Association between rs7901695 and rs7903146 polymorphisms of the TCF7L2 gene and gestational diabetes in the population of Southern Poland

Objectives: The etiology of gestational diabetes mellitus (GDM) remains to be fully elucidated. Elevated risk for type 2 diabetes in patients with history of GDM and for GDM in women with familial history of diabetes may suggest that GDM and type 2 diabetes share a common genetic and environmental background. The TCF7L2 (Transcription Factor 7 Like 2) gene is one of the most important genetic factors of the established correlation with type 2 diabetes, and it may also play a role in the pathophysiology of GDM.The aim of the study was to assess the influence of two polymorphisms of the TCF7L2 gene (rs7901695 and rs7903146), which are associated with the development of type 2 diabetes, in women with GDM.Material and methods: The study included 50 women with glucose tolerance disorders diagnosed for the first time during the current pregnancy. Single nucleotide polymorphisms (SNPs) were genotyped using allelic discrimination. The results were confirmed using the sequencing method. Selected clinical parameters were also analyzed.Results: No correlation between the studied polymorphisms of the TCF7L2 gene and GDM was observed. Glycemic control with diet or diet and insulin was associated with better control of the weight gain during pregnancy.Conclusions: No correlation between rs7903146 and rs7901695 polymorphisms of the TCF7L2 gene and GDM was found. Glycemic control with diet or diet and insulin is associated with better control of the weight gain during pregnancy

Level of Serum Fetuin-A Correlates with Heart Rate in Obstructive Sleep Apnea Patients without Metabolic and Cardiovascular Comorbidities

Obstructive sleep apnea (OSA) is the most common type of sleep-induced breathing disorder in the adult population and significantly affects the condition of the cardiovascular system. Fetuin-A (Fet-A) is a hepato- and adipokine, which prevents vessel calcification, and its level correlates with atherogenesis and metabolic disorders. The associations of cardiovascular diseases (CVD) both with OSA, which increases CVD risk, and Fet-A, which prevents CVD, justify the question of their mutual interactions in patients with OSA. Therefore, we sought to analyze Fet-A as an early biomarker of CVD risk in OSA patients without metabolic and cardiovascular comorbidities except for properly controlled arterial hypertension. We have found that in these patients, OSA does not appear to directly affect Fet-A levels. However, high Fet-A levels were more common in the group of patients with OSA, and the hypopnea index was significantly higher among subjects with the highest Fet-A levels. The level of Fet-A in OSA patients positively correlates with pulse rate, and it does not correlate with pulse pressure in this group unlike in the control group, where such a relationship exists. To our best knowledge, this is the first study to analyze this relationship in OSA patients without any significant cardiovascular comorbidities

Depression in the elderly with type 2 diabetes mellitus

Background: The aim of this work was to explore the association of depression in elderly patients with type 2 diabetes mellitus (T2DM) with disease duration, microvascular complications and level of diabetes education. Methods: Patients were divided into three main groups: group 1 aged 37–58 years, group 2 aged 70–79, group 3 aged ≥ 80 years. On the basis of collected medical records mean diabetes duration, microvascular complications, diabetes education level and depression severity were determined in particular age groups. Results: Microvascular complications occurred more frequently in older groups of patients with lower diabetes education level. In the oldest group moderately severe and severe depression was most frequent, while in the youngest group 50% of patients did not have any signs of depression, 43.4% presented mild depression, moderate and moderately severe depression was the least frequent (3.3%). Differences were statistically significant (p < 0.00001). Conclusions: In patients with T2DM depression is more common in older age groups with longer average diabetes duration, lower diabetes education level and greater severity of microvascular disease complications

Depresja u osób starszych z cukrzycą typu 2

Wstęp: Celem pracy było zbadanie związku między depresją u starszych pacjentów z cukrzycą typu 2 a czasem trwania choroby, powikłaniami mikronaczyniowymi i poziomem edukacji diabetologicznej. Materiał i metody: Chorych podzielono na trzy główne grupy: grupa badana I w wieku 37–58 lat, grupa badana II w wieku 70–79 lat, grupa badana III w wieku 80 lat więcej. Na podstawie zgromadzonej dokumentacji medycznej określono średni czas trwania cukrzycy, występowanie powikłań mikronaczyniowych, poziom edukacji diabetologicznej oraz nasilenie depresji w poszczególnych grupach wiekowych. Wyniki: Powikłania mikronaczyniowe częściej występowały w grupach pacjentów starszych i z niższym poziomem edukacji diabetologicznej. W najstarszej grupie najczęściej występowała depresja umiarkowanie ciężka i ciężka, natomiast w grupie najmłodszej 50% pacjentów nie miało objawów depresji, u 43,4% stwierdzono łagodną depresję, a najrzadziej występowała depresja umiarkowana i umiarkowanie ciężka (3,3%). Różnice były istotne statystycznie (p < 0,00001). Wnioski: U chorych z cukrzycą typu 2 depresja częściej występuje w starszych grupach wiekowych z dłuższym średnim czasem trwania cukrzycy, niższym poziomem edukacji diabetologicznej i większym nasileniem powikłań mikronaczyniowych

Obstructive sleep apnea may increase the risk of Alzheimer's disease.

ObjectivesAmyloid-β 1-40 (Aβ 1-40) and amyloid-β 1-42 (Aβ 1-42) are the proteins known to be involved in the pathogenesis of Alzheimer's disease (AD)-the most common cause of dementia in the elderly. Hypoxia is suspected to be one of conditions associated with Aβ plasma level increase. A common reason of hypoxia is obstructive sleep apnea (OSA), characterized by recurrent episodes of apnea.AimThe aim of the study was to evaluate plasma Aβ 1-40 and Aβ 1-42 concentrations in patients with OSA.MethodsPatients with suspected OSA (n = 112) underwent polygraphic examinations Patients with confirmed OSA (n = 81) showed apnea/hypopnea index greater than or equal to 5. Mild and moderate form of the disease was defined when AHI was 5-30 (n = 38, OSA+), severe-when AHI was >30 (n = 43, OSA++). Individuals with AHIResultsAβ 1-40 concentrations in OSA++ (191.1 pg/ml) group was significantly (pConclusionIn patients with severe OSA Aβ 1-40 plasma concentrations are significantly higher compared with OSA- and OSA+ and seem to be related to hypoxia severity, which may indicate increased risk of AD development in this group of patients

Coronary arteritis as a cause of cardiac rhythm disorders

Rymkiewicz Emilia, Karczewska Agnieszka, Lis Beata, Mosiewicz Barbara, Sołdaj–Bukszyńska Katarzyna, Ścirka Natalia, Grzywa‑Celińska Anna, Rękas‑Wójcik Agata, Grochowski Cezary, Dzida Grzegorz, Mosiewicz Jerzy. Coronary arteritis as a cause of cardiac rhythm disorders. Journal of Education, Health and Sport. 2017;7(9):33-44. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.854838 http://ojs.ukw.edu.pl/index.php/johs/article/view/4751 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.08.2017. Revised: 02.08.2017. Accepted: 28.08.2017. Coronary arteritis as a cause of cardiac rhythm disorders Emilia Rymkiewicz, Agnieszka Karczewska, Beata Lis, Barbara Mosiewicz, Katarzyna Sołdaj–Bukszyńska, Natalia Ścirka, Anna Grzywa-Celińska, Agata Rękas‑Wójcik, Cezary Grochowski, Grzegorz Dzida, Jerzy Mosiewicz Katedra i Klinika Chorób Wewnętrznych prof. dr hab. n. med. Jerzy Mosiewicz Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie Abstract Ischemic heart disease is a unit consisting of all heart ischemic states regardless of their pathomechanism. Despite common knowledge about risk factors, it remains the most frequent cause of death in industrialized countries. Aim of this paper is to present a case of 23-year-old patient hospitalized in the Department of Internal Diseases because of sensation of heart palpitation and weakness due to acute coronary syndrome in course of coronary arteritis, which occurred 7 years earlier. After performing 24-hour cardiac rhythm observation using Holter monitor, episodes of atrioventricular block Mobitz II, sinoatrial block and multiple supraventricular and ventricular excitations were found. Key words: coronary arteritis, myocardial infarction

Coronary arteritis as a cause of cardiac rhythm disorders

Rymkiewicz Emilia, Karczewska Agnieszka, Lis Beata, Mosiewicz Barbara, Sołdaj–Bukszyńska Katarzyna, Ścirka Natalia, Grzywa‑Celińska Anna, Rękas‑Wójcik Agata, Grochowski Cezary, Dzida Grzegorz, Mosiewicz Jerzy. Coronary arteritis as a cause of cardiac rhythm disorders. Journal of Education, Health and Sport. 2017;7(9):33-44. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.854838 http://ojs.ukw.edu.pl/index.php/johs/article/view/4751 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.08.2017. Revised: 02.08.2017. Accepted: 28.08.2017. Coronary arteritis as a cause of cardiac rhythm disorders Emilia Rymkiewicz, Agnieszka Karczewska, Beata Lis, Barbara Mosiewicz, Katarzyna Sołdaj–Bukszyńska, Natalia Ścirka, Anna Grzywa-Celińska, Agata Rękas‑Wójcik, Cezary Grochowski, Grzegorz Dzida, Jerzy Mosiewicz Katedra i Klinika Chorób Wewnętrznych prof. dr hab. n. med. Jerzy Mosiewicz Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie Abstract Ischemic heart disease is a unit consisting of all heart ischemic states regardless of their pathomechanism. Despite common knowledge about risk factors, it remains the most frequent cause of death in industrialized countries. Aim of this paper is to present a case of 23-year-old patient hospitalized in the Department of Internal Diseases because of sensation of heart palpitation and weakness due to acute coronary syndrome in course of coronary arteritis, which occurred 7 years earlier. After performing 24-hour cardiac rhythm observation using Holter monitor, episodes of atrioventricular block Mobitz II, sinoatrial block and multiple supraventricular and ventricular excitations were found. Key words: coronary arteritis, myocardial infarction