Effects of product usage scenarios on environmental performance for road transport refrigeration units

A significant issue for the transport refrigeration industry is its high use of non-renewable energy for both motion and refrigeration. With the goal of reducing the environmental footprint, this study is focused on the Life Cycle Assessment (LCA) of Truck Refrigeration Units (TRU). Contrary to most studies about TRU, this study considers alternative impact categories, including energy consumption, refrigerant fluids and their associated impacts. The LCA reveals that the operation phase is a significant source of environmental impact, while the usage-scenario also has a high influence on the impact. The purpose of this paper is to demonstrate the weight of the transported product profile (frozen or fresh), type of transport (distribution or long haul) and the operating mode (continuous run, start/stop) on the environmental footprint of transport refrigeration. Finally, the LCA results highlight the necessity to consider the role of customer behavior on the environmental performance of transport refrigeration units

A gain-of-function TBX20 mutation causes congenital atrial septal defects, patent foramen ovale and cardiac valve defects

BACKGROUND: Ostium secundum atrial septal defects (ASDII) account for approximately 10% of all congenital heart defects (CHD) and mutations in cardiac transcription factors, including TBX20, were identified as an underlying cause for ASDII. However, very little is known about disease penetrance in families and functional consequences of inherited TBX20 mutations. METHODS: The coding region of TBX20 was directly sequenced in 170 ASDII patients. Functional consequences of one novel mutation were investigated by surface plasmon resonance, CD spectropolarymetry, fluorescence spectrophotometry, luciferase assay and chromatin immunoprecipitation. RESULTS: We found a novel mutation in a highly conserved residue in the T-box DNA-binding domain (I121M) segregating with CHD in a three generation kindred. Four mutation carriers revealed cardiac phenotypes in terms of cribriform ASDII, large patent foramen ovale or cardiac valve defects. Interestingly, tertiary hydrophobic interactions within the mutant TBX20 T-box were significantly altered leading to a more dynamic structure of the protein. Moreover, Tbx20-I121M resulted in a significantly enhanced transcriptional activity, which was further increased in the presence of co-transcription factors GATA4/5 and NKX2-5. Occupancy of DNA binding sites on target genes was also increased. CONCLUSIONS: We suggest that TBX20-I121M adopts a more fluid tertiary structure leading to enhanced interactions with cofactors and more stable transcriptional complexes on target DNA sequences. Our data, combined with that of others, suggest that human ASDII may be related to loss- as well as gain-of-function TBX20 mutations

Impact of Baricitinib on Patients’ Quality of Life after One Year of Treatment for Atopic Dermatitis in Real-World Practice: Results of the Observatory of Chronic Inflammatory Skin Diseases Registry

The efficacy and safety of baricitinib for treatment of atopic dermatitis have been demonstrated in clinical trials; however, very few real-life studies have been published to date. The Observatory of Chronic Inflammatory Skin Diseases (OMCCI) registry was initiated to prospectively determine the long-term impairment caused by chronic inflammatory dermatoses on patients’ lives. The study included 88 patients starting baricitinib for treatment of atopic dermatitis. Clinical evaluation and patient-reported outcomes were recorded at baseline and after 6 and 12 months. After 6 months and 1 year of follow-up, 65 and 47 patients, respectively, were still being treated with baricitinib. Treatment failure was the main reason for discontinuation. Only 1 patient stopped baricitinib because of a side-effect. After 1 year of follow-up, the mean Eczema Area and Severity Index score decreased significantly from 20.7 to 6.4; the percentage of patients with severe atopic dermatitis decreased from 42.9% to 6.5% and a significant improvement in most patient-reported outcomes was noted. There was no difference in terms of efficacy whether or not patients were previously treated with dupilumab. The results remained stable after 6 and 12 months of treatment, which suggests a sustained efficacy of the treatment in patients who initially responded well

A census of dense cores in the Aquila cloud complex: SPIRE/PACS observations from the <i>Herschel</i> Gould Belt survey

We present and discuss the results of the $Herschel$ Gould Belt survey (HGBS) observations in an ~11 $deg^2$ area of the Aquila molecular cloud complex at $d$ ~ 260 pc, imaged with the SPIRE and PACS photometric cameras in parallel mode from $70\mu m$ to $500\mu m$. Using the multi-scale, multi-wavelength source extraction algorithm $getsources$, we identify a complete sample of starless dense cores and embedded (Class 0-I) protostars in this region, and analyze their global properties and spatial distributions. We find a total of 651 starless cores, ~60% ± 10% of which are gravitationally bound prestellar cores, and they will likely form stars in the future. We also detect 58 protostellar cores. The core mass function (CMF) derived for the large population of prestellar cores is very similar in shape to the stellar initial mass function (IMF), confirming earlier findings on a much stronger statistical basis and supporting the view that there is a close physical link between the stellar IMF and the prestellar CMF. The global shift in mass scale observed between the CMF and the IMF is consistent with a typical star formation efficiency of ~40% at the level of an individual core. By comparing the numbers of starless cores in various density bins to the number of young stellar objects (YSOs), we estimate that the lifetime of prestellar cores is ~1 Myr, which is typically ~4 times longer than the core free-fall time, and that it decreases with average core density. We find a strong correlation between the spatial distribution of prestellar cores and the densest filaments observed in the Aquila complex. About 90% of the $Herschel$-identified prestellar cores are located above a background column density corresponding to $A_V$ ~ 7, and ~75% of them lie within filamentary structures with supercritical masses per unit length ≳16 $M_{\odot}/pc$. These findings support a picture wherein the cores making up the peak of the CMF (and probably responsible for the base of the IMF) result primarily from the gravitational fragmentation of marginally supercritical filaments. Given that filaments appear to dominate the mass budget of dense gas at $A_V> 7$, our findings also suggest that the physics of prestellar core formation within filaments is responsible for a characteristic “efficiency” $SFR/M_{dense}$ ~$5^{+2}_{-2}x 10^{-8}yr^{-1}$ for the star formation process in dense gas

Dix ans d'histoire culturelle

L'association pour le développement de l'histoire culturelle (ADHC) est née, en 1999, du constat de la place croissante, en même temps que problématique, de l'histoire culturelle dans l'historiographie contemporaine. Revendiquée par les uns, dénoncée par les autres, cette place méritait l'institution d'un lieu de rencontres où tous ceux qui se reconnaissent dans cette qualification pourraient échanger sur le fond et sur la forme de leur travail. L'association a tenu son premier congrès en 2000. Au terme d'une décennie et plus d'activité, il était temps de tirer le bilan et, comme il se doit, de tracer de nouvelles perspectives. Cette anthologie des conférences et tables rondes organisées dans le cadre du congrès annuel de l'association propose un panorama unique en son genre des propositions avancées par l'histoire culturelle en France et, dans une moindre mesure, à l'étranger depuis dix ans. Regroupés en sections thématiques (définitions et frontières, objets, regards et transferts, débats), ces textes rédigés par d'éminents spécialistes venus de divers horizons (historiens, sociologues, philosophes, historiens de l'art ou de la littérature) donnent à voir à la fois la permanence de certains questionnements et leur renouvellement

Potential of Core-Collapse Supernova Neutrino Detection at JUNO

JUNO is an underground neutrino observatory under construction in Jiangmen, China. It uses 20kton liquid scintillator as target, which enables it to detect supernova burst neutrinos of a large statistics for the next galactic core-collapse supernova (CCSN) and also pre-supernova neutrinos from the nearby CCSN progenitors. All flavors of supernova burst neutrinos can be detected by JUNO via several interaction channels, including inverse beta decay, elastic scattering on electron and proton, interactions on C12 nuclei, etc. This retains the possibility for JUNO to reconstruct the energy spectra of supernova burst neutrinos of all flavors. The real time monitoring systems based on FPGA and DAQ are under development in JUNO, which allow prompt alert and trigger-less data acquisition of CCSN events. The alert performances of both monitoring systems have been thoroughly studied using simulations. Moreover, once a CCSN is tagged, the system can give fast characterizations, such as directionality and light curve

Detection of the Diffuse Supernova Neutrino Background with JUNO

As an underground multi-purpose neutrino detector with 20 kton liquid scintillator, Jiangmen Underground Neutrino Observatory (JUNO) is competitive with and complementary to the water-Cherenkov detectors on the search for the diffuse supernova neutrino background (DSNB). Typical supernova models predict 2-4 events per year within the optimal observation window in the JUNO detector. The dominant background is from the neutral-current (NC) interaction of atmospheric neutrinos with 12C nuclei, which surpasses the DSNB by more than one order of magnitude. We evaluated the systematic uncertainty of NC background from the spread of a variety of data-driven models and further developed a method to determine NC background within 15\% with {\it{in}} {\it{situ}} measurements after ten years of running. Besides, the NC-like backgrounds can be effectively suppressed by the intrinsic pulse-shape discrimination (PSD) capabilities of liquid scintillators. In this talk, I will present in detail the improvements on NC background uncertainty evaluation, PSD discriminator development, and finally, the potential of DSNB sensitivity in JUNO