An Environmental Led Response to Black Creek Community Farm

An Environmental Led Response to Black Creek Community Farm is the documentation of my process of building a curriculum that is a directly responds to the site itself. My is based around the concept of land-based education for children as a means of community self sustainability, collective community care and understanding sense of self and place. This major project is a compilation of photographs, academic theory, community-based research, interviews and a curriculum based on my research

Fatores associados à diarreia em menores de cinco anos, no estado de Pernambuco, segundo inquéritos realizados em 1997 e 2006

OBJECTIVE: Describe and compare variations of the factors associated with the prevalence of diarrhea in children under five years old in the state of Pernambuco. METHODS: We used the databases of two population-based surveys from the years 1997 and 2006, with 2,078 and 1,650 children, respectively, evaluated in 18 municipalities of Pernambuco (Metropolitan Region of Recife, urban and rural interior). The variables, allocated at hierarchical levels, were analyzed using prevalence and Poisson regression ratios. RESULTS: Only four variables were independently associated and were included in the final hierarchical model: geographical area, number of people per room, maternal age and the age of the child. In 1997: urban interior = 1.33 (95%CI 1.06–1.66), rural interior = 1.22 (95%CI 0.97–1.53) and in 2006: urban interior = 1.87 (95%CI 1.31–2.66), rural interior = 2.07 (95%CI 1.50–2.85); number of persons per room (1997): 1 to less than 2 = 1.29 (95%CI 0.98–1.68), two or more = 1.47 (95%CI 1.11–1.95) and in 2006: 1 to less than 2 = 0.86 (95%CI 0.68–1.09), two or more = 1.29 (95%CI 0.94–1.75); maternal age (1997): 10 to 19 years = 1.48 (95%CI 1.05–2.08), 20 to 24 years = 1.23 (95%CI 0.94–1.60), 25 to 34 years = 1.01 (95%CI 0.78–1.30) and in 2006: 10 to 19 years old = 1.70 (95%CI 1.08–2.66), 20 to 24 years old = 1.64 (95%CI 1.16–2.32), 25 to 34 years = 1.20 (95%CI 0.89–1.62); and age of the child (1997): 0–11 months = 1.57 (95%CI 1.27–1.94), 12–23 months = 1.73 (95%CI 1.41–2.12) and in 2006: 0–11 months = 1.04 (95%CI 0.76–1.41), 12–23 months = 1.77 (95%CI 1.41–2.23). CONCLUSIONS: There was a great variability of the conditioners of diarrhea in children between the two periods analyzed. At the public policy level, despite changes in terms of people, time sequences, and geographic spaces, diarrhea remains on an important scale in the ranking of government power.OBJETIVO: Descrever e comparar variações dos fatores associados à prevalência de diarreia em menores de cinco anos no estado de Pernambuco. MÉTODOS: Foram utilizados os bancos de dados de dois inquéritos de base populacional nos anos de 1997 e 2006, com 2.078 e 1.650 crianças, respectivamente, avaliadas em 18 municípios de Pernambuco (Região Metropolitana do Recife, interior urbano e rural). As variáveis, alocadas em níveis hierárquicos, foram analisadas por meio de razões de prevalência e regressão de Poisson. RESULTADOS: Apenas quatro variáveis se mostraram independentemente associadas e constaram no modelo final hierarquizado: área geográfica, número de pessoas por cômodo, idade materna e idade da criança. Em 1997: interior urbano = 1,33 (IC95% 1,06–1,66), interior rural = 1,22 (IC95% 0,97–1,53) e em 2006: interior urbano = 1,87 (IC95% 1,31–2,66), interior rural = 2.07 (IC95% 1.50–2.85); número de pessoas por cômodo (1997): 1 a menos de 2 = 1,29 (IC95% 0,98-1,68), dois ou mais = 1,47 (IC95% 1,11–1,95) e em 2006: 1 a menos de 2 = 0.86 (IC95% 0,68–1,09), dois ou mais = 1,29 (IC95% 0,94–1,75); idade materna (1997): 10 a 19 anos = 1,48 (IC95% 1,05–2,08), 20 a 24 anos = 1,23 (IC95% 0,94–1,60), 25 a 34 anos = 1,01 (IC95% 0,78–1,30) e em 2006: 10 a 19 anos = 1,70 (IC95% 1,08–2,66), 20 a 24 anos = 1,64 (IC95% 1,16–2,32), 25 a 34 anos = 1,20 (IC95% 0,89–1,62); e idade da criança (1997): 0–11 meses = 1,57 (IC95% 1,27–1,94), 12–23 meses = 1,73 (IC95% 1,41–2,12) e em 2006: 0–11 meses = 1,04 (IC95% 0,76–1,41), 12–23 meses = 1,77 (IC95% 1,41–2,23). CONCLUSÕES: Houve uma grande variabilidade dos condicionantes das diarreias em crianças entre os dois períodos analisados. Em nível de políticas públicas, apesar de mudanças em termos de pessoas, sequências temporais e espaços geográficos, as diarreias continuam em uma escala importante no elenco de prioridades do poder governamental

Hypoxia Due to Cardiac Arrest Induces a Time-Dependent Increase in Serum Amyloid β Levels in Humans

Amyloid β (Aβ) peptides are proteolytic products from amyloid precursor protein (APP) and are thought to play a role in Alzheimer disease (AD) pathogenesis. While much is known about molecular mechanisms underlying cerebral Aβ accumulation in familial AD, less is known about the cause(s) of brain amyloidosis in sporadic disease. Animal and postmortem studies suggest that Aβ secretion can be up-regulated in response to hypoxia. We employed a new technology (Single Molecule Arrays, SiMoA) capable of ultrasensitive protein measurements and developed a novel assay to look for changes in serum Aβ42 concentration in 25 resuscitated patients with severe hypoxia due to cardiac arrest. After a lag period of 10 or more hours, very clear serum Aβ42 elevations were observed in all patients. Elevations ranged from approximately 80% to over 70-fold, with most elevations in the range of 3–10-fold (average approximately 7-fold). The magnitude of the increase correlated with clinical outcome. These data provide the first direct evidence in living humans that ischemia acutely increases Aβ levels in blood. The results point to the possibility that hypoxia may play a role in the amyloidogenic process of AD

On-chip spectrophotometry for bioanalysis using microring resonators

We measure optical absorption in color-producing enzymatic reactions for biochemical analysis with a microscale optofluidic device. Cavity-enhanced laser spectrophotometry is performed on analytes within a microfluidic channel at visible wavelengths with silicon nitride microring resonators of 100 µm radius and quality factor of ~180,000. The resonator transmission spectrum is analyzed to determine optical absorption with a detection limit of 0.12 cm−1. The device can be used to detect the activity of individual enzymes in a few minutes within a 100 fL sensing volume. The high sensitivity, small footprint, and low analyte consumption make absorption-based microring resonators attractive for lab-on-a-chip applications

Disease Detection by Ultrasensitive Quantification of Microdosed Synthetic Urinary Biomarkers

The delivery of exogenous agents can enable noninvasive disease monitoring, but existing low-dose approaches require complex infrastructure. In this paper, we describe a microdose-scale injectable formulation of nanoparticles that interrogate the activity of thrombin, a key regulator of clotting, and produce urinary reporters of disease state. We establish a customized single molecule detection assay that enables urinary discrimination of thromboembolic disease in mice using doses of the nanoparticulate diagnostic agents that fall under regulatory guidelines for “microdosing.”National Science Foundation (U.S.). Graduate Research FellowshipNational Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award F32CA159496-02)Burroughs Wellcome Fund (Career Award at the Scientific Interface)National Cancer Institute (U.S.) (Koch Institute Support (Core) Grant P30-CA14051)David H. Koch Institute for Integrative Cancer Research at MIT (Frontier Research Program

Complication rates and patient satisfaction with removable dentures

PURPOSE. The purpose of this clinical study was to evaluate the frequency and type of prosthetic complications in relation to type and properties of removable dentures and to investigate the influence of these complications and several data about the existing dentures on patient satisfaction. MATERIALS AND METHODS. Ninety nine patients (44 males and 55 females) wearing removable dentures have been included in the study. The complications of the patients were recorded; patient satisfaction was determined with a Visual Analog Scale (VAS) and the relationship of complications and patient satisfaction with several data about the dentures such as denture age, type of denture, centric relation and vertical dimension was investigated. Kruskal Wallis, Mann Whitney U and Chi square tests were used for statistical analyses. The results were evaluated statistically at a significance level of P<.05. RESULTS. Need for addition of artificial teeth for dentures with correct centric relations was found to be significantly lower than dentures with wrong centric relations (P<.01). Loss of retention, ulcerations and high vertical dimension affected the VAS chewing ability scores negatively and ulcerations affected the VAS phonation scores negatively (P<.05). CONCLUSION. Considering the results of this study, it can be concluded that loss of retention, ulcerations and high vertical dimension caused patient dissatisfaction. Additionally, dentures with wrong centric relations caused need for addition of artificial teeth. [J Adv Prosthodont 2012;4:109-15

Perfil de adultos jovens praticantes de exercícios físicos em academias de ginástica da cidade de São Paulo

Introdução: A busca por um corpo padrão tem se tornado cada vez mais visível na sociedade entre os adultos jovens, principalmente em razão do fácil acesso à mídia onde há uma intensa divulgação de informações. Consequentemente, tomam medidas, como dietas, suplementos e exercícios físicos, para conseguirem o que desejam. Quando não supervisionadas por profissionais capacitados, podem se tornar prejudiciais à saúde. A prática de exercícios físicos combinada com uma alimentação saudável deve visar a saúde e não somente a imagem corporal. Objetivo: Avaliar o perfil de adultos jovens, praticantes de exercícios físicos e frequentadores de academias de ginástica da Cidade de São Paulo. Materiais e métodos: Estudo transversal, realizado em academias de ginástica da cidade de São Paulo no período de agosto a novembro de 2019. Utilizou-se questionário desenvolvido e aplicado pelos próprios pesquisadores, contendo questões sobre prática de exercícios, principais tipos de alimentos consumidos, dietas, uso de suplementos, entre outros. Resultados: A maior parte frequenta academias entre 3 e 5 vezes por semana, sendo a saúde e a estética os principais motivos. Quase 50% já realizou algum tipo de dieta, indicadas, em sua maioria, por nutricionistas. Além disso, 60,9% não usa suplementos alimentares e grande parte diz ter conhecimento sobre os efeitos que podem causar no organismo humano. Dentre os consumidores, 48% dizem consumir por iniciativa própria. Conclusão: Há uma busca por equilíbrio entre alimentação saudável e a prática de exercícios pelos participantes, notando um bom consumo de todos os grupos de alimentos, exceto o de oleaginosas e cereais integrais