Response: Rights as Trumps of What?

Background: Smartphone technology presents a novel and promising opportunity to extend the reach of psychotherapeutic interventions by moving selected parts of the therapy into the real-life situations causing distress. This randomised controlled trial will investigate the effects of a transdiagnostic, Internet-administered cognitive behavioural (iCBT) self-help program for anxiety, supplemented with a smartphone application. The effect of added therapist support will also be studied. Methods/Design: One hundred and fifty participants meeting diagnostic criteria for social anxiety disorder and/or panic disorder will be evenly randomised to either one of three study groups: 1, smartphone-supplemented iCBT with therapist support; 2, smartphone-supplemented iCBT without therapist support; or 3, an active waiting list control group with delayed treatment. Primary outcome measure will be the Generalised Anxiety Disorder 7-item self-rating scale. Secondary measures include other anxiety, depression and quality of life measures. In addition to pre- and post-treatment measurements, the study includes two mid-treatment (days 24 and 48) and two follow-up assessments (12 and 36 months) to assess rapid and long-term effects. Discussion: To our knowledge, this is the first study to investigate the effectiveness of smartphone-supplemented iCBT for anxiety disorders. Hence, the findings from this trial will constitute great advancements in the burgeoning and promising field of smartphone-administered psychological interventions. Limitations are discussed

Stress management for middle managers via an acceptance and commitment-based smartphone application: A randomized controlled trial

AbstractStress is a major health problem in today's workplace. Recent studies suggest that acceptance and commitment therapy (ACT) is effective for reducing stress at work, specifically among managers. Moreover, smartphone-delivered treatments have been developed and increasingly used in research. The objective of our study was to evaluate the efficacy of an ACT-based smartphone treatment among middle managers at medium- and large-sized companies (>50 employees) in Sweden. A total of 73 participants were randomized to either receive the six-week stress intervention (n=36) or to a waitlist control group (n=37). Results showed small to moderate within-group effect sizes (Cohen's d range 0.37–0.62) for the treatment group, and small to moderate between group effects (Cohen's d range 0.41–0.50). In conclusion, the study indicates that a smartphone administered stress intervention based on ACT can reduce perceived stress and increase general health among Swedish middle managers in the private sector

Optimal scheduling of large-scale wind-hydro-thermal systems with fixed-head short-term model

© 2020 by the authors. In this paper, a Modified Adaptive Selection Cuckoo Search Algorithm (MASCSA) is proposed for solving the Optimal Scheduling of Wind-Hydro-Thermal (OSWHT) systems problem. The main objective of the problem is to minimize the total fuel cost for generating the electricity of thermal power plants, where energy from hydropower plants and wind turbines is exploited absolutely. The fixed-head short-term model is taken into account, by supposing that the water head is constant during the operation time, while reservoir volume and water balance are constrained over the scheduled time period. The proposed MASCSA is compared to other implemented cuckoo search algorithms, such as the conventional Cuckoo Search Algorithm (CSA) and Snap-Drift Cuckoo Search Algorithm (SDCSA). Two large systems are used as study cases to test the real improvement of the proposed MASCSA over CSA and SDCSA. Among the two test systems, the wind-hydro-thermal system is a more complicated one, with two wind farms and four thermal power plants considering valve effects, and four hydropower plants scheduled in twenty-four one-hour intervals. The proposed MASCSA is more effective than CSA and SDCSA, since it can reach a higher success rate, better optimal solutions, and a faster convergence. The obtained results show that the proposed MASCSA is a very effective method for the hydrothermal system and wind-hydro-thermal systems

A Simple Linear Time Algorithm for Computing a 1-Median on Cactus Graphs

We address the problem of finding a 1-median on a cactus graph. The problem has already been solved in linear time by the algorithms of Burkard and Krarup (1998), and Lan and Wang (2000). These algorithms are complicated and need efforts. Hence, we develop in this paper a simpler algorithm. First, we construct a condition for a cycle that contains a 1-median or for a vertex that is indeed a 1-median of the cactus. Based on this condition, we localize the search for deriving a 1-median on the underlying cactus. Complexity analysis shows that the approach runs in linear time

Экология человека как предмет преподавания в медицинском вузе

ОБРАЗОВАНИЕ МЕДИЦИНСКОЕМЕДИЦИНСКИЕ УЧЕБНЫЕ ЗАВЕДЕНИЯВУЗЫЭКОЛОГИЯ ЧЕЛОВЕКАМЕТОДИКА ПРЕПОДАВАНИ

De novo copy number variations in candidate genomic regions in patients of severe autism spectrum disorder in Vietnam

Autism spectrum disorder (ASD) is a developmental disorder with a prevalence of around 1% children worldwide and characterized by patient behaviour (communication, social interaction, and personal development). Data on the efficacy of diagnostic tests using copy number variations (CNVs) in candidate genes in ASD is currently around 10% but it is overrepresented by patients of Caucasian background. We report here that the diagnostic success of de novo candidate CNVs in Vietnamese ASD patients is around 6%. We recruited one hundred trios (both parents and a child) where the child was clinically diagnosed with ASD while the parents were not affected. We performed genetic screening to exclude RETT syndrome and Fragile X syndrome and performed genome-wide DNA microarray (aCGH) on all probands and their parents to analyse for de novo CNVs. We detected 1708 non-redundant CNVs in 100 patients and 118 (7%) of them were de novo. Using the filter for known CNVs from the Simons Foundation Autism Research Initiative (SFARI) database, we identified six CNVs (one gain and five loss CNVs) in six patients (3 males and 3 females). Notably, 3 of our patients had a deletion involving the SHANK3 gene–which is the highest compared to previous reports. This is the first report of candidate CNVs in ASD patients from Vietnam and provides the framework for building a CNV based test as the first tier screening for clinical management

Study on total lipid content, lipid class composition of some fire and soft corals collected in Nha Trang, Vietnam

For the first time, the total lipid content and lipid class composition of  the Vietnamese soft corals (Sinularia brassica, Sinularia flexibilis) and fire corals (Millepora dichotoma, Millepora platyphylla) were investigated. The results indicated that the total lipid content of the investigated species was significantly different. Compositions of the lipid classes were analyzed using TLC and image analysis program Sorbfil TLC Videodensitometer DV and the results showed that phospholipids (PL, 10.91–16.02%), monoalkyldiacylglycerols (MADAG, 20.69-39.92%) and hydrocarbon wax (HW, 29.83-37.17%) were the main lipid classes of the total lipid in soft coral species. Meanwhile, PL (24.11-33.23%), TG (14.27–34.92%), ST (10.10–14.50%) and HW (12.08–19.95%) were predominant in fire coral species. ST, TG and FFA contents in soft and fire corals were at low level. DG was only present in the Sinularia flexibilis but not in other studied corals

Interactions between climate change, urban infrastructure and mobility are driving dengue emergence in Vietnam.

Dengue is expanding globally, but how dengue emergence is shaped locally by interactions between climatic and socio-environmental factors is not well understood. Here, we investigate the drivers of dengue incidence and emergence in Vietnam, through analysing 23 years of district-level case data spanning a period of significant socioeconomic change (1998-2020). We show that urban infrastructure factors (sanitation, water supply, long-term urban growth) predict local spatial patterns of dengue incidence, while human mobility is a more influential driver in subtropical northern regions than the endemic south. Temperature is the dominant factor shaping dengue's distribution and dynamics, and using long-term reanalysis temperature data we show that warming since 1950 has expanded transmission risk throughout Vietnam, and most strongly in current dengue emergence hotspots (e.g., southern central regions, Ha Noi). In contrast, effects of hydrometeorology are complex, multi-scalar and dependent on local context: risk increases under either short-term precipitation excess or long-term drought, but improvements in water supply mitigate drought-associated risks except under extreme conditions. Our findings challenge the assumption that dengue is an urban disease, instead suggesting that incidence peaks in transitional landscapes with intermediate infrastructure provision, and provide evidence that interactions between recent climate change and mobility are contributing to dengue's expansion throughout Vietnam

Optical tactile sensor for slip detection of a grasped object

Empirical thesis.Bibliography: pages 56-57.1. Introduction -- 2. Background theory -- 3. Deformation component design -- 4. Infrared sensor -- 5. Mouse sensor -- 6. SG gripper -- 7. Slip detection system -- 8. Conclusions, improvements and future work -- 9. Abbreviations -- Appendix -- Bibliography.Intelligent grasping is required by autonomous robots to lift objects with unknown weight. This requires the gripper robot to have enough grasping force so that the object does not slip out of the gripper, but not too much force, for otherwise the object may be damaged. The development of an optical tactile sensor can be an approach to intelligent grasping for a robotic gripper. Initial results collected showed that using an infrared sensor in a deforming material will provide slip detection for the gripper robot. Combining this tactile sensor with the gripper robot will create a feedback system that can detect slip and adjust gripping strength for intelligent grasping. The low cost and the small size of the tactile sensor offers a cost efficient and adaptable tactile sensor design for an autonomous small gripper robot used to pick and place packages.The aim of this thesis is to improve an existing design and incorporate elements from other successful tactile sensor designs. Various issues are present with the proposed design which are solved. The infrared sensor will be affected by ambient lighting which can be controlled by placing the sensor in a cavity which no external light sources can affect. There is also the issue of choosing a deformable material which is not too soft otherwise it will always deform or too stiff otherwise it will not deform when the object is slipping. The system must also have a fast response time to detect slip in under one second as well as when slippage occurs at 1mm or less. This may be solved by using a mouse sensor which has a high response time in microseconds and can detect changes in position under 1 mm.Mode of access: World wide web.1 online resource (xiv, 57 pages illustrations (some colour)