824 research outputs found
GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling
The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates nutrient and growth factor signals for the co-ordinated regulation of cellular metabolism and cell growth. Herein, we demonstrate that suppressing the cellular activity of glycogen synthase kinase-3 (GSK3), by use of pharmacological inhibitors or shRNA-mediated gene silencing, results in substantial reduction in amino acid (AA)-regulated mTORC1-directed signalling, as assessed by phosphorylation of multiple downstream mTORC1 targets. We show that GSK3 regulates mTORC1 activity through its ability to phosphorylate the mTOR-associated scaffold protein raptor (regulatory-associated protein of mTOR) on Ser(859). We further demonstrate that either GSK3 inhibition or expression of a S859A mutated raptor leads to reduced interaction between mTOR and raptor and under these circumstances, irrespective of AA availability, there is a consequential loss in phosphorylation of mTOR substrates, such as p70S6K1 (ribosomal S6 kinase 1) and uncoordinated-51-like kinase (ULK1), which results in increased autophagic flux and reduced cellular proliferation
AMiBA: scaling relations between the integrated Compton-y and X-ray derived temperature, mass, and luminosity
We investigate the scaling relations between the X-ray and the thermal
Sunyaev-Zel'dovich Effect (SZE) properties of clusters of galaxies, using data
taken during 2007 by the Y.T. Lee Array for Microwave Background Anisotropy
(AMiBA) at 94 GHz for the six clusters A1689, A1995, A2142, A2163, A2261, and
A2390. The scaling relations relate the integrated Compton-y parameter Y_{2500}
to the X-ray derived gas temperature T_{e}, total mass M_{2500}, and bolometric
luminosity L_X within r_{2500}. Our results for the power-law index and
normalization are both consistent with the self-similar model and other studies
in the literature except for the Y_{2500}-L_X relation, for which a physical
explanation is given though further investigation may be still needed. Our
results not only provide confidence for the AMiBA project but also support our
understanding of galaxy clusters.Comment: Accepted by ApJ; 8 pages, 3 figures, 5 table
AMiBA Wideband Analog Correlator
A wideband analog correlator has been constructed for the Yuan-Tseh Lee Array
for Microwave Background Anisotropy. Lag correlators using analog multipliers
provide large bandwidth and moderate frequency resolution. Broadband IF
distribution, backend signal processing and control are described. Operating
conditions for optimum sensitivity and linearity are discussed. From
observations, a large effective bandwidth of around 10 GHz has been shown to
provide sufficient sensitivity for detecting cosmic microwave background
variations.Comment: 28 pages, 23 figures, ApJ in press
AMiBA: Broadband Heterodyne CMB Interferometry
The Y. T. Lee Array for Microwave Background (AMiBA) has reported the first
science results on the detection of galaxy clusters via the Sunyaev Zel'dovich
effect. The science objectives required small reflectors in order to sample
large scale structures (20') while interferometry provided modest resolutions
(2'). With these constraints, we designed for the best sensitivity by utilizing
the maximum possible continuum bandwidth matched to the atmospheric window at
86-102GHz, with dual polarizations. A novel wide-band analog correlator was
designed that is easily expandable for more interferometer elements. MMIC
technology was used throughout as much as possible in order to miniaturize the
components and to enhance mass production. These designs will find application
in other upcoming astronomy projects. AMiBA is now in operations since 2006,
and we are in the process to expand the array from 7 to 13 elements.Comment: 10 pages, 6 figures, ApJ in press; a version with high resolution
figures available at
http://www.asiaa.sinica.edu.tw/~keiichi/upfiles/AMiBA7/mtc_highreso.pd
Mass and Hot Baryons in Massive Galaxy Clusters from Subaru Weak Lensing and AMiBA SZE Observations
We present a multiwavelength analysis of a sample of four hot (T_X>8keV)
X-ray galaxy clusters (A1689, A2261, A2142, and A2390) using joint AMiBA
Sunyaev-Zel'dovich effect (SZE) and Subaru weak lensing observations, combined
with published X-ray temperatures, to examine the distribution of mass and the
intracluster medium (ICM) in massive cluster environments. Our observations
show that A2261 is very similar to A1689 in terms of lensing properties. Many
tangential arcs are visible around A2261, with an effective Einstein radius
\sim 40 arcsec (at z \sim 1.5), which when combined with our weak lensing
measurements implies a mass profile well fitted by an NFW model with a high
concentration c_{vir} \sim 10, similar to A1689 and to other massive clusters.
The cluster A2142 shows complex mass substructure, and displays a shallower
profile (c_{vir} \sim 5), consistent with detailed X-ray observations which
imply recent interaction. The AMiBA map of A2142 exhibits an SZE feature
associated with mass substructure lying ahead of the sharp north-west edge of
the X-ray core suggesting a pressure increase in the ICM. For A2390 we obtain
highly elliptical mass and ICM distributions at all radii, consistent with
other X-ray and strong lensing work. Our cluster gas fraction measurements,
free from the hydrostatic equilibrium assumption, are overall in good agreement
with published X-ray and SZE observations, with the sample-averaged gas
fraction of = 0.133 \pm 0.027, for our sample = (1.2 \pm
0.1) \times 10^{15} M_{sun} h^{-1}. When compared to the cosmic baryon fraction
f_b = \Omega_b/\Omega_m constrained by the WMAP 5-year data, this indicates
/f_b = 0.78 \pm 0.16, i.e., (22 \pm 16)% of the baryons are missing
from the hot phase of clusters.Comment: accepted for publication in ApJ; high resolution figures available at
http://www.asiaa.sinica.edu.tw/~keiichi/upfiles/AMiBA7/ms_highreso.pd
The Yuan-Tseh Lee Array for Microwave Background Anisotropy
The Yuan-Tseh Lee Array for Microwave Background Anisotropy (AMiBA) is the
first interferometer dedicated to studying the cosmic microwave background
(CMB) radiation at 3mm wavelength. The choice of 3mm was made to minimize the
contributions from foreground synchrotron radiation and Galactic dust emission.
The initial configuration of seven 0.6m telescopes mounted on a 6-m hexapod
platform was dedicated in October 2006 on Mauna Loa, Hawaii. Scientific
operations began with the detection of a number of clusters of galaxies via the
thermal Sunyaev-Zel'dovich effect. We compare our data with Subaru weak lensing
data in order to study the structure of dark matter. We also compare our data
with X-ray data in order to derive the Hubble constant.Comment: accepted for publication in ApJ (13 pages, 7 figures); a version with
high resolution figures available at
http://www.asiaa.sinica.edu.tw/~keiichi/upfiles/AMiBA7/pho_highreso.pd
AMiBA: Sunyaev-Zel'Dovich Effect-derived Properties and Scaling Relations of Massive Galaxy Clusters
99學年度劉國欽研究獎助論文
100學年度劉國欽升等參考著作[[abstract]]The Sunyaev-Zel'dovich Effect (SZE) has been observed toward six massive galaxy clusters, at redshifts 0.091 ≤ z ≤ 0.322 in the 86-102 GHz band with the Y. T. Lee Array for Microwave Background Anisotropy (AMiBA). We modify an iterative method, based on the isothermal β models, to derive the electron temperature T e, total mass M t, gas mass M g, and integrated Compton Y within r 2500, from the AMiBA SZE data. Non-isothermal universal temperature profile (UTP) β models are also considered in this paper. These results are in good agreement with those deduced from other observations. We also investigate the embedded scaling relations, due to the assumptions that have been made in the method we adopted, between these purely SZE-deduced T e, M t, M g, and Y. Our results suggest that cluster properties may be measurable with SZE observations alone. However, the assumptions built into the pure-SZE method bias the results of scaling relation estimations and need further study.[[journaltype]]國外[[incitationindex]]SCI[[booktype]]紙本[[booktype]]電子版[[countrycodes]]US
Tests of AMiBA Data Integrity
We describe methods used to validate data from the Y.T. Lee Array for
Microwave Background Anisotropy (AMiBA), an interferometric array designed to
measure the Sunyaev-Zel'dovich effect and the anisotropy of the Cosmic
Microwave Background (CMB). We perform several statistical tests on data from
pointed galaxy cluster observations taken in 2007 and noise data from long-term
blank sky observations and measurements with the feeds covered by the
absorbers. We apply power spectrum analysis, cross power spectrum analysis
among different outputs with different time lags in our analog correlator, and
sample variance law tests to noise data. We find that (1) there is no time
variation of electronic offsets on the time scale of our two-patch observations
(~10 minutes); (2) noise is correlated by less than 10% between different lags;
and (3) the variance of noise scales with the inverse of time. To test the
Gaussianity of the data, we apply Kolmogorov-Smirnov (K-S) tests to cluster
data, and find that a 5% significance level efficiently detects data sets with
known hardware problems without rejecting an excess of acceptable data. We also
calculate third- and fourth-order moments and cumulants for the noise residual
visibilities and find that about 95% of our data are within the 99% confidence
regions of Gaussianity.Comment: 15 pages, 5 figures, accepted for publication in Ap
AMiBA: System Performance
The Y.T. Lee Array for Microwave Background Anisotropy (AMiBA) started
scientific operation in early 2007. This work describes the optimization of the
system performance for the measurements of the Sunyaev-Zel'dovich effect for
six massive galaxy clusters at redshifts . We achieved a point
source sensitivity of mJy with the seven 0.6m dishes in 1 hour of
on-source integration in 2-patch differencing observations. We measured and
compensated for the delays between the antennas of our platform-mounted
interferometer. Beam switching was used to cancel instrumental instabilities
and ground pick up. Total power and phase stability were good on time scales of
hours, and the system was shown to integrate down on equivalent timescales of
300 hours per baseline/correlation, or about 10 hours for the entire array.
While the broadband correlator leads to good sensitivity, the small number of
lags in the correlator resulted in poorly measured bandpass response. We
corrected for this by using external calibrators (Jupiter and Saturn). Using
Jupiter as the flux standard, we measured the disk brightness temperature of
Saturn to be K.Comment: 9 pages, 7 figures, 1 table, accepted for publication in Ap
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