Strategies for the Reduction of Cybersecurity Breaches in Hospitals

AbstractRecent cyberattacks in hospitals show the urgency of the need to enhance secure information technology (IT) infrastructure. Hospitals are statistically more at cyber risk than all the multiple industries against ransomware, malware, hacking and internal threats. Guided by routine activity theory, the purpose of this exploratory multiple case study was to explore strategies utilized by hospitals\u27 IT security managers to reduce cybersecurity breaches associated with sensitive data. The participants were nine IT security managers from hospitals in the eastern United States. Data were collected via semistructured interviews and supporting documentation from the consenting participants and hospitals\u27 websites. Through thematic analysis, seven core themes emerged: (a) ensure adherence to top cybersecurity framework, (b) implement adequate and effective cybersecurity controls, (c) conduct a regular cybersecurity risk assessment, (d) maintain an air gap technique backup, (e) cultivate security awareness culture, (f) encrypt all data at rest and in transit, and (g) keep abreast with cybersecurity news and risks. A key recommendation for IT security managers is to utilize the maintenance of regularly updated backup as a crucial tactic for reducing exposure to cybercriminals. The implication for positive social change includes the potential to increase patients\u27 trust and reduce the threat to human life

Anti-androgens act jointly in suppressing spiggin concentrations in androgen-primed female three-spined sticklebacks - Prediction of combined effects by concentration addition

This is the post-print version of the final paper published in Aquatic Toxicology. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2013 Elsevier B.V.Increasing attention is being directed at the role played by anti-androgenic chemicals in endocrine disruption of wildlife within the aquatic environment. The co-occurrence of multiple contaminants with anti-androgenic activity highlights a need for the predictive assessment of combined effects, but information about anti-androgen mixture effects on wildlife is lacking. This study evaluated the suitability of the androgenised female stickleback screen (AFSS), in which inhibition of androgen-induced spiggin production provides a quantitative assessment of anti-androgenic activity, for predicting the effect of a four component mixture of anti-androgens. The anti-androgenic activity of four known anti-androgens (vinclozolin, fenitrothion, flutamide, linuron) was evaluated from individual concentration-response data and used to design a mixture containing each chemical at equipotent concentrations. Across a 100-fold concentration range, a concentration addition approach was used to predict the response of fish to the mixture. Two studies were conducted independently at each of two laboratories. By using a novel method to adjust for differences between nominal and measured concentrations, good agreement was obtained between the actual outcome of the mixture exposure and the predicted outcome. This demonstrated for the first time that androgen receptor antagonists act in concert in an additive fashion in fish and that existing mixture methodology is effective in predicting the outcome, based on concentration-response data for individual chemicals. The sensitivity range of the AFSS assay lies within the range of anti-androgenicity reported in rivers across many locations internationally. The approach taken in our study lays the foundations for understanding how androgen receptor antagonists work together in fish and is essential in informing risk assessment methods for complex anti-androgenic mixtures in the aquatic environment.European Commission and Natural Environment Research Council

Feather corticosterone content in predatory birds in relation to body condition and hepatic metal concentration

This study investigated the feasibility of measuring corticosterone in feathers from cryo-archived raptor specimens, in order to provide a retrospective assessment of the activity of the stress axis in relation to contaminant burden. Feather samples were taken from sparrowhawk Accipiter nisus, kestrel Falco tinnunculus, buzzard Buteo buteo, barn owl Tyto alba, and tawny owl Strix aluco and the variation in feather CORT concentrations with respect to species, age, sex, feather position, and body condition was assessed. In sparrowhawks only, variation in feather CORT content was compared with hepatic metal concentrations. For individuals, CORT concentration (pg mm-1) in adjacent primary flight feathers (P5 and P6), and left and right wing primaries (P5), was statistically indistinguishable. The lowest concentrations of CORT were found in sparrowhawk feathers and CORT concentrations did not vary systematically with age or sex for any species. Significant relationships between feather CORT content and condition were observed in only tawny owl and kestrel. In sparrowhawks, feather CORT concentration was found to be positively related to the hepatic concentrations of five metals (Cd, Mn, Co, Cu, Mo) and the metalloid As. There was also a negative relationship between measures of condition and total hepatic metal concentration in males. The results suggest that some factors affecting CORT uptake by feathers remain to be resolved but feather CORT content from archived specimens has the potential to provide a simple effects biomarker for exposure to environmental contaminants

Low genetic variation detected in New Zealand populations of Phaeomoniella chlamydospora

Phaeomoniella chlamydospora is considered to be the causal agent of Petri disease. This disease causes decline of grapevines in most grape growing regions of the world. Genetic variation within 39 New Zealand isolates of Phaeomoniella chlamydospora was compared to six isolates from Italy using randomly amplified polymorphic DNA (RAPD), randomly amplified microsatellites (RAM), amplified fragment length polymorphism (AFLP), and universally primed polymerase chain reaction (UP-PCR). Using each method, genetic variation within New Zealand and Italian isolates of P. chlamydospora was shown to be low, with a maximum of seven genetic groups identified by each primer. The greatest amount of genetic variation was shown using AFLP analysis, with 21 different groups identified. RAPD, AFLP and UP-PCR primers detected inter-vineyard, intra-vineyard and intra-vine variation of New Zealand isolates. A subset of five New Zealand and one Italian isolate was further investigated using mycelial compatibility groups (MCGs). One MCG was identified, supporting low genetic variation within P. chlamydospora isolates. Low genetic variation within the New Zealand and the Italian populations suggests that asexual reproduction predominates, and the presence of intra-vineyard and intra-vine variation in New Zealand indicates that multiple introductions have occurred

The National Cancer Institute Cohort Consortium : An International Pooling Collaboration of 58 Cohorts from 20 Countries

Cohort studies have been central to the establishment of the known causes of cancer. To dissect cancer etiology in more detail-for instance, for personalized risk prediction and prevention, assessment of risks of subtypes of cancer, and assessment of small elevations in risk-there is a need for analyses of far larger cohort datasets than available in individual existing studies. To address these challenges, the NCI Cohort Consortium was founded in 2001. It brings together 58 cancer epidemiology cohorts from 20 countries to undertake large-scale pooling research. The cohorts in aggregate include over nine million study participants, with biospecimens available for about two million of these. Research in the Consortium is undertaken by >40 working groups focused on specific cancer sites, exposures, or other research areas. More than 180 publications have resulted from the Consortium, mainly on genetic and other cancer epidemiology, with high citation rates. This article describes the foundation of the Consortium; its structure, governance, and methods of working; the participating cohorts; publications; and opportunities. The Consortium welcomes newmembers with cancer-oriented cohorts of 10,000 or more participants and an interest in collaborative research. (C) 2018 AACR.Peer reviewe

SemLAV: Local-As-View Mediation for SPARQL Queries

International audienceThe Local-As-View(LAV) integration approach aims at querying heterogeneous data in dynamic environments. In LAV, data sources are described as views over a global schema which is used to pose queries. Query processing requires to generate and execute query rewritings, but for SPARQL queries, the LAV query rewritings may not be generated or executed in a reasonable time. In this paper, we present SemLAV, an alternative technique to process SPARQL queries over a LAV integration system without generating rewritings. SemLAV executes the query against a partial instance of the global schema which is built on-the-fly with data from the relevant views. The paper presents an experimental study for SemLAV, and compares its performance with traditional LAV-based query processing techniques. The results suggest that SemLAV scales up to SPARQL queries even over a large number of views, while it significantly outperforms traditional solutions

Secular Trends in Nosocomial Bloodstream Infections: Antibiotic-Resistant Bacteria Increase the Total Burden of Infection

In this international study, we demonstrate that increasing rates of nosocomial bloodstream infections caused by antibiotic-resistant bacteria do not replace infections caused by antibiotic-susceptible bacteria, but occur in addition to these infections, thereby increasing the total burden of diseas

VIS: the visible imager for Euclid

Euclid-VIS is the large format visible imager for the ESA Euclid space mission in their Cosmic Vision program, scheduled for launch in 2020. Together with the near infrared imaging within the NISP instrument, it forms the basis of the weak lensing measurements of Euclid. VIS will image in a single r+i+z band from 550-900 nm over a field of view of ~0.5 deg2. By combining 4 exposures with a total of 2260 sec, VIS will reach to V=24.5 (10σ) for sources with extent ~0.3 arcsec. The image sampling is 0.1 arcsec. VIS will provide deep imaging with a tightly controlled and stable point spread function (PSF) over a wide survey area of 15000 deg2 to measure the cosmic shear from nearly 1.5 billion galaxies to high levels of accuracy, from which the cosmological parameters will be measured. In addition, VIS will also provide a legacy dataset with an unprecedented combination of spatial resolution, depth and area covering most of the extra-Galactic sky. Here we will present the results of the study carried out by the Euclid Consortium during the period up to the Preliminary Design Review. © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only