Hagiografía y filología: el caso peculiar de la "Vita Didaci" (Santa María de Benevívere)

Sobre el ejemplo de la Vita Didaci, un poema del s. XIII sobre Diego Martínez, fundador del monasterio de Santa María de Benevivere (Carrión de los Condes, Palencia), la autora muestra, por un lado, la utilidad de la labor filológica para conseguir un mejor conocimiento de los textos hagiográficos y, por otro, cómo encaja una obra medieval concreta en la etiqueta generalizadora de hagiografía. Para esto último se han examinado en la Vita todos los aspectos definidos por los estudiosos como específicamente hagiográficos y se ha observado que no todos están presentes y algunos de ellos ofrecen características muy peculiares y distintas.Against the background provided by the Vita Didaci -a 13th-century poem on Diego Martínez, the founder of the monastery of St. Maria de Benevivere (Carrión de los Condes)-, the author shows, on the one hand, the usefulness of philological study for a better understanding of hagiographical texts, and, on the other, how a specific medieval work fits into the generalizing label of hagiography. As regards the latter issue, all the aspects considered by the scholars as typically hagiographical have been examined in the Vita. It has been observed that not all of them appear, while some have very peculiar and distinct features

Environmental drivers of the seasonal exposure to airborne Alternaria spores in Spain.

Alternaria conidia have high allergenic potential and they can trigger important respiratory diseases. Due to that and to their extensive detection period, airborne Alternaria spores are considered as a relevant airborne allergenic particle. Several studies have been developed in order to predict the human exposure to this aeroallergen and to prevent their negative effects on sensitive population. These studies revealed that some sampling locations usually have just one single Alternaria spore season while other locations generally have two seasons within the same year. However, the reasons of these two different seasonal patterns remain unclear. To understand them better, the present study was carried out in order to determine if there are any weather conditions that influence these different behaviours at different sampling locations. With this purpose, the airborne Alternaria spore concentrations of 18 sampling locations in a wide range of latitudinal, altitudinal and climate ranges of Spain were studied. The aerobiological samples were obtained by means of Hirst-Type volumetric pollen traps, and the seasonality of the airborne Alternaria spores were analysed. The optimal weather conditions for spore production were studied, and the main weather factor affecting Alternaria spore seasonality were analysed by means of random forests and regression trees. The results showed that the temperature was the most relevant variable for the Alternaria spore dispersion and it influenced both the spore integrals and their seasonality. The water availability was also a very significant variable. Warmer sampling locations generally have a longer period of Alternaria spore detection. However, the spore production declines during the summer when the temperatures are extremely warm , what splits the favourable period for Alternaria spore production and dispersion into two separate ones, detected as two Alternaria spore seasons within the same year.This work was partially financed by the Ministry of Science and Innovation of Spain and FEDER fundings inside the Operational Plurirregional Program of Spain 2014-2020 and the Operational Program of Smart Growing (Project Environmental and Biodiversity Climate Change Lab, EnBiC2-Lab). This work counted also with the economical support of the Spanish Ministry of Economy and Competitiveness [project CGL2014-54731-R]; the Ministry of Science and Innovation [project RTI2018-096392-B-C22]; the Junta de Andalucía [contract 8.06/503.4764]; the Area of Environment and Sustainability of the Malaga City Council [contracts 8.06/5.03.4721 and 8.07/5.03.5159]; the Junta Comunidades de Castilla-La Mancha, which provides financial support for the Castilla-La Mancha Aerobiology Network (AEROCAM); and the financial support of Health Department of Madrid region (Consejería de Sanidad de Comunidad de Madrid) to the palynological network PALINOCAM. The pollen trap installed in Sierra de las Nieves was funded by the Herbarium MGC of the SCAI (Central Services of Research Support) of the University of Malaga under the agreement signed between the Junta de Andalucía and the University of Malaga [contract 8.07/5.034764]. Antonio Picornell was supported by a predoctoral grant financed by the Spanish Ministry of Education, Culture and Sport, in the Program for the Promotion of Talent and its Employability [grant number FPU15/01668]. Navarra sampling locations were supported by the Navarra Institute of Public and Occupational Health (ISPLN) with funding from the LIFE+NADAPTA project. Valladolid and Salamanca sampling locations were supported by the Regional Health Authority, Junta of Castile and León, Spain [Project GRS 1862/A/18]. Seville sampling location was supported by the Project MEC I+D+I CGL2009-10683

Long-Term Outcomes After Autologous Versus Allogeneic Stem Cell Transplantation in Molecularly-Stratified Patients With Intermediate Cytogenetic Risk Acute Myeloid Leukemia: A PETHEMA Study

PETHEMA (Programa Español de Tratamientos en Hematología) and GETH (Grupo Espa~nol de Trasplante Hematopoyético y Terapia Celular) Cooperative GroupsAcute myeloid leukemia (AML) with intermediate risk cytogenetics (IRcyto) comprises a variety of biological entities with distinct mutational landscapes that translate into differential risks of relapse and prognosis. Optimal postremission therapy choice in this heterogeneous patient population is currently unsettled. In the current study, we compared outcomes in IRcyto AML recipients of autologous (autoSCT) (n = 312) or allogeneic stem cell transplantation (alloSCT) (n = 279) in first complete remission (CR1). Molecular risk was defined based on CEBPA, NPM1, and FLT3-ITD mutational status, per European LeukemiaNet 2017 criteria. Five-year overall survival (OS) in patients with favorable molecular risk (FRmol) was 62% (95% confidence interval [CI], 50-72) after autoSCT and 66% (95% CI, 41-83) after matched sibling donor (MSD) alloSCT (P = .68). For patients of intermediate molecular risk (IRmol), MSD alloSCT was associated with lower cumulative incidence of relapse (P < .001), as well as with increased nonrelapse mortality (P = .01), as compared to autoSCT. The 5-year OS was 47% (95% CI, 34-58) after autoSCT and 70% (95% CI, 59-79) after MSD alloSCT (P = .02) in this patient subgroup. In a propensity-score matched IRmol subcohort (n = 106), MSD alloSCT was associated with superior leukemia-free survival (hazard ratio [HR] 0.33, P = .004) and increased OS in patients alive 1 year after transplantation (HR 0.20, P = .004). These results indicate that, within IRcyto AML in CR1, autoSCT may be a valid option for FRmol patients, whereas MSD alloSCT should be the preferred postremission strategy in IRmol patients.Supported by a Río Hortega academic clinical fellowship (CM19/00194) from the Instituto de Salud Carlos III, Spain (E.R.A.). Additional funding has been provided by CIBERONC grants to J.P.S. (CB16/12/00480), M.M.S. (CB16/12/00369) and B.V. (CB16/12/00233)

Impact of FLT3–ITD Mutation Status and Its Ratio in a Cohort of 2901 Patients Undergoing Upfront Intensive Chemotherapy: A PETHEMA Registry Study

FLT3–ITD results in a poor prognosis in terms of overall survival (OS) and relapse-free survival (RFS) in acute myeloid leukemia (AML). However, the prognostic usefulness of the allelic ratio (AR) to select post-remission therapy remains controversial. Our study focuses on the prognostic impact of FLT3–ITD and its ratio in a series of 2901 adult patients treated intensively in the pre-FLT3 inhibitor era and reported in the PETHEMA registry. A total of 579 of these patients (20%) harbored FLT3–ITD mutations. In multivariate analyses, patients with an FLT3–ITD allele ratio (AR) of >0.5 showed a lower complete remission (CR rate) and OS (HR 1.47, p = 0.009), while AR > 0.8 was associated with poorer RFS (HR 2.1; p 0.5). Using the maximally selected log-rank statistics, we established an optimal cutoff of FLT3–ITD AR of 0.44 for OS, and 0.8 for RFS. We analyzed the OS and RFS according to FLT3–ITD status in all patients, and we found that the group of FLT3–ITD-positive patients with AR 0.44, allo-HSCT was superior to auto-HSCT in terms of OS and RFS. This study provides more evidence for a better characterization of patients with AML harboring FLT3–ITD mutations.This study was fundedby Instituto de Salud Carlos III (ISCIII) through the project PI19/01518 and PI19/00730 and co- funded by the European Union, the CRIS Against Cancer Foundation, grant 2018/001, and by the Instituto de Investigación Hospital 12 de Octubre (IMAS12). APeer reviewe

Adaptación de la asignatura “Clínica Jurídica de Acción Social” a un modelo de Aprendizaje-servicio con docencia semipresencial u online

Memoria ID-102. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2020-2021

HTLV-1 infection in solid organ transplant donors and recipients in Spain

HTLV-1 infection is a neglected disease, despite infecting 10-15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated illnesses due to immunosuppression, screening is being widely considered in the transplantation setting. Herein, we report the experience with universal HTLV testing of donors and recipients of solid organ transplants in a survey conducted in Spain. All hospitals belonging to the Spanish HTLV network were invited to participate in the study. Briefly, HTLV antibody screening was performed retrospectively in all specimens collected from solid organ donors and recipients attended since the year 2008. A total of 5751 individuals were tested for HTLV antibodies at 8 sites. Donors represented 2312 (42.2%), of whom 17 (0.3%) were living kidney donors. The remaining 3439 (59.8%) were recipients. Spaniards represented nearly 80%. Overall, 9 individuals (0.16%) were initially reactive for HTLV antibodies. Six were donors and 3 were recipients. Using confirmatory tests, HTLV-1 could be confirmed in only two donors, one Spaniard and another from Colombia. Both kidneys of the Spaniard were inadvertently transplanted. Subacute myelopathy developed within 1 year in one recipient. The second recipient seroconverted for HTLV-1 but the kidney had to be removed soon due to rejection. Immunosuppression was stopped and 3 years later the patient remains in dialysis but otherwise asymptomatic. The rate of HTLV-1 is low but not negligible in donors/recipients of solid organ transplants in Spain. Universal HTLV screening should be recommended in all donor and recipients of solid organ transplantation in Spain. Evidence is overwhelming for very high virus transmission and increased risk along with the rapid development of subacute myelopathy

Caput in the medieval Latin from Asturias and León

Producción CientíficaAnálisis de los usos y significados del sustantivo latino 'caput' en el latín medieval del reino de Asturias y León entre el s. VIII y 1230, para lo que ha utilizado un corpus de 7 crónicas y ca. 8000 diplomas notariales. Se compara también 'caput' con su par romance 'cabeza', que también se usa en dicho corpus textual. Además se examinan la distribución cronológica y las variantes gráficas y morfológicas de ambos sustantivos

M. Tullius Cicero, Scripta quae manserunt omnia, Fasc. 3. De oratore, ed. K. F. Kumaniecki, editio stereotypa ed. 1ª (1969), Stuttgar-Leipzig, B. G. Teubner, 1995, LX + 413 pp.

Reseña de M. Tullius Cicero, Scripta quae manserunt omnia, Fasc. 3. De oratore, ed. K. F. Kumaniecki, editio stereotypa ed. 1ª (1969), Stuttgar-Leipzig, B. G. Teubner, 1995, LX + 413 pp

Cantvs in laudem Virginis. La poesía religiosa de Juan Gil de Zamora: su oficio poético

Estudio del oficio poético sobre la Virgen, compuesto por el franciscano Juan Gil de Zamora, a petición del rey Alfonso X el Sabio y dedicado a él. La autora determina su pertenencia al cursus catedralicio y analiza los cantos que componen sus dos horas litúrgicas: maitines y laudes, en su aspecto formal, su contenido, su estilo y sus fuentes, así como algunos problemas textuales de su trasmisión