Programa de educación para la salud para el afrontamiento del embarazo en instituciones penitenciarias

El proceso de embarazo requiere aumento del cuidado y la atención especializada, dándose así un incremento de vulnerabilidad en la persona gestante que afecta a su calidad de vida. Esta afectación es mayor si se añade a la misma el encierro en medio penitenciario, el cual conlleva implícito: desigualdad entre géneros y etnias, mayor riesgo de patología física y mental, déficit de instalaciones adecuadas a sus necesidades, etc. Factores que afectan a una gran cantidad de población puesto que la población penitenciaria va en aumento y destacan los rangos de edad propios de la etapa fértil femenina.<br /

Transactive Response DNA-Binding Protein (TARDBP/TDP-43) Regulates Cell Permissivity to HIV-1 Infection by Acting on HDAC6

The transactive response DNA-binding protein (TARDBP/TDP-43) influences the processing of diverse transcripts, including that of histone deacetylase 6 (HDAC6). Here, we assessed TDP-43 activity in terms of regulating CD4+ T-cell permissivity to HIV-1 infection. We observed that overexpression of wt-TDP-43 increased both mRNA and protein levels of HDAC6, resulting in impaired HIV-1 infection independently of the viral envelope glycoprotein complex (Env) tropism. Consistently, using an HIV-1 Env-mediated cell-to-cell fusion model, the overexpression of TDP-43 levels negatively affected viral Env fusion capacity. Silencing of endogenous TDP-43 significantly decreased HDAC6 levels and increased the fusogenic and infection activities of the HIV-1 Env. Using pseudovirus bearing primary viral Envs from HIV-1 individuals, overexpression of wt-TDP-43 strongly reduced the infection activity of Envs from viremic non-progressors (VNP) and rapid progressors (RP) patients down to the levels of the inefficient HIV-1 Envs observed in long-term non-progressor elite controllers (LTNP-EC). On the contrary, silencing endogenous TDP-43 significantly favored the infectivity of primary Envs from VNP and RP individuals, and notably increased the infection of those from LTNP-EC. Taken together, our results indicate that TDP-43 shapes cell permissivity to HIV-1 infection, affecting viral Env fusion and infection capacities by altering the HDAC6 levels and associated tubulin-deacetylase anti-HIV-1 activity.This work is supported by the Spanish AIDS network “Red Temática Cooperativa de Investigación en SIDA” RD12/0017/0002, RD12/0017/0028, RD12/0017/0034, RD16/0025/0011, RDCIII16/0002/0005 and RD16/0025/0041 as part of the Plan Nacional R + D+I and co-funded by the Spanish “Instituto de Salud Carlos III (ISCIII)-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER)”. J.B. is a researcher from “Fundació Institut de Recerca en Ciències de la Salut Germans Trias i Pujol” supported by the Health Department of the Catalonian Government/Generalitat de Catalunya and ISCIII grant numbers PI17/01318 and PI20/00093 (to J.B.). Work in CC Lab was supported by grants SAF (2010-17226) and (2016-77894-R) from MINECO (Spain), FIS (PI 13/02269, ISCIII) and PI20/00093. Work in CF Lab was supported by the Cabildo Insular de Tenerife (grants CGIEU0000219140 and “Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19”); the agreement with the Instituto Tecnológico y de Energías Renovables (ITER) to strengthen scientific and technological education, training research, development and innovation in Genomics, Personalized Medicine and Biotechnology (grant number OA17/008). A.V.-F.’s Lab is supported by the European Regional Development Fund (ERDF), RTI2018-093747-B-100 (“Ministerio de Ciencia e Innovación”, Spain), “Ministerio de Ciencia, Innovación y Universidades” (Spain), ProID2020010093 (“Agencia Canaria de Investigación, Innovación y Sociedad de la Información” and European Social Fund), UNLL10-3E-783 (ERDF and “Fundación CajaCanarias”) and “SEGAI-ULL”. S.P-Y is funded by “Fundación Doctor Manuel Morales” (La Palma, Spain) and “Contrato Predoctoral Ministerio-ULL Formación de Doctores” (2019 Program) (“Ministerio de Ciencia, Innovación y Universidades”, Spain). R.C.-R. is funded by RD16/0025/0011 and ProID2020010093 (“Agencia Canaria de Investigación, Innovación y Sociedad de la Información” and European Social Fund). J.G.-L. is funded by the “Juan de la Cierva de Incorporación” Spanish Program (IJC2019-038902-I) (“Ayudas Juan de la Cierva de incorporación; Agencia Estatal de Investigación. Ministerio de Ciencia e Innovación”).S

Evaluation of health care systems and primary health care strategy

Objetivo: evaluar la calidad de los sistemas de salud y la estrategia de Atención Primaria de la Salud (APS) en distintas áreas geográficas del país. Método: estudio de corte transversal con abordaje metodológico triangular que involucró: a) encuestas a las personas que demandan la atención, b) entrevistas a referentes claves del equipo de salud y c) grupos focales con los equipos de salud. Los componentes de estructura, proceso y resultados de los sistemas de salud basados en APS se evaluaron por medio de indicadores específicos. Resultados: el análisis de la información muestra un déficit evidente de la integración del equipo profesional, principalmente en la actividad comunitaria y social, la carencia de normativas adecuadas y problemas de accesibilidad estructural para población discapacitada. Se destaca, además, el alto porcentaje de personal que desconoce los programas en ejecución dentro de la institución, así como la falta de un sistema de información adecuado sobre la población del área y de registros de los procesos de gestión en la mayoría de las unidades analizadas. Conclusión: a pesar de los esfuerzos para definir y ejecutar la estrategia de APS, los centros de salud continúan realizando sus actividades en base al modelo tradicional de atención exclusiva de la demanda.Objective: the aim of this project was to evaluate the quality of health care systems based on the strategy of Primary Health Care in different areas of the country. Method: cross-sectional study with a triangular approach, including a) a survey to the population demanding care, b) interviews to key referents of the health team, and c) health team focus groups. The components of structure, process and outcomes of the health system based on PHC were evaluated by specific indicators. Results: the analysis of the information shows an evident deficit of the integration of the professional team, mainly in the activities towards community, the lack of norms and lack of facilities for disable people. It must be noted also the high percentage of the health care team that does not know about current institutional health programs and the lack of an adequate information system for the area population and for the administrative process in most of the sites studied. Conclusion: in spite of the efforts to implement the PHC strategy, most of health centers evaluated are still providing care based on the traditional model oriented to the demands of care.Facultad de Ciencias Médica

A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility

Introduction: A recent genome-wide association study (GWAS) comprising a French cohort of systemic sclerosis (SSc) reported several non-HLA single-nucleotide polymorphisms (SNPs) showing a nominal association in the discovery phase. We aimed to identify previously overlooked susceptibility variants by using a follow-up strategy.&lt;p&gt;&lt;/p&gt; Methods: Sixty-six non-HLA SNPs showing a P value &#60;10-4 in the discovery phase of the French SSc GWAS were analyzed in the first step of this study, performing a meta-analysis that combined data from the two published SSc GWASs. A total of 2,921 SSc patients and 6,963 healthy controls were included in this first phase. Two SNPs, PPARG rs310746 and CHRNA9 rs6832151, were selected for genotyping in the replication cohort (1,068 SSc patients and 6,762 healthy controls) based on the results of the first step. Genotyping was performed by using TaqMan SNP genotyping assays. Results: We observed nominal associations for both PPARG rs310746 (PMH = 1.90 × 10-6, OR, 1.28) and CHRNA9 rs6832151 (PMH = 4.30 × 10-6, OR, 1.17) genetic variants with SSc in the first step of our study. In the replication phase, we observed a trend of association for PPARG rs310746 (P value = 0.066; OR, 1.17). The combined overall Mantel-Haenszel meta-analysis of all the cohorts included in the present study revealed that PPARG rs310746 remained associated with SSc with a nominal non-genome-wide significant P value (PMH = 5.00 × 10-7; OR, 1.25). No evidence of association was observed for CHRNA9 rs6832151 either in the replication phase or in the overall pooled analysis.&lt;p&gt;&lt;/p&gt; Conclusion: Our results suggest a role of PPARG gene in the development of SSc

DVINO: A RISC-V vector processor implemented in 65nm technology

This paper describes the design, verification, implementation and fabrication of the Drac Vector IN-Order (DVINO) processor, a RISC-V vector processor capable of booting Linux jointly developed by BSC, CIC-IPN, IMB-CNM (CSIC), and UPC. The DVINO processor includes an internally developed two-lane vector processor unit as well as a Phase Locked Loop (PLL) and an Analog-to-Digital Converter (ADC). The paper summarizes the design from architectural as well as logic synthesis and physical design in CMOS 65nm technology.The DRAC project is co-financed by the European Union Regional Development Fund within the framework of the ERDF Operational Program of Catalonia 2014-2020 with a grant of 50% of total eligible cost. The authors are part of RedRISCV which promotes activities around open hardware. The Lagarto Project is supported by the Research and Graduate Secretary (SIP) of the Instituto Politecnico Nacional (IPN) from Mexico, and by the CONACyT scholarship for Center for Research in Computing (CIC-IPN).Peer ReviewedArticle signat per 43 autors/es: Guillem Cabo∗, Gerard Candón∗, Xavier Carril∗, Max Doblas∗, Marc Domínguez∗, Alberto González∗, Cesar Hernández†, Víctor Jiménez∗, Vatistas Kostalampros∗, Rubén Langarita∗, Neiel Leyva†, Guillem López-Paradís∗, Jonnatan Mendoza∗, Francesco Minervini∗, Julian Pavón∗, Cristobal Ramírez∗, Narcís Rodas∗, Enrico Reggiani∗, Mario Rodríguez∗, Carlos Rojas∗, Abraham Ruiz∗, Víctor Soria∗, Alejandro Suanes‡, Iván Vargas∗, Roger Figueras∗, Pau Fontova∗, Joan Marimon∗, Víctor Montabes∗, Adrián Cristal∗, Carles Hernández∗, Ricardo Martínez‡, Miquel Moretó∗§, Francesc Moll∗§, Oscar Palomar∗§, Marco A. Ramírez†, Antonio Rubio§, Jordi Sacristán‡, Francesc Serra-Graells‡, Nehir Sonmez∗, Lluís Terés‡, Osman Unsal∗, Mateo Valero∗§, Luís Villa† // ∗Barcelona Supercomputing Center (BSC), Barcelona, Spain. Email: [email protected]; †Centro de Investigación en Computación, Instituto Politécnico Nacional (CIC-IPN), Mexico City, Mexico; ‡ Institut de Microelectronica de Barcelona, IMB-CNM (CSIC), Spain. Email: [email protected]; §Universitat Politecnica de Catalunya (UPC), Barcelona, Spain. Email: [email protected] (author's final draft

Search for flavour-changing neutral tqH interactions with H -> gamma gamma in pp collisions at root s=13 TeV using the ATLAS detector

A search for flavour-changing neutral interactions involving the top quark, the Higgs boson and an up-type quark q ( q = c, u) is presented. The proton-proton collision data set used, with an integrated luminosity of 139 fb(-1), was collected at root s = 13TeV by the ATLAS experiment at the Large Hadron Collider. Both the decay process t -> qH in tt production and the production process pp. tH, with the Higgs boson decaying into two photons, are investigated. No significant excess is observed and upper limits are set on the t. cH and the t. uH branching ratios of 4.3x10(-4) and 3.8x10(-4), respectively, at the 95% confidence level, while the expected limits in the absence of signal are 4.7x10(-4) and 3.9x10(-4). Combining this search with ATLAS searches in the H. t+ t- and H. b b final states yields observed (expected) upper limits on the t -> cH branching ratio of 5.8 x 10(-4) (3.0 x 10(-4)) at the 95% confidence level. The corresponding observed (expected) upper limit on the t -> uH branching ratio is 4.0 x 10(-4) (2.4 x 10(-4))

Combined Measurement of the Higgs Boson Mass from the Formula Presented and Formula Presented Decay Channels with the ATLAS Detector Using Formula Presented, 8, and 13 TeV Formula Presented Collision Data

A measurement of the mass of the Higgs boson combining the Formula Presented and Formula Presented decay channels is presented. The result is based on Formula Presented of proton-proton collision data collected by the ATLAS detector during LHC run 2 at a center-of-mass energy of 13 TeV combined with the run 1 ATLAS mass measurement, performed at center-of-mass energies of 7 and 8 TeV, yielding a Higgs boson mass of Formula Presented. This corresponds to a 0.09% precision achieved on this fundamental parameter of the Standard Model of particle physics

Test of CP Invariance in Higgs Boson Vector-Boson-Fusion Production Using the H→γγ Channel with the ATLAS Detector

A test of CP invariance in Higgs boson production via vector-boson fusion has been performed in the H→γγ channel using 139  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV collected by the ATLAS detector at the LHC. The optimal observable method is used to probe the CP structure of interactions between the Higgs boson and electroweak gauge bosons, as described by an effective field theory. No sign of CP violation is observed in the data. Constraints are set on the parameters describing the strength of the CP-odd component in the coupling between the Higgs boson and the electroweak gauge bosons in two effective field theory bases: d[over ˜] in the HISZ basis and c_{HW[over ˜]} in the Warsaw basis. The results presented are the most stringent constraints on CP violation in the coupling between Higgs and weak bosons. The 95% C.L. constraint on d[over ˜] is derived for the first time and the 95% C.L. constraint on c_{HW[over ˜]} has been improved by a factor of 5 compared to the previous measurement

Observation of an Excess of Dicharmonium Events in the Four-Muon Final State with the ATLAS Detector

A search is made for potential ccc[over ¯]c[over ¯] tetraquarks decaying into a pair of charmonium states in the four muon final state using proton-proton collision data at sqrt[s]=13  TeV, corresponding to an integrated luminosity of 140  fb^{-1} recorded by the ATLAS experiment at LHC. Two decay channels, J/ψ+J/ψ→4μ and J/ψ+ψ(2S)→4μ, are studied. Backgrounds are estimated based on a hybrid approach involving Monte Carlo simulations and data-driven methods. Statistically significant excesses with respect to backgrounds dominated by the single parton scattering are seen in the di-J/ψ channel consistent with a narrow resonance at 6.9 GeV and a broader structure at lower mass. A statistically significant excess is also seen in the J/ψ+ψ(2S) channel. The fitted masses and decay widths of the structures are reported