Foscolo e la traduzione del "Viaggio sentimentale" di Sterne : la redazione inedita del 1812

Nella primavera del 2019 Prassi Ecdotiche della Modernit\ue0 Letteraria ha organizzato, insieme con la classe di Italianistica dell\u2019Accademia Ambrosiana, un ciclo di seminari che portano il titolo: Stesure, redazioni, revisioni, riscritture: problemi di definizione. Il punto di partenza di questa proposta nasce da una domanda, cui si intrecciano subito numerose altre: c\u2019\ue8 differenza tra \uabstesura\ubb e \uabredazione\ubb, spesso usati come sinonimi in filologia e nelle pagine critiche? Se una differenza c\u2019\ue8, qual \ue8 la specificit\ue0 o la particolarit\ue0 dell\u2019una e dell\u2019altra? Quali definizioni si possono quindi dare? E, muovendosi nella stessa direzione, fino a quando si pu\uf2 parlare di \uabrevisione\ubb e quando si incomincia a parlare di \uabriscrittura\ubb? E come cambia un\u2019opera cambiando i suoi indici? Tentare di rispondere alle domande sopra poste significa sia aprire una riflessione su un possibile glossario condiviso, sia fare i conti con i singoli casi che la storia della letteratura o della critica presenta continuamente agli studiosi. Nella sezione di \u201cConvegni aperti\u201d di questo secondo fascicolo del numero 4(2019) di PEML si propongono dunque alcune relazioni del ciclo, che si sono tenute nei mesi di settembre, ottobre e novembre 2019. La prima di queste \ue8 quella di Giulia Ravera, Foscolo e la traduzione del "Viaggio sentimentale" di Sterne: la redazione inedita del 1812.Foscolo e la traduzione del "Viaggio sentimentale" di Sterne: la redazione inedita del 181

TOPOI TROBADORICI NEI RERUM VULGARIUM FRAGMENTA

My research focuses on the relationship between Petrarch and the troubadours, with particular reference to conventional expressive elements, such as genres structures and topical images. My primary objective is to analyse which aspects of the courtly tradition Petrarch chose to gain in building his own lyric language, in order to prove how the poet was able to transform his sources according to a new, personal perspective. I also intend to highlight how Petrarch\u2019s reuse of Proven\ue7al models was functional to his auto-legitimation within the vulgar literary tradition, from its origins to his most recent auctoritas, Dante. In conclusion, I propose to offer some concrete data and a functional hypothesis about which Occitan materials Petrarch may have read and in which context, as tools in his widening the knowledge of troubadours\u2019 poetry

Three-dimensional Maxwellian extended Newtonian gravity and flat limit

In the present work we find novel Newtonian gravity models in three space-time dimensions. We first present a Maxwellian version of the extended Newtonian gravity, which is obtained as the non-relativistic limit of a particular U(1)-enlargement of an enhanced Maxwell Chern-Simons gravity. We show that the extended Newtonian gravity appears as a particular sub-case. Then, the introduction of a cosmological constant to the Maxwellian extended Newtonian theory is also explored. To this purpose, we consider the non-relativistic limit of an enlarged symmetry. An alternative method to obtain our results is presented by applying the semigroup expansion method to the enhanced Nappi-Witten algebra. The advantages of considering the Lie algebra expansion procedure is also discussed

Climate Science, Development Practice, and Policy Interactions in Dryland Agroecological Systems

The literature on drought, livelihoods, and poverty suggests that dryland residents are especially vulnerable to climate change. However, assessing this vulnerability and sharing lessons between dryland communities on how to reduce vulnerability has proven difficult because of multiple definitions of vulnerability, complexities in quantification, and the temporal and spatial variability inherent in dryland agroecological systems. In this closing editorial, we review how we have addressed these challenges through a series of structured, multiscale, and interdisciplinary vulnerability assessment case studies from drylands in West Africa, southern Africa, Mediterranean Europe, Asia, and Latin America. These case studies adopt a common vulnerability framework but employ different approaches to measuring and assessing vulnerability. By comparing methods and results across these cases, we draw out the following key lessons: (1) Our studies show the utility of using consistent conceptual frameworks for vulnerability assessments even when quite different methodological approaches are taken; (2) Utilizing narratives and scenarios to capture the dynamics of dryland agroecological systems shows that vulnerability to climate change may depend more on access to financial, political, and institutional assets than to exposure to environmental change; (3) Our analysis shows that although the results of quantitative models seem authoritative, they may be treated too literally as predictions of the future by policy makers looking for evidence to support different strategies. In conclusion, we acknowledge there is a healthy tension between bottom-up/ qualitative/place-based approaches and top-down/quantitative/generalizable approaches, and we encourage researchers from different disciplines with different disciplinary languages, to talk, collaborate, and engage effectively with each other and with stakeholders at all levels

Flipping the Tortilla: Social-ecological innovations and traditional ecological knowledge for more sustainable agri-food systems in Spain

The conventional dominant global agri-food system is a main driver in the Anthropocene: food production entails profound global environmental changes from greenhouse gas emissions to biodiversity loss, and shifting diets further impact planetary and human health. Innovative approaches are needed to shift towards more sustainable, equitable and healthy agri-food systems. Building on the increasing recognition of the relevance of traditional agroecological knowledge (TAeK) in sustainable food systems, this paper aims to describe innovative agri-food initiatives and explore how the use and valorization of TAeK may transform conventional agri-food systems. It employs a case-study approach in Spain, where we conducted semi-structured interviews with 12 representatives of alternative agri-food initiatives. We found that, to promote sustainable agri-food systems, TAeK has to span from farm-to-fork. Innovative agroecological practices and knowledge help to safeguard biocultural diversity, while gastronomic knowledge among consumers on how to process and prepare local varieties and species is crucial for the implementation of shorter value chains. We discuss how TAeK enhances the success of conventional systems of innovation, challenging dominant epistemological frameworks. By scaling deep (changing values), scaling out (dissemination, reproduction) and scaling up (changing institutions), the agri-food initiatives may act on leverage points to enable broader transformation of the Spanish agri-food system

The diversity of gendered adaptation strategies to climate change of Indian farmers: a feminist intersectional approach

This paper examines climate change adaptation and gender issues through an application of a feminist intersectional approach. This approach permits the identification of diverse adaptation responses arising from the existence of multiple and fragmented dimensions of identity (including gender) that intersect with power relations to shape situation-specific interactions between farmers and ecosystems. Based on results from contrasting research cases in Bihar and Uttarakhand, India, this paper demonstrates, inter alia, that there are geographically determined gendered preferences and adoption strategies regarding adaptation options and that these are influenced by the socio-ecological context and institutional dynamics. Intersecting identities, such as caste, wealth, age and gender, influence decisions and reveal power dynamics and negotiation within the household and the community, as well as barriers to adaptation among groups. Overall, the findings suggest that a feminist intersectional approach does appear to be useful and worth further exploration in the context of climate change adaptation. In particular, future research could benefit from more emphasis on a nuanced analysis of the intra-gender differences that shape adaptive capacity to climate change

Metric-Affine Vector-Tensor correspondence and implications in F(R, T, Q, T, D) gravity

We extend the results of antecedent literature on quadratic Metric-Affine Gravity by studying a new quadratic gravity action in vacuum which, besides the usual (non-Riemannian) Einstein-Hilbert contri-bution, involves all the parity even quadratic terms in torsion and non-metricity plus a Lagrangian that is quadratic in the field-strengths of the torsion and non-metricity vector traces. The theory results to be equivalent, on-shell, to a Vector-Tensor theory. We also discuss the sub-cases in which the contribution to the Lagrangian quadratic in the field-strengths of the torsion and non-metricity vectors just exhibits one of the aforementioned quadratic terms. We then report on cosmological aspects of the general quadratic theory in the presence of a perfect cosmological hyperfluid and on implications of our findings in the context of F(R, T, Q, T, D) gravity.(c) 2022 Elsevier B.V. All rights reserved

A multistationary loop model of ALS unveils critical molecular interactions involving mitochondria and glucose metabolism

Amyotrophic lateral sclerosis (ALS) is a poor-prognosis disease with puzzling pathogenesis and inconclusive treatments. We develop a mathematical model of ALS based on a system of interactive feedback loops, focusing on the mutant SOD1G93A mouse. Misfolded mutant SOD1 aggregates in motor neuron (MN) mitochondria and triggers a first loop characterized by oxidative phosphorylation impairment, AMP kinase over-activation, 6-phosphofructo-2-kinase (PFK3) rise, glucose metabolism shift from pentose phosphate pathway (PPP) to glycolysis, cell redox unbalance, and further worsening of mitochondrial dysfunction. Oxidative stress then triggers a second loop, involving the excitotoxic glutamatergic cascade, with cytosolic Ca2+ overload, increase of PFK3 expression, and further metabolic shift from PPP to glycolysis. Finally, cytosolic Ca2+ rise is also detrimental to mitochondria and oxidative phosphorylation, thus closing a third loop. These three loops are overlapped and positive (including an even number of inhibitory steps), hence they form a candidate multistationary (bistable) system. To describe the system dynamics, we model the interactions among the functional agents with differential equations. The system turns out to admit two stable equilibria: the healthy state, with high oxidative phosphorylation and preferential PPP, and the pathological state, with AMP kinase activation, PFK3 over expression, oxidative stress, excitotoxicity and MN degeneration. We demonstrate that the loop system is monotone: all functional agents consistently act toward the healthy or pathological condition, depending on low or high mutant SOD1 input. We also highlight that molecular interactions involving PFK3 are crucial, as their deletion disrupts the system\u2019s bistability leading to a single healthy equilibrium point. Hence, our mathematical model unveils that promising ALS management strategies should be targeted to mechanisms that keep low PFK3 expression and activity within MNs

Effects of walking speed and age on the muscle forces of unimpaired gait subjects

Clinical gait analysis provides great contributions to the understanding of gait disorders and also provides a mean for a more comprehensive treatment plan. However, direct measures of muscle forces are difficult to obtain in clinical settings because it generally requires invasive techniques. Techniques of musculoskeletal modeling have been used for several decades to improve the benefits of clinical gait analysis, but many of the previous studies were focused on analyzing separately the muscle forces distribution of children or adult subjects with only one condition of walking speed. For these reason, the present study aims to enhance the current literature by describing the age and speed gait effects on muscle forces during walking. We used a musculoskeletal model with 23 degrees of freedom and 92 musculotendon actuators to represent 76 muscles in the lower extremities and torso. The computed muscle control algorithm was used to estimate the muscle forces from the kinematics and to adjust the model obtained in the residual reduction algorithm. We find that hamstrings has an important peak in the mid-stance phase in the adult group but this peak disappears in the children group with the same walking speed condition. Furthermore, the rectus femoris presents an increase in the muscle force during the pre- and mid-swing in concordance with the increment in the walking speed of subjects. This behavior could be associated with the role that the rectus femoris has in the acceleration of the knee joint. Finally, we show that the soleus is the muscle that perform the major force throughout the gait cycle regardless of age and walking speed.Fil: Fliger, Carlos G.. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaFil: Crespo, Marcos J.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Braidot, Ariel A.. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaFil: Ravera, Emiliano Pablo. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH3COO)Cl2(NH3)2(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier-Mediated Cellular Uptake

The biological behavior of the axially unsymmetric antitumor prodrug (OC-6-44)-acetatodiamminedichloridohydroxidoplatinum(IV), 2, was deeply investigated and compared with that of analogous symmetric Pt(IV) complexes, namely, dihydroxido 1 and diacetato 3, which have a similar structure. The complexes were tested on a panel of human tumor cell lines. Complex 2 showed an anomalous higher cytotoxicity (similar to that of cisplatin) with respect to their analogues 1 and 3. Their reduction potentials, reduction kinetics, lipophilicity, and membrane affinity are compared. Cellular uptake and DNA platination of Pt(IV) complexes were deeply investigated in the sensitive A2780 human ovarian cancer cell line and in the corresponding resistant A2780cisR subline. The unexpected activity of 2 appears to be related to its peculiar cellular accumulation and not to a different rate of reduction or a different efficacy in DNA platination and/or efficiency in apoptosis induction. Although the exact mechanism of cell uptake is not fully deciphered, a series of naive experiments indicates an energy-dependent, carrier-mediated transport: the organic cation transporters (OCTs) are the likely proteins involved