Tablero de altar y elementos constructivos tardoantiguos del yacimiento de Nuestra Señora del Buen Suceso, término municipal de Aznalcóllar (Sevilla)

9 páginas, 10 figuras.[EN]During the archaeological excavation of the site Nuestra Señora del Buen Suceso (Aznalcóllar, Sevilla), elements corresponding to various phases of occupation, from Roman times to present times, were documented. Integrated in a 17th. century AD building, a marble fragment was recovered,identified as an altar panel, with a chronology between the 5th. and 7th. centuries AD. The revision of the archaeological record of the excavaction has allowed the identification, also found in Modern contexts, of other constructive elements of the same chronology.[ES]Durante el proceso de excavación del yacimiento de Nuestra Señora del Buen Suceso, Aznalcóllar (Sevilla), fueron documentados restos correspondientes a diversas fases de ocupación, desde época romana a la actualidad. Integrado en un edificio del siglo XVII d.C. se recuperó un fragmento de mármol que se ha identificado como tablero de altar, con una cronología entre los siglos V y VII d.C. La revisión del registro arqueológico ha permitido identificar, encontrados también en contextos modernos, otros elementos constructivos de la misma cronología.Peer reviewe

Mortalidad asociada a infección por el virus de Chikungunya

 La infección por el virus de Chikungunya presenta manifestaciones clínicas típicas: fiebre, erupción cutánea y artralgia. La enfermedad es generalmente autolimitada y de evolución benigna. Las complicaciones graves y la muerte ocurren en raras ocasiones y en pacientes con factores de riesgo, principalmente en aquellos con comorbilidades o que se encuentran en edades extremas de la vida. En este artículo describimos un paciente, sin comorbilidades previas conocidas, con infección por el virus de Chickungunya que progresó rápidamente a disfunción orgánica múltiple y murió luego de 36 horas de su ingreso. Este caso ilustra la dificultad del diagnóstico y el tratamiento de la infección grave por el virus de Chikungunya

Molecular phylogenetic relationships and generic placement of dryaderces inframaculata Boulenger, 1882 (Anura: Hylidae)

Dryaderces inframaculata Boulenger, 1882, is a rare species known only from a few specimens and localities in the southeastern Amazonia rainforest. It was originally described in the genus Hyla, after ~ 130 years transferred to Osteocephalus, and more recently to Dryaderces. These taxonomic changes were based solely on the similarity of morphological characters. Herein, we investigate the phylogenetic relationships and generic placement of D. inframaculata using molecular data from a collected specimen from the middle Tapajós River region, state of Pará, Brazil. Two mitochondrial DNA fragments (16S and COI) were assessed among representative species in the subfamily Lophiohylinae (Anura: Hylidae) to reconstruct phylogenetic trees under Bayesian and Maximum Likelihood criteria. Our results corroborate the monophyly of Dryaderces and the generic placement of D. inframaculata with high support. Dryaderces inframaculata is sister to an undescribed taxon, Dryaderces pearsoni Ca1 Jungfer et al., 2013, and both are sister to Dryaderces pearsoni Gaige, 1929. These findings are relevant for further research on the systematics and biogeography of the genus

Guillermo de ockham, o.f.m. el nominalismo y su irrupción en la universidad de parís.

Bogotá: Siglo del Hombre / Universidad San Buenaventura, 2011. 247 pp

The hepatocyte nuclear factor 4 (HNF-4) represses the mitochondrial HMG-CoA synthase gene

We have recently shown that the gene for the mitochondrial HMG-CoA synthase is a target for PPAR and that this receptor mediates the induction of this gene by fatty acids. With the aim of gaining further insight into the function and regulation of this gene we examined the effect of other members of the nuclear hormone receptor superfamily on its expression. We previously identified a regulatory element in the mitochondrial HMG-CoA synthase gene promoter that confers transcriptional regulation by PPAR, RXR and the orphan nuclear receptor COUP-TF, In this study we demonstrate a trans-repressing regulatory function for HNF-4 at this same nuclear receptor response element (NRRE). HNF-4 binds to the mitochondrial HMG-CoA synthase NRRE, and, in cotransfection assays in HepG2 cells, it represses PPAR-dependent activation of a reporter gene linked to the mitochondrial HMG-CoA synthase gene promoter. These results suggest that the mitochondrial HMG-CoA synthase gene is subject to differential regulation by the interplay of multiple members of the nuclear hormone receptor superfamily

Experiences Developing Safe and Fault-Tolerant Tele-Operated Service Robots. A Case Study in Shipyards

Human operators use tele-operated service robots for performing more or less hazardous operations (manipulation of heavy and/or dangerous products) in more or less hostile environments (nuclear reactors, space missions, warehouses, etc). Anyway, independently of the operation, the robot has to interact with both the environment it is working on and with human operators. Therefore, it is essential that the design (which include both software and hardware) of the robot involves no risk, or at least an acceptable level of risk, neither for the operators, nor for the environment nor for the robot itself. Nevertheless, it is not always possible to make a system free of failures in its design or operation. Apart from the risk inherent to the use of the mechanisms themselves, these systems work in hazardous environments, where the probability of the risk is higher than normal. Should a failure happen, its consequences could even involve the loss of human lives. (Neumann, 1994) documents many cases of computer-related failures, such as the Therac-25 (a radiation-therapy device), the missiles shield in Saudi Arabia, etc. Nevertheless, safety aspects are seldom included in the early phases of the system design process from the beginning, even though they are a critic aspect. Generally, safety has to conform and adapt to the already designed system and not vice versa, when it is widely known that safety involves not only the design of the software but also the hardware. Even more, a simple hardware solution can eliminate a hazard or simplify the software design in many situations.This research has been funded by the Spanish CICYT project MEDWSA (TIN2006-15175- C05-02) and the Regional Government of Murcia Séneca Program (02998-PI-05)

Path planning for quadrotors in 3D dynamic environments

Un tema de interés sobre los vehículos aéreos no tripulados es la determinación de trayectorias apropiadas que le permitan moverse de una posición inicial a una posición objetivo, garantizando que la trayectoria sea segura, es decir, que no existan riesgos de colisión. En este artículo se presentan dos técnicas de planificación de trayectorias y una estrategia de evasión de obstáculos para cuadricópteros, ambas técnicas funcionales sobre ambientes tridimensionales con obstáculos estáticos o dinámicos restringidos a velocidades constantes. Las técnicas funcionan sobre un ambiente modelado con planos que generan un campo de potencial artificial. La primera técnica está basada en puntos móviles que interconectan la posición inicial con la meta, posteriormente cada punto se mueve hacia zonas libres de la influencia de los obstáculos siguiendo el campo potencial, lo que hace que se encuentren caminos libres de obstáculos. La segunda técnica usa el concepto de zonas seguras, el cual se utiliza como criterio para actualizar la posición de los puntos. Adicionalmente, se propone una metodología de evasión de obstáculos dinámicos, que consiste en transformar el problema de planeación de trayectorias con obstáculos dinámicos al caso de planeación de trayectorias con obstáculos estáticos mediante un proceso de análisis de las posibilidades de colisión. Los resultados muestran que estas técnicas superan los inconvenientes de los algoritmos basados en gradiente descendente como mínimos locales y oscilaciones inestables.A topic of interest on unmanned aerial vehicles is determining appropriate paths that allow them to move from an initial position to a target position, ensuring that the path is safe, in other words, that there is no risk of collision. In this article, two techniques of path planning and an obstacle avoidance strategy for quadricopters are presented. Both techniques are functional on three-dimensional environments with static or dynamic obstacles restricted to constant speeds. The techniques work on an environment modeling with planes which generate an artificial potential field. The first technique is based on moving points that connect the initial position to the goal, and then every point moves towards free zones of influence of obstacles along the potential field, which makes unobstructed paths. The second technique uses the concept of safe areas, which is used as a criterion for updating the position of the points. Additionally, a methodology of dynamic obstacles avoidance is proposed, which is to transform the problem of trajectory planning with dynamic obstacles to the case of path planning with static obstacles through a process of analyzing the possibility of a collision. The results show that these techniques overcome the drawbacks of the gradient descent-based algorithms as local minima and unstable oscillations problems

Sex-Specific Effects of High Yolk Androgen Levels on Constitutive and Cell-Mediated Immune Responses in Nestlings of an Altricial Passerine

Avian embryos are exposed to yolk androgens that are incorporated into the egg by the ovulating female. These steroids can affect several aspects of embryo development, often resulting in increases in overall size or the speed of growth of different traits. However, several studies suggest that they also entail immune costs to the offspring. In this study, we explored whether variation in yolk androgen concentration affected several measures of the constitutive and cell-mediated immune axes in the spotless starling (Sturnus unicolor). Using a within-brood design, we injected different doses of androgens (testosterone and androstenedione) into the eggs. Our study showed that experimentally increased yolk androgens led to sex-specific immunosuppression in both the innate and adaptive axes of the immune system. Both cell-mediated immune response (CMI) and lysozyme activity decreased with increasing androgen levels injected into the egg in the case of male nestlings, whereas there were no effects on females. The effects that we found were always linear: no quadratic or threshold patterns were detected. We found no effects of the experimental treatment in hemolysis or agglutination capacity, but these measures were negatively correlated with CMI, suggesting negative correlation among different branches of the immune system. Blood (trypanosomes and hemosporidians) and intestinal (coccidia) parasites were not affected by the experimental increase of yolk androgen levels. Our results show that in our study species yolk androgens induce immunosuppression in some axes of the male nestling immune system. Further studies should analyze the proximate causes for these contrasting effects in different axes of the immune system and the reason for the differential impact on males and females

Temporal Phase Synchrony Disruption in Dyslexia: Anomaly Patterns in Auditory Processing

The search for a dyslexia diagnosis based on exclusively objective methods is currently a challenging task. Usually, this disorder is analyzed by means of behavioral tests prone to errors due to their subjective nature; e.g. the subject’s mood while doing the test can affect the results. Understanding the brain processes involved is key to proportionate a correct analysis and avoid these types of problems. It is in this task, biomarkers like electroencephalograms can help to obtain an objective measurement of the brain behavior that can be used to perform several analyses and ultimately making a diagnosis, keeping the human interaction at minimum. In this work, we used recorded electroencephalograms of children with and without dyslexia while a sound stimulus is played. We aim to detect whether there are significant differences in adaptation when the same stimulus is applied at different times. Our results show that following this process, a machine learning pipeline can be built with AUC values up to 0.73.Spanish Government PGC2018-098813-BC32 PGC2018-098813-B-C31Junta de Andalucia UMA20-FEDERJA-086 P18-RT-1624European CommissionBioSiP research group TIC-251MCIN/AEI by "ESF Investing in your future" PRE2019-087350 MICINN "Juan de la Cierva -Incorporacion" FellowshipLeeduca research groupJunta de Andalucia Spanish Governmen