Analysis of alpha defensin variation in samples from periodontitis patients

Background: In recent years, many studies have found positive associations between copy number variants and predisposition to human complex disease. On chromosome 8p23.1, a copy number variation locus, named DEFA1A3 is associated with susceptibility to IgA nephropathy, and is more generally thought to be involved in the host immune response in people with periodontitis. Objective: The main objective of this study was to undertake DEFA1A3 copy number measurement in 744 European samples with periodontitis and also to determine if there is an association between the copy numbers and periodontitis. Results and Conclusions: In this study we have used the Paralogue Ratio Tests to type 741 DNA samples from individuals with periodontitis and assessed the accuracy in typing copy number. As a second part of our work, we have found that there is an association between copy number distribution and periodontitis, but further work needs to be done in order to fully confirm and explore this conclusion

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages

Analysis of alpha defensin variation in samples from periodontitis patients

Background: In recent years, many studies have found positive associations between copy number variants and predisposition to human complex disease. On chromosome 8p23.1, a copy number variation locus, named DEFA1A3 is associated with susceptibility to IgA nephropathy, and is more generally thought to be involved in the host immune response in people with periodontitis. Objective: The main objective of this study was to undertake DEFA1A3 copy number measurement in 744 European samples with periodontitis and also to determine if there is an association between the copy numbers and periodontitis. Results and Conclusions: In this study we have used the Paralogue Ratio Tests to type 741 DNA samples from individuals with periodontitis and assessed the accuracy in typing copy number. As a second part of our work, we have found that there is an association between copy number distribution and periodontitis, but further work needs to be done in order to fully confirm and explore this conclusion

Model-Independent Observation of Exotic Contributions to B0→J/ψK+π−B^0\to J/\psi K^+\pi^- Decays

International audienceAn angular analysis of B0→J/ψK+π- decays is performed, using proton-proton collision data corresponding to an integrated luminosity of 3  fb-1 collected with the LHCb detector. The m(K+π-) spectrum is divided into fine bins. In each m(K+π-) bin, the hypothesis that the three-dimensional angular distribution can be described by structures induced only by K* resonances is examined, making minimal assumptions about the K+π- system. The data reject the K*-only hypothesis with a large significance, implying the observation of exotic contributions in a model-independent fashion. Inspection of the m(J/ψπ-) vs m(K+π-) plane suggests structures near m(J/ψπ-)=4200 and 4600 MeV

Study of Υ\Upsilon production in ppPb collisions at sNN=8.16\sqrt{s_{NN}}=8.16 TeV

International audienceThe production of ϒ(nS) mesons (n = 1, 2, 3) in pPb and Pbp collisions at a centre-of-mass energy per nucleon pair $\sqrt{s_{\mathrm{NN}}}=8.16$ TeV is measured by the LHCb experiment, using a data sample corresponding to an integrated luminosity of 31.8 nb$^{−1}$. The ϒ(nS) mesons are reconstructed through their decays into two opposite-sign muons. The measurements comprise the differential production cross-sections of the ϒ(1S) and ϒ(2S) states, their forward-to-backward ratios and nuclear modification factors. The measurements are performed as a function of the transverse momentum p$_{T}$ and rapidity in the nucleon-nucleon centre-of-mass frame y$^{*}$ of the ϒ(nS) states, in the kinematic range p$_{T}$ < 25 GeV/c and 1.5 < y$^{*}$ < 4.0 (−5.0 < y$^{*}$ < −2.5) for pPb (Pbp) collisions. In addition, production cross-sections for ϒ(3S) are measured integrated over phase space and the production ratios between all three ϒ(nS) states are determined. Suppression for bottomonium in proton-lead collisions is observed, which is particularly visible in the ratios. The results are compared to theoretical models

Observation of an excited Bc+B_c^+ state

International audienceUsing pp collision data corresponding to an integrated luminosity of 8.5  fb-1 recorded by the LHCb experiment at center-of-mass energies of s=7, 8, and 13 TeV, the observation of an excited Bc+ state in the Bc+π+π- invariant-mass spectrum is reported. The observed peak has a mass of 6841.2±0.6(stat)±0.1(syst)±0.8(Bc+)  MeV/c2, where the last uncertainty is due to the limited knowledge of the Bc+ mass. It is consistent with expectations of the Bc*(2S31)+ state reconstructed without the low-energy photon from the Bc*(1S31)+→Bc+γ decay following Bc*(2S31)+→Bc*(1S31)+π+π-. A second state is seen with a global (local) statistical significance of 2.2σ (3.2σ) and a mass of 6872.1±1.3(stat)±0.1(syst)±0.8(Bc+)  MeV/c2, and is consistent with the Bc(2S10)+ state. These mass measurements are the most precise to date

Measurement of the branching fraction and CPCP asymmetry in B+→J/ψρ+B^{+}\rightarrow J/\psi \rho^{+} decays

International audienceThe branching fraction and direct $C\!P$ asymmetry of the decay ${{{B} ^+}} \!\rightarrow {{J /\psi }} {{\rho } ^+}$ are measured using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7 and 8 TeV, corresponding to a total integrated luminosity of 3 $\,\text{ fb }^{-1}$ . The following results are obtained: $\begin{aligned} \mathcal {B}({{B} ^+} \!\rightarrow {{J /\psi }} {{\rho } ^+} )&= (3.81^{+0.25-0.24} \pm 0.35) \times 10^{-5},\\ \mathcal {A}^{{C\!P}} ({{B} ^+} \!\rightarrow {{J /\psi }} {{\rho } ^+} )&= -0.045^{+0.056-0.057} \pm 0.008, \end{aligned}$ where the first uncertainties are statistical and the second systematic. Both measurements are the most precise to date

Amplitude analysis of the B(s)0→K∗0K‾∗0B^0_{(s)} \to K^{*0} \overline{K}^{*0} decays and measurement of the branching fraction of the B0→K∗0K‾∗0B^0 \to K^{*0} \overline{K}^{*0} decay

International audienceThe ${B}^0\to {K}^{\ast 0}{\overline{K}}^{\ast 0}$ and ${B}_s^0\to {K}^{\ast 0}{\overline{K}}^{\ast 0}$ decays are studied using proton-proton collision data corresponding to an integrated luminosity of 3 fb$^{−1}$. An untagged and timeintegrated amplitude analysis of B_{( s}_{)}^{0}  → (K$^{+}$π$^{−}$)(K$^{−}$π$^{+}$) decays in two-body invariant mass regions of 150 MeV/c$^{2}$ around the K$^{∗0}$ mass is performed. A stronger longitudinal polarisation fraction in the ${B}^0\to {K}^{\ast 0}{\overline{K}}^{\ast 0}$ decay, f$_{L}$ = 0.724 ± 0.051 (stat) ± 0.016 (syst), is observed as compared to f$_{L}$ = 0.240 ± 0.031 (stat) ± 0.025 (syst) in the ${B}_s^0\to {K}^{\ast 0}{\overline{K}}^{\ast 0}$ decay. The ratio of branching fractions of the two decays is measured and used to determine $\mathrm{\mathcal{B}}\left({B}^0\to {K}^{\ast 0}{\overline{K}}^{\ast 0}\right)=\left(8.0\pm 0.9\left(\mathrm{stat}\right)\pm 0.4\left(\mathrm{syst}\right)\right)\times {10}^{-7}$

Measurement of CPCP-violating and mixing-induced observables in Bs0→ϕγB_s^0 \to \phi\gamma decays

International audienceA time-dependent analysis of the Bs0→ϕγ decay rate is performed to determine the CP -violating observables Sϕγ and Cϕγ and the mixing-induced observable AϕγΔ. The measurement is based on a sample of pp collision data recorded with the LHCb detector, corresponding to an integrated luminosity of 3  fb-1 at center-of-mass energies of 7 and 8 TeV. The measured values are Sϕγ=0.43±0.30±0.11, Cϕγ=0.11±0.29±0.11, and AϕγΔ=-0.67-0.41+0.37±0.17, where the first uncertainty is statistical and the second systematic. This is the first measurement of the observables S and C in radiative Bs0 decays. The results are consistent with the standard model predictions