Estimate black hole masses of AGNs using ultraviolet emission line properties

Based on the measured sizes of broad line region of the reverberation-mapping AGN sample, two new empirical relations are introduced to estimate the central black hole masses of radio-loud high-redshift ($z > 0.5$) AGNs. First, using the archival $IUE/HST$ spectroscopy data at UV band for the reverberation-mapping objects, we obtained two new empirical relations between the BLR size and \Mg/\C emission line luminosity. Secondly, using the newly determined black hole masses of the reverberation-mapping sample for calibration, two new relationships for determination of black hole mass with the full width of half maximum and the luminosity of \Mg/\C line are also found. We then apply the relations to estimate the black hole masses of AGNs in Large Bright Quasar Surveyq and a sample of radio-loud quasars. For the objects with small radio-loudness, the black hole mass estimated using the R_{\rm BLR} - L_{\eMg/\eC} relation is consistent with that from the $R_{BLR} - L_{3000\AA/1350 \AA}$ relation. But for radio-loud AGNs, the mass estimated from the R_{BLR} - L_{\eMg/\eC} relation is systematically lower than that from the continuum luminosity $L_{3000\AA/1350\AA}$. Because jets could have significant contributions to the UV/optical continuum luminosity of radio-loud AGNs, we emphasized again that for radio-loud AGNs, the emission line luminosity may be a better tracer of the ionizing luminosity than the continuum luminosity, so that the relations between the BLR size and UV emission line luminosity should be used to estimate the black hole masses of high redshift radio-loud AGNs.Comment: 19 pages, 10 figure

Knowledge Distillation-aided End-to-End Learning for Linear Precoding in Multiuser MIMO Downlink Systems with Finite-Rate Feedback

We propose a deep learning-based channel estimation, quantization, feedback, and precoding method for downlink multiuser multiple-input and multiple-output systems. In the proposed system, channel estimation and quantization for limited feedback are handled by a receiver deep neural network (DNN). Precoder selection is handled by a transmitter DNN. To emulate the traditional channel quantization, a binarization layer is adopted at each receiver DNN, and the binarization layer is also used to enable end-to-end learning. However, this can lead to inaccurate gradients, which can trap the receiver DNNs at a poor local minimum during training. To address this, we consider knowledge distillation, in which the existing DNNs are jointly trained with an auxiliary transmitter DNN. The use of an auxiliary DNN as a teacher network allows the receiver DNNs to additionally exploit lossless gradients, which is useful in avoiding a poor local minimum. For the same number of feedback bits, our DNN-based precoding scheme can achieve a higher downlink rate compared to conventional linear precoding with codebook-based limited feedback.Comment: 6 pages, 4 figures, submitted to IEEE Transactions on Vehicular Technolog

Meteorin regulates mesendoderm development by enhancing nodal expression

During gastrulation, distinct lineage specification into three germ layers, the mesoderm, endoderm and ectoderm, occurs through an elaborate harmony between signaling molecules along the embryonic proximo-distal and anterior-posterior axes, and Nodal signaling plays a key role in the early embryonic development governing embryonic axis formation, mesoderm and endoderm specification, and left-right asymmetry determination. However, the mechanism by which Nodal expression is regulated is largely unknown. Here, we show that Meteorin regulates Nodal expression and is required for mesendoderm development. It is highly expressed in the inner cell mass of blastocysts and further in the epiblast and extra-embryonic ectoderm during gastrulation. Genetic ablation of the Meteorin gene resulted in early embryonic lethality, presumably due to impaired lineage allocation and subsequent cell accumulation. Embryoid body culture using Meteorin-null embryonic stem (ES) cells showed reduced Nodal expression and concomitant impairment of mesendoderm specification. Meteorin-null embryos displayed reduced levels of Nodal transcripts before the gastrulation stage, and impaired expression of Goosecoid, a definitive endoderm marker, during gastrulation, while the proximo-distal and anterior-posterior axes and primitive streak formation were preserved. Our results show that Meteorin is a novel regulator of Nodal transcription and is required to maintain sufficient Nodal levels for endoderm formation, thereby providing new insights in the regulation of mesendoderm allocation.open1113sciescopu

Kinematic aspects of trunk motion and gender effect in normal adults

<p>Abstract</p> <p>Background</p> <p>The purpose of this study was to analyze kinematic trunk motion data in normal adults and to investigate gender effect.</p> <p>Methods</p> <p>Kinematic trunk motion data were obtained for 20 healthy subjects (11 men and 9 women; age from 21 to 40 years) during walking a 9 m long lane at a self selected speed, namely, motions in the sagittal (tilt), coronal (obliquity), and transverse (rotation) planes, which were all expressed as motions in global (relative to the ground) and those in pelvic reference frame (relative to pelvis), i.e., tilt (G), obliquity (G), rotation (G), tilt (P), obliquity (P), rotation (P).</p> <p>Results</p> <p>Range of tilt (G), obliquity (G) and rotation (G) showed smaller motion than that of tilt (P), obliquity (P) and rotation (P), respectively. When genders were compared, female trunks showed a 5 degree more extended posture during gait than male trunks (p = 0.002), which appeared to be caused by different lumbar lordosis. Ranges of coronal and transverse plane motion appeared to be correlated. In gait cycle, the trunk motion appeared to counterbalance the lower extremity during swing phase in sagittal plane, and to reduce the angular velocity toward the contralateral side immediate before the contralateral heel strike in the coronal plane.</p> <p>Conclusions</p> <p>Men and women showed different lumbar lordosis during normal gait, which might be partly responsible for the different prevalence of lumbar diseases between genders. However, this needs further investigation.</p

EFFECTS OF LEISURE SPORTS PARTICIPATION PERIOD ON BALANCE AND THE LOWER EXTREMITY ASYMMETRY

The aim of this study was to investigate the effect of the sports participation on balance measurements and lower extremity symmetry. Eighty healthy middle-aged adults (male 35, women 45) were participated in this study. COP related variables were selected for both double and single leg standing as center of pressure anterior posterior (COP-AP) and medial lateral (COP-ML) displacement, center of pressure mean velocity (COP-MV), center of pressure area (COP-Area), and the symmetry index (SI) of dominant and non-dominant leg. Only the COP-MV showed statistically difference for both double and single leg standing test. However, no significant differences were observed for single leg standing asymmetries. As a result, long term sports participation has positive effects on balance which can be helpful to prevent falls in middle-aged adults

A case study : basis for development of a curriculum based on images of self and environment.

<p><b>(a)</b> Right-handed twofold helical chain in 1 linked by intermolecular C–H···π interactions (red dotted line); <b>(b)</b> 3D supramolecular architecture construcated by C–H···π, O–H···O and C–H···O interactions.</p

Molecular basis for SMC rod formation and its dissolution upon DNA binding.

SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge" dimerization domain with an ATP-regulated "head" dimerization module. Here, we address the structural arrangement of the long coiled coils in SMC complexes. We unequivocally show that prokaryotic Smc-ScpAB, eukaryotic condensin, and possibly also cohesin form rod-like structures, with their coiled coils being closely juxtaposed and accurately anchored to the hinge. Upon ATP-induced binding of DNA to the hinge, however, Smc switches to a more open configuration. Our data suggest that a long-distance structural transition is transmitted from the Smc head domains to regulate Smc-ScpAB's association with DNA. These findings uncover a conserved architectural theme in SMC complexes, provide a mechanistic basis for Smc's dynamic engagement with chromosomes, and offer a molecular explanation for defects in Cornelia de Lange syndrome

Mind Bomb 1-Expressing Intermediate Progenitors Generate Notch Signaling to Maintain Radial Glial Cells

SummaryNotch signaling is critical for the stemness of radial glial cells (RGCs) during embryonic neurogenesis. Although Notch-signal-receiving events in RGCs have been well characterized, the signal-sending mechanism by the adjacent cells is poorly understood. Here, we report that conditional inactivation of mind bomb-1 (mib1), an essential component for Notch ligand endocytosis, in mice using the nestin and hGFAP promoters resulted in complete loss of Notch activation, which leads to depletion of RGCs, and premature differentiation into intermediate progenitors (IPs) and finally neurons, which were reverted by the introduction of active Notch1. Interestingly, Mib1 expression is restricted in the migrating IPs and newborn neurons, but not in RGCs. Moreover, sorted Mib1+ IPs and neurons can send the Notch signal to neighboring cells. Our results reveal that not only newborn neurons but also IPs are essential Notch-ligand-presenting cells for maintaining RGC stemness during both symmetric and asymmetric divisions

Electromagnetic Wave Theory and Applications

Contains reports on eleven research projects.Joint Services Electronics Program (Contract DAAG29-83-K-0003)Joint Services Electronics Program (Contract DAAL03-86-K-0002)National Science Foundation (Grant ECS82-03390)National Science Foundation (Grant ECS85-04381)Schlumberger-Doll Research CenterNational Aeronautics and Space Administration (Contract NAG 5-141)National Aeronautics and Space Administration (Contract NAS 5-26861)National Aeronautics and Space Administration (Contract NAG 5-270)U.S. Navy - Office of Naval Research (Contract N00014-83-K-0258)National Aeronautics and Space Administration (Contract NAG 5-725)International Business Machines, Inc.Lincoln Laborator

Incidence and risk factors of subsyndromal delirium after curative resection of gastric cancer

Background: Subsyndromal delirium, a condition in which patients exhibit some, but not all, of the symptoms of delirium, can negatively affect the outcomes of patients with cancer. However, the incidence of subsyndromal delirium in patients with gastric cancer is unknown. Here, we investigated the incidence and risk factors of subsyndromal delirium after curative resection of gastric cancer. Methods: We recruited consecutive patients with gastric cancer who were scheduled for curative resection at a tertiary hospital. Patients&apos; subsyndromal delirium symptoms were serially assessed preoperatively and 1, 2, 3, and 7 days postoperatively using the Delirium Rating Scale-Revised-98 (DRS-R-98). A DRS-R-98 score of 8-14 at any postoperative assessment was considered to indicate subsyndromal delirium. Sociodemographic and pre-/intraoperative clinical data were also assessed. Logistic regression analyses were used to determine the associated risk factors. Results: Data were analysed from 163 out of 217 eligible patients. Postoperative delirium occurred in one patient (0.6%) and subsyndromal delirium occurred in 19 patients (11.7%). Age &gt;= 70 years (odds ratio, [OR] 3.85; 95% confidence interval [0], 136-10.92; p = 0.011) and education level &lt;= 9 years (OR, 3.98; 95% CI, 139-11.41; p= 0.010) were independent risk factors of subsyndromal delirium after adjusting for preoperative cognitive function. Other pre-/intra-operative variables including anxiety/depression, poor sleep quality, and anaesthesia duration were not associated with subsyndromal delirium. Conclusions: In contrast to the low incidence of delirium among patients undergoing curative resection of gastric cancer, a substantial proportion of such patients experienced subsyndromal delirium. Considering the prognostic implications, more careful detection and management of subsyndromal delirium may be warranted in patients with gastric cance