu
- Sundermann Jan Erik
- Suruliz Kerim
- Susinno Giancarlo
- Sutton Mark
- Suzuki Shota
- Svatos Michal
- Swedish Stephen
- Swiatlowski Maximilian
- Sykora Ivan
- Sykora Tomas
- Sánchez Javier
- Ta Duc
- Taccini Cecilia
- Tackmann Kerstin
- Taenzer Joe
- Taffard Anyes
- Tafirout Reda
- Taiblum Nimrod
- Takai Helio
- Takashima Ryuichi
- Takeda Hiroshi
- Takeshita Tohru
- Takubo Yosuke
- Talby Mossadek
- Talyshev Alexey
- Tam Jason
- Tan Kong Guan
- Tanaka Junichi
- Tanaka Reisaburo
- Tanaka Shuji
- Tannenwald Benjamin B
- Tannoury Nancy
- Tapprogge Stefan
- Tarem Shlomit
- Tarrade Fabien
- Tartarelli Giuseppe F
- Tas Petr
- Tasevsky Marek
- Tashiro Takuya
- Tassi Enrico
- Tavares Delgado Ademar
- Tayalati Yahya
- Taylor Frank
- Taylor Geoffrey
- Taylor Wendy
- Teischinger Florian Al
- Teixeira Dias Castanheira Matilde
- Teixeira-Dias Pedro
- Temming Kim Katrin
- Ten Kate Herman
- Teng Ping-Kun
- Teoh Jia Jian
- Tepel Fabian-Phi
- Terada Susumu
- Terashi Koji
- Terron Juan
- Terzo Stefano
- Testa Marianna
- Teuscher Richard
- Theveneaux-Pelzer Timothée
- Thomas Juergen
- Thomas-Wilsker Joshuha
- Thompson Emily
- Thompson Paul
- Thompson Ray
- Thompson Stan
- Thomsen Lotte Ansg
- Thomson Evelyn
- Thomson Mark
- Thun Rudolf
- Tibbetts Mark James
- Ticse Torres Royer Edso
- Tikhomirov Vladimir
- Tikhonov Yury
- Timoshenko Sergey
- Tiouchichine Elodie
- Tipton Paul
- Tisserant Sylvain
- Todome Kazuki
- Todorov Theodore
- Todorova-Nova Sharka
- Tojo Junji
- Tokushuku Katsuo
- Tokár Stanislav
- Tollefson Kirsten
- Tolley Emma
- Tomlinson Lee
- Tomoto Makoto
- Tompkins Lauren
- Toms Konstantin
- Torrence Eric
- Torres Heberth
- Torró Pastor Emma
- Toth Jozsef
- Touchard Francois
- Tovey Daniel
- Trefzger Thomas
- Tremblet Louis
- Tricoli Alessandro
- Trigger Isabel Mar
- Trincaz-Duvoid Sophie
- Tripiana Martin
- Trischuk William
- Trocmé Benjamin
- Troncon Clara
- Trottier-McDonald Michel
- Trovatelli Monica
- True Patrick
- Truong Loan
- Trzebinski Maciej
- Trzupek Adam
- Tsarouchas Charilaos
- Tseng Jeffrey
- Tsiareshka Pavel
- Tsionou Dimitra
- Tsipolitis Georgios
- Tsirintanis Nikolaos
- Tsiskaridze Shota
- Tsiskaridze Vakhtang
- Tskhadadze Edisher
- Tsukerman Ilya
- Tsulaia Vakhtang
- Tsuno Soshi
- Tsybychev Dmitri
- Tudorache Alexandra
- Tudorache Valentina
- Tuna Alexander
- Tupputi Salvatore
- Turchikhin Semen
- Turecek Daniel
- Turra Ruggero
- Turvey Andrew Joh
- Tuts Michael
- Tykhonov Andrii
- Tylmad Maja
- Tyndel Mike
- Ueda Ikuo
- Ueno Ryuichi
- Ughetto Michael
- Ugland Maren
- Uhlenbrock Mathias
- Ukegawa Fumihiko
- Unal Guillaume
- Undrus Alexander
- Unel Gokhan
- Ungaro Francesca
- Unno Yoshinobu
- Unverdorben Christophe
- Urban Jozef
- Urquijo Phillip
- Urrejola Pedro
- Usai Giulio
- Usanova Anna
- Vacavant Laurent
- Vacek Vaclav
- Vachon Brigitte
- Valderanis Chrysostom
- Valencic Nika
- Valentinetti Sara
- Valero Alberto
- Valery Loic
- Valkar Stefan
- Valladolid Gallego Eva
- Vallecorsa Sofia
- Valls Ferrer Juan Anton
- Van Den Wollenberg Wouter
- Van Der Deijl Pieter
- van der Geer Rogier
- van der Graaf Harry
- Van Der Leeuw Robin
- van Eldik Niels
- van Gemmeren Peter
- Van Nieuwkoop Jacobus
- van Vulpen Ivo
- van Woerden Marius Cor
- Vanadia Marco
- Vandelli Wainer
- Vanguri Rami
- Vaniachine Alexandre
- Vannucci Francois
- Vardanyan Gagik
- Vari Riccardo
- Varnes Erich
- Varol Tulin
- Varouchas Dimitris
- Vartapetian Armen
- Varvell Kevin
- Vazeille Francois
- Vazquez Schroeder Tamara
- Veatch Jason
- Veloce Laurelle M
- Veloso Filipe
- Velz Thomas
- Veneziano Stefano
- Ventura Andrea
- Ventura Daniel
- Venturi Manuela
- Venturi Nicola
- Venturini Alessio
- Vercesi Valerio
- Verducci Monica
- Verkerke Wouter
- Vermeulen Jos
- Vest Anja
- Vetterli Michel
- Viazlo Oleksandr
- Vichou Irene
- Vickey Boeriu Oana Elena
- Vickey Trevor
- Viehhauser Georg
- Viel Simon
- Vigne Ralph
- Villa Mauro
- Villaplana Perez Miguel
- Vilucchi Elisabetta
- Vincter Manuella
- Vinogradov Vladimir
- Vivarelli Iacopo
- Vives Vaque Francesc
- Vlachos Sotirios
- Vladoiu Dan
- Vlasak Michal
- Vogel Marcelo
- Vokac Petr
- Volpi Guido
- Volpi Matteo
- von der Schmitt Hans
- von Radziewski Holger
- von Toerne Eckhard
- Vorobel Vit
- Vorobev Konstantin
- Vos Marcel
- Voss Rudiger
- Vossebeld Joost
- Vranjes Milosavljevic Marija
- Vranjes Nenad
- Vrba Vaclav
- Vreeswijk Marcel
- Vuillermet Raphael
- Vukotic Ilija
- Vykydal Zdenek
- Wagner Peter
- Wagner Wolfgang
- Wahlberg Hernan
- Wahrmund Sebastian
- Wakabayashi Jun
- Walder James
- Walker Rodney
- Walkowiak Wolfgang
- Wang Chao
- Wang Fuquan
- Wang Haichen
- Wang Hulin
- Wang Jike
- Wang Jin
- Wang Kuhan
- Wang Rui
- Wang Song-Ming
- Wang Tan
- Wang Tingting
- Wang Xiaoxiao
- Wanotayaroj Chaowaroj
- Warburton Andreas
- Ward Patricia
- Wardrope David Robe
- Warsinsky Markus
- Washbrook Andrew
- Wasicki Christoph
- Watkins Peter
- Watson Alan
- Watson Ian
- Watson Miriam
- Watts Gordon
- Watts Stephen
- Waugh Ben
- Webb Samuel
- Weber Michele
- Weber Stefan Wol
- Webster Jordan S
- Weidberg Anthony
- Weinert Benjamin
- Weingarten Jens
- Weiser Christian
- Weits Hartger
- Wells Phillippa
- Wenaus Torre
- Wengler Thorsten
- Wenig Siegfried
- Wermes Norbert
- Werner Matthias
- Werner Per
- Wessels Martin
- Wetter Jeffrey
- Whalen Kathleen
- Wharton Andrew Mar
- White Andrew
- White Martin
- White Ryan
- White Sebastian
- Whiteson Daniel
- Wickens Fred
- Wiedenmann Werner
- Wielers Monika
- Wienemann Peter
- Wiglesworth Craig
- Wiik-Fuchs Liv Antje
- Wildauer Andreas
- Wilkens Henric Geo
- Williams Hugh
- Williams Sarah
- Willis Christophe
- Willocq Stephane
- Wilson Alan
- Wilson John
- Wingerter-Seez Isabelle
- Winklmeier Frank
- Winter Benedict T
- Wittgen Matthias
- Wittkowski Josephine
- Wollstadt Simon Jako
- Wolter Marcin Wla
- Wolters Helmut
- Wosiek Barbara
- Wotschack Jorg
- Woudstra Martin
- Wozniak Krzysztof
- Wu Mengqing
- Wu Miles
- Wu Sau Lan
- Wu Xin
- Wu Yusheng
- Wyatt Terry Rich
- Wynne Benjamin
- Xella Stefania
- Xu Da
- Xu Lailin
- Yabsley Bruce
- Yacoob Sahal
- Yakabe Ryota
- Yamada Miho
- Yamaguchi Yohei
- Yamamoto Akira
- Yamamoto Shimpei
- Yamanaka Takashi
- Yamauchi Katsuya
- Yamazaki Yuji
- Yan Zhen
- Yang Haijun
- Yang Hongtao
- Yang Yi
- Yao Weiming
- Yasu Yoshiji
- Yatsenko Elena
- Yau Wong Kaven Henr
- Ye Jingbo
- Ye Shuwei
- Yeletskikh Ivan
- Yen Andy L
- Yildirim Eda
- Yorita Kohei
- Yoshida Rikutaro
- Yoshihara Keisuke
- Young Charles
- Young Christophe
- Youssef Saul
- Yu David Ren-
- Yu Jaehoon
- Yu Jiaming
- Yu Jie
- Yuan Li
- Yuen Stephanie
- Yurkewicz Adam
- Yusuff Imran
- Zabinski Bartlomiej
- Zaidan Remi
- Zaitsev Alexander
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanello Lucia
- Zanzi Daniele
- Zeitnitz Christian
- Zeman Martin
- Zemla Andrzej
- Zengel Keith
- Zenin Oleg
- Zerwas Dirk
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhong Jiahang
- Zhou Bing
- Zhou Chen
- Zhou Lei
- Zhou Li
- Zhou Ning
- Zhu Cheng Guan
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- zur Nedden Martin
- Zurzolo Giovanni
- Zwalinski Lukasz
- Åkesson Torsten Pa
- Åsman Barbro
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/10/2015
- Field of study
Interessenverbaende in den neuen Bundeslaendern
- Author
- Publication venue
- Publication date
- 01/01/1992
- Field of study
UuStB Koeln(38)-930106697 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman
Citizens' United? A Comparison of Constitutional Concepts in U.S. and German Law: Market, State, and Constitution (Rechtsvergleichung der Erfassungsbegriffen im Deutschen und U.S. Recht: Markt, Staat, Verfassung)
- Author
- Art
- Ashvroft V Al-Kidd
- Barber
- Barber Dazu
- Basedow
- Basedow
- Blackstone
- Bspw
- Bspw
- Bspw
- Bspw
- Catharine Mackinnon
- Chris Leggett
- Dall
- Edward Bloustein
- Edward J Eberle�
- Eric Allen Engle
- Eric Engle
- Eric Engle
- Eugh
- Ferguson V Skrupa
- Furman V
- Gloy / Leistner
- Gregg V Georgia
- Herbert Hart
- Hoerster Jus
- Jacobson V Massachusetts
- Klaus/Martina Schubert
- Krishnamurthy Sriramesh
- L Ed
- L Ed
- L Ed
- Lochner
- Lochner
- Locke
- Magna Charta
- Martin V Hunter
- Martin V Hunter
- Michael Wachter
- Miloszewski V Sears
- Munn V. Illinois
- N Bmw
- Nathan Goetting
- Nathan Goetting
- Neil Buckley
- Nikomachische Aristotles
- Njw Bverfg
- Njw Bverfg
- Ovg Koblenz
- Perry V Sinderman
- Richard Posner
- Roberts V
- Ronald The Coase
- Schink Pieroth
- Schink Pieroth
- Schink Pieroth
- Schink Pieroth
- Schlink Pieroth
- Schmerber V California
- Steven Shavell
- Steven Shavell
- Sungjoon Bspw
- Tennessee V Lane
- Tonia / Phil Novitz
- Vanhorne&apos
- Wirtschaftsneutralit�t Dazu
- Wolf Sauter
- Wolf Sauter
- Woody Clermont
- Youngjin / Qian Jung
- Z B
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
Bildung und subjektives Wohlbefinden im Zeitverlauf, 1984–2002. Eine Mehrebenenanalyse
- Author
- Abel Thomas
- Alexander Grob
- Andreas Hadjar
- Andrew J. Oswald
- Anthony S. Bryk
- Argyle Michael
- Baier Dirk
- Blossfeld Hans-Peter
- Borchelt Markus
- Braun Michael
- Bruno S. Frey
- Bürklin Wilhelm
- Büschges Günther
- Campbell Angus
- Clark Andrew
- De Leeuw Jan
- Dehlinger Erwin
- Di Tella Rafael
- Diener Ed
- Diener Ed
- Engel Uwe
- Ferraro Kenneth
- Festinger Leon
- Frank M. Andrews
- Frank Schubert
- Gary S. Becker
- Geiger Theodor
- Glatzer Wolfgang
- Hadjar Andreas
- Hadjar Andreas
- Hanefeld Ute
- James J. Jaccard
- James S. Coleman
- Klein Markus
- Klein Thomas
- Klein Thomas
- Klemm Klaus
- Krause Peter
- Kreft Ita
- Langer Wolfgang
- Markovsky Barry
- Mayer Karl Ulrich
- Mayer Karl Ulrich
- Mayer Karl Ulrich
- Mohr Hans-Michael
- Müller Walter
- Noll Heinz-Herbert
- Norman B. Ryder
- Norman M. Bradburn
- Norval D. Glenn
- Ormel Johan
- Philipp A. Mayring
- Plum Wolfgang
- Rippl Susanne
- Rolf Becker
- Ronald Inglehart
- Ronald Inglehart
- Sabine Lang
- Schneider Sven
- Schwarz Norbert
- Siegwart Lindenberg
- Sigrid Haunberger
- Solga Heike
- Spellerberg Anette
- Ted R. Gurr
- Terwey Michael
- Tom A.B. Snijders
- Tuma Nancy Brandon
- Veenhoven Ruut
- Veenhoven Ruut
- Veenhoven Ruut
- Wagner Michael
- Walter G. Runciman
- Walter G. Stephan
- William R. Klecka
- William S. Robinson
- Wilson Warner
- Winkelmann Liliana
- Wolfgang Glatzer
- Publication venue
- Publication date
- 01/01/2008
- Field of study
Diese Analyse des subjektiven Wohlbefindens verfolgt zwei Ziele. Zum einen wird die Entwicklung des subjektiven Wohlbefindens über die Periode zwischen 1984 und 2002 untersucht. Dabei werden Alters-, Perioden- und Kohorteneffekte simultan betrachtet. Als soziale Mechanismen hinter den Wandlungsprozessen, das heißt als Prädiktoren für das subjektive Wohlbefinden und die Variation im Zeitverlauf, werden Bildung und Bildungsexpansion thematisiert und in die Analysemodelle eingeführt. Um die Lebenszufriedenheit unabhängig von gesundheitlichen Aspekten zu untersuchen, wird die Gesundheitszufriedenheit kontrolliert. Methodisch folgt der Beitrag einem Mehrebenenansatz. Zur Datenanalyse werden Hierarchisch Lineare Modelle (HLM) herangezogen. Detailliert wird auf die benötigte Datenstruktur, die Anwendbarkeit und die Parameter-Schätzungen von HLM eingegangen. Die Datengrundlage bildet das Sozio-Ökonomische Panel (SOEP), wobei nur die Teil-Stichprobe der Westdeutschen in die Analyse einbezogen wird. In den Resultaten zeigen sich – neben einem starken Einfluss der Gesundheitszufriedenheit – u. a. robuste Bildungseffekte, ein substanzieller Alterseffekt und ein schwacher negativer Kohorteneffekt auf die Lebenszufriedenheit
Education and Subjective Well-Being in Temporal Perspective, 1984-2002:
- Author
- Abel Thomas
- Alexander Grob
- Andreas Hadjar
- Andrew J. Oswald
- Anthony S. Bryk
- Argyle Michael
- Baier Dirk
- Blossfeld Hans-Peter
- Borchelt Markus
- Braun Michael
- Bruno S. Frey
- Bürklin Wilhelm
- Büschges Günther
- Campbell Angus
- Clark Andrew
- De Leeuw Jan
- Dehlinger Erwin
- Di Tella Rafael
- Diener Ed
- Diener Ed
- Engel Uwe
- Ferraro Kenneth
- Festinger Leon
- Frank M. Andrews
- Frank Schubert
- Gary S. Becker
- Geiger Theodor
- Glatzer Wolfgang
- Hadjar Andreas
- Hadjar Andreas
- Hanefeld Ute
- James J. Jaccard
- James S. Coleman
- Klein Markus
- Klein Thomas
- Klein Thomas
- Klemm Klaus
- Krause Peter
- Kreft Ita
- Langer Wolfgang
- Markovsky Barry
- Mayer Karl Ulrich
- Mayer Karl Ulrich
- Mayer Karl Ulrich
- Mohr Hans-Michael
- Müller Walter
- Noll Heinz-Herbert
- Norman B. Ryder
- Norman M. Bradburn
- Norval D. Glenn
- Ormel Johan
- Philipp A. Mayring
- Plum Wolfgang
- Rippl Susanne
- Rolf Becker
- Ronald Inglehart
- Ronald Inglehart
- Sabine Lang
- Schneider Sven
- Schwarz Norbert
- Siegwart Lindenberg
- Sigrid Haunberger
- Solga Heike
- Spellerberg Anette
- Ted R. Gurr
- Terwey Michael
- Tom A.B. Snijders
- Tuma Nancy Brandon
- Veenhoven Ruut
- Veenhoven Ruut
- Veenhoven Ruut
- Wagner Michael
- Walter G. Runciman
- Walter G. Stephan
- William R. Klecka
- William S. Robinson
- Wilson Warner
- Winkelmann Liliana
- Wolfgang Glatzer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
From Preadipocyte to Adipocyte: Differentiation-Directed Signals of Insulin from the Cell Surface to the Nucleus
- Author
- Abel ED
- Ailhaud G
- Alexander Sorisky
- Amri EZ
- Andjelkovic M
- Baldo A
- Benito M
- Benjamin WB
- Birnboim MJ
- Bouchard C
- Bray GA.
- Carpenter CL
- Carraro R
- Cheatham B
- Dani C
- de Groot RP
- Demora J
- Dhand R
- Dhand R
- Eckel RH
- Eckel RH.
- Entenmann G
- Faust IM
- Franke TF
- Franke WW
- Gaillard D
- Hall A.
- Hall A.
- Hauner H.
- Hawkins PT
- Hirsch J
- Hsueh W
- Hu E
- Ignotz RA
- Ignotz RA
- Irvine RF.
- Jr Frederich RC
- Jr Myers MG
- Juhan-Vague I
- Kim SJ
- Klaus S.
- Kletzien RF
- Klippel A
- Kohn AD
- Konishi H
- Konishi H
- Kuczmarski RJ Flegal KM, Campbell SM, et al. Increasing prevalence of overweight among US adults. The National Health and Nutrition Surveys
- Kuri-Harcuch W
- Lam K
- Lehmann JM
- Macdonald SM
- Magun R
- Marte BM
- Novikoff AB
- Ochi M
- Olefsky JM.
- Porras A
- Porras A
- Poznanski WJ
- Radeau T
- Reaven GM.
- Reginato MJ
- Regulating Downward J.
- Roncari DAK.
- Rubin CS
- Saad MJA
- Sale EM
- Schubert C
- Shen GX
- Shepherd PR
- Shillabeer G
- Shimabukuro M
- Sigal RJ
- Smith PJ
- Sorisky A
- Spiegelman BM
- Stephens LR
- Sugihara H
- The Sos Bar-Sagi D.
- Ui M
- Van RLR
- Wang N
- Wijkander J
- Wu Z
- Yeh WC
- Zachwieja JJ.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Systemlehre und Pflanzengeographie
- Author
- A Ade
- A Ade
- A Andersen
- A Bauhin
- A Becherer
- A Boros
- A Boros
- A Bouroz
- A Buschmann
- A Carozzi
- A Carozzi
- A Eisenalk
- A Eisenalk
- A Engler
- A Ensgraber
- A Fietz
- A Fischer
- A Gemmell
- A Gustafsson
- A Gustavsson
- A Gärtner
- A Hoff
- A Huger
- A Kaestner
- A Lawalrée
- A Lawalrée
- A Löve
- A Löve
- A Löve
- A Löve
- A Mayr
- A Morgen
- A Munk
- A Müntzing
- A Nocuchi
- A Nygren
- A Oppermann
- A Papp
- A Pascher
- A Pascher
- A Pascher
- A Pisek
- A Pisek
- A Pisek
- A Plessl
- A Pochmann
- A Printz
- A Rieth
- A Robyns
- A Rodôn
- A Rodôn
- A Rodôn
- A Rudzitis
- A Rühl
- A Schade
- A Schade
- A Schade
- A Schöntag
- A Sehnem
- A Straus
- A Straus
- A Trapp
- A Vaarama
- A Vietinghoff-Riesch
- A Zehnder
- AA Bullock
- AB Joly
- AG Winter
- AH Magnusson
- AH Magnusson
- AH Magnusson
- AH Magnusson
- AH Magnusson
- AJ Mix
- AJ Mix
- AL Cabrera
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- T Levring
- T Levring
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- T Lex
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- TB Diannelidis
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- TH Andersen
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- TH Delevoryas
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- TH Herzog
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- U Berger-Landefeldt
- U Berger-Landefeldt
- U Berger-Landefeldt
- U Horst
- U Horst
- U Rein
- V Erkamo
- V Grummann
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- V Tëckholm
- V Vareschi
- V Westhoff
- Vishnu-Mittre
- VN Sukacev
- VN Sukaev
- VP Maslov
- VS Kornilova
- W Baumeister
- W Baumeister
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- W Berger
- W Berger
- W Berger
- W Berger
- W Berger
- W Berger
- W Bublitz
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- W Kausch
- W Kausch
- W Klaus
- W Klaus
- W Klaus
- W Klaus
- W Klaus
- W Klaus
- W Kloft
- W Kloft
- W Koch
- W Koch
- W Kreh
- W Krutzsch
- W Krutzsch
- W Larchee
- W Lohmeyer
- W Lùdi
- W Lùdi
- W Lùdi
- W Meijer
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- W Remy
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- W Remy
- W Remy
- W Remy
- W Schmidt
- W Schmidt
- W Selle
- W Selle
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- W Steere
- W Steere
- W Steere
- W Steere
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- W Vlk
- W Vlk
- W Wagner
- W Watson
- W Watson
- W Weischet
- W Welch
- W Wettstein
- W Wetzel
- W Wetzel
- W Wetzel
- W Wetzel
- W Wiedmann
- W Zeidler
- W Zeist
- W Zeist
- W Zimmermann
- W Zimmermann
- W Zimmermann
- W Zimmermann
- WE Isaac
- WF Harris
- WG Chaloner
- WG Chaloner
- WG Chaloner
- WH Bradley
- WH Hodge
- WJ Jongmans
- WJ Jongmans
- WJ Jongmans
- WJ Jongmans
- WJ Koch
- WL Fry
- WN Edwards
- WN Stewart
- WS Lacey
- WS Lacey
- WS Lacey
- WW Umbreit
- Y Horikawa
- Y Ogura
- Y Ogura
- Z Slavnic
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1955
- Field of study
Literaturverzeichnis
- Author
- Abrahams Bradley
- Adam Konrad
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- Field of study
Second asymptomatic carotid surgery trial (ACST-2) : a randomised comparison of carotid artery stenting versus carotid endarterectomy
- Author
- \u160ercl Miroslav
- \u160koloud\uedk David
- \u160tekl\ue1cov\ue1 Anna
- Abd-Allah Foad
- Abdul-Hamiq Ahmed
- Abdulamit Timur
- Accrocca Federico
- Acosta Stefan
- Ahlhelm Frank J
- Aidashova Balzhan
- Akyea-Mensah Joyce
- Albuquerque e Castro Jo\ue3o
- Aleksic Nikola
- Allaire Eric
- Almekhlafi Mohammed A
- Alonso Angelika
- Alves Gon\ue7alo
- Alwis Lanka
- Amatucci Giovanni
- Ambrogi Cesare
- Amis Deborah
- Anderson Dawn
- Andonova Silva
- Andziak Piotr
- Angiletta Domenico
- Angus Jane
- Antonopoulos Constantine N
- Aparici Robles Fernando
- Argentieri Angelo
- Arnold Sebastian
- Ashleigh Ray
- Ashley Simon
- Asokanathan Asaipillai
- Astarci Parla
- Babic Srdan
- Bachvarov Chavdar
- Baht Hardeep
- Bajardi Guido
- Bajoriene Milda
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- Bal Simerpreet
- Ball Stephen
- Balogun Ibrahim
- Barbazza Renzo
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- Barer David
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- Bartko Daniel
- Barwell James
- Barz\uf3 P\ue1l
- Bastos Gon\ue7alves Frederico
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- Blanes Orti Paula
- Bodosi Mihaly
- Bombic Martin
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- Zimmermann Alexander
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- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background: Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-term protective effects requires large-scale randomised evidence.
Methods: ACST-2 is an international multicentre randomised trial of CAS versus CEA among asymptomatic patients with severe stenosis thought to require intervention, interpreted with all other relevant trials. Patients were eligible if they had severe unilateral or bilateral carotid artery stenosis and both doctor and patient agreed that a carotid procedure should be undertaken, but they were substantially uncertain which one to choose. Patients were randomly allocated to CAS or CEA and followed up at 1 month and then annually, for a mean 5 years. Procedural events were those within 30 days of the intervention. Intention-to-treat analyses are provided. Analyses including procedural hazards use tabular methods. Analyses and meta-analyses of non-procedural strokes use Kaplan-Meier and log-rank methods. The trial is registered with the ISRCTN registry, ISRCTN21144362.
Findings: Between Jan 15, 2008, and Dec 31, 2020, 3625 patients in 130 centres were randomly allocated, 1811 to CAS and 1814 to CEA, with good compliance, good medical therapy and a mean 5 years of follow-up. Overall, 1% had disabling stroke or death procedurally (15 allocated to CAS and 18 to CEA) and 2% had non-disabling procedural stroke (48 allocated to CAS and 29 to CEA). Kaplan-Meier estimates of 5-year non-procedural stroke were 2·5% in each group for fatal or disabling stroke, and 5·3% with CAS versus 4·5% with CEA for any stroke (rate ratio [RR] 1·16, 95% CI 0·86-1·57; p=0·33). Combining RRs for any non-procedural stroke in all CAS versus CEA trials, the RR was similar in symptomatic and asymptomatic patients (overall RR 1·11, 95% CI 0·91-1·32; p=0·21).
Interpretation: Serious complications are similarly uncommon after competent CAS and CEA, and the long-term effects of these two carotid artery procedures on fatal or disabling stroke are comparable