The Changing Shopping Space in Georgia: The Influence from the Chinese ‘Belt and Road Initiative’

The Caucasus region is where the east meets the west and is known as an area in whichconflictsandopportunitiesoccursimultaneously.Thedevelopmentofthisregion used to be constricted by its geographic and political conditions. However, due to advancements in transport and the dissolution of Soviet Union, the Caucasus region has become a strategic region for development. ThisresearchfocusesonGeorgiainCaucasusduetothecountry’sintimaterelationships with many European and Asian countries. In addition, China announced that it will invest more infrastructure and capital in Georgia. Due to the influence of the Chinese ‘BeltandRoadInitiative’(B&R),Georgiaiscurrentlyundergoingmanychanges,despite discussions focusing on political or economic perspectives. With the global free market and the Chinese ‘Belt and Road Initiative’, Georgia seeks to increase its economic development. Shopping space is one of the most affected spaces of development. Attributes such as the placement of shops can be analysed to indicate the change of internal public space, as shops become very Chinese style and the traditional Georgian shopping spaces gradually disappear due to the constant chasing of cash flows. As a pilot study, this research hopes to uncover potentials and threats of shopping space development in Georgia, and it aims to discover the underlying principles for the changes. Mapping and case studies are employed in the investigation. The research hopes to contribute to a healthy urban development by finding the balance between economic and spatial development

Expediente penal N° 07081-2013. Robo agravado

El documento presentado está referido al expediente civil N° 2007-307-JMW interpuesto ante el Juzgado Mixto de Wanchaq, sobre Desalojo seguido por Víctor Alarcón Torres contra su hijo Alfredo Gregorio Alarcón Parisaca quien se encontraba ocupando el L.1, Mz. K, del Jirón Espinar de la Urbanización el Progreso, Distrito de Wanchaq, Cusco. Es importante señalar que Víctor Alarcón Torres mantuvo una relación de hecho con doña Alejandrina Parisaca Mamani con quien procreó un hijo de nombre Alfredo Gregorio Alarcón Parisaca, pero también tenía una hija extramatrimonial llamada Olga Alarcón Romaña. Durante la vigencia de la convivencia adquirieron el inmueble en controversia, pero cuando decidieron poner fin a la unión de hecho, ambas partes de mutuo acuerdo decidieron adjudicarse los bienes adquiridos y específicamente respecto del bien inmueble acordaron que doña Alejandrina Parisaca tendría el derecho de usufructo sobre él pero del derecho de propiedad correspondía a sus hijos, según Escritura de División y Partición del 28 de setiembre de 1966, otorgada ante Notario Público de Cusco, Dr. Reynaldo Alviz. El demandado por su parte ha sustentado que no es ocupante precario, pues de acuerdo a todos los medios de prueba presentados habría estado en legítima posesión del bien al haber pagado sido declarado socio por la Asociación Pro-Vivienda progreso, encontrarse al día en sus aportaciones, el impuesto predial y arbitrios, así como en los servicios de luz, agua que por cierto figuran a su nombre y finalmente por la escritura pública en la que la Asociación le adjudicó el bien en propiedad

Translating the Knowledge Gap Between Researchers and Communication Designers for Improved mHealth Research

Our industry insight focuses on the challenges for health researchers collaborating with communication designers during the development of an App for improving maternal mental health and parenting stress. We discuss the challenges around explicating and communicating tacit and domain knowledge across disciplinary boundaries. We believe this report can widen communication design’s traditional focus on users in mHealth research to consider partnerships with academic researchers. The lessons learned from our experience developing a mHealth program can be used to reduce challenges in future mHealth research, especially for collaborations between health researchers and communications designers. Considering the growth of interest in mHealth, this is extremely relevant for future team satisfaction, the optimal use of research funds and industry time, and faster development of effective mHealth tools.This is the accepted manuscript version of the following publication: Rioux, C., Weedon, S., MacKinnon, A. L., Watts, D., Salisbury, M. R., Penner-Goeke, L., Simpson, K. M., Harrington, J., Tomfohr-Madsen, L. M. & Roos, L. E. (2022). Translating the Knowledge Gap Between Researchers and Communication Designers for Improved mHealth Research. SIGDOC '22: The 40th ACM International Conference on Design of Communication, USA, 157–160. doi: 10.1145/3513130.3558997BEAM was funded by a Research Manitoba COVID-19 Rapid Response Operating Grant. CR was supported by a Postdoctoral fellowship from Research Manitoba and the Children’s Hospital Foundation of Manitoba. ALM was supported by a Social Sciences & Humanities Research Council (SSHRC) Banting Postdoctoral Fellowship (#01353-000).Ye

Assessing climate risk to support urban forests in a changing climate

We thank Leslie Brandt and Gregory McPherson (USDA Forest Service, USA), Jakub Kronenberg (University of Lodz, Poland), Shawn Landry (University of South Florida, USA) and Per Anker Pedersen (Faculty of Landscape and Society, Norwegian University of Life Sciences) for their thoughts and contributions. MER, PR, SP and MGT thank Leigh Staas (Macquarie University) and funding from the Hort Frontiers Green Cities Fund, part of the Hort Frontiers strategic partnership initiative developed by Hort Innovation, with coinvestment from Macquarie University, Western Sydney University and the NSW Department of Planning, Industry and Environment and contributions from the Australian Government. DNB acknowledges support from the Research Council of Norway to the ENABLE project through the BiodivERsA COFUND 2015-2016 call for research proposals. BW acknowledges support from FORMAS (dia.nr 2016-20098). Finally, we thank the anonymous reviewers for their critical observations and thoughtful contributions that improved this work. The opinions and findings expressed in this paper are those of the authors and should not be construed to represent any official USDA or US Government determination or policy.Societal Impact Statement Globally, cities are planning for resilience through urban greening initiatives as governments understand the importance of urban forests in improving quality of life and mitigating climate change. However, the persistence of urban forests and the ecosystem benefits they provide are threatened by climate change, and systematic assessments of causes of tree dieback and mortality in urban environments are rare. Long-term monitoring studies and adaptive management are needed to identify and prevent climate change-driven failures and mortality. Research and monitoring when coupled with systematic forecasting will enable governments to incorporate climate change resilience into urban forestry planning. Future scenarios in which urban forests are resilient or in decline will depend on the management and planning actions we make today.The management of urban forests is a key element of resilience planning in cities across the globe. Urban forests provide ecosystem services as well as other nature-based solutions to 4.2 billion people living in cities. However, to continue to do so effectively, urban forests need to be able to thrive in an increasingly changing climate. Trees in cities are vulnerable to extreme heat and drought events, which are predicted to increase in frequency and severity under climate change. Knowledge of species' vulnerability to climate change, therefore, is crucial to ensure provision of desired ecosystem benefits, improve species selection, maintain tree growth and reduce tree mortality, dieback and stress in urban forests. Yet, systematic assessments of causes of tree dieback and mortality in urban environments are rare. We reviewed the state of knowledge of tree mortality in urban forests globally, finding very few frameworks that enable detection of climate change impacts on urban forests and no long-term studies assessing climate change as a direct driver of urban tree dieback and mortality. The effects of climate change on urban forests remain poorly understood and quantified, constraining the ability of governments to incorporate climate change resilience into urban forestry planning.Hort Frontiers Green Cities Fund, Hort Frontiers strategic partnership initiativeResearch Council of NorwaySwedish Research Council Formas 2016-2009

Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease

We investigated the effects of glial cell line-derived neurotrophic factor (GDNF) in Parkinson’s disease, using intermittent intraputamenal convection-enhanced delivery via a skull-mounted transcutaneous port as a novel administration paradigm to potentially afford putamen-wide therapeutic delivery. This was a single-centre, randomized, double-blind, placebo-controlled trial. Patients were 35–75 years old, had motor symptoms for 5 or more years, and presented with moderate disease severity in the OFF state [Hoehn and Yahr stage 2–3 and Unified Parkinson’s Disease Rating Scale motor score (part III) (UPDRS-III) between 25 and 45] and motor fluctuations. Drug delivery devices were implanted and putamenal volume coverage was required to exceed a predefined threshold at a test infusion prior to randomization. Six pilot stage patients (randomization 2:1) and 35 primary stage patients (randomization 1:1) received bilateral intraputamenal infusions of GDNF (120 mg per putamen) or placebo every 4 weeks for 40 weeks. Efficacy analyses were based on the intention-to-treat principle and included all patients randomized. The primary outcome was the percentage change from baseline to Week 40 in the OFF state (UPDRS-III). The primary analysis was limited to primary stage patients, while further analyses included all patients from both study stages. The mean OFF state UPDRS motor score decreased by 17.3 17.6% in the active group and 11.8 15.8% in the placebo group (least squares mean difference: 4.9%, 95% CI: 16.9, 7.1, P = 0.41). Secondary endpoints did not show significant differences between the groups either. A post hoc analysis found nine (43%) patients in the active group but no placebo patients with a large clinically important motor improvement (510 points) in the OFF state (P = 0.0008). 18F-DOPA PET imaging demonstrated a significantly increased uptake throughout the putamen only in the active group, ranging from 25% (left anterior putamen; P = 0.0009) to 100% (both posterior putamina; P50.0001). GDNF appeared to be well tolerated and safe, and no drug-related serious adverse events were reported. The study did not meet its primary endpoint. 18F-DOPA imaging, however, suggested that intermittent convection-enhanced delivery of GDNF produced a putamen-wide tissue engagement effect, overcoming prior delivery limitations. Potential reasons for not proving clinical benefit at 40 weeks are discussed

Extended Treatment with Glial Cell Line-Derived Neurotrophic Factor in Parkinson's Disease

Background: Intraputamenal glial cell line-derived neurotrophic factor (GDNF), administered every 4 weeks to patients with moderately advanced Parkinson’s disease, did not show significant clinical improvements against placebo at 40 weeks, although it significantly increased [18F]DOPA uptake throughout the entire putamen. Objective: This open-label extension study explored the effects of continued (prior GDNF patients) or new (prior placebo patients) exposure to GDNF for another 40 weeks. Methods: Using the infusion protocol of the parent study, all patients received GDNF without disclosing prior treatment allocations (GDNF or placebo). The primary outcome was the percentage change from baseline to Week 80 in the OFF state Unified Parkinson’s Disease Rating Scale (UPDRS) motor score. Results: All 41 parent study participants were enrolled. The primary outcome decreased by 26.7±20.7% in patients on GDNF for 80 weeks (GDNF/GDNF; N = 21) and 27.6±23.6% in patients on placebo for 40 weeks followed by GDNF for 40 weeks (placebo/GDNF, N = 20; least squares mean difference: 0.4%, 95% CI: –13.9, 14.6, p = 0.96). Secondary endpoints did not show significant differences between the groups at Week 80 either. Prespecified comparisons between GDNF/GDNF at Week 80 and placebo/GDNF at Week 40 showed significant differences for mean OFF state UPDRS motor (–9.6±6.7 vs. –3.8±4.2 points, p = 0.0108) and activities of daily living score (–6.9±5.5 vs. –1.0±3.7 points, p = 0.0003). No treatment-emergent safety concerns were identified. Conclusions: The aggregate study results, from the parent and open-label extension suggest that future testing with GDNF will likely require an 80- rather than a 40-week randomized treatment period and/or a higher dose

Global Spatial Risk Assessment of Sharks Under the Footprint of Fisheries

Effective ocean management and conservation of highly migratory species depends on resolving overlap between animal movements and distributions and fishing effort. Yet, this information is lacking at a global scale. Here we show, using a big-data approach combining satellite-tracked movements of pelagic sharks and global fishing fleets, that 24% of the mean monthly space used by sharks falls under the footprint of pelagic longline fisheries. Space use hotspots of commercially valuable sharks and of internationally protected species had the highest overlap with longlines (up to 76% and 64%, respectively) and were also associated with significant increases in fishing effort. We conclude that pelagic sharks have limited spatial refuge from current levels of high-seas fishing effort. Results demonstrate an urgent need for conservation and management measures at high-seas shark hotspots and highlight the potential of simultaneous satellite surveillance of megafauna and fishers as a tool for near-real time, dynamic management

Diving into the vertical dimension of elasmobranch movement ecology

Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements