3,665 research outputs found
In vivo methods and applications of xenon-129 magnetic resonance
Hyperpolarised gas lung MRI using xenon-129 can provide detailed 3D images of the ventilated lung airspaces, and can be applied to quantify lung microstructure and detailed aspects of lung function such as gas exchange. It is sensitive to functional and structural changes in early lung disease and can be used in longitudinal studies of disease progression and therapy response. The ability of 129Xe to dissolve into the blood stream and its chemical shift sensitivity to its local environment allow monitoring of gas exchange in the lungs, perfusion of the brain and kidneys, and blood oxygenation. This article reviews the methods and applications of in vivo 129Xe MR in humans, with a focus on the physics of polarisation by optical pumping, radiofrequency coil and pulse sequence design, and the in vivo applications of 129Xe MRI and MRS to examine lung ventilation, microstructure and gas exchange, blood oxygenation, and perfusion of the brain and kidneys
Detection of early sub-clinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarized gas MRI
Hyperpolarised 3He ventilation-MRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6–16 years) with clinically stable mild cystic fibrosis (CF) (FEV1>−1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ventilation-MRI was the most sensitive method of detecting abnormalities, present in 89% of patients with CF, compared with CT abnormalities in 68%, LCI 47% and conventional MRI 22%. Ventilation defects were present in the absence of CT abnormalities and in patients with normal physiology, including LCI. Ventilation-MRI is thus feasible in young children, highly sensitive and provides additional information about lung structure–function relationships
Developing and enhancing biodiversity monitoring programmes: a collaborative assessment of priorities
1.Biodiversity is changing at unprecedented rates, and it is increasingly important that these changes are quantified through monitoring programmes. Previous recommendations for developing or enhancing these programmes focus either on the end goals, that is the intended use of the data, or on how these goals are achieved, for example through volunteer involvement in citizen science, but not both. These recommendations are rarely prioritized.
2.We used a collaborative approach, involving 52 experts in biodiversity monitoring in the UK, to develop a list of attributes of relevance to any biodiversity monitoring programme and to order these attributes by their priority. We also ranked the attributes according to their importance in monitoring biodiversity in the UK. Experts involved included data users, funders, programme organizers and participants in data collection. They covered expertise in a wide range of taxa.
3.We developed a final list of 25 attributes of biodiversity monitoring schemes, ordered from the most elemental (those essential for monitoring schemes; e.g. articulate the objectives and gain sufficient participants) to the most aspirational (e.g. electronic data capture in the field, reporting change annually). This ordered list is a practical framework which can be used to support the development of monitoring programmes.
4.People's ranking of attributes revealed a difference between those who considered attributes with benefits to end users to be most important (e.g. people from governmental organizations) and those who considered attributes with greatest benefit to participants to be most important (e.g. people involved with volunteer biological recording schemes). This reveals a distinction between focussing on aims and the pragmatism in achieving those aims.
5.Synthesis and applications. The ordered list of attributes developed in this study will assist in prioritizing resources to develop biodiversity monitoring programmes (including citizen science). The potential conflict between end users of data and participants in data collection that we discovered should be addressed by involving the diversity of stakeholders at all stages of programme development. This will maximize the chance of successfully achieving the goals of biodiversity monitoring programmes
High precision X-ray logN-logS distributions: implications for the obscured AGN population
We have constrained the extragalactic source count distributions over a broad
range of X-ray fluxes and in various energy bands to test whether the
predictions from X-ray background synthesis models agree with the observational
constraints provided by our measurements. We have used 1129 XMM-Newton
observations at |b|>20 deg covering a sky area of 132.3 deg^2 to compile the
largest complete samples of X-ray objects to date in the 0.5-1 keV, 1-2 keV,
2-4.5 keV, 4.5-10 keV, 0.5-2 keV and 2-10 keV energy bands. Our survey includes
in excess of 30,000 sources down to ~10^-15 erg/cm^2/s below 2 keV and down to
~10^{-14} erg/cm^2/s above 2 keV. A break in the source count distributions was
detected in all energy bands except the 4.5-10 keV band. An analytical model
comprising 2 power-law components cannot adequately describe the curvature seen
in the source count distributions. The shape of the logN(>S)-logS is strongly
dependent on the energy band with a general steepening apparent as we move to
higher energies. This is due to non-AGN populations, comprised mainly of stars
and clusters of galaxies, contribute up to 30% of the source population at
energies 10^{-13} erg/cm^2/s, and these populations of
objects have significantly flatter source count distributions than AGN. We find
a substantial increase in the relative fraction of hard X-ray sources at higher
energies, from >55% below 2 keV to >77% above 2 keV. However the majority of
sources detected above 4.5 keV still have significant flux below 2 keV.
Comparison with predictions from the synthesis models suggest that the models
might be overpredicting the number of faint absorbed AGN, which would call for
fine adjustment of some model parameters such as the obscured to unobscured AGN
ratio and/or the distribution of column densities at intermediate obscuration.Comment: Accepted for publication in Astronomy and Astrophysics. Abridged
Abstract. 23 pages, 47 figures, 8 table
Enhanced spontaneous emission from nanodiamond colour centres on opal photonic crystal
Colour centres in diamond are promising candidates as a platform for quantum
technologies and biomedical imaging based on spins and/or photons. Controlling
the emission properties of colour centres in diamond is a key requirement for
developing efficient single photon sources with high collection efficiency. A
number of groups have produced enhancement in the emission rate over narrow
wavelength ranges by coupling single emitters in nanodiamond crystals to
resonant electromagnetic structures. Here we characterise in detail the
spontaneous emission rates of nitrogen-vacancy centres positioned in various
locations on a structured substrate. We show an average factor of 1.5
enhancement of the total emission rate when nanodiamonds are on an opal
photonic crystal surface, and observe changes in the lifetime distribution. We
present a model to explain these observations and associate the lifetime
properties with dipole orientation and polarization effects.Comment: 16 pages, 10 figure
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