26,296 research outputs found
Interface refactoring in performance-constrained web services
This paper presents the development of REF-WS an approach to enable a Web Service provider to reliably evolve their service through the application of refactoring transformations. REF-WS is intended to aid service providers, particularly in a reliability and performance constrained domain as it permits upgraded ’non-backwards compatible’ services to be deployed into a performance constrained network where existing consumers depend on an older version of the service interface. In order for this to be successful, the refactoring and message mediation needs to occur without affecting functional compatibility with the services’ consumers, and must operate within the performance overhead expected of the original service, introducing as little latency as possible. Furthermore, compared to a manually programmed solution, the presented approach enables the service developer to apply and parameterize refactorings with a level of confidence that they will not produce an invalid or ’corrupt’ transformation of messages. This is achieved through the use of preconditions for the defined refactorings
Heater improves cold-temperature capacity of silver-cadmium batteries
Eight heaters are included in 14-cell package to provide 14-Vdc. Each heater is 11-ohm self-adhesive strip placed across broad face of each pair of cells. They are installed before cells are wired. Heaters are in series and are connected through pair of redundant thermostats
Opportunities and challenges for modelling epidemiological and evolutionary dynamics in a multihost, multiparasite system: Zoonotic hybrid schistosomiasis in West Africa
Multihost multiparasite systems are evolutionarily and ecologically dynamic, which presents substantial trans‐disciplinary challenges for elucidating their epidemiology and designing appropriate control. Evidence for hybridizations and introgressions between parasite species is gathering, in part in line with improvements in molecular diagnostics and genome sequencing. One major system where this is becoming apparent is within the Genus Schistosoma, where schistosomiasis represents a disease of considerable medical and veterinary importance, the greatest burden of which occurs in sub‐Saharan Africa. Interspecific hybridizations and introgressions bring an increased level of complexity over and above that already inherent within multihost, multiparasite systems, also representing an additional source of genetic variation that can drive evolution. This has the potential for profound implications for the control of parasitic diseases, including, but not exclusive to, widening host range, increased transmission potential and altered responses to drug therapy. Here, we present the challenging case example of haematobium group Schistosoma spp. hybrids in West Africa, a system involving multiple interacting parasites and multiple definitive hosts, in a region where zoonotic reservoirs of schistosomiasis were not previously considered to be of importance. We consider how existing mathematical model frameworks for schistosome transmission could be expanded and adapted to zoonotic hybrid systems, exploring how such model frameworks can utilize molecular and epidemiological data, as well as the complexities and challenges this presents. We also highlight the opportunities and value such mathematical models could bring to this and a range of similar multihost, multi and cross‐hybridizing parasites systems in our changing world
Categorification of quantum symmetric pairs I
We categorify a coideal subalgebra of the quantum group of
by introducing a -category \`a la
Khovanov-Lauda-Rouquier, and show that self-dual indecomposable -morphisms
categorify the canonical basis of this algebra. This allows us to define a
categorical action of this coideal algebra on the categories of modules over
cohomology rings of partial flag varieties and on the BGG category
of type B/C.Comment: final version, to appear in Quantum Topolog
Quasar-galaxy associations
There is controversy about the measurement of statistical associations
between bright quasars and faint, presumably foreground galaxies. We look at
the distribution of galaxies around an unbiased sample of 63 bright, moderate
redshift quasars using a new statistic based on the separation of the quasar
and its nearest neighbour galaxy. We find a significant excess of close
neighbours at separations less than about 10 arcsec which we attribute to the
magnification by gravitational lensing of quasars which would otherwise be too
faint to be included in our sample. About one quarter to one third of the
quasars are so affected although the allowed error in this fraction is large.Comment: uuencoded Postscript file (including figures and tables), SUSSEX-AST
94/8-
3d-electron induced magnetic phase transition in half-metallic semi-Heusler alloys
We study the effect of the non-magnetic 3\textit{d} atoms on the magnetic
properties of the half-metallic (HM) semi-Heusler alloys CoCuMnSb
and NiCuMnSb () using first-principles
calculations. We determine the magnetic phase diagram of both systems at zero
temperature and obtain a phase transition from a ferromagnetic to an
antiferromagnetic state. For low Cu concentrations the ferromagnetic RKKY-like
exchange mechanism is dominating, while the antiferromagnetic superexchange
coupling becomes important for larger Cu content leading to the observed
magnetic phase transition. A strong dependence of the magnetism in both systems
on the position of the Fermi level within the HM gap is obtained. Obtained
results are in good agreement with the available experimental data
Fine-grained timing using genetic programming
In previous work, we have demonstrated that it is possible to use Genetic Programming to minimise the resource consumption of software, such as its power consumption or execution time. In this paper, we investigate the extent to which Genetic Programming can be used to gain fine-grained control over software timing. We introduce the ideas behind our work, and carry out experimentation to find that Genetic Programming is indeed able to produce software with unusual and desirable timing properties, where it is not obvious how a manual approach could replicate such results. In general, we discover that Genetic Programming is most effective in controlling statistical properties of software rather than precise control over its timing for individual inputs. This control may find useful application in cryptography and embedded systems
Hybridisations within the genus Schistosoma: implications for evolution, epidemiology and control
SUMMARYHybridization of parasites is an emerging public health concern in our changing world. Hybridization and introgression in parasites and pathogens can have major impacts on the host and the epidemiology and evolution of disease. Schistosomiasis is a Neglected Tropical Disease of profound medical and veterinary importance across many parts of the world, with the greatest human burden within sub-Saharan Africa. Here we review how early phenotypic identification and recent confirmation through molecular studies on naturally occurring infections, combined with experimental manipulations, have revealed evidence of viable hybridization and introgressions within and between human and animal schistosome species. Environmental and anthropogenic changes in selective pressures following, for instance, new dam constructions, altered agricultural practices, together with mass drug administration programmes, may all be predicted to further impact the availability of suitable definitive and intermediate hosts for schistosomes. It is therefore imperative to understand the distribution and role of such novel zoonotic hybrid schistosomes on host range, drug efficacy, and hence ultimately transmission potential, if we are to achieve and maintain sustainable control.</jats:p
Introgressed Animal Schistosomes Schistosoma curassoni and S. bovis Naturally Infecting Humans
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