Optimització del procés d'arrencada d'un sistema multiprocessador

L'objectiu d'aquest projecte és el d'optimitzar l'arrencada d'un sistema encastatEl objetivo de este proyecto es el de optimizar el arranque de un sistema empotradoThe aim of this project is to optimaze the boot process with different computin

Cas pràctic d'adaptació metodològica a les directrius EEES d'una assignatura d'enginyeria informàtica

En el curs 2004-2005, l'assignatura de primer curs Fonaments de Computadors [4], de la titulació d'Enginyeria en Informàtica, fou una de les assignatures escollides dins del pla pilot DURSI [5] de la Universitat Autònoma de Barcelona per començar amb el nous sistema de crèdits ECTS. Així doncs, el curs 04-05 fou un any intens en quan a canvis i el present curs ha estat la consolidació del nou sistema. La implementació d'aquests és encara més impactant, ja que es van realitzar mantenint exactament els mateixos recursos humans (mateixos professors i mateixa capacitat docent) que en anys anteriors. L'assignatura va sofrir una reestructuració conceptual total, i en aquest article analitzarem els canvis realitzats per adaptar-nos a aquesta nova realitat en la que vivim, la nostra experiència com a docents i els seus resultats

Effectiveness of a cognitive behavioral intervention in patients with medically unexplained symptoms: cluster randomized trial

BACKGROUND: Medically unexplained symptoms are an important mental health problem in primary care and generate a high cost in health services.Cognitive behavioral therapy and psychodynamic therapy have proven effective in these patients. However, there are few studies on the effectiveness of psychosocial interventions by primary health care. The project aims to determine whether a cognitive-behavioral group intervention in patients with medically unexplained symptoms, is more effective than routine clinical practice to improve the quality of life measured by the SF-12 questionary at 12 month. METHODS/DESIGN: This study involves a community based cluster randomized trial in primary healthcare centres in Madrid (Spain). The number of patients required is 242 (121 in each arm), all between 18 and 65 of age with medically unexplained symptoms that had seeked medical attention in primary care at least 10 times during the previous year. The main outcome variable is the quality of life measured by the SF-12 questionnaire on Mental Healthcare. Secondary outcome variables include number of consultations, number of drug (prescriptions) and number of days of sick leave together with other prognosis and descriptive variables. Main effectiveness will be analyzed by comparing the percentage of patients that improve at least 4 points on the SF-12 questionnaire between intervention and control groups at 12 months. All statistical tests will be performed with intention to treat. Logistic regression with random effects will be used to adjust for prognostic factors. Confounding factors or factors that might alter the effect recorded will be taken into account in this analysis. DISCUSSION: This study aims to provide more insight to address medically unexplained symptoms, highly prevalent in primary care, from a quantitative methodology. It involves intervention group conducted by previously trained nursing staff to diminish the progression to the chronicity of the symptoms, improve quality of life, and reduce frequency of medical consultations. TRIAL REGISTRATION: The trial was registered with ClinicalTrials.gov, number NCT01484223 [http://ClinicalTrials.gov].S

What pulmonologists think about the asthma–COPD overlap syndrome

Background: Some patients with COPD may share characteristics of asthma; this is the so-called asthma–COPD overlap syndrome (ACOS). There are no universally accepted criteria for ACOS, and most treatments for asthma and COPD have not been adequately tested in this population. Materials and methods: We performed a survey among pulmonology specialists in asthma and COPD aimed at collecting their opinions about ACOS and their attitudes in regard to some case scenarios of ACOS patients. The participants answered a structured questionnaire and attended a face-to-face meeting with the Metaplan methodology to discuss different aspects of ACOS. Results: A total of 26 pulmonologists with a mean age of 49.7 years participated in the survey (13 specialists in asthma and 13 in COPD). Among these, 84.6% recognized the existence of ACOS and stated that a mean of 12.6% of their patients might have this syndrome. In addition, 80.8% agreed that the diagnostic criteria for ACOS are not yet well defined. The most frequently mentioned characteristics of ACOS were a history of asthma (88.5%), significant smoking exposure (73.1%), and postbronchodilator forced expiratory volume in 1 second/forced vital capacity ,0.7 (69.2%). The most accepted diagnostic criteria were eosinophilia in sputum (80.8%), a very positive bronchodilator test (69.2%), and a history of asthma before 40 years of age (65.4%). Up to 96.2% agreed that first-line treatment for ACOS was the combination of a long-acting β2-agonist and inhaled steroid, with a long-acting antimuscarinic agent (triple therapy) for severe ACOS. Conclusion: Most Spanish specialists in asthma and COPD agree that ACOS exists, but the diagnostic criteria are not yet well defined. A previous history of asthma, smoking, and not fully reversible airflow limitation are considered the main characteristics of ACOS, with the most accepted first-line treatment being long-acting β2-agonist/inhaled corticosteroids

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Optimització del procés d'arrencada d'un sistema multiprocessador

L'objectiu d'aquest projecte és el d'optimitzar l'arrencada d'un sistema encastatEl objetivo de este proyecto es el de optimizar el arranque de un sistema empotradoThe aim of this project is to optimaze the boot process with different computin

Cas pràctic d'adaptació metodològica a les directrius EEES d'una assignatura d'enginyeria informàtica

En el curs 2004-2005, l'assignatura de primer curs Fonaments de Computadors [4], de la titulació d'Enginyeria en Informàtica, fou una de les assignatures escollides dins del pla pilot DURSI [5] de la Universitat Autònoma de Barcelona per començar amb el nous sistema de crèdits ECTS. Així doncs, el curs 04-05 fou un any intens en quan a canvis i el present curs ha estat la consolidació del nou sistema. La implementació d'aquests és encara més impactant, ja que es van realitzar mantenint exactament els mateixos recursos humans (mateixos professors i mateixa capacitat docent) que en anys anteriors. L'assignatura va sofrir una reestructuració conceptual total, i en aquest article analitzarem els canvis realitzats per adaptar-nos a aquesta nova realitat en la que vivim, la nostra experiència com a docents i els seus resultats

Transcriptional Regulation of Yin-Yang 1 Expression through the Hypoxia Inducible Factor-1 in Pediatric Acute Lymphoblastic Leukemia

Yin-Yang transcription factor 1 (YY1) is involved in tumor progression, metastasis and has been shown to be elevated in different cancers, including leukemia. The regulatory mechanism underlying YY1 expression in leukemia is still not understood. Bioinformatics analysis reveal three Hypoxia-inducible factor 1-alpha (HIF-1α) putative binding sites in the YY1 promoter region. The regulation of YY1 by HIF-1α in leukemia was analyzed. Mutation of the putative YY1 binding sites in a reporter system containing the HIF-1α promoter region and CHIP analysis confirmed that these sites are important for YY1 regulation. Leukemia cell lines showed that both proteins HIF-1α and YY1 are co-expressed under hypoxia. In addition, the expression of mRNA of YY1 was increased after 3 h of hypoxia conditions and affect several target genes expression. In contrast, chemical inhibition of HIF-1α induces downregulation of YY1 and sensitizes cells to chemotherapeutic drugs. The clinical implications of HIF-1α in the regulation of YY1 were investigated by evaluation of expression of HIF-1α and YY1 in 108 peripheral blood samples and by RT-PCR in 46 bone marrow samples of patients with pediatric acute lymphoblastic leukemia (ALL). We found that the expression of HIF-1α positively correlates with YY1 expression in those patients. This is consistent with bioinformatic analyses of several databases. Our findings demonstrate for the first time that YY1 can be transcriptionally regulated by HIF-1α, and a correlation between HIF-1α expression and YY1 was found in ALL clinical samples. Hence, HIF-1α and YY1 may be possible therapeutic target and/or biomarkers of ALL

Cartografías de nuestras realidades

Universidad Nacional Autónoma de México/Programas de Apoyo a Proyectos para la Innovación y Mejoramiento de la Enseñanza/"PAPIME-UNAM PE 404115"//[Cuerpo, territorio y violencia en Nuestra América. Cartografías materiales y simbólicas]La cartografía nos permite contar con diversas coordenadas para abordar la realidad, pues para transformarla es necesario entenderla. También sirve para ampliar la mirada o para desenfocarla, y así identificar la relación entre lo material y lo inmaterial, lo experimentado y lo imaginado, con el fin de propiciar la reflexión acerca de sus posibilidades pedagógicas y de investigación social. Además de intentar explicar la realidad vivida, procura proyectarnos más allá de las fronteras trazadas en nuestros mapas, con lo que cobra valores catafóricos, al adelantar lo que podrá venir.Libro