143 research outputs found
Lepton flavour violating semileptonic tau decays in constrained MSSM-seesaw scenarios
In this work we study the Lepton Flavour Violating semileptonic
decays: 1) with ; 2) with and 3) with . We work within the context of two constrained
MSSM scenarios: the CMSSM and NUHM. A full one-(SUSY)loop computation is
presented and the importance of the various contributions, the -, -,
and Higgs bosons mediated ones are analysed. The hadronization of quark
bilinears is performed within the chiral framework. Some discrepancies in the
predicted rates for BR(), BR() and
BR() are found with respect to previous estimates, which
will be commented here. These three channels will be shown to be the most
competitive ones to test simultaneously the Lepton Flavour Violation and the
Higgs sector. We further present here a set of approximate formulas for all the
semileptonic channels which we believe can be useful for further comparison
with present and future data.Comment: 51 pages, 18 figures. Version published in JHEP06(2008)07
Gas chromatography–tandem mass spectrometry with atmospheric pressure chemical ionization for fluorotelomer alcohols and perfluorinated sulfonamides determination
Ionization and in source-fragmentation behavior of four fluorotelomer alcohols (FTOH) (4:2 FTOH, 6:2 FTOH, 8:2 FTOH and 10:2 FTOH) and four N-alkyl fluorooctane sulfonamides/-ethanols (N-MeFOSA, N-EtFOSA, N-MeFOSE and N-EtFOSE) by APCI has been studied and compared with the traditionally used EI and CI. Protonated molecule was the base peak of the APCI spectrum in all cases giving the possibility of selecting it as a precursor ion for MS/MS experiments. Following, CID fragmentation showed common product ions for all FOSAs/FOSEs (C4F7 and C3F5). Nevertheless, the different functionality gave characteristic pattern fragmentations. For instance, FTOHs mainly loss H2O + HF, FOSAs showed the losses of SO2 and HF while FOSEs showed the losses of H2O and SO2. Linearity, repeatability and LODs have been studied obtaining instrumental LODs between 1 and 5 fg. Finally, application to river water and influent and effluent waste water samples has been carried out in order to investigate the improvements in detection capabilities of this new source in comparison with the traditionally used EI/CI sources. Matrix effects in APCI have been evaluated in terms of signal enhancement/suppression when comparing standards in solvent and matrix. No matrix effects were observed and concentrations found in samples were in the range of 1–100 pg L−1 far below the LODs achieved with methods previously reported. Unknown related perfluoroalkyl substances, as methyl-sulfone and methyl-sulfoxide analogues for FTOHs, were also discovered and tentatively identified.The authors wish to acknowledge the financial support received from Spanish Ministry of Economy and Competitiveness under the project CTQ2012-30836 and from the Agency for Administration of University and Research Grants (Generalitat de Catalunya, Spain) under the project 2014 SGR-539. They are very grateful to the Serveis Centrals d’Instrumentació Científica (SCIC) of University Jaume I for the use of the GC XevoTQ-S
Relating Andreev Bound States and Supercurrents in Hybrid Josephson Junctions
We investigate superconducting quantum interference devices consisting of two
highly transmissive Josephson junctions coupled by a superconducting loop, all
defined in an epitaxial InAs/Al heterostructure. A novel device design allows
for independent measurements of the Andreev bound state spectrum within the
normal region of a junction and the resulting current-phase relation. We show
that knowledge of the Andreev bound state spectrum alone is enough to derive
the independently measured phase dependent supercurrent. On the other hand, the
opposite relation does not generally hold true as details of the energy
spectrum are averaged out in a critical current measurement. Finally,
quantitative understanding of field dependent spectrum and supercurrent require
taking into account the second junction in the loop and the kinetic inductance
of the epitaxial Al film
Adipokines and Inflammation: Focus on Cardiovascular Diseases
It is well established that adipose tissue, apart from its energy storage function, acts as an endocrine organ that produces and secretes a number of bioactive substances, including hormones commonly known as adipokines. Obesity is a major risk factor for the development of cardiovascular diseases, mainly due to a low grade of inflammation and the excessive fat accumulation produced in this state. The adipose tissue dysfunction in obesity leads to an aberrant release of adipokines, some of them with direct cardiovascular and inflammatory regulatory functions. Inflammation is a common link between obesity and cardiovascular diseases, so this review will summarise the role of the main adipokines implicated in the regulation of the inflammatory processes occurring under the scenario of cardiovascular diseases
The Discrepancy Between tau and e+e- Spectral Functions Revisited and the Consequences for the Muon Magnetic Anomaly
We revisit the procedure for comparing the pi pi spectral function measured
in tau decays to that obtained in e+e- annihilation. We re-examine the
isospin-breaking corrections using new experimental and theoretical input, and
find improved agreement between the tau- --> pi- pi0 nu_tau branching fraction
measurement and its prediction using the isospin-breaking-corrected e+e- -->
pi+pi- spectral function, though not resolving all discrepancies. We recompute
the lowest order hadronic contributions to the muon g-2 using e+e- and tau data
with the new corrections, and find a reduced difference between the two
evaluations. The new tau-based estimate of the muon magnetic anomaly is found
to be 1.9 standard deviations lower than the direct measurement.Comment: 10 pages, 6 figures, submitted to Eur. Phys. J. C; (v2): Revised
version with improved and uniform treatment of tau and e+e- data with
HVPTools and a few minor bug fixes; (v3): Final version accepted for
publicatio
Evaluation of Haptic Feedback on Bimanually Teleoperated Laparoscopy for Endometriosis Surgery
Robotic minimal invasive surgery is gaining acceptance in surgical care. In contrast with the appreciated 3D vision and enhanced dexterity, haptic feedback is not offered. For this reason robotics is not considered beneficial for delicate interventions such the endometriosis. Overall, haptic feedback remains debatable and yet unproven except for some simple scenarios such as Fundamentals of Laparoscopic Surgery exercises. OBJECTIVE: The present work investigates the benefits of haptic feedback on more complex surgical gestures, manipulating delicate tissue through coordination between multiple instruments. Methods: A new training exercise, “Endometriosis Surgery Exercise” (ESE) has been devised approximating the setting for monocular robotic endometriosis treatment. A bimanual bilateral teleoperation setup was designed for laparoscopic laser surgery. Haptic guidance and haptic feedback are respectively offered to the operator. User experiments have been conducted to i) assess the validity of ESE and to ii) examine possible advantages of haptic technology during execution of bimanual surgery. RESULTS: i) Content and face validity of ESE was established by participating surgeons. Surgeons suggested ESE also as a means to train lasering skills, ii) interaction forces on endometriotic tissue were found to be significantly lower when a bilateral controller is used. Collisions between instruments and the environment were less frequent and so were situations marked as potentially dangerous. CONCLUSION: This study provides some promising results suggesting that haptics may offer a distinct advantage in complex robotic interventions were fragile tissue is manipulated. SIGNIFICANCE: Patients need to know whether it should be incorporated. Improved understanding of the value of haptics is important as current commercial surgical robots are widely used but do not offer haptics
American heart association's life simple 7 and the risk of atrial fibrillation in the PREDIMED study cohort
Background and aims
The American Heart Association proposed 7 ideal cardiovascular health metrics (Life's Simple 7 [LS7]) namely, not smoking, body mass index <25 kg/m2, healthy diet, moderate physical activity ≥150 min/week, total blood cholesterol <200 mg/dL, blood pressure <120/80 mmHg and fasting blood glucose <100 mg/dL. Our objective was to assess the association between these LS7 metrics and the incidence of atrial fibrillation (AF).
Methods and results
A total of 6,479 participants of the PREDIMED study were included. We calculated the participants’ baseline LS7 index ranging 0–7 points to categorize them according to their adherence to these LS7 health metrics. Multivariable Cox regression models were used to estimate Hazard Ratios (HR) and their 95% Confidence Intervals (95% CI). After a median follow-up of 4.8 years, we identified 250 incident cases of AF. After adjusting for potential confounders, adherence to LS7 index was not associated with the incidence of AF (adjusted HR 0.90 [95% CI: 0.56–1.45] for highest vs. lowest LS7 categories). Body mass index <25 kg/m2 was the only health metric individually associated with a lower risk of AF (HR 0.36 [95% CI: 0.16–0.78]).
Conclusions
In a high cardiovascular risk Spanish population, adherence to American Heart Association's LS7 metrics was not associated with the risk of incident AF
The Standard Model Prediction of the Muon Anomalous Magnetic Moment
This article reviews and updates the Standard Model prediction of the muon
g-2. QED, electroweak and hadronic contributions are presented, and open
questions discussed. The theoretical prediction deviates from the present
experimental value by 2-3 standard deviations, if e+e- annihilation data are
used to evaluate the leading hadronic term.Comment: 30 pages, 8 figures. v2: Updated version to appear in J.Phys.G.
Comments and references added, typo corrected in eq.(17
Effects of Antibiotics on the Growth and Physiology of Chlorophytes, Cyanobacteria, and a Diatom
The occurrence of antibiotics in surface waters has been reported worldwide with concentrations ranging from ng L−1 to low µg L−1 levels. During environmental risk assessments, effects of antibiotics on algal species are assessed using standard test protocols (e.g., the OECD 201 guideline), where the cell number endpoint is used as a surrogate for growth. However, the use of photosynthetic related endpoints, such as oxygen evolution rate, and the assessment of effects on algal pigments could help to inform our understanding of the impacts of antibiotics on algal species. This study explored the effects of three major usage antibiotics (tylosin, lincomycin, and trimethoprim) on the growth and physiology of two chlorophytes (Desmodesmus subspicatus and Pseudokirchneriella subcapitata), a cyanobacteria (Anabaena flos-aquae), and a diatom (Navicula pelliculosa) using a battery of parameters, including cell density, oxygen evolution rate, total chlorophyll content, carotenoids, and the irradiance–photosynthesis relationship. The results indicated that photosynthesis of chlorophytes was a more sensitive endpoint than growth (i.e., EC50 derived based on the effects of tylosin on the growth of D. subspicatus was 38.27 µmol L−1 compared with an EC50 of 17.6 µmol L−1 based on photosynthetic rate), but the situation was reversed when testing cyanobacteria and the diatom (i.e., EC50 derived based on the effects of tylosin on the growth of A. flos-aquae was 0.06 µmol L−1; EC50 0.33 µmol L−1 based on photosynthetic rate). The pigment contents of algal cells were affected by the three antibiotics for D. subspicatus. However, in some cases, pigment content was stimulated for P. subcapitata, N. pelliculosa, and A. flos-aquae. The light utilization efficiency of chlorophytes and diatom was decreased markedly in the presence of antibiotics. The results demonstrated that the integration of these additional endpoints into existing standardised protocols could provide useful insights into the impacts of antibiotics on algal species
Direct Visualization of Peptide/MHC Complexes at the Surface and in the Intracellular Compartments of Cells Infected In Vivo by Leishmania major
Protozoa and bacteria infect various types of phagocytic cells including macrophages, monocytes, dendritic cells and eosinophils. However, it is not clear which of these cells process and present microbial antigens in vivo and in which cellular compartments parasite peptides are loaded onto Major Histocompatibility Complex molecules. To address these issues, we have infected susceptible BALB/c (H-2d) mice with a recombinant Leishmania major parasite expressing a fluorescent tracer. To directly visualize the antigen presenting cells that present parasite-derived peptides to CD4+ T cells, we have generated a monoclonal antibody that reacts to an antigenic peptide derived from the parasite LACK antigen bound to I-Ad Major Histocompatibility Complex class II molecule. Immunogold electron microscopic analysis of in vivo infected cells showed that intracellular I-Ad/LACK complexes were present in the membrane of amastigote-containing phagosomes in dendritic cells, eosinophils and macrophages/monocytes. In both dendritic cells and macrophages, these complexes were also present in smaller vesicles that did not contain amastigote. The presence of I-Ad/LACK complexes at the surface of dendritic cells, but neither on the plasma membrane of macrophages nor eosinophils was independently confirmed by flow cytometry and by incubating sorted phagocytes with highly sensitive LACK-specific hybridomas. Altogether, our results suggest that peptides derived from Leishmania proteins are loaded onto Major Histocompatibility Complex class II molecules in the phagosomes of infected phagocytes. Although these complexes are transported to the cell surface in dendritic cells, therefore allowing the stimulation of parasite-specific CD4+ T cells, this does not occur in other phagocytic cells. To our knowledge, this is the first study in which Major Histocompatibility Complex class II molecules bound to peptides derived from a parasite protein have been visualized within and at the surface of cells that were infected in vivo
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