Smart tourist information points by combining agents, semantics and AI techniques

The tourism sector in the province of Teruel (Aragon, Spain) is increasing rapidly. Although the number of domestic and foreign tourists is continuously growing, there are some tourist attractions spread over a wide geographical area, which are only visited by a few people at specific times of the year. Additionally, having human tourist guides everywhere and speaking different languages is unfeasible. An integrated solution based on smart and interactive Embodied Conversational Agents (ECAs) tourist guides combined with ontologies would overcome this problem. This paper presents a smart tourist information points approach which gathers tourism information about Teruel, structured according to a novel lightweight ontology built on OWL (Ontology Web Language), known as TITERIA (Touristic Information of TEruel for Intelligent Agents). Our proposal, which combines TITERIA with the Maxine platform, is capable of responding appropriately to the users thanks to its Artificial Intelligence Modeling Language (AIML) database and the AI techniques added to Maxine. Preliminary results indicate that our prototype is able to inform users about interesting topics, as well as to propose other related information, allowing them to acquire a complete information about any issue. Furthermore, users can directly talk with an artificial actor making communication much more natural and closer

Confusion Assessment Method for the intensive care unit (CAM-ICU) for the diagnosis of delirium in adults in critical care settings

© 2018 The Cochrane Collaboration. This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: To determine the diagnostic accuracy of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) for the diagnosis of delirium in adult patients in critical care settings

Multimedia e-learning on technologies for efficient water use

One of the Millennium Development Goals is “To ensure environmental sustainability”, with a special task dedicated to halve by 2015 the proportion of people without sustainable access to safe drinking water. This task collides with alarming studies that, for instance, foresee an acute water shortage in India and other Asian countries by 2050. In this conflicting context we present ED-WAVE, a developing project funded by the Asia-Link Programme, participating six countries (India, Sri Lanka, Thailand, Greece, Spain and Finland). Its goal is to create a sustainable international cooperation framework and to develop a multimedia tool for e-Learning on technologies for conservation, reclamation and reuse of natural resources. We therefore use IT tools aimed at improving people’s education, including analysis of current water use status in Asia and Europe, review of potential technological interventions, simulation of impacts of specific technology interventions and translation of knowledge into electronic teaching material

Efficacy of Metreleptin in Obese Patients With Type 2 Diabetes: Cellular and Molecular Pathways Underlying Leptin Tolerance

Objective: Metreleptin has been efficacious in improving metabolic control in patients with lipodystrophy, but its efficacy has not been tested in obese patients with type 2 diabetes. Research Design and Methods: We studied the role of leptin in regulating the endocrine adaptation to long-term caloric deprivation and weight loss in obese diabetic subjects over 16 weeks in the context of a double-blinded, placebo–controlled, randomized trial. We then performed detailed interventional and mechanistic signaling studies in humans in vivo, ex vivo, and in vitro. Results: In obese patients with diabetes, metreleptin administration for 16 weeks did not alter body weight or circulating inflammatory markers but reduced HbA$_{1c}$ marginally (8.01 $\pm$ 0.93–7.96 $\pm$ 1.12, P = 0.03). Total leptin, leptin-binding protein, and antileptin antibody levels increased, limiting free leptin availability and resulting in circulating free leptin levels of $\sim$50 ng/mL. Consistent with clinical observations, all metreleptin signaling pathways studied in human adipose tissue and peripheral blood mononuclear cells were saturable at $\sim$50 ng/mL, with no major differences in timing or magnitude of leptin-activated STAT3 phosphorylation in tissues from male versus female or obese versus lean humans in vivo, ex vivo, or in vitro. We also observed for the first time that endoplasmic reticulum (ER) stress in human primary adipocytes inhibits leptin signaling. Conclusions: In obese patients with diabetes, metreleptin administration did not alter body weight or circulating inflammatory markers but reduced HbA$_{1c}$ marginally. ER stress and the saturable nature of leptin signaling pathways play a key role in the development of leptin tolerance in obese patients with diabetes

Carnegie Supernova Project: The First Homogeneous Sample of Super-Chandrasekhar-mass/2003fg-like Type Ia Supernovae

We present a multiwavelength photometric and spectroscopic analysis of 13 super-Chandrasekhar-mass/2003fg-like Type Ia supernovae (SNe Ia). Nine of these objects were observed by the Carnegie Supernova Project. The 2003fg-like SNe have slowly declining light curves (Δm 15(B) < 1.3 mag), and peak absolute B-band magnitudes of -19 < M B < -21 mag. Many of the 2003fg-like SNe are located in the same part of the luminosity-width relation as normal SNe Ia. In the optical B and V bands, the 2003fg-like SNe look like normal SNe Ia, but at redder wavelengths they diverge. Unlike other luminous SNe Ia, the 2003fg-like SNe generally have only one i-band maximum, which peaks after the epoch of the B-band maximum, while their near-IR (NIR) light-curve rise times can be ⪆40 days longer than those of normal SNe Ia. They are also at least 1 mag brighter in the NIR bands than normal SNe Ia, peaking above M H = -19 mag, and generally have negative Hubble residuals, which may be the cause of some systematics in dark-energy experiments. Spectroscopically, the 2003fg-like SNe exhibit peculiarities such as unburnt carbon well past maximum light, a large spread (8000-12,000 km s-1) in Si ii λ6355 velocities at maximum light with no rapid early velocity decline, and no clear H-band break at +10 days. We find that SNe with a larger pseudo-equivalent width of C ii at maximum light have lower Si ii λ6355 velocities and more slowly declining light curves. There are also multiple factors that contribute to the peak luminosity of 2003fg-like SNe. The explosion of a C-O degenerate core inside a carbon-rich envelope is consistent with these observations. Such a configuration may come from the core-degenerate scenario.Fil: Ashall, C.. University Hawaii Institute For Astronomy; Estados UnidosFil: Lu, J.. Florida State University; Estados UnidosFil: Hsiao, E. Y.. Florida State University; Estados UnidosFil: Hoeflich, P.. Florida State University; Estados UnidosFil: Phillips, M. M.. Las Campanas Observatory; ChileFil: Galbany, Lluís. Instituto de Ciencias del Espacio; EspañaFil: Burns, C. R.. Las Campanas Observatory; ChileFil: Contreras, C.. Las Campanas Observatory; ChileFil: Krisciunas, K.. Texas A&M University; Estados UnidosFil: Morrell, Nidia Irene. Las Campanas Observatory; ChileFil: Stritzinger, M. D.. University Aarhus; DinamarcaFil: Suntzeff, Nicholas B.. Texas A&M University; Estados UnidosFil: Taddia, F.. University Aarhus; DinamarcaFil: Anais, J.. Las Campanas Observatory; ChileFil: Baron, E.. Oklahoma State University; Estados Unidos. Universitat Hamburg; AlemaniaFil: Brown, P. J.. Texas A&M University; Estados UnidosFil: Busta, L.. Las Campanas Observatory; ChileFil: Campillay, A.. Universidad de La Serena; ChileFil: Castellón, S.. Las Campanas Observatory; ChileFil: Corco, C.. Las Campanas Observatory; Chile. Soar Telescope; ChileFil: Davis, S.. University of California at Davis; Estados UnidosFil: Folatelli, Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Förster, F.. Universidad de Chile; Chile. Instituto Milenio de Astrofísica; ChileFil: Freedman, W. L.. University of Chicago; Estados UnidosFil: Gonzaléz, C.. Las Campanas Observatory; ChileFil: Hamuy, M.. Universidad de Chile; ChileFil: Holmbo, S.. University Aarhus; DinamarcaFil: Kirshner, R. P.. Harvard-Smithsonian Center for Astrophysics; Estados UnidosFil: Kumar, S.. Florida State University; Estados UnidosFil: Marion, G. H.. University of Texas at Austin; Estados UnidosFil: Mazzali, P.. Liverpool John Moores University; Reino UnidoFil: Morokuma, T.. The University Of Tokyo; JapónFil: Nugent, P. E.. Lawrence Berkeley National Laboratory; Estados Unidos. University of California at Berkeley; Estados UnidosFil: Persson, S. E.. Las Campanas Observatory; ChileFil: Piro, A. L.. Las Campanas Observatory; ChileFil: Roth, M.. Las Campanas Observatory; ChileFil: Salgado, F.. Las Campanas Observatory; ChileFil: Sand, D.J.. University of Arizona; Estados UnidosFil: Seron, J.. Las Campanas Observatory; ChileFil: Shahbandeh, M.. Florida State University; Estados UnidosFil: Shappee, B. J.. University Hawaii Institute For Astronomy; Estados Unido

The banff 2019 kidney meeting report (I): updates on and clarification of criteria for T cell- and antibody-mediated rejection.

The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of the American Society for Histocompatibility and Immunogenetics in Pittsburgh, PA (USA) and focused on refining recent updates to the classification, advances from the Banff working groups, and standardization of molecular diagnostics. This report on kidney transplant pathology details clarifications and refinements to the criteria for chronic active (CA) T cell-mediated rejection (TCMR), borderline, and antibody-mediated rejection (ABMR). The main focus of kidney sessions was on how to address biopsies meeting criteria for CA TCMR plus borderline or acute TCMR. Recent studies on the clinical impact of borderline infiltrates were also presented to clarify whether the threshold for interstitial inflammation in diagnosis of borderline should be i0 or i1. Sessions on ABMR focused on biopsies showing microvascular inflammation in the absence of C4d staining or detectable donor-specific antibodies; the potential value of molecular diagnostics in such cases and recommendations for use of the latter in the setting of solid organ transplantation are presented in the accompanying meeting report. Finally, several speakers discussed the capabilities of artificial intelligence and the potential for use of machine learning algorithms in diagnosis and personalized therapeutics in solid organ transplantation

The Banff 2019 Kidney Meeting Report (I): Updates on and clarification of criteria for T cell– and antibody-mediated rejection

The XV. Banff conference for allograft pathology was held in conjunction with the annual meeting of the American Society for Histocompatibility and Immunogenetics in Pittsburgh, PA (USA) and focused on refining recent updates to the classification, advances from the Banff working groups, and standardization of molecular diagnostics. This report on kidney transplant pathology details clarifications and refinements to the criteria for chronic active (CA) T cell–mediated rejection (TCMR), borderline, and antibody-mediated rejection (ABMR). The main focus of kidney sessions was on how to address biopsies meeting criteria for CA TCMR plus borderline or acute TCMR. Recent studies on the clinical impact of borderline infiltrates were also presented to clarify whether the threshold for interstitial inflammation in diagnosis of borderline should be i0 or i1. Sessions on ABMR focused on biopsies showing microvascular inflammation in the absence of C4d staining or detectable donor-specific antibodies; the potential value of molecular diagnostics in such cases and recommendations for use of the latter in the setting of solid organ transplantation are presented in the accompanying meeting report. Finally, several speakers discussed the capabilities of artificial intelligence and the potential for use of machine learning algorithms in diagnosis and personalized therapeutics in solid organ transplantation

It's not what you say but the way that you say it: an fMRI study of differential lexical and non-lexical prosodic pitch processing

<p>Abstract</p> <p>Background</p> <p>This study aims to identify the neural substrate involved in prosodic pitch processing. Functional magnetic resonance imaging was used to test the premise that prosody pitch processing is primarily subserved by the right cortical hemisphere.</p> <p>Two experimental paradigms were used, firstly pairs of spoken sentences, where the only variation was a single internal phrase pitch change, and secondly, a matched condition utilizing pitch changes within analogous tone-sequence phrases. This removed the potential confounder of lexical evaluation. fMRI images were obtained using these paradigms.</p> <p>Results</p> <p>Activation was significantly greater within the right frontal and temporal cortices during the tone-sequence stimuli relative to the sentence stimuli.</p> <p>Conclusion</p> <p>This study showed that pitch changes, stripped of lexical information, are mainly processed by the right cerebral hemisphere, whilst the processing of analogous, matched, lexical pitch change is preferentially left sided. These findings, showing hemispherical differentiation of processing based on stimulus complexity, are in accord with a 'task dependent' hypothesis of pitch processing.</p

Gender Dimorphism in Skeletal Muscle Leptin Receptors, Serum Leptin and Insulin Sensitivity

To determine if there is a gender dimorphism in the expression of leptin receptors (OB-R170, OB-R128 and OB-R98) and the protein suppressor of cytokine signaling 3 (SOCS3) in human skeletal muscle, the protein expression of OB-R, perilipin A, SOCS3 and alpha-tubulin was assessed by Western blot in muscle biopsies obtained from the m. vastus lateralis in thirty-four men (age = 27.1±6.8 yr) and thirty-three women (age = 26.7±6.7 yr). Basal serum insulin concentration and HOMA were similar in both genders. Serum leptin concentration was 3.4 times higher in women compared to men (P<0.05) and this difference remained significant after accounting for the differences in percentage of body fat or soluble leptin receptor. OB-R protein was 41% (OB-R170, P<0.05) and 163% (OB-R128, P<0.05) greater in women than men. There was no relationship between OB-R expression and the serum concentrations of leptin or 17β-estradiol. In men, muscle OB-R128 protein was inversely related to serum free testosterone. In women, OB-R98 and OB-R128 were inversely related to total serum testosterone concentration, and OB-R128 to serum free testosterone concentration. SOCS3 protein expression was similar in men and women and was not related to OB-R. In women, there was an inverse relationship between the logarithm of free testosterone and SCOS3 protein content in skeletal muscle (r = −0.46, P<0.05). In summary, there is a gender dimorphism in skeletal muscle leptin receptors expression, which can be partly explained by the influence of testosterone. SOCS3 expression in skeletal muscle is not up-regulated in women, despite very high serum leptin concentrations compared to men. The circulating form of the leptin receptor can not be used as a surrogate measure of the amount of leptin receptors expressed in skeletal muscles