160 research outputs found

    Instalación fotovoltáica y centro de transformación en nave industrial

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    EL presente proyecto pretende el desarrollo y creación de una instalación fotovoltaica y un centro de transformación en una nave industrial, la cual estará situada en el polígono industrial La Mora, en la localidad de La Cistérniga. Se dedicará al mecanizado de tubos, perfiles y elementos metálicos variados. Por lo que para el desarrollo de dicha actividad se necesitará el uso de maquinaria pesada, para la que deberemos crear una instalación de abastecimiento eléctrico, debido a la alta potencia demandada. Dicha nave estará compuesta por dos plantas, en una el taller y en otra la zona de oficinas.Departamento de Ingeniería EléctricaIngeniero Técnico Industrial, Especialidad en Electrónica Industria

    Analysis of the COVID-19 Lockdown¿s Impact on Air Quality in the Larger Cities of Spain

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    [EN] During the period of the COVID-19 pandemic, the air quality reached the best levels to be recorded in large cities in Spain. To analyze and demonstrate this improvement in air quality levels, the evolution of the average nitrogen dioxide (NO2) levels in 78 Spanish cities with more than 50,000 inhabitants during the pre-COVID-19 years (2017¿2019), the period of the COVID-19 lockdown, and the post-COVID-19 year (2021) was analyzed. The results show an improvement in the air quality in most of the cities analyzed for 2020 due to the COVID-19 restrictions. In addition, in 2021, without the COVID-19 restrictions, the air quality levels of the largest cities in Spain showed important improvements in terms of NO2 concentration compared to the levels in the pre-COVID-19 years (2017¿2019). Nevertheless, in 2021, only 11 cities were below the average annual limit of 10 µg/m3 NO2 established by the World Health Organization (WHO). In addition, no cities with more than 500,000 inhabitants achieved NO2 levels below the WHO limit. Finally, a detailed monthly analysis indicated that the pre-COVID-19 levels were reached again during the last months of the monitored period.Lorenzo-Sáez, E.; Coll-Aliaga, E.; Oliver Villanueva, JV.; Prieto Del Campo, F.; Lerma Arce, V. (2022). Analysis of the COVID-19 Lockdown¿s Impact on Air Quality in the Larger Cities of Spain. Sustainability. 14(9):1-9. https://doi.org/10.3390/su140956131914

    Oral insulin-mimetic compounds that act independently of insulin

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    The hallmarks of insulin action are the stimulation and suppression of anabolic and catabolic responses, respectively. These responses are orchestrated by the insulin pathway and are initiated by the binding of insulin to the insulin receptor, which leads to activation of the receptor's intrinsic tyrosine kinase. Severe defects in the insulin pathway, such as in types A and B and advanced type 1 and 2 diabetes lead to severe insulin resistance, resulting in a partial or complete absence of response to exogenous insulin and other known classes of antidiabetes therapies. We have characterized a novel class of arylalkylamine vanadium salts that exert potent insulin-mimetic effects downstream of the insulin receptor in adipocytes. These compounds trigger insulin signaling, which is characterized by rapid activation of insulin receptor substrate-1, Akt, and glycogen synthase kinase-3 independent of insulin receptor phosphorylation. Administration of these compounds to animal models of diabetes lowered glycemia and normalized the plasma lipid profile. Arylalkylamine vanadium compounds also showed antidiabetic effects in severely diabetic rats with undetectable circulating insulin. These results demonstrate the feasibility of insulin-like regulation in the complete absence of insulin and downstream of the insulin receptor. This represents a novel therapeutic approach for diabetic patients with severe insulin resistance
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