Space history, space policy, and executive leadership

A lecture that attempts to establish the role of space historians in formulating space policy is presented. The discussion focusses on two adages and their relevance to space policy. The adages are as follows: 'write about what you know;' and 'good managers do things right; good executives do the right things.

The history of space exploration

Presented are the acknowledgements and introduction sections of the book 'Space: Discovery and Exploration.' The goal of the book is to address some basic questions of American space history, including how this history compares with previous eras of exploration, why the space program was initiated when it was, and how the U.S. space program developed. In pursuing these questions, the intention is not to provide exhaustive answers, but to point the reader toward a more varied picture of how our venture in space has intersected with American government, politics, business, and science

Grand Challenges: Improving HIV Treatment Outcomes by Integrating Interventions for Co-Morbid Mental Illness.

In the fourth article of a five-part series providing a global perspective on integrating mental health, Sylvia Kaaya and colleagues discuss the importance of integrating mental health interventions into HIV prevention and treatment platforms. Please see later in the article for the Editors' Summary

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 Genomes project, promise to identify novel loci that have been missed by previous efforts. To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-analysis of kidney function based on the estimated glomerular filtration rate (eGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 × 10(-8) previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2, and EPB41L3) are tagged by common SNPs unique to the 1000 Genomes reference panel. Using pathway analysis, we identified 39 significant (FDR < 0.05) genes and 127 significantly (FDR < 0.05) enriched gene sets, which were missed by our previous analyses. Among those, the 10 identified novel genes are part of pathways of kidney development, carbohydrate metabolism, cardiac septum development and glucose metabolism. These results highlight the utility of re-imputing from denser reference panels, until whole-genome sequencing becomes feasible in large samples

The importance of open and closed styles of energy research

This paper explores the styles of research associated with wind turbines, ethanol and fuel cells in six countries. The concept of a ‘research style’ emphasizes that values and interests, along with deeper historical and cultural influences, shape research and get built into technology. Open research styles are epitomized by a broad inclusion of actors in the research process, participatory ownership of its results, cooperation among stakeholders and users, and experimentation and flexibility. Closed research styles are distinguished by limited access and ownership, competition among researchers, centralization of the research process and rigidity in dictating programme goals and preferences. The paper uses the concept of open and closed research styles to compare the experiences of Denmark, Brazil and China (open) with those in the USA, France and Norway (closed)