Rzeczywistość edukacyjna osób z głęboką niepełnosprawnością intelektualną

The article presents the an assessment of the educational reality of people with profound intellectual disabilities in the opinion of employees of the Education and Reha- bilitation Center. The objective of the article is a preliminary knowledge of the educational reality of people with profound intellectual disabilities, in order to conduct further in-depth analyzes of the discussed issue

Identification of Residual Stresses in a Surface Layer of Ti6AL4V and Inconel 718 after Process of Peripheral Milling

Titanium based alloy – Ti6Al4V and nickel based alloy – Inconel 718 belong to the group of difficult-to-cut materials. Thanks to their unique properties they can be used in constructions that need to withstand the high reliability requirements which are required inter alia in the aircraft industry. The physical properties of cutting layer, including residual stresses, play an important role during exploitation of products made out of difficult-to-cut materials. In the article, the method of residual stresses determination is described and the exemplary results of carried out studies are provided. Described method is based on the measurement of the defects in the crystal lattice. The carried out studies show that the state of residual stresses, in a subsurface layer, can be formed by the selection of machining conditions

Objawy otolaryngologiczne u chorych leczonych z powodu chorób przenoszonych przez kleszcze

Wstęp: Choroby przenoszone przez kleszcze stały się w ciągu kilkunastu ostatnich lat bardzo poważnym problemem. Najbardziej rozpowszechnionymi są borelioza oraz kleszczowe zapalenie mózgu (KZM). W ostatnim czasie znacząco rośnie również liczba zakażeń patogenami z rodzaju Bartonella, Babesia, Anaplasma, Brucella i in. Podobieństwo objawów chorób odkleszczowych do objawów innych chorób jest poważnym wyzwaniem diagnostycznym. Materiały i metody: Badaniem objęto grupę 216 chorych w wieku 18–55 lat, zgłaszających się na wizytę w poradni otolaryngologicznej z powodu chorób odkleszczowych w latach 2014–2016. Chorzy mieli zdiagnozowaną boreliozę i koinfekcje, a głównymi testami potwierdzającymi obecność tych chorób były testy: ELISA, Western-Blot oraz badanie KKI (krążące kompleksy immunologiczne). Wyniki: Spośród 216 chorych wyodrębniono grupę 162 pacjentów manifestujących objawy otolaryngologiczne. Głównym objawem zgłaszanym przez pacjentów były uciążliwe szumy uszne (76,5%) – w przeważającej mierze wysokoczęstotliwościowe, zawroty głowy i zaburzenia równowagi (53,7%), bóle głowy (39%), niedosłuch odbiorczy jednostronny (16,7%). Wśród badanych oprócz boreliozy zaobserwowano również obecność innych chorób odkleszczowych. Najliczniejszą grupę stanowili pacjenci zakażeni bakteriami z rodzaju Bartonella henselae (33,4%) oraz Bartonella quintana (13%). Dyskusja: Objawy otolaryngologiczne są częstą manifestacją chorób przenoszonych przez kleszcze. Najczęściej występują w przebiegu boreliozy oraz zakażeń bakteriami z rodzaju Bartonella spp. Objawy ze strony narządów głowy i szyi najczęściej występują w przebiegu przewlekłego procesu chorobowego. Świadczy o tym zdecydowana przewaga przeciwciał IgG i antygenu VlsE w grupie badanych chorych

Components of the metabolic syndrome in girls with Turner syndrome treated with growth hormone in a long term prospective study

BackgroundComponents of the metabolic syndrome are more common in patients with Turner syndrome (TS) than in the general population. Long-term growth hormone (GH) treatment also affects the parameters of carbohydrate metabolism. Therefore, all these factors should be monitored in girls with TS.ObjectiveTo assess the occurrence of metabolic syndrome components in TS girls before GH treatment and to monitor changes in metabolic parameters throughout GH therapy.Patients and method89 TS patients were enrolled in the study. Clinical and laboratory data after the 1st (V1), 3rd (V3), 5th (V5) and 10th (V10) year of GH therapy was available respectively in 60, 76, 50 and 22 patients. The patients’ biochemical phenotypes were determined by glucose 0’, 120’, insulin 0’, 120’, HOMA-IR, Ins/Glu ratio, HDL-cholesterol and triglycerides (TG) concentration.ResultsObesity was found during V0 in 7.9% of patients,V1 - 5%, V3 - 3.9%, V5 - 2%, V10 – 0%. No patient met diagnostic criteria for diabetes. A significant increase in the basal plasma glucose 0’ was found in the first five years of therapy (pV0-V1 < 0.001; pV0-V3 = 0.006; pV0-V5 < 0.001). V10 glucose 120’ values were significantly lower than at the onset of GH treatment (pV0-V10 = 0.046). The serum insulin 0’ and 120’ concentrations as well as insulin resistance increased during treatment. No statistically significant differences in serum TG and HDL-cholesterol levels during GH therapy were found.ConclusionThe development of insulin resistance and carbohydrate metabolism impairment have the greatest manifestations during GH therapy in girls with TS. Monitoring the basic parameters of carbohydrate-lipid metabolism in girls with TS seems particularly important

Intima-media thickness and ankle-brachial index are correlated with the extent of coronary artery disease measured by the SYNTAX score

Introduction: The extent of peripheral artery disease (PAD) measured by the ankle-brachial index (ABI) and intima-media thickness (IMT) is correlated with the complexity of coronary artery disease (CAD) in stable angina patients. However, data regarding patients with acute coronary syndromes are still lacking. Aim: To compare coronary complexity measured by the SYNTAX score in patients with and without PAD presenting with myocardial infarction (MI). Material and methods: Both ABI and IMT were measured in 101 consecutive patients who underwent primary diagnostic due to MI. Patients were divided into three tertile groups depending on the SYNTAX score (0–4; 5–11; 12 and more points). Results: Mean ABI in the general population was 0.9 ±0.26, mean IMT was 0.8 ±0.3 mm and mean SYNTAX score was 7.8 ±5.4 points. We found significant correlations between ABI and SYNTAX score (p = 0.01), IMT and SYNTAX score (p < 0.001), and IMT and ABI (p < 0.001). The highest mean values of IMT (p < 0.001) and lowest mean values of ABI (p = 0.015) were found in patients in the highest SYNTAX score group. When analyzing receiver operating characteristics (ROC) curves, IMT had greater specificity and sensitivity than ABI. Conclusions: Both IMT and ABI are correlated with SYNTAX score (positively for IMT and negatively for ABI values). In our study, IMT was a better predictor of SYNTAX score than ABI. Our study suggests that the higher rate of cardiovascular events in patients with PAD presenting with MI may be partially explained by greater coronary lesion complexity

Real-life data of abiraterone acetate and enzalutamide treatment in post-chemotherapy metastatic castration-resistant prostate cancer in Poland

BackgroundAbiraterone acetate (ABI) and Enzalutamide (ENZA) are second-generation hormone drugs that show breakthrough activity in post-chemotherapy, metastatic castration-resistant prostate cancer (mCRPC). The leading oncological and urological guidelines indicate both drugs with the same strong recommendation. There is a lack of randomized trials which compare the efficacy of ABI and ENZA. The current study aimed to compare the effectiveness of the drugs with an analysis of prognostic factors related to those drugs.Patients and methodsThe study included 420 patients with docetaxel (DXL) pretreated mCRPC from seven Polish cancer centers. Patients were treated according to inclusion and exclusion criteria in the Polish national drug program (1000 mg ABI and 10 mg prednisone, n=76.2%; ENZA, 160 mg; n=23.8%). The study retrospectively analyzed the overall survival (OS), time to treatment failure (TTF), PSA 50% decline rate (PSA 50%) and selected clinic-pathological data.ResultsIn the study group, the median OS was 17 months (95% CI: 15.6-18.3). The median OS (26.1 vs. 15.7 mo.; p&lt;0.001), TTF (14.2 vs. 7.6 mo.; p&lt;0.001) and PSA 50% (87.5 vs. 56%; p&lt;0.001) were higher in ENZA than in ABI treatment. Multivariate analysis shows that ENZA treatment and PSA nadir &lt;17.35 ng/mL during or after DXL treatment were related to longer TTF. ENZA treatment, DXL dose ≥750 mg, PSA nadir &lt;17.35 ng/mL during or after DXL treatment was related to longer OS.ConclusionsENZA treatment may be related to more favorable oncological outcomes than ABI treatment in the studied Polish population of patients. A 50% decline in PSA is an indicator of longer TTF and OS. Due to the non-randomized and retrospective nature of the analysis, the current results require prospective validation

ARTEFACTS: How do we want to deal with the future of our one and only planet?

The European Commission’s Science and Knowledge Service, the Joint Research Centre (JRC), decided to try working hand-in-hand with leading European science centres and museums. Behind this decision was the idea that the JRC could better support EU Institutions in engaging with the European public. The fact that European Union policies are firmly based on scientific evidence is a strong message which the JRC is uniquely able to illustrate. Such a collaboration would not only provide a platform to explain the benefits of EU policies to our daily lives but also provide an opportunity for European citizens to engage by taking a more active part in the EU policy making process for the future. A PILOT PROGRAMME To test the idea, the JRC launched an experimental programme to work with science museums: a perfect partner for three compelling reasons. Firstly, they attract a large and growing number of visitors. Leading science museums in Europe have typically 500 000 visitors per year. Furthermore, they are based in large European cities and attract local visitors as well as tourists from across Europe and beyond. The second reason for working with museums is that they have mastered the art of how to communicate key elements of sophisticated arguments across to the public and making complex topics of public interest readily accessible. That is a high-value added skill and a crucial part of the valorisation of public-funded research, never to be underestimated. Finally museums are, at present, undergoing something of a renaissance. Museums today are vibrant environments offering new techniques and technologies to both inform and entertain, and attract visitors of all demographics.JRC.H.2-Knowledge Management Methodologies, Communities and Disseminatio

Interdyscyplinarna opieka nad pacjentem z chorobą nowotworową

Praca recenzowana / peer-reviewed paperZ przyjemnością przekazujemy Państwu kolejny tom monografii Interdyscyplinarna opieka nad pacjentem z chorobą nowotworową, która powstała przy współpracy Polskiego Stowarzyszenia Pielęgniarek Onkologicznych z Wydziałem Zdrowia i Nauk Medycznych Krakowskiej Akademii im. Andrzeja Frycza Modrzewskiego. Problematyka przedstawiona w publikacji dotyczy wieloaspektowej opieki nad chorym na nowotwór. Opracowania są doniesieniami z badań naukowych, w których autorzy przedstawiają wnioski i kierunki działań dla praktyków. Równie dużą wartość mają rozdziały, w których praktycy dzielą się swoją wiedzą i doświadczeniem z pracy z chorymi i ich rodzinami. Tematyka monografi i dotyczy m.in.: edukacji zdrowotnej, komunikowania się, opieki nad chorym poddawanym chemioterapii, leczeniu chirurgicznemu, radioterapii i rehabilitacji. Pragniemy, aby ta książka swoją merytoryczną zawartością stała się istotnym wkładem w uczczenie tak ważnych dla pielęgniarstwa rocznic, obchodzonych w 2011 r

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe

The 42nd Symposium Chromatographic Methods of Investigating Organic Compounds : Book of abstracts

The 42nd Symposium Chromatographic Methods of Investigating Organic Compounds : Book of abstracts. June 4-7, 2019, Szczyrk, Polan