Relato de experiência do Pibid química do Colégio Estadual Professora Elzira Correa de Sá

Anais do II Seminário Seminário Estadual PIBID do Paraná: tecendo saberes / organizado por Dulcyene Maria Ribeiro e Catarina Costa Fernandes — Foz do Iguaçu: Unioeste; Unila, 2014O presente trabalho relata algumas das experiências vivenciadas e atividades desenvolvidas pelos pibidianos, na visão de um bolsista do PIBID do curso de Licenciatura em Química, realizado no Colégio Estadual Professora Elzira Correa de Sá, no período de abril a setembro de 2014. Algumas das atividades desenvolvidas pelos pibidianos foram oficinas sobre o tema "doping no esporte" e "história do colégio Elzira". Os bolsistas também realizaram o reconhecimento da realidade escolar e ministraram aulas de diferentes conteúdos de Química, utilizando a experimentação e outras metodologias de ensino. As atividades desenvolvidas proporcionaram um contato mais direto do licenciando com a realidade escolar e auxiliaram na formação desses futuros professore

Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease

AbstractOxidative stress and endoplasmic reticulum (ER) stress have been associated with Alzheimer's disease (AD) progression. In this study we analyzed whether oxidative stress involving changes in Nrf2 and ER stress may constitute early events in AD pathogenesis by using human peripheral blood cells and an AD transgenic mouse model at different disease stages. Increased oxidative stress and increased phosphorylated Nrf2 (p(Ser40)Nrf2) were observed in human peripheral blood mononuclear cells (PBMCs) isolated from individuals with mild cognitive impairment (MCI). Moreover, we observed impaired ER Ca2+ homeostasis and increased ER stress markers in PBMCs from MCI individuals and mild AD patients. Evidence of early oxidative stress defense mechanisms in AD was substantiated by increased p(Ser40)Nrf2 in 3month-old 3xTg-AD male mice PBMCs, and also with increased nuclear Nrf2 levels in brain cortex. However, SOD1 protein levels were decreased in human MCI PBMCs and in 3xTg-AD mice brain cortex; the latter further correlated with reduced SOD1 mRNA levels. Increased ER stress was also detected in the brain cortex of young female and old male 3xTg-AD mice. We demonstrate oxidative stress and early Nrf2 activation in AD human and mouse models, which fails to regulate some of its targets, leading to repressed expression of antioxidant defenses (e.g., SOD-1), and extending to ER stress. Results suggest markers of prodromal AD linked to oxidative stress associated with Nrf2 activation and ER stress that may be followed in human peripheral blood mononuclear cells

Effects of different types of verbal encouragement on ankle force and muscle activity

The aim of this study is to investigate (i) the effect of live and recorded verbal encouragement on muscle activity and ankle force; (ii) the effect of communication/extroversion on the variables; (iii) the reliability intra and inter examiners of the variables. Twenty healthy-youngers were assessed by surface electromyography of tibialis anterior and ankle flexion force by an ergometer twice, with one week apart. No difference was found between ankle force (p = 0.373) and root mean square values (RMS) (p = 0.207) for any of the conditions assessed on day 1 nor between examiners 1 and 2 for both live and recorded conditions in RMS (p = 0.207) and force (p = 0.373). Between the 1st and 7th days, there were no differences for any of the conditions on RMS (main effect “Day” p = 0.261, “condition” p = 0.568, interaction p = 0.936) or force (main effect“Day” p = 0.889, “condition” p = 0.781, interaction p = 0.961). Intraclass correlation coefficients (ICCs) for the ankle force were, for without verbal encouragement (ICC2, k = 0.880), live verbal encouragement of examiner 1 (ICC2, k = 0.870), and recorded verbal encouragement of examiner 1 (ICC2, k = 0.920). RMS without verbal encouragement condition (ICC2, k = 0.860), live verbal encouragement of examiner 1 (ICC2, k = 0.930) and recorded verbal encouragement of examiner 1 (ICC2, k = 0.920). Reproducibility between the two examiner’s live encouragements for ankle force (ICC3, k = 0.981) and RMS (ICC3, k = 0.920). There was no effect of the presence or type of the augmented feedback in RMS and ankle force. We conclude that verbal encouragement does not influence ankle torque or muscle activity and there is good to excellent intra and inter rater reliability for subjects’ performance regardless of verbal encouragement modality. In addition, we observed that psychological traits Communication and Emotional stability does not affect the subjects’ strength performance at the ankle

European Red List of Trees

The European Red List is a review of the status of European species according to IUCN regional Red Listing guidelines. It identifies those species that are threatened with extinction at the regional level – in order that appropriate conservation action can be taken to improve their status. This publication summarises results for all Europe’s native species of tree (454 species), of which 265 species (over 58%) are endemic to continental Europe, with 56% (252 species) endemic to the 28 EU Member States. Of these, 168 (42%) of the species are threatened with extinction at the European level, however, for 57 species (nearly 13%) there was insufficient information to assign a conservation status, and are therefore classified as Data Deficient, and in need of further research. The main threat to tree species in Europe has been identified as invasive or problematic species, impacting 38% of tree species, followed by deforestation and wood harvesting, and urban development (both affecting 20% of tree species). For threatened species, livestock farming, land abandonment, changes in forest and woodland management, and other ecosystem modifications such as fire are the major threats, impacting the survival of trees.Peer reviewe

Transient Changes in Bacterioplankton Communities Induced by the Submarine Volcanic Eruption of El Hierro (Canary Islands)

Postprint4,411

Avaliação da intervenção cognitivo-comportamental em gestão do stress em pacientes com fadiga oncológica, em radioterapia

Apresentam-se os resultados relativos a padrões de regulação emocional, percepção e satisfação com o suporte social após intervenção cognitivo-comportamental em gestão do stress (IGSCC) em pacientes em radioterapia com fadiga oncológica. Compara-se o grupo de controlo (n=35 radioterapia sem IGSCC) e o grupo experimental (n=35 radioterapia com IGSCC) no início e fim do tratamento tendo em conta variáveis sociodemográficas, Escala de ansiedade, depressão e stress, Escala de perceção e satisfação com o suporte social e o Termómetro da emoção. No grupo experimental, após IGSCC, há descida significativa (p<.001) da ansiedade, depressão e stress e aumento da percepção e satisfação com o suporte social. No grupo de controlo há subida significativa (p<.001) da desregulação emocional (ansiedade, depressão e stress) e subida da insatisfação com o suporte social. Salienta-se a eficácia da IGSCC sobre estados emocionais e percepção e satisfação com o suporte social em pacientes em radioterapia e com fadiga oncológica

Simposio internacional. Trabajo infantil y su erradicación en el marco de la meta 8.7 de la agenda 2030. Cuestiones plurales

En esta obra se recogen las contribuciones del Simposio Internacional celebrado los días 9 y 10 de diciembre de 2021, dedicado a la erradicación del trabajo infantil, en el marco del Objetivo de Desarrollo Sostenible 8 de la Agenda 2030 de Naciones Unidas. A pesar de que ya existen normativas nacionales e internacional, que prohíben el trabajo infantil, especialmente en sus peores formas, hay tres ámbitos pendientes de desarrollo, que explicar que aún en 2022 haya 160 millones de niñas y niñas trabajando en el mundo. En efecto, la existencia de cadenas mundiales de suministro, los déficits de los sistemas de protección social, y la ausencia de igualdad efectiva por razón de género, con factores condicionantes de que la meta 8.7 (erradicación del trabajo infantil en 2025) no vaya a poder cumplirse. Referidas a todos estos ejes, la obra aglutina experiencias internacionales, en orden a construir un punto de partida de los futuros debates pendientes, en el ámbito de las ciencias sociales y las relaciones internacionales.El derecho penal económico como garante de los derechos humanos. Especialmente ante las peores formas de trabajo infantil y otras formas contemporáneas de esclavitud / Tania García Sedano : Este trabajo se enmarca en el Proyecto I+D La responsabilidad penal de empresas trasnacionales por violaciones a los derechos humanos y al medio ambiente (DER-2017-85144-C2), del Ministerio de Ciencia, Innovación y Universidades.Agradecimientos / Gema Quintero Lima (pp. 7-10). -- Prólogo / Eva María Blázquez Agudo (pp. 11-12). -- Trabajo infantil en América latina. Una perspectiva desde la experiencia brasileña = Child labor in latin america. A perspective from the brazilian experiences / Eugenio Santana Marques (pp. 13-32). -- El derecho penal económico como garante de los derechos humanos. Especialmente ante las peores formas de trabajo infantil y otras formas contemporáneas de esclavitud = Economic criminal law as a guarantor of human rights. Especially of the worst forms of child labor and other contemporary forms of slavery / Tania García Sedano (pp. 33-55). -- La eficacia de la norma argentina en la erradicación del trabajo infantil = The effectiveness of the argentine standard in the erradication of childs labor / Rodrigo Méndez Filleul (pp. 57-74). -- La responsabilidad social corporativa en una nueva fase para la sostenibilidad en las cadenas mundiales de suministro. Su relación con el trabajo infantil = Corporate social responsibility in a new phase for sustainability in global supply chains. Its relationship with child labor / Víctor Garrido Sotomayor e Isabel Boix Lluch (pp. 75-97). -- Empresas trasnacionales, derechos humanos y protección contra el trabajo infantil. De la responsabilidad social empresarial a la necesidad de aprobar un instrumento vinculante = Transnational corporations, human rights and protection against child labor. From corporate social responsibility to the need to adopt a binding instrument / Daniel Peres Díaz (pp. 99-139). -- Trayectorias educativas y trabajo de niñas, niños y adolescentes. Problemáticas en tensión en el marco de una relación compleja = Educational trajectories and child/adolescent labour. Issues in tension within the framework of a complex relationship / Anahí Julia Aizpuru, María Laura Raffo, Rosana Paz, Vanina Van Raap, Julieta Vera, María Marta Pregona (pp. 141-173). -- Las políticas de inclusión tecnológica educativa como mecanismo de lucha contra el trabajo infantil en Brasil = The policies of educational technological inclusion as a mechanism of lucha against child work in Brazil / Kátia Magalhães Arruda, Bruno Louis Maurice Guerard y Mariana Ferrucci Bega (pp. 175-196). -- Datos, retos y evidencias para poner fin al trabajo infantil desde un enfoque multidisciplinar y de género = Data, evidence and a multidisciplinary gender based approach to end child labour / Rocío Vicente Senra (pp. 197-208). -- Trabajo infantil en las actividades domésticas y de cuidado. Una mirada desde las brechas de género = Child labor in domestic and care activities. A look from the gender gaps / Anahí Julia Aizpuru, María Laura Raffo, Rosana Paz, Vanina Van Raap, Julieta Vera, María Marta Pregona (pp. 209-228). -- Trabajo infantil desde una perspectiva interseccional = Child labour from an intersectional perspective / Daniela Schneider (pp. 229-241). -- El trabajo infantil. Una respuesta desde el movimiento sindical = Child labor. A response from the trade union movement / Esther Caballé i Pallarès y Maribel Ayné Domingo (pp. 243-253)

Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort

Background: Pathological brain iron deposition has been implicated as a source of neurotoxic reactive oxygen species in Alzheimer (AD) and Parkinson diseases (PD). Iron metabolism is associated with the gene hemochromatosis (HFE Human genome nomenclature committee ID: 4886), and mutations in HFE are a cause of the iron mismetabolism disease, hemochromatosis. Several reports have tested the association of HFE variants with neurodegenerative diseases, such as AD and PD with conflicting results.Methods: Genotypes were analysed for the two most common variants of HFE in a series of 130 AD, 55 Mild Cognitive Impairment (MCI) and 132 PD patients. Additionally, a series of 115 healthy age-matched controls was also screened.Results: A statistically significant association was found in the PD group when compared to controls, showing that the presence of the C282Y variant allele may confer higher risk for developing the disease.Conclusion: Taken together these results suggest that the common variants in HFE may be a risk factor for PD, but not for AD in the Portuguese population

White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study

Frontotemporal dementia (FTD) is a heterogeneous group of neurodegenerative disorders with both sporadic and genetic forms. Mutations in the progranulin gene (GRN) are a common cause of genetic FTD, causing either a behavioural presentation or, less commonly, language impairment. Presence on T2-weighted images of white matter hyperintensities (WMH) has been previously shown to be more commonly associated with GRN mutations rather than other forms of FTD. The aim of the current study was to investigate the longitudinal change in WMH and the associations of WMH burden with grey matter (GM) loss, markers of neurodegeneration and cognitive function in GRN mutation carriers. 336 participants in the Genetic FTD Initiative (GENFI) study were included in the analysis: 101 presymptomatic and 32 symptomatic GRN mutation carriers, as well as 203 mutation-negative controls. 39 presymptomatic and 12 symptomatic carriers, and 73 controls also had longitudinal data available. Participants underwent MR imaging acquisition including isotropic 1 mm T1-weighted and T2-weighted sequences. WMH were automatically segmented and locally subdivided to enable a more detailed representation of the pathology distribution. Log-transformed WMH volumes were investigated in terms of their global and regional associations with imaging measures (grey matter volumes), biomarker concentrations (plasma neurofilament light chain, NfL, and glial fibrillary acidic protein, GFAP), genetic status (TMEM106B risk genotype) and cognition (tests of executive function). Analyses revealed that WMH load was higher in both symptomatic and presymptomatic groups compared with controls and this load increased over time. In particular, lesions were seen periventricularly in frontal and occipital lobes, progressing to medial layers over time. However, there was variability in the WMH load across GRN mutation carriers – in the symptomatic group 25.0% had none/mild load, 37.5% had medium and 37.5% had a severe load – a diffe

Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes

Introduction: Apathy adversely affects prognosis and survival of patients with frontotemporal dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is associated with cognitive decline and brain atrophy. Methods: Presymptomatic carriers of MAPT, GRN or C9orf72 mutations (N = 304), and relatives without mutations (N = 296) underwent clinical assessments and MRI at baseline, and annually for 2 years. Longitudinal changes in apathy, cognition, gray matter volumes, and their relationships were analyzed with latent growth curve modeling. Results: Apathy severity increased over time in presymptomatic carriers, but not in non-carriers. In presymptomatic carriers, baseline apathy predicted cognitive decline over two years, but not vice versa. Apathy progression was associated with baseline low gray matter volume in frontal and cingulate regions. Discussion: Apathy is an early marker of FTD-related changes and predicts a subsequent subclinical deterioration of cognition before dementia onset. Apathy may be a modifiable factor in those at risk of FTD