164 research outputs found
A systematic review of cannabidiol dosing in clinical populations
Aims: Cannabidiol is a cannabis-derived medicinal product with potential application in a wide-variety of contexts, however its effective dose in different disease states remains unclear. This review aimed to investigate what doses have been applied in clinical populations, in order to understand the active range of cannabidiol in a variety of medical contexts. Methods: Publications involving administration of cannabidiol alone were collected by searching PubMed, EMBASE and ClinicalTrials.gov. Results: A total of 1038 articles were retrieved, of which 35 studies met inclusion criteria covering 13 medical contexts. 23 studies reported a significant improvement in primary outcomes (e.g. psychotic symptoms, anxiety, seizures), with doses ranging betwee
Determining the effects of clumping and porosity on the chemistry in a non-uniform AGB outflow
The importance of OH radicalâneutral low temperature tunnelling reactions in interstellar clouds using a new model
Recent laboratory experiments using a pulsed Laval nozzle apparatus have shown that reactions between a neutral molecule and the radical OH can occur efficiently at low temperatures despite activation energy barriers if there is a hydrogen-bonded complex in the entrance channel which allows the system to tunnel efficiently under the barrier. Since OH is a major radical in the interstellar medium, this class of reactions may well be important in the chemistry that occurs in the gas phase of interstellar clouds. Using a new gas-grain chemical network with both gas-phase reactions and reactions on the surfaces of dust particles, we studied the role of OHâneutral reactions in dense interstellar clouds at 10, 50, and 100 K. We determined that at least one of these reactions can be significant, especially at the lowest temperatures studied, where the rate constants are large. It was found in particular that the reaction between CH3OH and OH provides an effective and unambiguous gas-phase route to the production of the gaseous methoxy radical (CH3O), which has been recently detected in cold, dense interstsellar clouds. The role of other reactions in this class is explored
Chemical telemetry of OH observed to measure interstellar magnetic fields
We present models for the chemistry in gas moving towards the ionization
front of an HII region. When it is far from the ionization front, the gas is
highly depleted of elements more massive than helium. However, as it approaches
the ionization front, ices are destroyed and species formed on the grain
surfaces are injected into the gas phase. Photodissociation removes gas phase
molecular species as the gas flows towards the ionization front. We identify
models for which the OH column densities are comparable to those measured in
observations undertaken to study the magnetic fields in star forming regions
and give results for the column densities of other species that should be
abundant if the observed OH arises through a combination of the liberation of
H2O from surfaces and photodissociation. They include CH3OH, H2CO, and H2S.
Observations of these other species may help establish the nature of the OH
spatial distribution in the clouds, which is important for the interpretation
of the magnetic field results.Comment: 11 pages, 2 figures, accepted by Astrophysics and Space Scienc
Probing the Abundance of SiO and HCN throughout the Stellar Wind of R Dor
FWN â Publicaties zonder aanstelling Universiteit Leide
The James Clerk Maxwell Telescope Spectral Legacy Survey
Original article can be found at: http://www.journals.uchicago.edu/loi/pasp Copyright University of Chicago Press / AAS. DOI: 10.1086/511161Stars form in the densest, coldest, most quiescent regions of molecular clouds. Molecules provide the only probes that can reveal the dynamics, physics, chemistry, and evolution of these regions, but our understanding of the molecular inventory of sources and how this is related to their physical state and evolution is rudimentary and incomplete. The Spectral Legacy Survey (SLS) is one of seven surveys recently approved by the James Clerk Maxwell Telescope (JCMT) Board of Directors. Beginning in 2007, the SLS will produce a spectral imaging survey of the content and distribution of all the molecules detected in the 345 GHz atmospheric window (between 332 and 373 GHz) toward a sample of five sources. Our intended targets are a low-mass core (NGC 1333 IRAS 4), three high-mass cores spanning a range of star-forming environments and evolutionary states (W49, AFGL 2591, and IRAS 20126), and a photodissociation region (the Orion Bar). The SLS will use the unique spectral imaging capabilities of HARP-B/ACSIS (Heterodyne Array Receiver Programme B/Auto- Correlation Spectrometer and Imaging System) to study the molecular inventory and the physical structure of these objects, which span different evolutionary stages and physical environments and to probe their evolution during the star formation process. As its name suggests, the SLS will provide a lasting data legacy from the JCMT that is intended to benefit the entire astronomical community. As such, the entire data set (including calibrated spectral data cubes, maps of molecular emission, line identifications, and calculations of the gas temperature and column density) will be publicly available.Peer reviewe
Understanding the Chemical Complexity in Circumstellar Envelopes of C-rich AGB Stars: the Case of IRC +10216
The circumstellar envelopes of carbon-rich AGB stars show a chemical
complexity that is exemplified by the prototypical object IRC +10216, in which
about 60 different molecules have been detected to date. Most of these species
are carbon chains of the type CnH, CnH2, CnN, HCnN. We present the detection of
new species (CH2CHCN, CH2CN, H2CS, CH3CCH and C3O) achieved thanks to the
systematic observation of the full 3 mm window with the IRAM 30m telescope plus
some ARO 12m observations. All these species, known to exist in the
interstellar medium, are detected for the first time in a circumstellar
envelope around an AGB star. These five molecules are most likely formed in the
outer expanding envelope rather than in the stellar photosphere. A pure gas
phase chemical model of the circumstellar envelope is reasonably successful in
explaining the derived abundances, and additionally allows to elucidate the
chemical formation routes and to predict the spatial distribution of the
detected species.Comment: 4 pages, 4 figures; to appear in Astrophysics and Space Science,
special issue of "Science with ALMA: a new era for Astrophysics" conference,
November, 13-17 2006, ed. R. Bachille
The composition of the protosolar disk and the formation conditions for comets
Conditions in the protosolar nebula have left their mark in the composition
of cometary volatiles, thought to be some of the most pristine material in the
solar system. Cometary compositions represent the end point of processing that
began in the parent molecular cloud core and continued through the collapse of
that core to form the protosun and the solar nebula, and finally during the
evolution of the solar nebula itself as the cometary bodies were accreting.
Disentangling the effects of the various epochs on the final composition of a
comet is complicated. But comets are not the only source of information about
the solar nebula. Protostellar disks around young stars similar to the protosun
provide a way of investigating the evolution of disks similar to the solar
nebula while they are in the process of evolving to form their own solar
systems. In this way we can learn about the physical and chemical conditions
under which comets formed, and about the types of dynamical processing that
shaped the solar system we see today.
This paper summarizes some recent contributions to our understanding of both
cometary volatiles and the composition, structure and evolution of protostellar
disks.Comment: To appear in Space Science Reviews. The final publication is
available at Springer via http://dx.doi.org/10.1007/s11214-015-0167-
Grain Surface Models and Data for Astrochemistry
AbstractThe cross-disciplinary field of astrochemistry exists to understand the formation, destruction, and survival of molecules in astrophysical environments. Molecules in space are synthesized via a large variety of gas-phase reactions, and reactions on dust-grain surfaces, where the surface acts as a catalyst. A broad consensus has been reached in the astrochemistry community on how to suitably treat gas-phase processes in models, and also on how to present the necessary reaction data in databases; however, no such consensus has yet been reached for grain-surface processes. A team of âŒ25 experts covering observational, laboratory and theoretical (astro)chemistry met in summer of 2014 at the Lorentz Center in Leiden with the aim to provide solutions for this problem and to review the current state-of-the-art of grain surface models, both in terms of technical implementation into models as well as the most up-to-date information available from experiments and chemical computations. This review builds on the results of this workshop and gives an outlook for future directions
- âŠ