Virtually Standing Up or Standing By? Correlates of Enacting Social Control Online

Research has consistently established the robustness of the bystander effect, or the tendency of individuals to not intervene on behalf of others in emergency situations. This study examines the bystander effect in an online setting, focusing on factors that lead individuals to intervene, and therefore enact informal social control, on behalf of others who are being targeted by hate material. To address this question, we use an online survey (N=647) of youth and young adults recruited from a demographically balanced sample of Americans. Results demonstrate that the enactment of social control is positively affected by the existence of strong offline and online social bonds, collective efficacy, prior victimization, self-esteem, and an aversion for the hate material in question. Additionally, the amount of time that individuals spend online affects their likelihood of intervention. These findings provide important insights into the processes that underlie informal social control and begin to bridge the gap in knowledge between social control in the physical and virtual realms

Banishment in Public Housing: Testing an Evolution of Broken Windows

Banishment policies grant police the authority to formally ban individuals from entering public housing and arrest them for trespassing if they violate the ban. Despite its widespread use and the social consequences resulting from it, an empirical evaluation of the effectiveness of banishment has not been performed. Understanding banishment enforcement is an evolution of broken windows policing, this study explores how effective bans are at reducing crime in public housing. We analyze crime data, spanning the years 2001–2012, from six public housing communities and 13 surrounding communities in one southeastern U.S. city. Using Arellano-Bond dynamic panel models, we investigate whether or not issuing bans predicts reductions in property and violent crimes as well as increases in drug and trespass arrests in public housing. We find that this brand of broken windows policing does reduce crime, albeit relatively small reductions and only for property crime, while resulting in an increase in trespass arrests. Given our findings that these policies have only a modest impact on property crime, yet produce relatively larger increases in arrests for minor offenses in communities of color, and ultimately have no significant impact on violent crime, it will be important for police, communities, and policy makers to discuss whether the returns are worth the potential costs

CIVIIC: Cybercrime in Virginia: Impacts on Industry and Citizens Final Report

[First paragraph] Victimization from cybercrime is a major concern in Virginia, the US, and the world. As individuals and businesses spend more time online, it becomes increasingly important to understand cybercrime and how to protect against it. Such an understanding is dependent on valid and reliable baseline data that identifies the specific nature, extent, and outcomes of cybercrime activity. A better understanding of cybercrime activity is needed to target and prevent it more effectively, minimize its consequences, and provide support for both individual and corporate victims. Before that can occur, however, better baseline data are required, and this project was designed to provide those data for the Commonwealth of Virginia. The purpose of this study was to describe the experiences of Virginia residents and businesses around cybercrime, identify the specific vulnerabilities that are exploited, and discover the consequences of victimization

Defending Others Online : The Influence of Observing Formal and Informal Social Control on One’s Willingness to Defend Cyberhate Victims

This paper examines factors correlated with online self-help—an informal form of social control vis-à-vis intervention—upon witnessing a cyberhate attack. Using online surveys from 18- to 26-year-old respondents in the United States, we explore the roles of various types of online and offline formal and informal social control mechanisms on the enactment of self-help through the use of descriptive statistics and ordinal logistic regression. The results of the multivariate analyses indicate that online collective efficacy is positively related to self-help, as is having close ties to individuals and groups offline and online. Formal online social control, however, is not significantly related to engaging in self-help. Other findings demonstrate that personal encounters with cyberhate affect the likelihood that an individual will intervene when witnessing an attack, and that individuals with high levels of empathy are more likely to intervene to assist others. This work indicates that pro-social online behavior is contagious and can potentially foster online spaces in which harmful behaviors, such as propagating cyberhate, are not condoned.Peer reviewe

Factors Associated with Online Hate Acceptance: A Cross-National Six-Country Study among Young Adults

The Internet, specifically social media, is among the most common settings where young people encounter hate speech. Understanding their attitudes toward the phenomenon is crucial for combatting it because acceptance of such content could contribute to furthering the spread of hate speech as well as ideology contamination. The present study, theoretically grounded in the General Aggression Model (GAM), investigates factors associated with online hate acceptance among young adults. We collected survey data from participants aged 18–26 from six countries: Finland (n = 483), France (n = 907), Poland (n = 738), Spain (n = 739), the United Kingdom (n = 959), and the United States (n = 1052). Results based on linear regression modeling showed that acceptance of online hate was strongly associated with acceptance of violence in all samples. In addition, participants who admitted to producing online hate reported higher levels of acceptance of it. Moreover, association with social dominance orientation was found in most of the samples. Other sample-specific significant factors included participants’ experiences with the Internet and online hate, as well as empathy and institutional trust levels. Significant differences in online hate acceptance levels and the strength of its connections to individual factors were found between the countries. These results provide important insights into the phenomenon, demonstrating that online hate acceptance is part of a larger belief system and is influenced by cultural background, and, therefore, it cannot be analyzed or combatted in isolation from these factors.</p

Microarray-Based Analysis of Differential Gene Expression between Infective and Noninfective Larvae of Strongyloides stercoralis

Strongyloides stercoralis is a soil-transmitted helminth that affects an estimated 30–100 million people worldwide. Chronically infected persons who are exposed to corticosteroids can develop disseminated disease, which carries a high mortality (87–100%) if untreated. Despite this, little is known about the fundamental biology of this parasite, including the features that enable infection. We developed the first DNA microarray for this parasite and used it to compare infective third-stage larvae (L3i) with non-infective first stage larvae (L1). Using this method, we identified 935 differentially expressed genes. Functional characterization of these genes revealed L3i biased expression of heat shock proteins and genes with products that have previously been shown to be immunoreactive in infected humans. Genes putatively involved in transcription were found to have L1 biased expression. Potential chemotherapeutic and vaccine targets such as far-1, ucr 2.1 and hsp-90 were identified for further study

Secretion of Protective Antigens by Tissue-Stage Nematode Larvae Revealed by Proteomic Analysis and Vaccination-Induced Sterile Immunity

Gastrointestinal nematode parasites infect over 1 billion humans, with little evidence for generation of sterilising immunity. These helminths are highly adapted to their mammalian host, following a developmental program through successive niches, while effectively down-modulating host immune responsiveness. Larvae of Heligmosomoides polygyrus, for example, encyst in the intestinal submucosa, before emerging as adult worms into the duodenal lumen. Adults release immunomodulatory excretory-secretory (ES) products, but mice immunised with adult H. polygyrus ES become fully immune to challenge infection. ES products of the intestinal wall 4th stage (L4) larvae are similarly important in host-parasite interactions, as they readily generate sterile immunity against infection, while released material from the egg stage is ineffective. Proteomic analyses of L4 ES identifies protective antigen targets as well as potential tissue-phase immunomodulatory molecules, using as comparators the adult ES proteome and a profile of H. polygyrus egg-released material. While 135 proteins are shared between L4 and adult ES, 72 are L4 ES-specific; L4-specific proteins correspond to those whose transcription is restricted to larval stages, while shared proteins are generally transcribed by all life cycle forms. Two protein families are more heavily represented in the L4 secretome, the Sushi domain, associated with complement regulation, and the ShK/SXC domain related to a toxin interfering with T cell signalling. Both adult and L4 ES contain extensive but distinct arrays of Venom allergen/Ancylostoma secreted protein-Like (VAL) members, with acetylcholinesterases (ACEs) and apyrase APY-3 particularly abundant in L4 ES. Serum antibodies from mice vaccinated with L4 and adult ES react strongly to the VAL-1 protein and to ACE-1, indicating that these two antigens represent major vaccine targets for this intestinal nematode. We have thus defined an extensive and novel repertoire of H. polygyrus proteins closely implicated in immune modulation and protective immunity

Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity

Helminths are masterful immunoregulators. A characteristic feature of helminth infection is a Th2-dominated immune response, but stimulation of immunoregulatory cell populations, such as regulatory T cells and alternatively activated macrophages, is equally common. Typically, Th1/17 immunity is blocked and productive effector responses are muted, allowing survival of the parasite in a “modified Th2” environment. Drug treatment to clear the worms reverses the immunoregulatory effects, indicating that a state of active suppression is maintained by the parasite. Hence, research has focussed on “excretory–secretory” products released by live parasites, which can interfere with every aspect of host immunity from initial recognition to end-stage effector mechanisms. In this review, we survey our knowledge of helminth secreted molecules, and summarise current understanding of the growing number of individual helminth mediators that have been shown to target key receptors or pathways in the mammalian immune system