La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia. Departamento de Cundinamarca, Bogotá.

La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia. Departamento de Cundinamarca, Bogotá.El presente documento contiene los resultados logrados en atención a la apropiación de las fuentes temáticas sugeridas en el Diplomado de Profundización de Acompañamiento Psicosocial en Escenarios de Violencia, mediante el cual se dio lugar en principio al análisis y reflexión resultante de los ejercicios prácticos realizados en contextos reales, de los que se pudo significar la alta influencia en la calidad de vida de las diferentes comunidades y de la sociedad en general. Teniendo en cuenda la violencia que ha enmarcado a nuestro país, por más de 50 años que ha dejado diferentes víctimas del conflicto armado, como lo es el desplazamiento forzado, masacres, además de centenares de familias destruidas, muertos y los diferentes traumas psicológicos que dejan el contexto de la violencia en nuestro país. Se hace necesario generar entornos de reflexión que facilite profundizar en cada uno de estos casos, para logra buscar las alternativas que permita ayudar a toda la población afectada. Haciendo uso de herramientas como la narración, que facilita la comprensión e intervención de los diferentes contextos, se dio paso a reflexionar y analizar los relatos puestos a disposición, de cara a coadyuvar a re direccionar las historias y las miradas hacia el futuro de las víctimas, cuya pretensión no es otra que mostrar otras facetas resilientes y conciliadoras de vida, haciendo uso de la narrativa.This document contains the results achieved in the attention to the appropriation of the thematic sources suggested in the Diploma of Deepening of Psychosocial Accompaniment in Scenarios of Violence, through which the analysis and reflection resulting from the practical exercises carried out in the beginning in real contexts, from which the high influence on the quality of life of the different communities and of society in general could be signified. Taking into account the violence that has framed in our country, for more than 50 years that has left different victims of the armed conflict, such as forced displacement, massacres, in addition to hundreds of families destroyed, dead and the different psychological traumas that They leave the context of violence in our country. It is necessary to generate reflection environments that facilita deepening in each of these cases, in order to find alternatives that help the entire affected population. Making use of tools such as storytelling, which facilitates the understanding and intervention of different contexts, we gave way to reflect and analyze the stories made available, in order to help redirect the stories and looks towards the future of the victims, whose claim is none other than to show other resistant and conciliatory facets of life, making use of the narrative

Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M&gt;70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0&lt;e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level

Ultralight vector dark matter search using data from the KAGRA O3GK run

Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM

Proceso de afrontamiento y adaptación durante el puerperio

Introduction: The puerperium is a stage that produces changes and adaptations in women, couples and family. Effective coping, during this stage, depends on the relationship between the demands of stressful or difficult situations and the recourses that the puerperal individual has. Roy (2004), in her Middle Range Theory about the Coping and Adaptation Processing, defines Coping as the “behavioral and cognitive efforts that a person makes to meet the environment demands”. For the puerperal individual, the correct coping is necessary to maintain her physical and mental well being, especially against situations that can be stressful like breastfeeding and return to work. According to Lazarus and Folkman (1986), a resource for coping is to have someone who receives emotional support, informative and / or tangible. Objective: To review the issue of women coping and adaptation during the puerperium stage and the strategies that enhance this adaptation. Methodology: search and selection of database articles: Cochrane, Medline, Ovid, ProQuest, Scielo, and Blackwell Synergy. Other sources: unpublished documents by Roy, published books on Roy´s Model, Websites from of international health organizations. Results: the need to recognize the puerperium as a stage that requires comprehensive care is evident, where nurses must be protagonist with the care offered to women and their families, considering the specific demands of this situation and recourses that promote effective coping and the family, education and health services. Introducción: el puerperio es una etapa que produce cambios y adaptaciones en la mujer, pareja y familia. El afrontamiento eficaz, durante esta etapa, depende de las relaciones entre las demandas de las situaciones estresantes o difíciles y los recursos que la puérpera posea. Roy (2004), en su Teoría de mediano rango, sobre el Proceso de Afrontamiento y Adaptación, define el Afrontamiento como “los esfuerzos comportamentales y cognitivos que realiza la persona para atender las demandas del ambiente”1,2. En la puérpera el afrontamiento adecuado es necesario para mantener el bienestar físico y mental, en especial frente a situaciones que pueden ser estresantes, como la lactancia y el regreso al trabajo. De acuerdo con Lazarus y Folkman (1986), un recurso de afrontamiento es tener alguien de quién recibir apoyo emocional, informativo y/o tangible3. Objetivo: revisar el tema sobre el afrontamiento y adaptación de la mujer, durante la etapa del puerperio y las estrategias que favorecen esta adaptación. Métodos: Se recopilaron artículos de investigación y sistematización relacionados con el tema en las bases de datos de Cochrane, Medline, Ovid, ProQuest, Scielo, Blackwell Synergy. Otras fuentes: documentos inéditos de Roy, libros publicados sobre el modelo de Roy. Sitios web de organizaciones de salud internacionales. Resultados: se evidencia la necesidad de reconocer el puerperio como una etapa que requiere atención integral, donde enfermería debe ser protagónica con el cuidado brindado a la mujer y su familia, considerando las demandas específicas ante esta situación y los recursos que favorezcan el afrontamiento eficaz como, la familia, la educación y los servicios de salud

The feeling of loss and abandonment among pregnant displaced women -bogotá

This research concentrates on the displaced population of our country, specifically pregnant displaced women, and along the research line of Prenatal Maternal Care from the nursing Faculty of the National University, i.e. from the "Enfermería Transcultural de la Facultad de Enfermería, of the Universidad Nacional de Colombia". We followed Leininger's which sees thehuman being asa subjectimmerseinanetworkofsocialrelations andinthe midst of a specific context, where such aspects permeate into behavior, i.e. that culture in which the subject believes and lives is part of the care practices. We used the ethnic nursing method proposed by Leininger (1985), with the intent of exploring the meaning of care for the pregnant displaced women and her unborn child, from the émic (native perspective), in Bogotá (sub municipalities of Suba and Ciudad Bolívar). The participants were displaced people from the Provinces of Tolima, Arauca, Cundinamarca, Caquetá, Bolívar, Guainía and Cauca. Their ages varied from 14 to 34 years, and the time of displacement was between two months and a year. Data was gathered via individual and group interviews (twelve participants) and via observation, and we applied Spradley's (1980) ethnographic analysis: domains (categories of meaning that include other minor categories) with the systematic relations, taxonomy (set of categories), component analysis (the search for associated attributes with cultural symbols) and issues (of the highest abstraction level). We obtained theissueofresilienceofhopeinthe midstofthe difficulty of being displaced and pregnant with the sub components of: the loss and abandonment as well as the way forward.Esta investigación se basa en la problemática de la población desplazada de nuestro país, específicamente de mujeres gestantes desplazadas, y en la línea de investigación Cuidado Materno Perinatal desde la Enfermería Transcultural de la Facultad de Enfermería, de la Universidad Nacional de Colombia. Setuvoencuentalateoríadel cuidadotransculturaldeLeininger (1978),lacualconsidera queelser humano está inmerso en una red de relaciones sociales y situado en un determinado contexto, aspectos estos que permean su comportamiento, es decir, la cultura en la cual él crece y vive hace partedesus prácticasdecuidado. Se usó el método de la etnoenfermería propuesto por Leininger (1985), con el objetivo de explorar el significado que tienen las gestantes desplazadas del cuidado de sí y de su hijo por nacer, desde lo émic punto de vista del nativo), en Bogotá (Localidades de Suba y Ciudad Bolívar). Las participantes fueron desplazadas de los departamentos de Tolima, Arauca, Cundinamarca, Caquetá, Bolívar, Guainía y Cauca, cuyas edades oscilaron entre los 14 y los 34 años, y el tiempo de desplazamiento estuvo entre los dos meses y un año. Los datos se obtuvieron por entrevista individual y grupal (doce participantes) y por observación, y se aplicó el análisis etnográfico de Spradley (1980): dominios (categorías de significado que incluye otras categorías menores) con sus relaciones semánticas, taxonomía (conjunto de categorías), análisis componencial (búsqueda de atributos asociados con símbolos culturales) y temas (el más alto nivel de abstracción). Se obtuvo el tema El surgimiento de la esperanza en medio de la dificultad del desplazamiento de la gestante, con los subtemas: La pérdida y el abandono y El camino a seguir

La pérdida y el abandono en gestantes desplazadas-bogotá

Esta investigación se basa en la problemática de la población desplazada de nuestro país, específicamente de mujeres gestantes desplazadas, y en la línea de investigación Cuidado Materno Perinatal desde la Enfermería Transcultural de la Facultad de Enfermería, de la Universidad Nacional de Colombia. Setuvoencuentalateoríadel cuidadotransculturaldeLeininger (1978),lacualconsidera queelser humano está inmerso en una red de relaciones sociales y situado en un determinado contexto, aspectos estos que permean su comportamiento, es decir, la cultura en la cual él crece y vive hace partedesus prácticasdecuidado. Se usó el método de la etnoenfermería propuesto por Leininger (1985), con el objetivo de explorar el significado que tienen las gestantes desplazadas del cuidado de sí y de su hijo por nacer, desde lo émic punto de vista del nativo), en Bogotá (Localidades de Suba y Ciudad Bolívar). Las participantes fueron desplazadas de los departamentos de Tolima, Arauca, Cundinamarca, Caquetá, Bolívar, Guainía y Cauca, cuyas edades oscilaron entre los 14 y los 34 años, y el tiempo de desplazamiento estuvo entre los dos meses y un año. Los datos se obtuvieron por entrevista individual y grupal (doce participantes) y por observación, y se aplicó el análisis etnográfico de Spradley (1980): dominios (categorías de significado que incluye otras categorías menores) con sus relaciones semánticas, taxonomía (conjunto de categorías), análisis componencial (búsqueda de atributos asociados con símbolos culturales) y temas (el más alto nivel de abstracción). Se obtuvo el tema El surgimiento de la esperanza en medio de la dificultad del desplazamiento de la gestante, con los subtemas: La pérdida y el abandono y El camino a seguir.This research concentrates on the displaced population of our country, specifically pregnant displaced women, and along the research line of Prenatal Maternal Care from the nursing Faculty of the National University, i.e. from the "Enfermería Transcultural de la Facultad de Enfermería, of the Universidad Nacional de Colombia". We followed Leininger's which sees thehuman being asa subjectimmerseinanetworkofsocialrelations andinthe midst of a specific context, where such aspects permeate into behavior, i.e. that culture in which the subject believes and lives is part of the care practices. We used the ethnic nursing method proposed by Leininger (1985), with the intent of exploring the meaning of care for the pregnant displaced women and her unborn child, from the émic (native perspective), in Bogotá (sub municipalities of Suba and Ciudad Bolívar). The participants were displaced people from the Provinces of Tolima, Arauca, Cundinamarca, Caquetá, Bolívar, Guainía and Cauca. Their ages varied from 14 to 34 years, and the time of displacement was between two months and a year. Data was gathered via individual and group interviews (twelve participants) and via observation, and we applied Spradley's (1980) ethnographic analysis: domains (categories of meaning that include other minor categories) with the systematic relations, taxonomy (set of categories), component analysis (the search for associated attributes with cultural symbols) and issues (of the highest abstraction level). We obtained theissueofresilienceofhopeinthe midstofthe difficulty of being displaced and pregnant with the sub components of: the loss and abandonment as well as the way forward