Prevalence of anti-sperm antibodies, risk factors associated and their impact on spermatobioscopy in infertile men

Background: The first immunological correlation with male infertility was reported in 1954 by Wilson and Rumke with the identification of anti-sperm antibodies. The prevalence of anti-sperm antibodies in infertile men varies from 9%-36%, the main cause being the loss of the blood-testicular barrier and otherwise the association with chronic inflammation. It has been shown that immune infertility is found in 15% of patients with varicocele.Methods: A transversal comparative study was carried out with 360 infertile men who were tested for anti-sperm antibodies between January 2011 and July 2018. Two groups were integrated; Group 1, infertile men with positive anti-sperm antibodies >50%, group 2, infertile men with negative anti-sperm <50%. Seminogram parameters were evaluated according to the WHO 5th edition and associated risk factors with anti-sperm antibodies.Results: 360 infertile men were evaluated during the study, 42 were excluded because they did not meet the inclusion criteria, the prevalence of anti-sperm antibodies was 14.5%. Group 1; n=46 (14.5%) and group 2, n=272 (85.5%), the clinical characteristics and the hormonal profile were compared at study admission without significant difference. There was a significant decrease in progressive motility in group 1 (38.7±23.8) vs group 2 (50.1±18.9) p=0.03. Analyzing the risk factors, varicocele was found to be significant 23.7%, OR 2.14 (1.27-3.61) p=0.004 as well as retractable testicle 26.4%, OR 2.13 (1.23-3.70) p= 0.008.Conclusions: The affectation of motility was confirmed, which leads to the suspect varicocele and retractable testicle as risk factors

SOCIAL DESIGN FROM PSYCHOSOCIAL PROCESSES, VISUAL COMMUNICATION AND PUBLICITY IN THE COMMUNITY

El diseño social es la actividad que conlleva la responsabilidad de los profesionales en el desarrollo económico, social y cultural de las comunidades con miras al progreso, por este motivo el objetivo de la presente investigación fue evaluar la aplicabilidad del diseño social desde los procesos psicosociales, la comunicación visual y la publicidad en la comunidad. La metodología fue documental, descriptiva y exploratoria de análisis cualitativos y cuantitativos teniendo como herramienta principal la encuesta, con el propósito de documentar el nivel de conocimiento que poseen los microempresarios de la zona con respecto a publicidad y comunicación visual en el entorno psicosocial en el que se desarrollan. Los resultados demostraron que al documentar las actividad comercial y los ingresos económicos percibidos, más los gastos de la casa y la familia, variables psicosociales importantes, de las cuales se notó una alta percepción en los indicadores regular y aceptable con respecto a los ingresos económicos que estas personas perciben y que se convierten para la mayoría en una ayuda para solventar los gastos de la casa y de la familia, pero con un marcado desconocimiento en las ventajas y beneficios que podría otorgar la publicidad y la comunicación visual en sus negocios, desde la&nbsp; aplicación del diseño social desde los procesos psicosociales, la comunicación visual y la publicidad, para impulsar proyectos que mejoren la matiz productiva, brindando conocimientos teóricos y técnicos sobre la importancia del diseño gráfico y la publicidad. &nbsp; Abstract Social design is the activity that involves the responsibility of professionals in the economic, social and cultural development of communities with a view to progress, for this reason the objective of this research it was to evaluate the applicability of social design from the processes psychosocial, visual communication and publicity in the community. The methodology was documentary, descriptive and exploratory of qualitative and quantitative analysis having as main tool the survey, with the purpose of documenting the level of knowledge that micro entrepreneurs in the area have regarding advertising and visual communication in the psychosocial environment in which they develop. The results showed that when documenting the commercial activity and the income received, plus the expenses of the house and the family, important psychosocial variables, of which a high perception was observed in the indicators, regular and acceptable with respect to the economic income that These people perceive and that for the majority they become an aid to solve the expenses of the house and the family, but with a marked ignorance in the advantages and benefits that the publicity and the visual communication in their businesses could grant, from the application of social design from psychosocial processes, visual communication and advertising, to promote projects that improve the productive nuance, providing theoretical and technical knowledge on the importance of graphic design and advertising

Anti-TNF-alpha-adalimumab therapy is associated with persistent improvement of endothelial function without progression of carotid intima-media wall thickness in patients with rheumatoid arthritis refractory to conventional therapy

To determine whether treatment with the anti-TNF-alpha blocker adalimumab yields persistent improvement of endothelial function and prevents from morphological progression of subclinical atherosclerosis in patients with rheumatoid arthritis (RA) refractory to conventional therapy, a series of 34 consecutive RA patients, attending hospital outpatient clinics and who were switched from disease modifying antirheumatic drug therapy to anti-TNF-alpha-adalimumab treatment because of severe disease, were assessed by ultrasonography techniques before the onset of adalimumab therapy (at day 0) and then at day 14 and at month 12. Values of flow-mediated endothelium-dependent vasodilatation at day 14 and at month 12 were significantly higher (mean ± standard deviation (SD): 6.1 ± 3.9%; median: 5.7% at day 14, and mean ± SD: 7.4 ± 2.8%; median: 6.9% at month 12) than those obtained at day 0 (mean: 4.5 ± 4.0%; median: 3.6%; P = 0.03 and P < 0.001, resp.). Endothelium-independent vasodilatation results did not significantly change compared with those obtained at day 0. No significant differences were observed when carotid artery intima-media wall thickness values obtained at month 12 (mean ± SD: 0.69 ± 0.21 mm) were compared with those found at day 0 (0.65 ± 0.16 mm) (P = 0.3). In conclusion, anti-TNF-alpha-adalimumab therapy has beneficial effects on the development of the subclinical atherosclerosis disease in RA

Spicule emission profiles observed in \ion{He}{i} 10830 \AA

Off-the-limb observations with high spatial and spectral resolution will help us understand the physical properties of spicules in the solar chromosphere Spectropolarimetric observations of spicules in the \ion{He}{i} 10830 \AA\ multiplet were obtained with the Tenerife Infrared Polarimeter on the German Vacuum Tower Telescope at the Observatorio del Teide (Tenerife, Spain). The analysis shows the variation of the off-limb emission profiles as a function of the distance to the visible solar limb. The ratio between the intensities of the blue and the red components of this triplet $({\cal R}=I_{\rm blue}/I_{\rm red})$ is an observational signature of the optical thickness along the light path, which is related to the intensity of the coronal irradiation. We present observations of the intensity profiles of spicules above a quiet Sun region. The observable ${\cal R}$ as a function of the distance to the visible limb is also given. We have compared our observational results to the intensity ratio obtained from detailed radiative transfer calculations in semi-empirical models of the solar atmosphere assuming spherical geometry. The agreement is purely qualitative. We argue that future models of the solar chromosphere and transition region should account for the observational constraints presented here.Comment: letter accepted in A&A. 5 figure

Estimation of solar prominence magnetic fields based on the reconstructed 3D trajectories of prominence knots

We present an estimation of the lower limits of local magnetic fields in quiescent, activated, and active (surges) promineces, based on reconstructed 3-dimensional (3D) trajectories of individual prominence knots. The 3D trajectories, velocities, tangential and centripetal accelerations of the knots were reconstructed using observational data collected with a single ground-based telescope equipped with a Multi-channel Subtractive Double Pass imaging spectrograph. Lower limits of magnetic fields channeling observed plasma flows were estimated under assumption of the equipartition principle. Assuming approximate electron densities of the plasma n_e = 5*10^{11} cm^{-3} in surges and n_e = 5*10^{10} cm^{-3} in quiescent/activated prominences, we found that the magnetic fields channeling two observed surges range from 16 to 40 Gauss, while in quiescent and activated prominences they were less than 10 Gauss. Our results are consistent with previous detections of weak local magnetic fields in the solar prominences.Comment: 14 pages, 12 figures, 1 tabl

ESTUDIO DE UNA ANTENA DE MICROCINTA FRACTAL TIPO E PARA LA BANDA DE LOS 2.4 GHZ

ResumenEn este trabajo, se presenta el estudio experimental y por simulación de una antena de parche basada en la geometría fractal tipo E para operar en la banda libre de los 2.4 GHz. La estructura electromagnética de la antena diseñada se analiza utilizando el simulador HFSS de ANSI, mientras que el prototipo experimental se caracteriza utilizando un analizador de redes de 6.5 GHz acoplado a un equipo de medición de campo cercano para medir los parámetros importantes de esta antena. Considerando la geometría fractal tipo E de dos iteraciones, los resultados en las simulaciones muestran que la antena diseñada presenta una frecuencia de resonancia de 2.463 GHz con pérdidas por retorno cercanas a -50 dB y un ancho de banda de acoplamiento de 74 MHz. Los parámetros correspondientes en el prototipo experimental resultaron ser de 2.624 GHz, -17 dB y 100 MHz, respectivamente. Estos resultados demuestran la factibilidad de utilizar la antena de microcinta fractal tipo E para aplicaciones en las comunicaciones inalámbricas para la banda de los 2.4 GHz.Palabras Claves: ancho de banda de acoplamiento, antenas de banda ancha, antenas de microcinta, bandas sin licencia, geometría fractal tipo E. STUDY OF AN ANTENNA OF FRACTAL MICROCINTA TYPE E FOR THE BAND OF THE 2.4 GHZAbstractIn this paper, the simulation and experimental study of an E-shape fractal patch antenna for the unlicensed band of 2.4 GHz is presented. The electromagnetic structure of this antenna is analyzed using the High Frequency Structure Simulator HFSS of ANSY, while the experimental antenna prototype is characterized using a network analyzer of 6.5 GHz and a (near-field based) antenna pattern measurement equipment. Simulation results show that the designed antenna presents a resonant frequency of 2.463 GHz with return losses equal to -50 dB, and a coupling bandwidth of 74 MHz. On the other hand, the corresponding experimental parameters are 2.56 GHz, -17 dB, and 100 MHz, respectively. The study performed in this paper demonstrates the suitability of using the E-shape fractal patch antenna for wireless applications at the 2.4 GHz unlicensed band.Keywords: broadband antennas, coupling bandwidth, ISM frequency bands, patch antennas, type-E fractal geometry

Stabilization of apoptotic cells: generation of zombie cells

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.Apoptosis is characterized by degradation of cell components but plasma membrane remains intact. Apoptotic microtubule network (AMN) is organized during apoptosis forming a cortical structure beneath plasma membrane that maintains plasma membrane integrity. Apoptotic cells are also characterized by high reactive oxygen species (ROS) production that can be potentially harmful for the cell. The aim of this study was to develop a method that allows stabilizing apoptotic cells for diagnostic and therapeutic applications. By using a cocktail composed of taxol (a microtubule stabilizer), Zn2+ (a caspase inhibitor) and coenzyme Q10 (a lipid antioxidant), we were able to stabilize H460 apoptotic cells in cell cultures for at least 72 h, preventing secondary necrosis. Stabilized apoptotic cells maintain many apoptotic cell characteristics such as the presence of apoptotic microtubules, plasma membrane integrity, low intracellular calcium levels and mitochondrial polarization. Apoptotic cell stabilization may open new avenues in apoptosis detection and therapy.This work was supported by FIS PI10/00543 grant, Ministerio de Sanidad, Spain, and Fondo Europeo de Desarrollo Regional (FEDER-Unión Europea), SAS 111242 grant, Servicio Andaluz de Salud-Junta de Andalucía, Proyecto de Investigación de Excelencia de la Junta de Andalucía CTS-5725, BFU2012-38208 and by AEPMI (Asociación de Enfermos de Patología Mitocondrial).Peer Reviewe

A taxonomic backbone for the global synthesis of species diversity in the angiosperm order caryophyllales

The Caryophyllales constitute a major lineage of flowering plants with approximately 12?500 species in 39 families. A taxonomic backbone at the genus level is provided that reflects the current state of knowledge and accepts 749 genera for the order. A detailed review of the literature of the past two decades shows that enormous progress has been made in understanding overall phylogenetic relationships in Caryophyllales. The process of re-circumscribing families in order to be monophyletic appears to be largely complete and has led to the recognition of eight new families (Anacampserotaceae, Kewaceae, Limeaceae, Lophiocarpaceae, Macarthuriaceae, Microteaceae, Montiaceae and Talinaceae), while the phylogenetic evaluation of generic concepts is still well underway. As a result of this, the number of genera has increased by more than ten percent in comparison to the last complete treatments in the “Families and genera of vascular plants” series. A checklist with all currently accepted genus names in Caryophyllales, as well as nomenclatural references, type names and synonymy is presented. Notes indicate how extensively the respective genera have been studied in a phylogenetic context. The most diverse families at the generic level are Cactaceae and Aizoaceae, but 28 families comprise only one to six genera. This synopsis represents a first step towards the aim of creating a global synthesis of the species diversity in the angiosperm order Caryophyllales integrating the work of numerous specialists around the world. © 2015 BGBM Berlin

Effects of external nutrient sources and extreme weather events on the nutrient budget of a Southern European coastal lagoon

The seasonal and annual nitrogen (N), phosphorus (P), and carbon (C) budgets of the mesotidal Ria Formosa lagoon, southern Portugal, were estimated to reveal the main inputs and outputs, the seasonal patterns, and how they may influence the ecological functioning of the system. The effects of extreme weather events such as long-lasting strong winds causing upwelling and strong rainfall were assessed. External nutrient inputs were quantified; ocean exchange was assessed in 24-h sampling campaigns, and final calculations were made using a hydrodynamic model of the lagoon. Rain and stream inputs were the main freshwater sources to the lagoon. However, wastewater treatment plant and groundwater discharges dominated nutrient input, together accounting for 98, 96, and 88 % of total C, N, and P input, respectively. Organic matter and nutrients were continuously exported to the ocean. This pattern was reversed following extreme events, such as strong winds in early summer that caused upwelling and after a period of heavy rainfall in late autumn. A principal component analysis (PCA) revealed that ammonium and organic N and C exchange were positively associated with temperature as opposed to pH and nitrate. These variables reflected mostly the benthic lagoon metabolism, whereas particulate P exchange was correlated to Chl a, indicating that this was more related to phytoplankton dynamics. The increase of stochastic events, as expected in climate change scenarios, may have strong effects on the ecological functioning of coastal lagoons, altering the C and nutrient budgets.Portuguese Science and Technology Foundation (FCT) [POCI/MAR/58427/2004, PPCDT/MAR/58427/2004]; Portuguese Science and Technology Foundation (FCT

Impact of regulated and emerging pollutants and microplastics in marine ecosystems (IMPACTA project)

Marine ecosystems are nowadays subjected to a massive input of synthetic chemicals from everywhere. Unfortunately only a small portion of them is being monitored, and it is necessary to identify which pollutants can produce adverse impacts in the marine environment. IMPACTA project (CTM2013-48194-C3) is characterizing the distribution of regulated and emerging contaminants and microplastics in marine sediments, and evaluating the biological effects that they can cause (sing sublethal embryotoxicity tests, endocrine disruption and biomarkers). Sensitive and selective analytical methods are being developed and validated for pharmaceuticals, perfluorinated compounds, organophosphorus pesticides, triazines, personal care products, nonylphenols and alkylated PAHs in sediments. Thus, relevant pollutants present in coastal and offshore areas will be identified. Furthermore potential toxic effects of the contaminants present in coastal sediments are being assessed through embryotoxicity bioassays and also the biological effects on different marine species as a consequence of their exposition to specific compounds. Another relevant contribution of this project will be the assessment of the impact of micro-plastics, first time in the Spanish coastal areas. Their potential toxic effects and their role in the transference of pollutants in the marine environment are being assessed. The concentration and composition of microplastics in sediments and demersal fish stomachs are being characterized, and their potential biological effects on marine invertebrates are also being investigated