1,327 research outputs found
The Added Value of [18F]FDG PET/CT in the Management of Invasive Fungal Infections
Anatomy-based imaging methods are the usual imaging methods used in assessing invasive fungal infections (IFIs). [18F]FDG PET/CT has also been used in the evaluation of IFIs. We assessed the added value of [18F]FDG PET/CT when added to the most frequently used anatomy-based studies in the evaluation of IFIs. The study was conducted in two University Medical Centers in the Netherlands. Reports of [18F]FDG PET/CT and anatomy-based imaging performed within two weeks of the [18F]FDG PET/CT scan were retrieved, and the presence and sites of IFI lesions were documented for each procedure. We included 155 [18F]FDG PET/CT scans performed in 73 patients. A total of 216 anatomy-based studies including 80 chest X-rays, 89 computed tomography studies, 14 magnetic resonance imaging studies, and 33 ultrasound imaging studies were studied. The anatomy-based studies were concordant with the [18F]FDG PET/CT for 94.4% of the scans performed. [18F]FDG PET/CT detected IFI lesions outside of the areas imaged by the anatomy-based studies in 48.6% of the scans. In 74% of the patients, [18F]FDG PET/CT added value in the management of the IFIs
Surprises in the Orbital Magnetic Moment and g-Factor of the Dynamic Jahn-Teller Ion C_{60}^-
We calculate the magnetic susceptibility and g-factor of the isolated
C_{60}^- ion at zero temperature, with a proper treatment of the dynamical
Jahn-Teller effect, and of the associated orbital angular momentum, Ham-reduced
gyromagnetic ratio, and molecular spin-orbit coupling. A number of surprises
emerge. First, the predicted molecular spin-orbit splitting is two orders of
magnitude smaller than in the bare carbon atom, due to the large radius of
curvature of the molecule. Second, this reduced spin-orbit splitting is
comparable to Zeeman energies, for instance, in X-band EPR at 3.39KGauss, and a
field dependence of the g-factor is predicted. Third, the orbital gyromagnetic
factor is strongly reduced by vibron coupling, and so therefore are the
effective weak-field g-factors of all low-lying states. In particular, the
ground-state doublet of C_{60}^- is predicted to show a negative g-factor of
\sim -0.1.Comment: 19 pages RevTex, 2 postscript figures include
Bayesian inference of biochemical kinetic parameters using the linear noise approximation
Background
Fluorescent and luminescent gene reporters allow us to dynamically quantify changes in molecular species concentration over time on the single cell level. The mathematical modeling of their interaction through multivariate dynamical models requires the deveopment of effective statistical methods to calibrate such models against available data. Given the prevalence of stochasticity and noise in biochemical systems inference for stochastic models is of special interest. In this paper we present a simple and computationally efficient algorithm for the estimation of biochemical kinetic parameters from gene reporter data.
Results
We use the linear noise approximation to model biochemical reactions through a stochastic dynamic model which essentially approximates a diffusion model by an ordinary differential equation model with an appropriately defined noise process. An explicit formula for the likelihood function can be derived allowing for computationally efficient parameter estimation. The proposed algorithm is embedded in a Bayesian framework and inference is performed using Markov chain Monte Carlo.
Conclusion
The major advantage of the method is that in contrast to the more established diffusion approximation based methods the computationally costly methods of data augmentation are not necessary. Our approach also allows for unobserved variables and measurement error. The application of the method to both simulated and experimental data shows that the proposed methodology provides a useful alternative to diffusion approximation based methods
Differences in overland flow, hydrophobicity and soil moisture dynamics between Mediterranean woodland types in a peri-urban catchment in Portugal
Attention to safety 2
Tot op heden heeft onderzoek naar toekomstig overstromingsrisico vooral gebruik gemaakt van de scenarioaanpak. Het belangrijkste doel van deze studie is om een demonstratie te geven van een methode voor het produceren van probabilistische schattingen van overstromingsrisico’s als gevolg van klimaatverandering. Het onderzoek richt zich op twee casestudy trajecten langs de Rijn: Bonn-Duisburg en Mainz-Koblenz
SNOMED CT – advances in concept mapping, retrieval, and ontological foundations. Selected contributions to the Semantic Mining Conference on SNOMED CT (SMCS 2006)
Suppression of Superconductivity in Single Crystals of UPt_3 by Pd Substitution
The suppression of superconductivity by substitution effects has been
measured in high quality single crystals of U(Pt_{1-x} Pd_x)_3 with 0 <= x <=
0.002. While the superconducting transition temperature T_c varies linearly
with residual resistivity r_0, consistent with pair-breaking by impurity
potential scattering, the rate of suppression of T_c with r_0 is much larger
for Pd substitution than for other impurity substitutions or by increased
defect density. This effect is correlated with an increase in the inelastic
scattering coefficient, and may be related to Pd-induced changes in the
magnetic fluctuation spectrum.Comment: 12 page in manuscript, plus 4 figure
The added value of [F-18]FDG PET/CT in the management of invasive fungal infections
Anatomy-based imaging methods are the usual imaging methods used in assessing invasive
fungal infections (IFIs). [18F]FDG PET/CT has also been used in the evaluation of IFIs. We assessed
the added value of [18F]FDG PET/CT when added to the most frequently used anatomy-based
studies in the evaluation of IFIs. The study was conducted in two University Medical Centers in
the Netherlands. Reports of [18F]FDG PET/CT and anatomy-based imaging performed within two
weeks of the [18F]FDG PET/CT scan were retrieved, and the presence and sites of IFI lesions were
documented for each procedure. We included 155 [18F]FDG PET/CT scans performed in 73 patients.
A total of 216 anatomy-based studies including 80 chest X-rays, 89 computed tomography studies,
14 magnetic resonance imaging studies, and 33 ultrasound imaging studies were studied. The
anatomy-based studies were concordant with the [18F]FDG PET/CT for 94.4% of the scans performed.
[18F]FDG PET/CT detected IFI lesions outside of the areas imaged by the anatomy-based studies
in 48.6% of the scans. In 74% of the patients, [18F]FDG PET/CT added value in the management of
the IFIs.https://www.mdpi.com/journal/diagnosticsam2022Nuclear Medicin
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