6 research outputs found
An analysis of the relationships between articulation and auditory discrimination in kindergarten children
- Publication venue
- Boston University
- Publication date
- 01/01/1953
- Field of study
Thesis (Ed.M.)--Boston Universit
Bisexual Women as Emblematic Sexual Healers and the Problematics of the Embodied Sacred Whore
- Author
- Adler Margot
- Anonymous
- Betty Meador
- Bird Phyllis A.
- Califia Pat.
- Christ Carol
- Corinne Tee
- Daly Mary
- Diamant Anita
- Dodson Betty
- Doraine Jiutchins
- Fabian Cosi
- Fuerstein Georg
- Gilmore Lee.
- Grahn Judy
- Hutchins Loraine
- Kenneth Ray Stubbs
- LaChapelle Dolores
- Lerner Gerda
- Mariechild Diane
- Merlin Stone
- Metzger Deena
- Metzger Deena
- Metzger Deena
- Monica Sjoo
- Qualls-Corbett Nancy
- Rosemary Curb
- Rudy Kathy
- Shannon Bell
- Sprinkle Annie
- Sprinkle Annie
- Sprinkle Annie
- Starhawk
- Starhawk
- Starhawk
- Walker Barbara G.
- Publication venue
- 'The Haworth Press'
- Publication date
- Field of study
Plasma trimethylamine-N-oxide and related metabolites are associated with type 2 diabetes risk in the Prevención con Dieta Mediterránea (PREDIMED) trial.
- Author
- Alhazmi
- Amenta
- Benjamini
- Bennett
- Cho
- Cho
- Cho
- Christopher Papandreou
- Clary Clish
- Cornelis
- Cristina Razquin
- Dambrova
- Dolores Corella
- Edward Yu
- Ejaz
- Elosua
- Emilio Ros
- Enrique Gómez-Gracia
- Estefanía Toledo
- Estruch
- Fennema
- Fernando Arós
- Floegel
- Frank B Hu
- Georgios A Fragkiadakis
- Gohil
- Huang
- Jordi Salas-Salvadó
- José Lapetra
- Kim
- Konstantinova
- Lever
- Lewis
- Liming Liang
- Lluís Serra-Majem
- Marta Guasch-Ferré
- Martínez-González
- Matthews
- McEntyre
- McEvoy
- Merlin
- Miguel Ruiz-Canela
- Mingrone
- Miquel Fiol
- Montserrat Fitó
- Mònica Bulló
- Nishimukai
- Obeid
- Pacifico
- Puri
- Ramon Estruch
- Rhee
- Rhee
- Rohrmann
- Salas-Salvadó
- Schröder
- Schwab
- Shaham
- Shan
- Stephens
- Tang
- Trøseid
- Velasquez
- Wallace
- Wang
- Wang
- Wang
- Yan Zheng
- Yea
- Zhong
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2018
- Field of study
The role of trimethylamine-N-oxide (TMAO) in type 2 diabetes (T2D) is currently partially understood and controversial. The aim of this study was to investigate associations between TMAO and related metabolites with T2D risk in subjects at high risk of cardiovascular disease. This is a case-cohort design study within the Prevención con Dieta Mediterránea (PREDIMED) study, with 251 incident T2D cases and a random sample of 694 participants (641 noncases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 y). We used liquid chromatography-tandem mass spectrometry to measure plasma TMAO, l-carnitine, betaine, lyso-phosphatidylcholine (LPC) and lyso-phosphatidylethanolamine (LPE) species, phosphocholine, α-glycerophosphocholine, and choline at baseline and after 1 y. We examined associations with the use of weighted Cox proportional hazard models, accounting for the weighted case-cohort design by the Barlow method. After adjustment for recognized T2D risk factors and multiple testing, individuals in the highest quartile of baseline TMAO and α-glycerophosphocholine had a lower risk of T2D [HR (95% CI): 0.52 (0.29, 0.89) and 0.46 (0.24, 0.89), respectively]. The HR (95% CI) comparing the extreme quartiles of betaine was 0.41 (0.23, 0.74). Similar trends were observed for C16:0 LPC, C18:1 LPC, C18:0 LPC, C20:4 LPC, C22:6 LPC, C18:1 LPC plasmalogen, and C16:0 LPE. After correcting for multiple comparisons, participants in the highest quartile of 1-y changes in oleic acid LPC plasmalogen concentrations had a lower T2D risk than the reference quartile. Whether the associations between plasma TMAO and certain metabolite concentrations with T2D risk reflect its pathophysiology or represent an epiphenomenon needs to be elucidated. This trial is registered at http://www.controlled-trials.com as ISRCTN35739639
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- A. Lina Rosengren
- Abram Burgher
- Adam B. Brosz
- Adam Rosen
- Adam Schwartz
- Adriana Sordo Duran
- Adrienna Marquez
- Adrienne E. Shapiro
- Aeiress Duhart
- Afsoon Roberts
- Albert Liu
- Alejandro Hoberman
- Alejandro Quintín Barrat Hernández
- Alex Greninger
- Alexander Clark
- Alfredo Gilberto Guerreros Benavides
- Alice McGarry
- Alicia Arrazcaeta
- Alisha Lutat
- Alison Bondell
- Alison Pellecchia
- Allie Oplinger
- Allison Green
- Allison O'Brien
- Alpa Patel
- Alyssa-Kay Peay
- Amanda Horn
- Amanda Lilienthal
- Amanda Occhino
- Amanda Philyaw
- Amaran Moodley
- Amber Grant
- Amber Stanford
- Amesika Nyaku
- Amie Shannon
- Amina Z. Haggag
- Amit Paliwal
- Amy Caldwell
- Amy Chamberlain
- Amy Dye
- Amy Falk
- Amy Kelley
- Amy Medina
- Amy Potts
- Amy Salzl
- Amy Sherman
- Amy Starr
- Amy Thompson
- Andrea Berry
- Andrea Clement
- Andrea Wendrow
- Andrea Zimmer
- Andres Bran
- Andres Camacho-Gonzalez
- Andrew Lauria
- Andrew McConnell
- Andrew McWilliams
- Anelgine C. Yoon
- Angela Lee
- Angela R. Branche
- Angelica Kottkamp
- Angella Webb
- Ann M. Milliken
- Ann R. Falsey
- Anna S. Lok
- Anna Wald
- Anne Marit de Groot
- Anne-Marie Rick
- Annette R. Bennett
- Annie Ciambruschini
- Annie Luetkemeyer
- Anthony Kim
- Anum Abbas
- Anyela Lara
- April Pixler
- Ariana C. Stanton
- Arthur L. Zemanek
- Asha Inniss
- Ashley Kennedy
- Ashley Perez
- Ashley Warden
- Asif Noor
- Atoya Adams
- Aurelio Cruz-Valdez
- Austin Chan
- Austin Swanson
- Ayanna Walters
- Ayoade Avworo
- Bailey Jordan
- Barbara Corral
- Barbara Rizzardi
- Barbara Rizzardi
- Barbara S. Taylor
- Barry S. Zingman
- Barton G. Williams
- Beatriz Grinsztejn
- Becky Martinez
- Ben Ladner
- Benjamin Eckhardt
- Benjamin J. Luft
- Bernard Grunstra
- Beth Safirstein
- Bethanie Wilkinson
- Beverly E. Sha
- Beverly Ewing
- Bindu Balani
- Blanca Gomez
- Bo Shopsin
- Boerries Brandenburg
- Brandie Taylor
- Brandon J. Essink
- Brandy Ball
- Breanz Watkins
- Brenda Dorcely
- Brendan Levy
- Brett Gray
- Brett Leav
- Brian D.W. Chow
- Brit Sovic
- Brittany Feijoo
- Brittany Stewart
- Bruce C. Gebhardt
- Bruce G. Rankin
- Bruce McClenathan
- Bruno Valenti
- Bryan Gordon
- C. Mary Healy
- Caitlin J. Guiney
- Caitlin Moran
- Candace Smith
- Candice Montros
- Carina A. Rodriguez
- Carl Fichtenbaum
- Carl P. Griffin
- Carlos A. Fierro
- Carlos del Rio
- Carlos Lopez
- Carlos Malvestutto
- Carmel B. Dyer
- Carmen A. Paez
- Carmen Amador
- Carmen D. Zorrilla
- Carmen Medina
- Carol Ann Linebarger
- Carol Kauffman
- Carol L. Mitchell
- Carolene Stephenson
- Caroline Greene
- Carolyn Scatamacchia
- Carolyn Tran
- Carrie Johnston
- Carrie Sopher
- Catherine A. Bunce
- Catherine Mary Healy
- Catherine Q. Gular
- Cathy Laflan
- Cecilia McKeown-Bragas
- Celia Gonzalez
- Celia Maxwell
- Charles Harper
- Charles M. Fogarty
- Charlotte-Paige Rolle
- Charnell Cromer
- Chelsea Miles
- Chelsie Nutsch
- Chelsie Nutsch
- Chen S. Tan
- Chenchen Yu
- Cheryl Nuss
- Cheryl Young
- Chimeremma Nnadi
- Chinar Desai
- Christian Tomaszewski
- Christina A. Rostad
- Christina Bacher
- Christina Kennelly
- Christine Akamine
- Christine B. Turley
- Christine Hull
- Christine Wilson
- Christopher Carpenter
- Christopher Dedon
- Christopher Galloway
- Christopher Matich
- Christy Schmeck
- Christy Sweet
- Clarence B. Creech II
- Clarisse Baudelaire
- Claudia De La Matta Rodriguez
- Claudia Espinosa
- Claudio Nuñez Lagos
- Clint C. Guillory
- Clint Wilson
- Codi M. Anthony
- Colleen F. Kelley
- Colleen Jacobsen
- Connie Moya
- Cora Sonnier
- Corey G. Anderson
- Corey M. Chen
- Cornell Calinescu
- Corrina Pavetto
- Cortney Burch
- Cory J. Huffine
- Craig Dietz
- Cristina Cicogna
- Crystal Rowell
- Cynthia Becher Strout
- Cynthia Brown
- Cynthia Bueno
- Cynthia L. Gay
- Cynthia L. Monaco
- Cynthia Montano-Pereira
- Cyrus Hoseyni
- Dakotah C. Lane
- Dalia Tovar
- Daniel Duncanson
- Daniel Hoft
- Daniel Kaul
- Daniel S. Graciaa
- Daniel T. Lawler
- Daniela Pineda Méndez
- Danielle Raley
- Danny Sugimoto
- Danyel Johnson
- Darlene Bartilucci
- David B. Musante
- David Beckmann
- David Browder
- David Dellaero
- David Fitz-Patrick
- David Halpert
- David I. Bernstein
- David J. Diemert
- David J. Ensz
- David Kline
- David L. Fried
- David Metzger
- David Pampe
- David Pitrak
- David R. Andes
- David Rosenberg
- David Tatelbaum
- David Wohl
- Dawn Furey
- Dawn Robison
- Dean Follmann
- Dean M. Boswell
- Deanna Cooper
- Debora Dunbar
- Deborah A. Theodore
- Deborah Murray
- Debra B. Schroeck
- Delia Bullock
- Denis Tarakjian
- Denise Casey
- Denise Roadman
- Denise Sample
- Denisse Alejandra González Estrada
- Derek Lewis
- Derek M. Smith
- Destiny S. Heinzig-Cartwright
- Diana Badillo
- Diana F. Florescu
- Diana Vegas
- Dianca Sierra
- Diane H. Johnson
- Dilek Ince
- Dima Dandachi
- Dirk Heerwegh
- Dolores Rijos
- Donald M. Brandon
- Donald Quinn
- Donna Percy
- Doris Franco-Vitteri
- Douglas S. Denham
- E. Javier Pretell Alva
- Edgar Garcia
- Edith Swann
- Eduardo Gabriel Vázquez Saldaña
- Edward C. Jones-López
- Edward E. Walsh
- Edward Ellerbeck
- Edward M. Tavel Jr.
- Elham Ghadishah
- Elie Gharib
- Elisa Swieboda
- Elissa Malkin
- Elizabeth Barranco-Santana
- Elizabeth Bennett
- Elizabeth Bruce
- Elizabeth Danford
- Elizabeth Duke
- Elizabeth E. Robison
- Elizabeth Everette
- Elizabeth Formentini
- Elizabeth Hammershaimb
- Elizabeth Parker
- Elizabeth Secord
- Ellie Carmody
- Elliot DeHaan
- Elwaleed Elnagar
- Emily Degan
- Emily Oppenheim
- Emma Bainbridge
- Emmanuel B. Walter
- Eneyda Giuvanela Llerena Zegarra
- Enrique Ocaña
- Eric A. Meyerowitz
- Eric Bravo
- Eric McGrath
- Eric Miller
- Erica Herc
- Erica Johnson
- Erica Osmundsen
- Erica Sanchez
- Erika A. Cutz
- Erika Mendoza
- Erin A. Goecker
- Erin Cooksey
- Erin Coston
- Ernesto Delgado
- Esther L. Harmon
- Esther S. Huffine
- Evan C. Ewers
- Evan J. Anderson
- Evelyn Hall
- Evelyn Lomasney
- Evelyn Quevedo
- Fan Yang
- Farah Irani
- Farhan Siddiqui
- Fernanda Morales
- Fernando L. Merino
- Filip Dubovsky
- Flora Castellino
- Florence Momplaisir
- Florida Aristy
- Frances Downing
- Frank James
- Frank S. Eder
- Frank Struyf
- Fred E. Newton
- Frederick Raiser III
- Fredric Santiago
- Gail Broder
- Gary Albert
- Gary Headden
- Gary Horwith
- Gary Luckasen
- Gary Simon
- Gayle D. Hennekes
- Genevieve Beninati
- Genevieve Iwuala
- George H. Bauer Jr.
- George H. Freeman
- Georgette Ebuh
- Georgettea Geuss
- Gerald Kelty
- Germán Áñez
- Getahun Abate
- Gina Rivero
- Glenda E. Gray
- Glenn Wortman
- Gowdhami Mohan
- Grant Ellsworth
- Grant Geiger
- Greg Hachigian
- Greg Wilson
- Gregg H. Lucksinger
- Gregory C. Utz
- Gregory Holt
- Gregory J. Feldman
- Gregory M. Glenn
- Gregory M. Gottschlich
- Griet Van Roey
- Guillermo Miguel Ruiz-Palacios
- Gysella Muniz
- Hala Webster
- Hana M. El Sahly
- Hanh Chu
- Hanh Chu
- Hannah Catan
- Hannah Harrington
- Hannah Nevarez
- Haoua Dunbar
- Hayes Williams
- Heather Rattenbury-Shaw
- Henry Peralta
- Hilario Alvarado
- Hillary Dunlevy
- Holli Hamilton
- Holly E. Janes
- Hong V. Tieu
- Horacio Marafioti
- Howard I. Schwartz
- Howard Schwartz
- Hussain Malbari
- Huub G. Gelderblom
- Hyman Scott
- Ian De Proost
- Ian Frank
- Ian Hirsch
- Iksung Cho
- Ilse Van Dromme
- Insiya Valika
- Irene Graham
- Irene McKnight
- Iris García
- Isaac Thomsen
- Isabel Pereira
- Issac Pena-Renteria
- Jack Stapleton
- Jacob Coleman
- Jacqueline Miller
- Jacqueline Muenzner
- Jaleh Ostovar
- Jaleh Ostovar
- Jalima Quintero
- James Andersen
- James Fry
- James G. Kublin
- James H. Conway
- James Longe
- James Lovell
- James N. Goldenberg
- James Peacock
- James Ramsey
- James T. Peterson
- James W. Hurst
- James Walker
- James Zhou
- Jamie Ackerman
- Jamshid Saleh
- Jan Patterson
- Janet Garvey
- Janet Hill
- Janet Mendez
- Janet Otto
- Janeth Pacheco-Flores
- Janice Suyehira
- Janine Maenza
- Jarek Juraszek
- Jason F. Okulicz
- Jason Milligan
- Jay Meyer
- Jayasree Krishnankutty
- Jeanne Blevins
- Jeb Andrews
- Jeff Kingsley
- Jeffrey A. Henderson
- Jeffrey Adelglass
- Jeffrey Dugas Sr.
- Jeffrey Klein
- Jeffrey M. Jacobson
- Jeffrey Meier
- Jeffrey Rosen
- Jeffrey S. Overcash
- Jeffrey Thessing
- Jeffry Jacqmein
- Jenina Garcia
- Jennie Johnson
- Jennifer A. Johnson
- Jennifer A. Whitaker
- Jennifer Bashour
- Jennifer Berry
- Jennifer Chang
- Jennifer Foley
- Jennifer Knishinsky
- Jennifer Knowles
- Jennifer L. Dong
- Jennifer McCarter
- Jennifer Petts
- Jennifer Schwartz
- Jennifer Winbigler
- Jenny Hendriks
- Jerald Sadoff
- Jeremy Ackermann
- Jeremy Brown
- Jerome Custers
- Jerome G. Naifeh
- Jesse L. Clark
- Jessica E. Justman
- Jessica G. Andriesen
- Jessica Heimonen
- Jessica Ibarra
- Jessica L. Ansel
- Jessica L. Lee
- Jessica L. Weidler
- Jessica M. Mena
- Jessica Ortega
- Jessica Rodriguez
- Jessica Stahl
- Jewel J. White
- Jill Blumenthal
- Jill Kessler
- Jill York
- Jim Callis
- Joan Rothenberg
- Joanne L. Billings
- Jocelyn Zuleica Olmos Vega
- Jodi Meck
- Joel Solis
- Johan Vingerhoets
- John A. Kirby
- John J. Treanor
- John Johnson
- John Lucaj
- John M. Hill
- John Mascola
- John S. Kizer
- John Sanders
- John W. McGettigan Jr.
- John Witbeck
- Jon F. Dedon
- Jon Finley
- Jonathan Staben
- Jonlyn McGettigan
- Jordan Coslet
- Jordan L. Whatley
- Jorge A. Benitez
- Jorge A. Chacón
- Jorge Caso
- Jorge F. Méndez Galván
- Jose A. Bazan
- Jose C. Mancilla
- Jose Castillo Mancilla
- Jose Gonzales-Zamora
- Joseph Bocchini
- Joseph Boscia
- Joseph D. Davis
- Joseph Eron Jr.
- Joseph Grillo
- Joseph J. Eron
- Joseph L. Newberg
- Joseph P. Connor
- Joseph Yusin
- Joshua Rindt
- José O. Alemán
- Joy Nelson
- Juan J. Rivera
- Juan Luis Yrivarren Giorza
- Juan P. Torres
- Juan V. Guanira-Carranza
- Juana R. Pavie
- Juana Rivera
- Judith Borger
- Judith Brady
- Judith L. Kirstein
- Judith Martin
- Judy Pi
- Julia Hutter
- Julia Lord
- Julian A. Torres
- Julie A. Ake
- Julie Hussey
- Julie Ledgerwood
- Julie White
- Julio Nasim
- Justin Singletary
- Kacie Sales
- Kami Kim
- Karen Deutsch
- Karen Freudemann
- Karen L. Kotloff
- Karen Ruperto
- Karen Sofia Vega Orozco
- Karen Tashima
- Karin Choquette
- Karina Cano Martínez
- Karl M. Thompson
- Karla Beatriz Tafur Bances
- Karla Zepeda
- Kary Kelly
- Kate Harden
- Kate Jaegle
- Kate Zenlea
- Katherine Smith
- Katherine Stapleton
- Kathleen Linder
- Kathleen M. Mullane
- Kathleen M. Neuzil
- Kathleen Menasche
- Kathleen S. Jones
- Kathryn E. Stephenson
- Kawsar R. Talaat
- Keith R. Jerome
- Keith W. Vrbicky
- Kelly Kush
- Kelly McQuarrie
- Ken Ho
- Kendra Enright
- Kendra Lisec
- Kenneth Finkelstein
- Kenneth H. Mayer
- Kenneth Steil
- Kevin D. Cannon
- Kevin Parks
- Kevin Zhang
- Kia Lee
- Kia Lee
- Kim Quillin
- Kimberly Mueller
- Kimberly Nieves
- Kimberly Nofz
- Kimberly Snell
- Kinara S. Yang
- Kirsten Hauge
- Kristen Johnson
- Kristen K. Pierce
- Kristen Kiersey
- Kristin Bialobok
- Kristin Marks
- Kristina Harrison
- Kristine J. Kucera
- LaKondria Curry
- Lalitha Parameswaran
- Larkin T. Wadsworth III
- LaShondra Cade
- LaTeshia Thomas-Seaton
- Laura Hernandez Guarin
- Laura Julia Camacho Choza
- Laura Kogelman
- Laura Pearlman
- Laura Pearlman
- Laura Porterfield
- Laura Ruy Sanchez Guerrero
- Laura Stulken
- Lauren Clement
- Lauren Newhouse
- Laurence Chu
- Laurie J. Han-Conrad
- Lawrence Corey
- Lawrence J. Purpura
- Lazaro Gonzalez
- Leana Woodside
- Lee Tomatsu
- Leena Paul
- Leila Hojat
- Leland N. Allen III
- Lena R. Freese
- Leonard Singer
- Les B. Forgosh
- Lesley Browder
- Leslie A. Edwards
- Leslie Iverson
- Lilly Immergluck
- Lily Aleman
- Lina M. Forero
- Linda M. Schipani
- Linda Murray
- Linda R. Belhorn
- Lindsey R. Baden
- Lisa A. Jackson
- Lisa Chrisley
- Lisa Cohen
- Lisa Holloway
- Lisa J. Sanders
- Lisa Johnson
- Lisa M. Dunkle
- Lisa S. Usdan
- Lisa Stangl
- Lisa Stevens Rameaka
- Logan Ledbetter
- Lois Katz
- Lora J. McGill
- Lori Nesbitt
- Lucy Ng-Price
- Luis H. González
- Luis I. De La Cruz
- Luke Friesen
- Luz Zapata
- Lyly Dang
- Lyndsea Folsom
- Lynn Eckert
- Lynne A. Haughey
- M. Juliana McElrath
- M. Mahdee Sobhanie
- Magdalena E. Sobieszczyk
- Maggie Bowers
- Maggie Lewis
- Mai Pham
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- Mamodikoe Makhene
- Mandy Vowell
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- Marguerite Neill
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- Maria Johnson
- Maria L. Alcaide
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- Maria Mileno
- Marian E. Shaw
- Marianela Carvajal
- Maricruz E. Ortegón
- Marina Lee
- Mario Castro
- Mark A. Turner
- Mark E. Kutner
- Mark Eickhoff
- Mark Hutchens
- Mark Leibowitz
- Mark Lerman
- Mark M. McKenzie
- Mark S. Adams
- Marshall A. Cross
- Marshall Nash
- Martha Carmen Medina
- Martha Cecilia Gómora Madrid
- Martha Nason
- Martha Sanchez
- Martín Bäcker
- Marvin Castellon
- Mary A. Marovich
- Mary Beth Manning
- Mary C. Walsh
- Mary Easley
- Mary Hussain
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- Mary Vogler
- Maryam Jahromi
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- Marysol Villegas
- María E. Santolaya
- María I. Rivera
- María José Reyes Fentanes
- Masaru Oshita
- Mashrur Islam Majumder
- Matthew B. Laurens
- Matthew D. Sims
- Matthew G. Davis
- Matthew Hepburn
- Matthew Hong
- Matthew Hong
- Matthew Miles
- Matthew W. Doust
- Maureen Cooney
- May-Yin Suen
- Mayur Ramesh
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- Merlin Robb
- Mesha M. Chadwick
- Michael B. Butcher
- Michael C. Keefer
- Michael Cancilla
- Michael Cancilla
- Michael Chung
- Michael Delgado
- Michael Desjardins
- Michael E. Dever
- Michael Fay
- Michael J. Cotugno
- Michael J. Koren
- Michael J. McCartney
- Michael J. Smith
- Michael Jacobs
- Michael L. Levin
- Michael Lewis
- Michael P. Dube
- Michael R. Adams
- Michael Sciaudone
- Michael Waters
- Michele Baka
- Michele D. Reynolds
- Michele P. Andrasik
- Michele Vertucci
- Michelle DallaPiazza
- Michelle Dickey
- Michelle Haynes
- Michelle King
- Michelle L. Burgett
- Michelle Maxwell
- Michelle Saemann
- Mike Delgado
- Milagritos Tapia
- Mildred Stull
- Millie Manalo
- Milton Haber
- Mimi Van Der Leden
- Mira Baron
- Mitul Shah
- Mohamed S. Al-Ibrahim
- Mohammed Allaw
- Mohammed Antwi
- Monica B. Carrascal
- Monica Mauri
- Monica McArthur
- Monica Murray
- Monica Ruiz
- Morgan Hussey
- Morgan McLaughlin
- Mouna G. Chebib
- Murray A. Kimmel
- Nadine Rouphael
- Nafisa Saleem
- Najat Khan
- Nan Zhai
- Naomi Devine
- Natalia Leistner
- Natalie Ramirez
- Natasa Jenson
- Natasha Montoya
- Natasha Rybak
- Natasha Wilson
- Nathan Alderson
- Nathan Segall
- Neil P. Sheth
- Nelia Sanchez-Crespo
- Nelson Michael
- Nga Le
- Nicholas A. Viens
- Nicole Harrell
- Nicole L. Nollen
- Niles Eaton
- Nina Ahmad
- Njira Lucia Lugogo
- Nolan Mackey
- Norberto Fas
- Noris Peraita
- Norma Vega
- Nzeera Ketter
- Obiageli Sogbetun
- Odette Olivieri
- Oyebisi Olanrewaju
- Padma N. Mangu
- Pamela Kane
- Paola Lichtenberger
- Parke Hedges
- Parul Desai
- Patricia L. Winokur
- Patrick A. Oliver
- Patrick Flume
- Patrick Newingham
- Patty Howenstine
- Patty Price-Abbott
- Patty Reed
- Paul A. Goepfert
- Paul Bondy
- Paul Coplan
- Paul Cramer
- Paul E. Wylie
- Paul G. Matherne
- Paul H. Wakefield
- Paul J. Nugent
- Paul Kilgore
- Paul Nee
- Paul Pickrell
- Paul S. Bradley
- Paulina Miller
- Paulina Rebolledo
- Pavitra Roychoudhury
- Peta-Gay Jackson-Booth
- Pete Ducheneaux
- Peter B. Gilbert
- Peter J. Winkle
- Peter Ronco
- Philip Ponce
- Phillip Claybrook
- Phillip Levy
- Pink Folmar
- Priti Patel
- Priyantha N. Wijewardane
- Purvi Parikh
- R. Michelle Chouteau
- R. Scott McClelland
- Rachael McClennen
- Rachel Rokser
- Rafael Calderon
- Rafael Lupercio
- Rafael Mendoza
- Rajan Merchant
- Rajesh K. Davit
- Rambod Rouhbakhsh
- Ramin Herati
- Ramy J. Toma
- Raphael J. Landovitz
- Raymond Cornelison
- Rebecca Boas
- Rebecca J. Kurnat
- Rebecca P. Madan
- Rebecca Pitotti
- Rebecca Zash
- Rebone M. Maboa
- Renea Henderson
- Reuben Martinez
- Reza Parungao
- Rhodna Fouts
- Rica Santiago
- Richard Calderone
- Richard Gorman
- Richard L. Gibson
- Richard M. Glover II
- Richard M. Novak
- Richard Powell
- Richard Rupp
- Richard Starlin
- Rickey D. Manning
- Riemke Brakema
- Ripley R. Hollister
- Robert Brownlee
- Robert J. Buynak
- Robert J. Ulrich
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- Tracy R. Klein
- Trina L. Reynolds
- Troy Holdeman
- Tyler D. Bold
- Uriel R. Felsen
- Valentine M. Ebuh
- Valeria D. Cantos
- Valerie K. Arnold
- Vanessa Abad
- Vanessa Raabe
- Veronica G. Fragoso
- Veronica Garcia-Fragoso
- Veronica Procasky
- Veronica Viar
- Vicki E. Miller
- Vickie Leathers
- Victoria Andriulis
- Victoria Engler
- Victoria Mosteller
- Victoria R. Anderson
- Vida Veronica Ruiz Herrera
- Vincent Huynh
- Vincent Mirkil
- Vivek Rajasekhar
- Viviana Gonzalez
- Vladimir Berthaud
- Walter Patton
- Wanda Ramon
- Waseem Chughtai
- Wayne L. Harper
- Wayne Woo
- Wendell Lewis
- Wendell Lewis III
- Wendy A. Keitel
- Wesley Campbell
- Wesley Van Ever
- Westly Keating
- Whitney West
- Will Hernandez
- William B. Davis
- William B. Smith
- William H. Jones
- William Jennings
- William Kirby
- William P. Silver
- William R. Hartman
- William S. Davis Jr.
- William Schnitz
- William Seger
- Winniberg Stephany Alvarez León
- Winston Cavert
- Xiaomi Tong
- Yaa D. Oppong
- Yi H. Wu
- Ying Huang
- Yogesh K. Paliwal
- Youyi Fong
- Yunda Huang
- Yunda Huang
- Yvonne Davis
- Zachary Bittner
- Zainab Rizvi
- Zindy Yazmín Zárate Hinojosa
- Zudi-Mwak Takizala
- Publication venue
- Elsevier
- Publication date
- 01/10/2023
- Field of study
Summary: Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
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Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- Abad Vanessa
- Abate Getahun
- Abbas Anum
- Ackerman Jamie
- Ackerman Ronald
- Ackermann Jeremy
- Adams Atoya
- Adams Mark S.
- Adams Michael R.
- Adelglass Jeffrey
- Afework Sarah
- Ahmad Nina
- Akamine Christine
- Ake Julie A.
- Al-Ibrahim Mohamed S.
- Albert Gary
- Alcaide Maria L.
- Alderson Nathan
- Aleman Lily
- Alemán José O.
- Allaw Mohammed
- Alva E. Javier Pretell
- Alvarado Hilario
- Amador Carmen
- Andersen James
- Anderson Corey G.
- Anderson Evan J.
- Anderson Victoria R.
- Andes David R.
- Andrasik Michele P.
- Andree Stephanie
- Andrews Jeb
- Andriesen Jessica G.
- Andriulis Victoria
- Ansel Jessica L.
- Anthony Codi M.
- Antwi Mohammed
- Arduino Roberto C.
- Aristy Florida
- Arnold Valerie K.
- Arrazcaeta Alicia
- Atmar Robert L.
- Avworo Ayoade
- Bacher Christina
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- Baka Michele
- Baker Sherrie
- Balani Bindu
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- Zingman Barry S.
- Zorrilla Carmen D.
- Áñez Germán
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2023
- Field of study
Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
B. Sprachwissenschaft
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- Abercrombie D.
- Abschluß II.
- Academia Espanola
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- Zueinzelnenillyrischen Eigennamen
- Zum Stand
- Zum XIII
- Zur
- Zur
- Zur
- Zur
- Zur Kritik
- Zur Lesung
- Zwei
- Zwirner E.
- ZÖ
- ßvrard Johanna
- ägäische Pflanzennamen
- Öerech Y.
- öes
- Öhmann E.
- Öihar V.
- Über
- Über
- Über den Begriff
- Über Ortsnamen
- Über Ortsnamen
- ΑνβΓςό Luis
- ΡοΙοΓηέΕ
- Publication venue
- 'Walter de Gruyter GmbH'
- Publication date
- 01/01/1961
- Field of study