237 research outputs found

    Teaching C/C ++ programming using a multimedia system with videos

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    The C programming language is widely used in computer and industrial engineering. Because of that, such programming language is also widely used as a language to teach programming to industrial engineering students. In Spain, many universities use this language compulsory in the first year, or even in higher courses. Our experience shows that learning computer programming in four months is an arduous task, but curricula require it. Such learning process is also tough by the fact that many students cannot attend classes regularly and, even if they attend, sometimes the class is no longer at the level they require. In this work we develop a series of files in "presentation" format (.ppsx) and videos that allow students to see several explanations about the most complicated programming C topics: functions, arrays, structures, strings, arrays with structures, etc. This multimedia material includes explanations (voice-over), and animations with examples. Students can watch and listen to the explanations whenever and wherever they want (tablet, PC, phone…). Surveys made to students reveal that it is also interesting for students who regularly attend classes, and they prefer to use this course material only at home, outside of regular classes.El lenguaje de programación C se utiliza mucho en informática e ingeniería industrial. Por tanto, dicho lenguaje de programación también se utiliza mucho como lenguaje para enseñar programación a estudiantes de ingeniería industrial. En España, muchas universidades usan este lenguaje de forma obligatoria durante el primer año, o incluso en cursos superiores. Nuestra experiencia indica que aprender programación de computadoras en cuatro meses es una tarea ardua, pero los currículos lo requieren. Tal proceso de aprendizaje también es difícil por el hecho de que muchos estudiantes no pueden asistir a clases regularmente e, incluso si asisten, a veces la clase ya no está en el nivel que requieren. En este trabajo desarrollamos una serie de archivos en formato de "presentación" (.ppsx) y videos que permiten a los estudiantes ver varias explicaciones sobre los temas de programación C más complicados: funciones, matrices, estructuras, cadenas, matrices con estructuras, etc. El material multimedia incluye explicaciones (voz en off) y animaciones con ejemplos. Los estudiantes pueden ver y escuchar las explicaciones cuando y donde quieran (tableta, PC, teléfono, etc.). Las encuestas realizadas revelan que también es interesante para los estudiantes que asisten regularmente a clases, y que prefieren usar este material del curso solo en casa, fuera de las clases regulares

    Estudio de la investigación turística a través de las coautorías de artículos: cálculo de indicadores de colaboración y análisis de redes sociales

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    Se analiza la colaboración científica de las universidades catalanas en el campo del turismo entre 2000 y 2010. A partir de las coautorías de artículos, se calculan indicadores de colaboración simples y se examina la red colaboración. Se estudia la colaboración entre investigadores, instituciones y territorios. Los resultados muestran un aumento de la colaboración, diferencias entre las revistas y ausencia de relación entre colaboración y multidisciplinariedad. La red de colaboración presenta una baja densidad y varias subredes.Catalan universities scientific collaboration in tourism is analyzed, from 2000 to 2010. Through coauthorship data, simple collaboration indicators are calculated and the collaboration network is examined. Collaboration among researchers, institutions and territories is investigated. Results show an increase in collaboration, differences among journals, and absence of relationship between collaboration and multidisciplinarity. The collaboration network presents a low density and several subnetworks

    Scientific collaboration in tourism: the case of catalan universities

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    Se analiza la colaboración científica de las universidades catalanas en el campo del turismo entre 2000 y 2010. A partir de las coautorías de artículos, se calculan indicadores de colaboración simples y se examina la red colaboración. Se estudia la colaboración entre investigadores, instituciones y territorios. Los resultados muestran un aumento de la colaboración, diferencias entre las revistas y ausencia de relación entre colaboración y multidisciplinariedad. La red de colaboración presenta una baja densidad y varias subredes.Catalan universities scientific collaboration in tourism is analyzed, from 2000 to 2010. Through coauthorship data, simple collaboration indicators are calculated and the collaboration network is examined. Collaboration among researchers, institutions and territories is investigated. Results show an increase in collaboration, differences among journals, and absence of relationship between collaboration and multidisciplinarity. The collaboration network presents a low density and several subnetworks

    A Luminescent MOF Based on Pyrimidine-4,6-dicarboxylate Ligand and Lead(II) with Unprecedented Topology

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    In the present work, we report on a 3D MOF of {[Pb5(μ3-OH)(μ3-NO3)3(μ6-pmdc)3]·H2O}n formula (pmdc = pyrimidine-4,6-dicarboxylate) synthesized by an oven-heated, solvent-free procedure. The large connectivity afforded by the three ligands in their coordination to lead(II) ions grows cubic building units characterized by a central Pb atom with an unusual coordination index of 12 and 6 pmdc ligands occupying the faces. These cubic units are linked to one another giving rise to a quite condensed structure that represents an unprecedented topology showing the (4·62)6(43)2(45·610)3(45·68·82)6(46·69)6(612·83) point symbol. The crystalline material has been characterized by routine physico-chemical techniques to confirm its purity, and its thermal behaviour has been also studied by thermogravimetric and thermodiffractometric analyses. The solid presents a greenish blue photoluminescent emission based on pmdc ligands, as revealed by time-dependent density-functional theory (TDDFT) calculations, which is substantially more intense than in the free H2pmdc ligand according to its improved quantum yield. The emissive capacity of the material is further analysed according to decreasing temperature of the polycrystalline sample, finding that sizeable, long-lasting phosphorescence is present.This research was funded by Gobierno Vasco/Eusko Jaurlaritza (IT1755-22, IT1722-22 and IT1500-22) and Junta de Andalucía (ProyExcel_00386 and FQM-394). This publication is also part of the I+D+i projects of PGC2018-102052-A-C22 and PGC2018-102052-B-C21 codes, funded by MCIN/ AEI/10.13039/501100011033/ and “FEDER Una manera de hacer Europa”

    Using the emotional functioning in clinical practice to detect psychological distress in patients with advanced thoracic and colorectal cancer

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    Purpose: Patients with advanced cancer suffer significant decline of their psychological state. A rapid and reliable evaluation of this state is essential to detect and treat it and improve quality of life. The aim was to probe the usefulness of the emotional function (EF) subscale of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EF-EORTC-QLQ-C30) to assess psychological distress in cancer patients. Methods: This is a multicenter, prospective, observational study involving 15 Spanish hospitals. Patients diagnosed with unresectable advanced thoracic or colorectal cancer were included. Participants completed the Brief Symptom Inventory 18 (BSI-18), the current the gold standard, and the EF-EORTC-QLQ-C30 to assess their psychological distress prior to initiating systemic antineoplastic treatment. Accuracy, sensitivity, positive predictive value (PPV), specificity, and negative predictive value (NPV) were calculated. Results: The sample comprised 639 patients: 283 with advanced thoracic cancer and 356 with advanced colorectal cancer. According to the BSI scale, 74% and 66% displayed psychological distress with an EF-EORTC-QLQ-C30 accuracy of 79% and 76% in detecting psychological distress in individuals with advanced thoracic and colorectal cancer, respectively. Sensitivity was 79 and 75% and specificity was 79 and 77% with a PPV of 92 and 86% and a NPV of 56 and 61% (scale cut-off point, 75) for patients with advanced thoracic and colorectal cancer, respectively. The mean AUC for thoracic cancer was 0.84 and, for colorectal cancer, it was 0.85. Conclusion: This study reveals that the EF-EORTC-QLQ-C30 subscale is a simple and effective tool for detecting psychological distress in people with advanced cancer

    Comparison of body mass index (BMI) with the CUN-BAE body adiposity estimator in the prediction of hypertension and type 2 diabetes

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    Background Obesity is a world-wide epidemic whose prevalence is underestimated by BMI measurements, but CUN-BAE (Clínica Universidad de Navarra - Body Adiposity Estimator) estimates the percentage of body fat (BF) while incorporating information on sex and age, thus giving a better match. Our aim is to compare the BMI and CUN-BAE in determining the population attributable fraction (AFp) for obesity as a cause of chronic diseases. Methods We calculated the Pearson correlation coefficient between BMI and CUN-BAE, the Kappa index and the internal validity of the BMI. The risks of arterial hypertension (AHT) and diabetes mellitus (DM) and the AFp for obesity were assessed using both the BMI and CUN-BAE. Results 3888 white subjects were investigated. The overall correlation between BMI and CUN-BAE was R2 = 0.48, which improved when sex and age were taken into account (R2 > 0.90). The Kappa coefficient for diagnosis of obesity was low (28.7 %). The AFp was 50 % higher for DM and double for AHT when CUN-BAE was used. Conclusions The overall correlation between BMI and CUN-BAE was not good. The AFp of obesity for AHT and DM may be underestimated if assessed using the BMI, as may the prevalence of obesity when estimated from the percentage of BF

    Cuantificación de erosiones aguas abajo del modelo físico de la presa Los Molinos (Jujuy)

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    Fil: Eder, Matías. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Corral, Mariano. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Hillman, Gerardo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Pagot, Mariana. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Gyssels, Paolo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: García, Carlos M. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Rodríguez, Andrés. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Moya, Gonzalo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Díaz Lozada, José M. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Quiroga, Lucas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Guillén, Nicolás. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Farias, H. Daniel. Universidad Nacional de Santiago del Estero. Facultad de Ciencias Exactas y Tecnologías. IRHi; Argentina.En este trabajo se presentan estudios experimentales realizados en el modelo físico del dique Los Molinos (Jujuy) construido en el Laboratorio de Hidráulica de la FCEFyN – UNC, el cual consiste en un modelo físico tridimensional (escala 1:65) con similitud de Froude, los estudios tienen como objetivo la caracterización de erosiones locales aguas abajo de la presa para diferentes escenarios de modelación. En primera instancia se realiza una descripción de la presa y de sus estructuras de descarga (Dique Fijo, Dique Móvil y Canal Moderador). Posteriormente se presentan las características del modelo físico y el método de selección del material granular del fondo móvil, describiendo las consideraciones realizadas para garantizar la correcta representación del fenómeno en el modelo. Se describen las dos técnicas de medición de erosión utilizadas durante la ejecución de los ensayos y finalizados los mismos. Por un lado, se utilizó la medición tradicional, que consiste en relevar las erosiones con nivel óptico y escala milimétrica y por otro, se utilizó una nueva técnica digital de medición a partir del relevamiento de las profundidades medidas con una cámara RGB-D, Kinect de Microsoft. Finalmente se presenta la comparación de los resultados obtenidos en los ensayos experimentales con los obtenidos de aplicar diferentes formulaciones matemáticas presentes en la literatura.Fil: Eder, Matías. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Corral, Mariano. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Hillman, Gerardo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Pagot, Mariana. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Gyssels, Paolo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: García, Carlos M. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Rodríguez, Andrés. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Moya, Gonzalo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Díaz Lozada, José M. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Quiroga, Lucas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Guillén, Nicolás. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Estudios y Tecnología del agua; Argentina.Fil: Farias, H. Daniel. Universidad Nacional de Santiago del Estero. Facultad de Ciencias Exactas y Tecnologías. IRHi; Argentina.Ingeniería Civi

    Integrating current and historical water chemistry data with long-term piezometric records to develop a regional-scale conceptual flow model: Las Salinas spring, Medina del Campo, Spain

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    Study region: Old Las Salinas spring in Medina del Campo, Duero river basin, central Spain. Study focus: Medina del Campo groundwater body (MCGWB) is a multilayer semiconfined aquifer subject to intensive pumping since the 1970’s, where the current existence of spas where there used to be traditional baths could confirm the existence of deep groundwater flow paths. The old spring of Las Salinas (OSLS) is a saline anomaly in an aquifer with predominance of CaCO3H waters whose occurrence has not yet been formally explained. Long-term geological, geophysical, hydrogeological and hydrochemical records were integrated and complemented with field work to clarify its existence. New hydrological insights for the region: Outcomes led to the conclusion that the hydrochemistry of the Olmedo and Palacio de las Salinas salt baths is associated with the existence of a major threshold in the impervious basement of the aquifer, which intercepted deep regional groundwater flow and caused upwelling to the surface under unperturbed conditions. These results allow for the development of a conceptual flow model at the regional scale that explains the changes in natural water chemistry that have been identified in recent decades

    Next generation flow for minimally-invasive blood characterization of MGUS and multiple myeloma at diagnosis based on circulating tumor plasma cells (CTPC)

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    © The Author(s) 2018.Here, we investigated for the first time the frequency and number of circulating tumor plasma cells (CTPC) in peripheral blood (PB) of newly diagnosed patients with localized and systemic plasma cell neoplasms (PCN) using next-generation flow cytometry (NGF) and correlated our findings with the distinct diagnostic and prognostic categories of the disease. Overall, 508 samples from 264 newly diagnosed PCN patients, were studied. CTPC were detected in PB of all active multiple myeloma (MM; 100%), and smoldering MM (SMM) patients (100%), and in more than half (59%) monoclonal gammopathy of undetermined significance (MGUS) cases (p <0.0001); in contrast, CTPC were present in a small fraction of solitary plasmacytoma patients (18%). Higher numbers of CTPC in PB were associated with higher levels of BM infiltration and more adverse prognostic features, together with shorter time to progression from MGUS to MM (p <0.0001) and a shorter survival in MM patients with active disease requiring treatment (p ≤ 0.03). In summary, the presence of CTPC in PB as assessed by NGF at diagnosis, emerges as a hallmark of disseminated PCN, higher numbers of PB CTPC being strongly associated with a malignant disease behavior and a poorer outcome of both MGUS and MM.This work has been supported by the International Myeloma Foundation-Black Swan Research Initiative and the EuroFlow Consortium; Centro de Investigación Biomédica en Red de Cáncer (CIBER-ONC; Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Madrid, Spain and FONDOS FEDER), numbers: CB16/12/00400, CB16/12/00369, CB16/12/00489 and CB16/12/00233; grant SA079U14 from the Consejería de Educación, Junta de Castilla y León, Valladolid, Spain and; grant DTS15/00119 from Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Madrid, Spain. Acuerdo de colaboración con Fundación de Hemoterapia y Hemodonación de Castilla y León, Valladolid, Spain. This study was also supported by the Qatar National Research Fund (QNRF) Award No. 7-916-3-237, the AACR-Millennium Fellowship in Multiple Myeloma Research (15-40-38-PAIV), ERA-NET TRANSCAN-2 (iMMunocell), by a 2017 Leonardo Grant (BZG10931) for Researchers and Cultural Creators, BBVA Foundation, and the European Research Council (ERC) 2015 Starting Grant (MYELOMANEXT)
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