Intencionalidad al suicidio y actitud hacia la comida en jóvenes universitarios del distrito de Trujillo

La presente investigación tuvo como objetivo determinar la relación entre la intencionalidad al suicidio y actitud hacia la comida; se utilizó un diseño correlacional de tipo básica. La muestra estuvo compuesta por 300 universitarios entre las edades de 18 a 25 años, para la recolección de los datos se utilizó la Escala de Ideación Suicida de Beck (SIS) y el Test de actitudes alimentarias (EAT-26). Los resultados indicaron que si existe una correlación directa significativa (Sig<0.05) de efecto mediano entre las dos variables. Respecto a los objetivos específicos, se obtuvo que, la variable intencionalidad al suicidio presentó una media de 8.52±7.51; actitud hacia la comida posee una media de 10.59±9.02; las dimensiones Dieta y Bulimia y preocupación por la comida, presentan una relación directa significativa, y la dimensión control oral evidencia una relación inversa significativa, estas 3 dimensiones, tienen relación con las dimensiones de la intencionalidad suicida

CCR5 deficiency predisposes to fatal outcome in influenza virus infection

Influenza epidemics affect all age groups, although children, the elderly and those with underlying medical conditions are the most severely affected. Whereas co-morbidities are present in 50% of fatal cases, 25-50% of deaths are in apparently healthy individuals. This suggests underlying genetic determinants that govern infection severity. Although some viral factors that contribute to influenza disease are known, the role of host genetic factors remains undetermined. Data for small cohorts of influenza-infected patients are contradictory regarding the potential role of chemokine receptor 5 deficiency (CCR5-Δ32 mutation, a 32 bp deletion in the CCR5 gene) in the outcome of influenza virus infection. We tested 171 respiratory samples from influenza patients (2009 pandemic) for CCR5-Δ32 and evaluated its correlation with patient mortality. CCR5-Δ32 patients (17.4%) showed a higher mortality rate than WT individuals (4.7%; P = 0.021), which indicates that CCR5-Δ32 patients are at higher risk than the normal population of a fatal outcome in influenza infection.This work was supported by the Instituto de Salud Carlos III (Programa especial de investigación sobre la gripe pandémica GR09/0040 and GR09/0023), Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES) and the Spanish Ministry of Science and Innovation (BFU 2011-26175)S

Potential Harm of IQOS Smoke to Rat Liver

The Food and Drug Administration has recently classified the IQOS electronic cigarette as a modified-risk tobacco product. However, IQOS cigarettes still release various harmful constituents typical of conventional cigarettes (CCs), although the concentrations are markedly lower. Here, we investigated the damaging effects of IQOS smoking on the liver. Male Sprague Dawley rats were exposed, whole body, 5 days/week for 4 weeks to IQOS smoke (4 sticks/day), and hepatic xenobiotic metabolism, redox homeostasis and lipidomic profile were investigated. IQOS boosted reactive radicals and generated oxidative stress. Exposure decreased cellular reserves of total glutathione (GSH) but not GSH-dependent antioxidant enzymes. Catalase and xanthine oxidase were greater in the exposed group, as were various hepatic CYP-dependent monooxygenases (CYP2B1/2, CYP1A1, CYP2A1, CYP2E1-linked). Respiratory chain activity was unaltered, while the number of liver mitochondria was increased. IQOS exposure had an impact on the hepatic lipid profile. With regard to the expression of some MAP kinases commonly activated by CC smoking, IQOS increased the p-p38/p38 ratio, while erythroid nuclear transcription factor 2 (Nrf2) was negatively affected. Our data suggest that IQOS significantly impairs liver function, supporting the precautionary stance taken by the WHO toward the use of these devices, especially by young people and pregnant women

Plan de gestión de responsabilidad social a través de la producción y venta de mermelada en el sector VII de El Milagro, Trujillo – Perú

Se realizó un trabajo de investigación con el propósito de mejorar la condición de vida de las madres de familia a través de su participación en la elaboración de mermeladas para la venta directa en el Sector VII del Milagro, Trujillo – Perú, con el supuesto que dicha actividad crece junto a una adecuada gestión de responsabilidad social. El estudio tuvo carácter proyectivo y aplicado, donde se dio solución a una necesidad de tipo práctica a las madres de familia, para ello como metodología se dispuso del diagnóstico, diseño y ejecución del plan de acciones para la elaboración de mermelada, utilizándose herramientas como encuestas, registro y/o base de datos, entrevistas y observación. Se identificó las mayores necesidades en base al Censo Poblacional UPN realizado el presente año. Se priorizó y determinó el problema socio-ambiental a resolver en la comunidad. Se analizó el problema por medio de la matriz de interrelación FDOR, y a partir de éste se formuló los objetivos del proyecto. Posteriormente, se elaboró y ejecutó el plan de acciones en base a la programación de actividades y sus respectivos indicadores. Se determinó que con la ejecución del plan de acciones para la elaboración de mermelada en base a la producción de un (1) frasco de mermelada, se genera una ganancia del 81.81% equivalente a 1.80 nuevos soles por frasco producido

Case-Control Analysis of the Impact of Anemia on Quality of Life in Patients with Cancer: A Qca Study Analysis

The impact of anemia on the quality of life (QoL) in cancer patients has been studied previously; however, the cut-off point used to define anemia differed among studies, thus providing inconsistent results. Therefore, we analysed the clinical impact of anemia on QoL using the same cut-off point for hemoglobin level to define anemia as that used in ESMO clinical practice guidelines. This post-hoc analysis aimed to determine the impact of anemia on QoL in cancer patients through the European Organization for Research and Treatment of Cancer Quality of life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. We found that cancer patients with anemia had significantly worse QoL in clinical terms. In addition, anemic patients had more pronounced symptoms than those in non-anemic patients. Anemia is a common condition in cancer patients and is associated with a wide variety of symptoms that impair quality of life (QoL). However, exactly how anemia affects QoL in cancer patients is unclear because of the inconsistencies in its definition in previous reports. We aimed to examine the clinical impact of anemia on the QoL of cancer patients using specific questionnaires. We performed a post-hoc analysis of a multicenter, prospective, case-control study. We included patients with cancer with (cases) or without (controls) anemia. Participants completed the European Organization for Research and Treatment of Cancer Quality of Life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. Statistically significant and clinically relevant differences in the global health status were examined. From 2015 to 2018, 365 patients were included (90 cases and 275 controls). We found minimally important differences in global health status according to the EORTC QLQ-C30 questionnaire (case vs. controls: 45.6 vs. 58%, respectively; mean difference: -12.4, p < 0.001). Regarding symptoms, cancer patients with anemia had more pronounced symptoms in six out of nine scales in comparison with those without anemia. In conclusion, cancer patients with anemia had a worse QoL both clinically and statistically

Heterozygous and Homozygous Variants in SORL1 Gene in Alzheimer's Disease Patients: Clinical, Neuroimaging and Neuropathological Findings

In the last few years, the SORL1 gene has been strongly implicated in the development of Alzheimer’s disease (AD). We performed whole-exome sequencing on 37 patients with early-onset dementia or family history suggestive of autosomal dominant dementia. Data analysis was based on a custom panel that included 46 genes related to AD and dementia. SORL1 variants were present in a high proportion of patients with candidate variants (15%, 3/20). We expand the clinical manifestations associated with the SORL1 gene by reporting detailed clinical and neuroimaging findings of six unrelated patients with AD and SORL1 mutations. We also present for the first time a patient with the homozygous truncating variant c.364C>T (p.R122*) in SORL1, who also had severe cerebral amyloid angiopathy. Furthermore, we report neuropathological findings and immunochemistry assays from one patient with the splicing variant c.4519+5G>A in the SORL1 gene, in which AD was confirmed by neuropathological examination. Our results highlight the heterogeneity of clinical presentation and familial dementia background of SORL1-associated AD and suggest that SORL1 might be contributing to AD development as a risk factor gene rather than as a major autosomal dominant gene.This work was supported by the Instituto de Salud Carlos III (PI17/01067) and AGAUR from the Autonomous Catalan Government (2017SGR1134). Dr. Víctor Antonio Blanco-Palmero is supported by the Instituto de Salud Carlos III (ISCIII, Spanish Biomedical Research Institute) through a “Río Hortega” contract (CM18/0095). Dr. Sara Llamas-Velasco is supported by the Instituto de Salud Carlos III (ISCIII; Spanish Biomedical Research Institute) through a “Juan Rodés” contract (JR 18/00046).S

Cortical thinning over two years after first-episode psychosis depends on age of onset

First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15–35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe

Investigación en matemáticas, economía y ciencias sociales

El resultado de este libro que reune inquietudes académicas en torno a temas tan estudiados como los que están alrededor del maíz, del frijol o del café; y tan contemporáneos como las aplicaciones concretas de las ciencias ya citadas, al estudio de la adopción del comercio electrónico en empresas del sector agroindustrial o, el caso de la generación de biogas o energía eléctrica por medio de biodigestores. Al editar este texto e incorporarlo a la bibliografía de los temas de referencia, se enriquecen opciones de consulta para los estudiosos de esos temas en general; pero también para interesados en aspectos tan específicos como la cadena de suministro del mercado hortofrutícola en Texcoco

Physical Therapy and Occupational Therapy student's motivation. A Comparative study in the University of Malaga, Spain

Purpose: The main purpose of this study is to know and compare motivational facts and vocational behaviour among students of physical therapy and occupational therapy. Other secondary objectives are: • To know the satisfaction these students report with their university studies • To analyze the level of academic decision about their professional future. • To know if these students have an effective academic behavior. Participants. Participants were 141 Spanish collegue students who volunteered for the study. They were students of second and third year of Physical therapy (69) and Occupational therapy (72) in the University of Malaga. Methods: Cross-sectional design. Paticipants completed in one setting the “Cuestionario de Biodatos Universitarios - CBU- The CBU is a 9 item scale that offers information about student academic motivation, academic decisions, satisfaction or future professional purpose. Each questionnaire response is assigned a value with a maximum possible total score of 26. Results: Regarding student satisfaction, 68.1% of physical therapy (PT) student are very satisfied with the career choices they made in thei day, like the 56.95% of students in occupational therapy (OT). Regarding the degree of academic decision on the professional expertise they would like to pursue in the future, 44,9% doe not have anything decided in PT, similar to the 36,1% found in OT. After completing his studies, 48,62% of OT students planning to do a Master or postgraduate course compared with the 81.1% referring this intention in PT. In relation to the exercise of the profession immediately obtained similar results in both degrees, 56.95% in OT and 66.2% in PT. Only 6.95% of repondents in OT and 14.49% in PT have not decided yet. Among the difficulties or problems for a decision by a specialty or area of works, 57.9% highlights the lack of information on the characteristics of that product in PT and 31.95% at OT, whereas only 2.9% and 5.56% refer to that no option would fully satisfied respectively. Comprehensively analyzed, and pre-vocational behaviour of respondents was fully efficient, so that in all cases there is an effective career development, slightly better in pupils PT. Conclusions: The descriptive analysis of a sample CBU draws us highly satisfied with their university studies, with an efficient vocational behaviour, who knows the need for specialization through graduate school, but lacks sufficient information in making their decisions.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Grupo español de cirugía torácica asistida por videoimagen: método, auditoría y resultados iniciales de una cohorte nacional prospectiva de pacientes tratados con resecciones anatómicas del pulmón

Introduction: our study sought to know the current implementation of video-assisted thoracoscopic surgery (VATS) for anatomical lung resections in Spain. We present our initial results and describe the auditing systems developed by the Spanish VATS Group (GEVATS). Methods: we conducted a prospective multicentre cohort study that included patients receiving anatomical lung resections between 12/20/2016 and 03/20/2018. The main quality controls consisted of determining the recruitment rate of each centre and the accuracy of the perioperative data collected based on six key variables. The implications of a low recruitment rate were analysed for '90-day mortality' and 'Grade IIIb-V complications'. Results: the series was composed of 3533 cases (1917 VATS; 54.3%) across 33 departments. The centres' median recruitment rate was 99% (25-75th:76-100%), with an overall recruitment rate of 83% and a data accuracy of 98%. We were unable to demonstrate a significant association between the recruitment rate and the risk of morbidity/mortality, but a trend was found in the unadjusted analysis for those centres with recruitment rates lower than 80% (centres with 95-100% rates as reference): grade IIIb-V OR=0.61 (p=0.081), 90-day mortality OR=0.46 (p=0.051). Conclusions: more than half of the anatomical lung resections in Spain are performed via VATS. According to our results, the centre's recruitment rate and its potential implications due to selection bias, should deserve further attention by the main voluntary multicentre studies of our speciality. The high representativeness as well as the reliability of the GEVATS data constitute a fundamental point of departure for this nationwide cohort