Authenticity in Discursive Practices of the Online Market for Second-Hand Luxury Clothing

Authenticity is a particularly sensitive and salient issue in the online market for second-hand luxury clothing, and it is still little explored in the field of consumption studies. In this study we sought to analyze how authenticity is represented in discursive practices of the Brazilian online market for second-hand luxury clothing. The corpus of the work consisted of data collected through interviews in five stores of the Brazilian online market of luxury second-hand clothing. The data were analyzed using the Critical Discourse Analysis (CDA), proposed by Fairclough (1992), articulated to the sociocultural perspective of consumption. From the discursive categories Subject, Interdiscursivity, Intertextuality, Transitivity System, and Appraisal System, we perceived that the process of legitimizing the stores and the representations of authenticity are overlapped and traversed significantly by historical, social, and cultural aspects. We conclude that insofar as it becomes difficult to ensure objective authenticity, an interpretative dimension emerges, elaborated from the influence of sociocultural factors that underlie the judgment on what is authentic luxury, which in the scenario investigated are indexes of expression of high luxury. In this case, the origins and trajectories that are recognized as references of elite distinction for Brazilian consumers are important elements for the interpretation of authenticity

Quality and effectiveness of different approaches to primary care delivery in Brazil

BACKGROUND: Since 1994, Brazil has developed a primary care system based on multidisciplinary teams which include not only a physician and a nurse, but also 4–6 lay community health workers. This system now consists of 26,650 teams, covering 46% of the Brazilian population. Yet relatively few investigations have examined its effectiveness, especially in contrast with that of the traditional multi-specialty physician team approach it is replacing, or that of other existing family medicine approaches placing less emphasis on lay community health workers. Primary health care can be defined through its domains of access to first contact, continuity, coordination, comprehensiveness, community orientation and family orientation. These attributes can be ascertained via instruments such as the Primary Care Assessment Tool (PCATool), and correlated with the effectiveness of care. The objectives of our study are to validate the adult version of this instrument in Portuguese, identify the extent (quality) of primary care present in different models of primary care services, and correlate this extent with measures of process and outcomes in patients with diabetes, hypertension and coronary heart disease (CHD). METHODS/DESIGN: We are conducting a population-based cross-sectional study of primary care in the municipality of Porto Alegre. We will interview a random sample totaling 3000 adults residing in geographic areas covered by four distinct models of primary care of the Brazilian national health system or, alternatively, by one nationally prominent complementary health care service, as well as the physicians and nurses of the health teams of these services. Interviews query perceived quality of care (PCATool-Adult Version), patient satisfaction, and process indicators of management of diabetes, hypertension and known CHD. We are measuring blood pressure, anthropometrics and, in adults with known diabetes, glycated hemoglobin. DISCUSSION: We hope to contribute not only by validating the PCATool-Adult Version for use in Brazil, but also by furnishing ample data concerning the appropriate mix of health care professionals in the primary care team, a question of international import. Once validated, future use of this instrument should help direct advances aiming at improving the quality of primary care in Brazil

Caderno de pós-graduação em direito: prática processual constitucional e administrativa

O primeiro artigo, elaborado por Rodolfo Moreira Alencastro Veiga, tem como foco a análise da legitimidade da imposição de tais restrições à luz do diálogo institucional entre os Poderes Legislativo e Judiciário. O segundo, escrito por Victor Lima Duque Estrada, caracteriza-se por uma abordagem eminentemente descritiva, pautada nos votos prolatados no julgamento da Ação Direta de Inconstitucionalidade nº 5.526/DF, na qual questionada a possibilidade de aplicação das medidas cautelares penais previstas nos artigos 312 e 319 do Código de Processo Penal a membros do Poder Legislativo, bem como, em caso positivo, a necessidade de se submeter tais decisões ao Congresso Nacional. O terceiro artigo, de autoria de Gabriela Rosa Coutinho, traz reflexões acerca das transformações ocorridas constitucionalismo pátrio, a fim de analisar se a preponderância do controle concentrado tem contribuído para conferir maior efetividade aos direitos e garantias fundamentais, assim como para o fortalecimento da democracia brasileira. No quarto trabalho, Eleonora Aparecida Vasconcelos Santana aborda “a modulação dos efeitos da declaração de inconstitucionalidade como um instrumento de mitigação da teoria clássica da nulidade da norma inconstitucional”, com o intuito de sustentar a consagração, no ordenamento jurídico brasileiro, de um modelo híbrido no tocante à natureza do ato inconstitucional. Após discorrer sobre as principais diferenças entre as teorias da nulidade e da anulabilidade do ato inconstitucional, a autora busca demonstrar como a possibilidade de modulação dos efeitos da declaração de inconstitucionalidade, prevista no artigo 27 da Lei nº 9.868/99, revela-se autêntico instrumento de mitigação do princípio da nulidade, tradicionalmente adotado pela doutrina e jurisprudência pátrias. No último artigo selecionado, Alana Laís da N. B. Oliveira defende a necessidade de uma reforma constitucional com o intuito de incluir o Defensor Público-Geral União no rol de legitimados do artigo 103 da Constituição da República. Tal medida, em sua visão, revela-se importante para a otimização da defesa dos hipossuficientes, bem como para o aprimoramento e uniformização do sistema de atendimento ao público carente

Bis(tetra­phenyl­phospho­nium) bis­[N-(trifluoro­methyl­sulfon­yl)dithio­carbimato(2−)-κ2 S,S′]zincate(II)

The title salt, (C24H20P)2[Zn(C2F3NO2S3)2], consists of a complex dianion and two tetra­phenyl­phospho­nium cations. The ZnII ion displays a distorted tetra­hedral coordination environment with four S atoms from two S,S′-chelated N-(trifluoro­methyl­sulfonyl­)dithio­carbimate anions. In the crystal, besides the ionic inter­action of the oppositely charged ions, inter­molecular C—H⋯O inter­actions between cations and anions are observed. One of the cations inter­acts with an inversion-related equivalent by π–π stacking between phenyl rings, with a centroid–centroid distance of 3.932 (4) Å

Vasoactive agents for the management of acute variceal bleeding: A systematic review and meta-analysis

Background & Aims: Vasoactive agents with endoscopic therapy are used to treat acute variceal bleeding (AVB). There are two main groups of vasoactive agents: terlipressin and vasopressin (T-V), and octreotide and somatostatin (O-S). However, the benefit/harm balance is unclear. Our aim was to assess the efficacy and safety of T-V versus O-S for the management of AVB. Methods: We performed a systematic search for randomized controlled trials (RCTs) in PubMed, Scopus, and CENTRAL. Our main outcomes were mortality and adverse events. Secondary outcomes were bleeding control, rebleeding, blood transfusion, hospital stay. We evaluated the certainty of evidence using GRADE methodology. Results: We included 21 RCTs. The risk of mortality (RR: 1.01; 95%CI: 0.83-1.22), bleeding control (RR: 0.96; 95%CI: 0.91-1.02; I2=53%), early rebleeding (RR: 0.91; 95%CI: 0.66-1.24: I2=0%), late rebleeding (RR: 0.94; 95 CI: 0.56-1.60; I2=0%), blood transfusion (MD: 0.04; 95%CI:-0.31-0.39; I2=68%) and hospital stay (MD:-1.06; 95%CI:-2.80-0.69; I2=0%) were similar between T-V and O-S groups. Only 15 studies reported adverse events, which were significantly higher in the T-V compared to the O-S group (RR 2.39; 95%CI: 1.58-3.63; I2=57%). The certainty of evidence was moderate for the main outcomes, and low or very low for others. Conclusions: In cirrhotic patients with AVB, those treated with T-V had similar mortality risk compared to O-S. However, the use of T-V showed an increased risk of adverse events compared to O-S.Revisión por pare

Alternativas de manejo para as populações de picão-preto (Bidens pilosa e Bidens subalternans) resistentes aos herbicidas inibidores da ALS

Resistant populations of Bidens pilosa and Bidens subalternans to the ALS inhibitors herbicides become more frequent at the soybeans fields from middle-west, that is due the intensive use of ALS herbicides, aimed to obtain data that can contribute on the choose of the best alternative of control for those populations. A trial in a green-house, in Piracicaba, SP, to test many herbicides as an possible alternatives of management of those resistant weeds. Initially we used two populations of Bidens pilosa and two populations of Bidens subalternans, one of these was resistant and the other was susceptible to each species. The herbicides treatments were sprayed when the plants showed up 2 to 4 leaves, chlorimuron (17,5 g.i.a.ha-1); imazethapyr (100 g.i.a.ha-1); chlorimuron + lactofen (10+96 g.i.a.ha-1); clomazone (800 g.i.a.ha-1 ); sulfentrazone (500 g.i.a.ha-1 ); glyphosate (600 g.i.a.ha-1); flumicorac (30+30 g.i.a.ha-1); flumicorac + bentazon (40+480 g.i.a.ha-1); bentazon (720 g.i.a.ha-1 ); fomesafen (250 g.i.a.ha-1 ); acifluorfen + bentazon (204+480 g.i.a.ha-1 ); lactofen (150 g.i.a.ha-1); metribuzin (480 g.i.a.ha-1); diclosulam + clomazone (30,24+800 g.i.a.ha-1 ); cloramsulan + lactofen (30,24+150 g.i.a.ha-1); lactofen (72+72 g.i.a.ha-1); lactofen (144 g.i.a.ha-1); nicosulfuron (50 g.i.a.ha-1 ). We analyzed the percentage of control at 7, 14, 21 and 28 days after the application (DAA) and dry weight at 28 DAA. Applied the test F over the variance analyses followed by tukey test at 5%. The herbicides chlorimuron, imazethapyr and nicosulfuron showed up poor control to all resistant populations, being more inefficient on Bidens subalternans than Bidens pilosa. The other herbicides treatments had a very good efficacy to all populations.         Populações de Bidens pilosa e Bidens subalternans resistentes aos herbicidas inibidores da ALS, tornam-se cada vez mais freqüentes nas lavouras de soja do centro-oeste, isso devido ao uso intensivo de herbicidas inibidores da ALS. Objetivando a obtenção de dados que possam contribuir na escolha da melhor alternativa de controle dessas populações resistentes, foi realizado um ensaio na casade- vegetação, em Piracicaba-SP, afim de testar herbicidas como possíveis alternativas de manejo para o controle de Bidens pilosa e Bidens subalternans resistentes aos inibidores da ALS. Inicialmente, utillizou-se duas populações de Bidens pilosa e duas populações de Bidens subalternans, uma sabidamente resistente e outra suscetível para cada espécie. Os herbicidas foram, aplicados quando as plantas de picão-preto estavam no estádio de 2 a 4 folhas, chlorimuron (17,5 g.i.a.ha -1); imazethapyr (100 g.i.a.ha-1); chlorimuron + lactofen (10+96 g.i.a.ha-1); clomazone (800 g.i.a.ha-1); sulfentrazone (500 g.i.a.ha -1); glyphosate (600 g.i.a.ha-1); flumicorac (30+30 g.i.a.ha-1); flumicorac +  bentazon (40+480 g.i.a.ha -1); bentazon (720 g.i.a.ha-1); fomesafen (250 g.i.a.ha-1);  acifluorfen + bentazon (204+480 g.i.a.ha -1); lactofen (150 g.i.a.ha-1); metribuzin (480 g.i.a.ha -1); diclosulam + clomazone (30,24+800 g.i.a.ha-1); cloramsulan + lactofen (30,24+150 g.i.a.ha -1); lactofen (72+72 g.i.a.ha-1); lactofen (144 g.i.a.ha-1); nicosulfuron  (50 g.i.a.ha -1), além das testemunhas sem aplicação. As variáveis avaliadas foram o controle percentual aos 07, 14, 21 e 28 dias após a aplicação (DAA) e massa seca aos 28 DAA. Aplicou-se o teste F sobre a análise da variância, seguido de teste 'Tukey' a 5%. Os herbicidas chlorimuron, imazethapyr e nicosulfuron apresentaram falhas de controle para todas as populações resistentes, sendo mais ineficientes para B. subalternans , que para B. pilosa. Os demais tratamentos herbicidas foram eficazes para todas as populações.

MRI-targeted or standard biopsy for prostate-cancer diagnosis

Background Multiparametric magnetic resonance imaging (MRI), with or without targeted biopsy, is an alternative to standard transrectal ultrasonography-guided biopsy for prostate-cancer detection in men with a raised prostate-specific antigen level who have not undergone biopsy. However, comparative evidence is limited. Methods In a multicenter, randomized, noninferiority trial, we assigned men with a clinical suspicion of prostate cancer who had not undergone biopsy previously to undergo MRI, with or without targeted biopsy, or standard transrectal ultrasonography-guided biopsy. Men in the MRI-targeted biopsy group underwent a targeted biopsy (without standard biopsy cores) if the MRI was suggestive of prostate cancer; men whose MRI results were not suggestive of prostate cancer were not offered biopsy. Standard biopsy was a 10-to-12-core, transrectal ultrasonography-guided biopsy. The primary outcome was the proportion of men who received a diagnosis of clinically significant cancer. Secondary outcomes included the proportion of men who received a diagnosis of clinically insignificant cancer. Results A total of 500 men underwent randomization. In the MRI-targeted biopsy group, 71 of 252 men (28%) had MRI results that were not suggestive of prostate cancer, so they did not undergo biopsy. Clinically significant cancer was detected in 95 men (38%) in the MRI-targeted biopsy group, as compared with 64 of 248 (26%) in the standard-biopsy group (adjusted difference, 12 percentage points; 95% confidence interval [CI], 4 to 20; P=0.005). MRI, with or without targeted biopsy, was noninferior to standard biopsy, and the 95% confidence interval indicated the superiority of this strategy over standard biopsy. Fewer men in the MRI-targeted biopsy group than in the standard-biopsy group received a diagnosis of clinically insignificant cancer (adjusted difference, -13 percentage points; 95% CI, -19 to -7; P<0.001). Conclusions The use of risk assessment with MRI before biopsy and MRI-targeted biopsy was superior to standard transrectal ultrasonography-guided biopsy in men at clinical risk for prostate cancer who had not undergone biopsy previously. (Funded by the National Institute for Health Research and the European Association of Urology Research Foundation; PRECISION ClinicalTrials.gov number, NCT02380027 .)

Deep neural network-estimated electrocardiographic age as a mortality predictor

The electrocardiogram (ECG) is the most commonly used exam for the evaluation of cardiovascular diseases. Here we propose that the age predicted by artificial intelligence (AI) from the raw ECG (ECG-age) can be a measure of cardiovascular health. A deep neural network is trained to predict a patient’s age from the 12-lead ECG in the CODE study cohort (n = 1,558,415 patients). On a 15% hold-out split, patients with ECG-age more than 8 years greater than the chronological age have a higher mortality rate (hazard ratio (HR) 1.79, p < 0.001), whereas those with ECG-age more than 8 years smaller, have a lower mortality rate (HR 0.78, p < 0.001). Similar results are obtained in the external cohorts ELSA-Brasil (n = 14,236) and SaMi-Trop (n = 1,631). Moreover, even for apparent normal ECGs, the predicted ECG-age gap from the chronological age remains a statistically significant risk predictor. These results show that the AI-enabled analysis of the ECG can add prognostic information

Serological and molecular evidence of hepadnavirus infection in swine

Introduction and objective Recently, investigations in a swine herd identified evidence of the existence of a novel member of the Hepadnavirus family endemic in swine. The aim of this study was to investigate the serological and molecular markers of Hepadnavirus circulation in Brazilian domestic swine and wild boar herds, and to evaluate the identity with HBV and other Hepadnaviruses reported previously. Material and Methods For the study, 376 swine were screened for hepatitis B virus serological markers. Analyses were performed in serum samples using commercial enzyme-linked immunosorbent assay (ELISA) kits (DiaSorin®) for anti-HBc, HBsAg and anti-HBs. Reactive and undetermined swine serum samples were selected to perform DNA viral extraction (QIAamp DNA Mini Kit, Qiagen®), partial genome amplification and genome sequencing. Results From 376 swine samples analysed, 28 (7.45%) were reactive to anti-HBc, 3 (0.80%) to HBsAg and 6 (1.6%) to anti-HBs. Besides, more 17 (4.52%) swine samples analyzed were classified in the grey zone of the EIA test to anti-HBc and 2 (0.53%) to HBsAg. From 49 samples molecularly analyzed after serological trial, 4 samples showed a positive result for the qualitative PCR for Hepadnavirus. Phylogenetic reconstruction using partial genome sequencing (360 bp) of 3 samples showed similarity with HBV with 90.8–96.3% of identity. Conclusions Serological and molecular data showed evidence of the circulation of a virus similar to hepatitis B virus in swine