Análisis de impactos generados por el turismo de bienestar a nivel socio-cultural. caso: Riviera Nayarit, México

En el presente trabajo de investigación, se identifica la forma en que se desarrolla el turismo de bienestar en diferentes puntos geográficos alrededor del mundo y la manera en que esta misma actividad se lleva a cabo en el reconocido destino turístico mexicano denominado Riviera Nayarit, con el fin de identificar los impactos que genera el turismo de bienestar en la sociedad. Para lograr lo anterior, se realiza una búsqueda de información que permita conocer cómo surgieron las diferentes actividades que se desarrollan en torno al turismo de bienestar y cómo han venido evolucionando con el pasar del tiempo hasta llegar a las prácticas modernas de bienestar tanto en Riviera Nayarit, México como alrededor del mundo

On the single and multiple associations of COVID‑19 post‑acute sequelae: 6‑month prospective cohort study

Medical research is progressing to clarify the full spectrum of sub-acute and long-term effects of the post-COVID-19 syndrome. However, most manuscripts published to date only analyze the effects of post-COVID-19 in patients discharged from hospital, which may induce significant bias. Here, we propose a pioneering study to analyze the single and multiple associations between post-COVID-19 characteristics with up to 6-months of follow-up in hospitalized and non-hospitalized COVID-19 patients. The cohort study was conducted from May to October 2020 at the University Hospital Virgen de la Nieves, the leading hospital assigned for patients with COVID-19 in Granada, Spain. A total of 372 and 217 patients—with 217 and 207 included in the first and second follow-up visits—were referred 2 and 6 months after diagnosing COVID-19, respectively. We find out that post-COVID-19 clinical and mental health impairment symptoms are correlated with patient gender. Logistic adjustments showed strong statistically robust single and multiple associations of demographic, clinical, mental health, X-ray, laboratory indices, and pulmonary function variables. The functional lung tests are good predictors of chest CT imaging abnormalities in elderly patients. Bilateral lung involvement, subpleural reticulum, ground-glass opacity, peripheral lung lesions, and bronchiectasis were the most common findings of the high-resolution computed tomography images. Nonhospitalized patients suffer more severe thromboembolic events and fatigue than those hospitalized

Time delay in the acquisition of verbal correspondence in adults: An exploratory study

A correspondência Dizer-Fazer é normalmente definida como um indivíduo que faz o que disse que faria e relata com precisão o que fez. Este estudo avalia os efeitos do atraso entre as respostas de correspondência verbal (dizer, fazer, relatar). Foram avaliados os efeitos do atraso temporal entre as respostas de correspondência (Dizer, Fazer e Relatar) em um procedimento de correspondência típico. Oito adultos foram atribuídos a um de dois grupos que foram diferenciados por atraso: Grupo não atrasado (i.e., 0 horas entre as respostas), Grupo atrasado (i.e., 24 horas entre as respostas). A tarefa consistia em três condições: 1) Dizer (respondendo a perguntas), 2) Fazer (realizando ações diferentes em relação a Dizer), 3) Relatar (respondendo a perguntas sobre o Fazer). Diferenças foram encontradas entre os dois grupos, sendo que o Grupo Atrasado apresentou menores percentuais de correspondência. No entanto, nenhuma diferença significativa foi encontrada entre os grupos. A discussão é realizada em termos do aumento no valor da variável de atraso e da relevância do atraso no emparelhamento em contextos clínicos.Palavras-Chaves: correspondência verbal; dizer-fazer; fazer-relatar; atraso temporal; adultos. Say-Do correspondence is typically defined as individuals’ doing what they said they would do and accurately reporting what they did. The present study evaluated the effects of the delay between responses of verbal correspondence (Say, Do, Report) and the relation among responses (Say-Do, Do-Report, Say-Report, and Say-Do-Report) in a correspondence procedure. Eight adults were assigned to one of two groups that were differentiated by the delay among responses: Non-Delayed group (i.e., 0 hours among responses), Delayed group (i.e., 24 hours among responses). The correspondence task consisted of three phases: (1) Say (answering questions), (2) Do (performing different actions in relation to Say), and (3) Report (answering questions about Do). The Delayed group presented lower percentages of correspondence, but no statistically significant differences were found between groups. We discuss the increase in value of the delay variable and relevance of this delay to matching in clinical contexts.Keywords: Verbal correspondence; Say-Do; Do-Report; temporal delay; adults

Can domestication shape Canidae brain morphology? the accessory olfactory bulb of the red fox as a case in point

Background: The accessory olfactory bulb (AOB) is the first integrative center of the vomeronasal system (VNS), and the general macroscopic, microscopic, and neurochemical organizational patterns of the AOB differ fundamentally among species. Therefore, the low degree of differentiation observed for the dog AOB is surprising. As the artificial selection pressure exerted on domestic dogs has been suggested to play a key role in the involution of the dog VNS, a wild canid, such as the fox, represents a useful model for studying the hypothetical effects of domestication on the AOB morphology. Methods: A comprehensive histological, lectin-histochemical, and immunohistochemical study of the fox AOB was performed. Anti-Gαo and anti-Gαi2 antibodies were particularly useful, as they label the transduction cascade of the vomeronasal receptor types 1 (V1R) and 2 (V2R), respectively. Other employed antibodies included those against proteins such as microtubule-associated protein 2 (MAP-2), tubulin, glial fibrillary acidic protein, growth-associated protein 43 (GAP-43), olfactory marker protein (OMP), calbindin, and calretinin. Results: The cytoarchitecture of the fox AOB showed a clear lamination, with neatly differentiated layers; a highly developed glomerular layer, rich in periglomerular cells; and large inner cell and granular layers. The immunolabeling of Gαi2, OMP, and GAP-43 delineated the outer layers, whereas Gαo and MAP-2 immunolabeling defined the inner layers. MAP-2 characterized the somas of AOB principal cells and their dendritic trees. Anti-calbindin and anti-calretinin antibodies discriminated neural subpopulations in both the mitral-plexiform layer and the granular cell layer, and the lectin Ulex europeus agglutinin I (UEA-I) showed selectivity for the AOB and the vomeronasal nervesS

Prácticas evaluativas en el contexto de la educación superior

No asociada a proyecto - vinculado a la línea de investigación derecho y problemáticas sociale

Analysis of the mood of students in different degrees of Health Sciences

[EN] The mood of students has an impact on the teaching-learning process by influencing motivation, memory and the ability to develop cognitive resources; therefore, mental health should be considered in the educational process. The main objective of this study is to evaluate the state of mind of our students, as well as to know the student diversity and their emotional maturity. The results derived could be the starting point for designing teaching methodologies that are better suited to each stage of their education according to their state of mind. To this end, we have resorted to the analysis of the Profile of Mood States (POMS) in undergraduate students of Health Sciences, from three Spanish universities. We analysed the results by degree and gender, finding that the degrees in Medicine and Pharmacy showed a worse mood compared to those in Nursing and Physiotherapy. The evolution was similar in men and women.[ES] El estado de ánimo del estudiantado repercute en los procesos de enseñanza-aprendizaje al incidir sobre la motivación, la memoria y la capacidad para desarrollar recursos cognitivos, por tanto, la salud mental debe ser considerado un factor a tener en cuenta en el proceso educativo. El objetivo principal de este estudio es evaluar el estado anímico de nuestro estudiantado, así como conocer la diversidad del alumnado y su madurez emocional. Los resultados derivados podrían ser el punto de partida para diseñar metodologías docentes que encajen mejor en cada momento de su formación en función de su estado de ánimo. Para lograr este fin, hemos recurrido al análisis del Perfil de los Estados de Ánimo (Profile of Mood States, POMS) en alumnado de grados de Ciencias de la Salud, perteneciente a tres universidades españolas. Hemos analizado los resultados por grados y por género, encontrando que los grados de Medicina y Farmacia presentaban un peor estado de ánimo comparado con los de Enfermería y Fisioterapia. La evolución fue similar en hombres y mujeres.San-Miguel, T.; Mauricio, MD.; González-Santos, Á.; Ortiz-Comino, L.; Postigo-Martín, P.; López-Garzón, M.; Lozano-Lozano, M.... (2022). Análisis del estado de ánimo del alumnado en diferentes grados de Ciencias de la Salud. Editorial Universitat Politècnica de València. 983-993. https://doi.org/10.4995/INRED2022.2022.1586498399

Mesoporous Thin Films for Acoustic Devices in the Gigahertz Range

The coherent manipulation of acoustic waves on the nanoscale usually requires multilayers with thicknesses and interface roughness defined down to the atomic monolayer. This results in expensive devices with predetermined functionality. Nanoscale mesoporous materials present a high surface-to-volume ratio and tailorable mesopores, which allow the incorporation of chemical functionalization to nanoacoustics. However, the presence of pores with sizes comparable to the acoustic wavelength is intuitively perceived as a major roadblock in nanoacoustics. Here, we present multilayered nanoacoustic resonators based on mesoporous SiO2 thin films showing acoustic resonances in the 5-100 GHz range. We characterize the acoustic response of the system using coherent phonon generation experiments. Despite resonance wavelengths comparable to the pore size, we observe for the first time well-defined acoustic resonances. Our results open the path to a promising platform for nanoacoustic sensing and reconfigurable acoustic nanodevices based on soft, inexpensive fabrication methods.Fil: López Abdala, Nicolás Andrés. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Esmann, Martin. Université de Paris-Saclay; Francia. Centre National de la Recherche Scientifique; FranciaFil: Fuertes, María Cecilia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Constituyentes | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Constituyentes.; ArgentinaFil: Angelome, Paula Cecilia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Constituyentes | Comision Nacional de Energia Atomica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia. Unidad Ejecutora Instituto de Nanociencia y Nanotecnologia - Nodo Constituyentes.; ArgentinaFil: Ortiz, Omar. Université de Paris-Saclay; Francia. Centre National de la Recherche Scientifique; FranciaFil: Bruchhausen, Axel Emerico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche; ArgentinaFil: Pastoriza, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche; ArgentinaFil: Perrin, Bernard. Sorbonne University; Francia. Centre National de la Recherche Scientifique; FranciaFil: Soler Illia, Galo Juan de Avila Arturo. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lanzillotti Kimura, Norberto Daniel. Université de Paris-Saclay; Francia. Centre National de la Recherche Scientifique; Franci

Estudio interuniversitario en estudiantes de Ciencias de la Salud: uso de los dispositivos móviles con fines educativos

[EN] The use of smartphones, despite being mainly social, has begun to be implemented in the university environment as a tool for working in class and for communication between students regarding teaching material. However, before creating teaching methodologies that use these devices, it is important to know the opinion that the students have of them. Our objective was to analyze the personal and academic use of Smartphones by Health Sciences students from different Universities. With this objective, a form was created consisting of sociodemographic questions and the Questionnaire on perceptions and attitudes towards learning through mobile devices (CPAAM). Subsequently, a descriptive analysis of the results was carried out. In total, 233 students participated. Our results showed that the personal is the largest use of Smartphones in these students, while the perception of their educational use is relatively low. Obtaining these data is a starting point for future analyzes that associate the use of these devices with the individual situation of the student, as well as for the effectiveness of the implementation of new learning methodologies.[ES] El uso de los dispositivos móviles, a pesar de ser principalmente social, se ha comenzado a implantar en el ámbito universitario como herramienta para trabajar en clase y para la comunicación entre estudiantes de cara al material docente. Sin embargo, antes de la creación de metodologías docentes que utilicen estos dispositivos, es importante conocer la opinión que el estudiantado tiene de los mismos. Nuestro objetivo fue analizar el uso personal y académico de los teléfonos móviles por el estudiantado de Ciencias de la Salud de diferentes Universidades. Para ello, se creó un formulario compuesto por preguntas de carácter sociodemográfico y por el Cuestionario sobre percepciones y actitudes hacia el aprendizaje por dispositivos móviles (CPAAM). Posteriormente, se realizó un análisis descriptivo de los resultados. En total, participaron 233 estudiantes. Nuestros resultados demuestran que el personal es el mayor de los usos de los dispositivos móviles en la población estudiada mientras que la percepción de su uso educativo es relativamente baja. La obtención de estos datos supone un punto de partida para futuros análisis que asocien el uso de estos dispositivos a la situación individual del estudiantado, así como para la efectividad de la implantación de nuevas metodologías docentes.González-Santos, Á.; Ortiz-Comino, L.; Postigo-Martín, P.; López-Garzón, M.; Serna, E.; Mauricio, M.; San Miguel, T.... (2021). Estudio interuniversitario en estudiantes de Ciencias de la Salud: uso de los dispositivos móviles con fines educativos. En IN-RED 2021: VII Congreso de Innovación Edicativa y Docencia en Red. Editorial Universitat Politècnica de València. 373-379. https://doi.org/10.4995/INRED2021.2021.13733OCS37337

The SRSF4–GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy.

RATIONALE: RBPs (RNA-binding proteins) play critical roles in human biology and disease. Aberrant RBP expression affects various steps in RNA processing, altering the function of the target RNAs. The RBP SRSF4 (serine/arginine-rich splicing factor 4) has been linked to neuropathies and cancer. However, its role in the heart is completely unknown. OBJECTIVE: To investigate the role of SRSF4 in the heart. METHODS AND RESULTS: Echocardiography of mice specifically lacking SRSF4 in the heart (SRSF4 KO) revealed left ventricular hypertrophy and increased cardiomyocyte area, which led to progressive diastolic dysfunction with age. SRSF4 KO mice showed altered electrophysiological activity under isoproterenol-induced cardiac stress, with a post-QRS depression and a longer QT interval, indicating an elevated risk of sudden cardiac death. RNA-Seq analysis revealed expression changes in several long noncoding RNAs, including GAS5 (growth arrest-specific 5), which we identified as a direct SRSF4 target in cardiomyocytes by individual-nucleotideresolution cross-linking and immuno-precipitation. GAS5 is a repressor of the GR (glucocorticoid receptor) and was downregulated in SRSF4 KO hearts. This corresponded with elevated GR transcriptional activity in cardiomyocytes, leading to increases in hypertrophy markers and cell size. Furthermore, hypertrophy in SRSF4 KO cardiomyocytes was reduced by overexpressing GAS5. CONCLUSIONS: Loss of SRSF4 expression results in cardiac hypertrophy, diastolic dysfunction, and abnormal repolarization. The molecular mechanism underlying this effect involves GAS5 downregulation and consequent elevation of GR transcriptional activity. Our findings may help to develop new therapeutic tools for the treatment of cardiac hypertrophy and myocardial pathology in patients with Cushing syndrome.post-print2695 K

The SRSF4–GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy.

RATIONALE: RBPs (RNA-binding proteins) play critical roles in human biology and disease. Aberrant RBP expression affects various steps in RNA processing, altering the function of the target RNAs. The RBP SRSF4 (serine/arginine-rich splicing factor 4) has been linked to neuropathies and cancer. However, its role in the heart is completely unknown. OBJECTIVE: To investigate the role of SRSF4 in the heart. METHODS AND RESULTS: Echocardiography of mice specifically lacking SRSF4 in the heart (SRSF4 KO) revealed left ventricular hypertrophy and increased cardiomyocyte area, which led to progressive diastolic dysfunction with age. SRSF4 KO mice showed altered electrophysiological activity under isoproterenol-induced cardiac stress, with a post-QRS depression and a longer QT interval, indicating an elevated risk of sudden cardiac death. RNA-Seq analysis revealed expression changes in several long noncoding RNAs, including GAS5 (growth arrest-specific 5), which we identified as a direct SRSF4 target in cardiomyocytes by individual-nucleotideresolution cross-linking and immuno-precipitation. GAS5 is a repressor of the GR (glucocorticoid receptor) and was downregulated in SRSF4 KO hearts. This corresponded with elevated GR transcriptional activity in cardiomyocytes, leading to increases in hypertrophy markers and cell size. Furthermore, hypertrophy in SRSF4 KO cardiomyocytes was reduced by overexpressing GAS5. CONCLUSIONS: Loss of SRSF4 expression results in cardiac hypertrophy, diastolic dysfunction, and abnormal repolarization. The molecular mechanism underlying this effect involves GAS5 downregulation and consequent elevation of GR transcriptional activity. Our findings may help to develop new therapeutic tools for the treatment of cardiac hypertrophy and myocardial pathology in patients with Cushing syndrome.post-print2695 K