Sanitation installation in a factory hygienic rooms

Cílem mé bakalářské práce je návrh zdravotně technické instalace hygienických zařízení v průmyslu. V teoretické části se zabývám spotřebou vody zejména její úsporou při instalaci vhodně zvolené armatury, respektive jejich doplňků. V praktické části se zabývám výpočty potřeby vody v zázemí výrobní haly a dimenzováním potrubní sítě tzn. návrh vodovodu, splaškové kanalizace a dešťové kanalizace. Jako výstup mé bakalářské práce je projekt, ve kterém jsou přiloženy jednotlivé výkresy zpracované v úrovni projektu pro provedení stavby.The aim of this thesis is a proposal for sanitary technology for the installation of sanitary facilities in industry. The theoretical part deals with water consumption, particularly the savings made when properly selected fixtures and fittings are installed. The practical part deals with a calculation of water demand in a factory and the dimensioning of the pipe network i.e. for water supply, sewage drains and storm drains. The output of this thesis is a project which includes process drawings for each level of a construction project.

Non-specific abdominal pain and air pollution: a novel association.

We studied whether short-term exposure to air pollution was associated with non-specific abdominal pain in epidemiologic and animal studies. Patients visiting the emergency department with non-specific abdominal pain were identified in Edmonton (1992 to 2002, n = 95,173) and Montreal (1997 to 2002, n = 25,852). We calculated the daily concentrations for ozone (O(3)), nitrogen dioxide (NO(2)), sulfur dioxide (SO(2)), carbon monoxide (CO), and particles <10 (PM(10)) or <2.5 (PM(2.5)) µm. A case crossover study design was used to estimate the odds ratio (OR) and 95% confidence interval (CI) associated with an increase in the interquartile range of the air pollutants. We investigated differential effects by age and sex. Mice were gavaged with urban particle extracts. In animal models, colonic motility was tested, and visceral abdominal pain was measured using a writhing test, and behavioral response to oil of mustard and neostigmine. Motility and pain was measured acutely (1.5 hours after gavage) and chronically (7-days and 21-days after gavage). Emergency department visits for non-specific abdominal pain were primarily by women between the ages of 15-24 years. Individuals aged 15 to 24 years were at increased risk of non-specific abdominal pain in Edmonton (same day CO: OR = 1.04, 95% CI = 1.02-1.06; and NO(2): OR = 1.06, 95% CI = 1.03-1.09). The risk of air pollution among 15-24 year olds in Montreal was significantly positive (same day CO: OR = 1.11, 95% CI = 1.05-1.17; NO(2): OR = 1.09, 95% CI = 1.01-1.16; SO(2): OR = 1.17, 95% CI = 1.10-1.25; PM(2.5): OR = 1.09, 95% CI = 1.04-1.15). Abdominal pain was increased by an acute gavage of pollution extract but not to chronic exposure to pollutants. Colonic transit was delayed following chronic but not acute exposure with the pollutants. Epidemiological and animal data suggest that short-term exposure to air pollution may trigger non-specific abdominal pain in young individuals

Attitudes Toward Physical Activities By Girls In Young School Age

Hodnocení postojů k pohybovým aktivitám dětí je aktuální u nás i v zahraničí. Cílem studie proto bylo provést evaluaci postojů k pohybovým aktivitám u dívek mladšího školního věku z Prahy a mimopražského regionu a porovnat výsledky obou skupin pomocí dotazníku CATPA/Grade Year 3. Dotazník postihuje šest dimenzí postojů − sociální cítění, zdraví, nebezpečí, sociální prožívání, estetično a radost z pohybu. Výzkumný soubor tvořilo 74 dívek (věk 10,32±0,12) ze čtvrtých tříd základních škol. Z toho 37 dívek bylo ze základních škol v Praze (DP) a 37 dívek z mimopražských základních škol (DM). Výsledky popsaly postoje dívek k pohybovým aktivitám podle jednotlivých dimenzí dotazníku CATPA/Grade Year 3. Komparace výsledků prokázala, že u dimenzí sociálního cítění, zdraví, nebezpečí a radosti z pohybu mají dívky (DM) (M=4,61; SD=0,51) pozitivnější postoj k pohybovým aktivitám než dívky (DP) (M=3,95; SD=0,87) při stanovené hladině významnosti p&lt;0,05. Zjištěné statistické a věcné rozdíly mezi skupinou dívekz pražského a mimopražského regionu potvrzují závěry českých i zahraničních autorů o postoji dětí k pohybovým aktivitám. Ve volném čase dívek z mimopražského regionu hraje pohybová aktivita důležitější roli než u jejich vrstevnic z Prahy.The evaluation of attitudes towards physical activity by children is a very often discussed issue. The main objective of this study was to determine the attitudes towards physical activities by girls from Prague (DP) and other regions (DM) in primary schools. The results were to compare both groups with the help of a questionnaire CATPA/Grade Year 3. The questionnaire compares six dimensions of attitudes (social sensibilities, health hazards, social perception, aesthetics and the joy of movement). The research sample consisted of 74 girls (age=10,32±0,12) from the fourth grade of elementary school. Of that, 37 were girls of primary school in Prague (DP) and the rest 37 girls were from outside Prague´s primary school (DM). The results of the study described the attitude to physical activities of girls from Prague and outside Prague elementary school elementary school in each dimension of the questionnaire CATPA/Grade Year 3. The results were compared. The result demonstrated that the dimensions of social engagement, health, danger and joy of movement girls (DM) (M=4,61; SD=0,51) have a more positive attitude towards physical activities than girls (DP) (M=3,95; SD=0,87), in determining the significance level of p&lt;0,05. This research confirmed the conclusion of both Czech and aboard researchers. The results confirm that girls from primary schools outside Prague have a positive relationship to physical activities than girls from primary schools of Prague

Electroweak symmetry breaking in supersymmetric models with heavy scalar superpartners

We propose a novel mechanism of electroweak symmetry breaking in supersymmetric models, as the one recently discussed by Birkedal, Chacko and Gaillard, in which the Standard Model Higgs doublet is a pseudo-Goldstone boson of some global symmetry. The Higgs mass parameter is generated at one loop level by two different, moderately fine-tuned sources of the global symmetry breaking. The mechanism works for scalar superpartner masses of order 10 TeV, but gauginos can be light. The scale at which supersymmetry breaking is mediated to the visible sector has to be low, of order 100 TeV. Fine-tuning in the scalar potential is at least two orders of magnitude smaller than in the MSSM with similar soft scalar masses. The physical Higgs boson mass is (for $\tan\beta\gg1$) in the range 120-135 GeV.Comment: 17 pages, no figures, LaTe

Bullying girls - Changes after brief strategic family therapy: A randomized, prospective, controlled trial with one-year follow-up

Background: Many girls bully others. They are conspicuous because of their risk-taking behavior, increased anger, problematic interpersonal relationships and poor quality of life. Our aim was to determine the efficacy of brief strategic family therapy (BSFT) for bullying-related behavior, anger reduction, improvement of interpersonal relationships, and improvement of health-related quality of life in girls who bully, and to find out whether their expressive aggression correlates with their distinctive psychological features. Methods: 40 bullying girls were recruited from the general population: 20 were randomly selected for 3 months of BSFT. Follow-up took place 12 months after the therapy had ended. The results of treatment were examined using the Adolescents' Risk-taking Behavior Scale (ARBS), the State-Trait Anger Expression Inventory (STAXI), the Inventory of Interpersonal Problems (IIP-D), and the SF-36 Health Survey (SF-36). Results: In comparison with the control group (CG) (according to the intent-to-treat principle), bullying behavior in the BSFT group was reduced (BSFT-G from n = 20 to n = 6; CG from n = 20 to n = 18, p = 0.05) and statistically significant changes in all risk-taking behaviors (ARBS), on most STAXI, IIP-D, and SF-36 scales were observed after BSFT. The reduction in expressive aggression (Anger-Out scale of the STAXI) correlated with the reduction on several scales of the ARBS, IIP-D, and SF-36. Follow-up a year later showed relatively stable events. Conclusions: Our findings suggest that bullying girls suffer from psychological and social problems which may be reduced by the use of BSFT. Expressive aggression in girls appears to correlate with several types of risk-taking behavior and interpersonal problems, as well as with health-related quality of life. Copyright (c) 2006 S. Karger AG, Basel

A realistic example of chaotic tunneling: The hydrogen atom in parallel static electric and magnetic fields

Statistics of tunneling rates in the presence of chaotic classical dynamics is discussed on a realistic example: a hydrogen atom placed in parallel uniform static electric and magnetic fields, where tunneling is followed by ionization along the fields direction. Depending on the magnetic quantum number, one may observe either a standard Porter-Thomas distribution of tunneling rates or, for strong scarring by a periodic orbit parallel to the external fields, strong deviations from it. For the latter case, a simple model based on random matrix theory gives the correct distribution.Comment: Submitted to Phys. Rev.

Are Elevated Levels of IGF-1 Caused by Coronary Arteriesoclerosis?: Molecular and Clinical Analysis

The importance of insulin-like growth factor-1 (IGF-1) in coronary artery disease (CAD) due to wide range of its biological effects and its therapeutic potential, has already been described. Our aim was to evaluate possible influence of IGF-1 serum level changes on coronary atherosclerosis. In case of existence of such association our further aim was to verify and explain this phenomenon by examination of promoter P1 of IGF-1gene and receptor gene for IGF-1. The study was performed in 101 consecutive patients undergo for routine coronary angiography. Quantitative and qualitative assessment of coronary atherosclerosis was performed respectively by estimation of the number of culprit lesions in coronary arteries and by Gensini score calculation. IGF-1, IGFBP3 and plasma lipoproteins were measured in all patients. In addition, we evaluated DNA from 101 patients, isolated from blood cells, which was amplified by using PCR with sophisticated primers for P1 promoter of IGF-1 gene and IGF-1 receptor gene, then analyzed utilizing SSCP technique and automatically sequenced. We observed significant increase of serum IGF-1 levels in patients with “3 vessel disease” and with high score in Gensini scale when compared to those without any narrowing lesions in coronary arteries and 0 Gensini score (in group with 3 vessel disease 215.0 ± 71.3 versuss 176.7 ± 34.2 ng/ml p = 0.04 and with high Gensini score 231.4 ± 59.3 versus 181.0 ± 37.8 ng/ml p = 0.01).We found different genotypes for five P1 promoter polymorphisms of IGF-1 gene (RS35767, RS5742612, RS228837, RS11829693, RS17879774). There were no significant associations between the observed single nucleotide polymorphism (SNP) and coronary atherosclerosis nor with levels of circulating IGF-1. We found no structural polymorphism in receptor gene for IGF-1 nor in its extracellular domain(exon 2–4) nor in internal domain (exon 16–21). The effect of increased IGF-1 serum level in our study was probably independent from structural polymorphism in promoter P1 for IGF-1 or in receptor gene for IGF-1

Mechanistic Characterization of RASGRP1 Variants Identifies an hnRNP-K-Regulated Transcriptional Enhancer Contributing to SLE Susceptibility

Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component. We recently identified a novel SLE susceptibility locus near RASGRP1, which governs the ERK/MAPK kinase cascade and B-/T-cell differentiation and development. However, precise causal RASGRP1 functional variant(s) and their mechanisms of action in SLE pathogenesis remain undefined. Our goal was to fine-map this locus, prioritize genetic variants likely to be functional, experimentally validate their biochemical mechanisms, and determine the contribution of these SNPs to SLE risk. We performed a meta-analysis across six Asian and European cohorts (9,529 cases; 22,462 controls), followed by in silico bioinformatic and epigenetic analyses to prioritize potentially functional SNPs. We experimentally validated the functional significance and mechanism of action of three SNPs in cultured T-cells. Meta-analysis identified 18 genome-wide significant (p &lt; 5 × 10−8) SNPs, mostly concentrated in two haplotype blocks, one intronic and the other intergenic. Epigenetic fine-mapping, allelic, eQTL, and imbalance analyses predicted three transcriptional regulatory regions with four SNPs (rs7170151, rs11631591-rs7173565, and rs9920715) prioritized for functional validation. Luciferase reporter assays indicated significant allele-specific enhancer activity for intronic rs7170151 and rs11631591-rs7173565 in T-lymphoid (Jurkat) cells, but not in HEK293 cells. Following up with EMSA, mass spectrometry, and ChIP-qPCR, we detected allele-dependent interactions between heterogeneous nuclear ribonucleoprotein K (hnRNP-K) and rs11631591. Furthermore, inhibition of hnRNP-K in Jurkat and primary T-cells downregulated RASGRP1 and ERK/MAPK signaling. Comprehensive association, bioinformatics, and epigenetic analyses yielded putative functional variants of RASGRP1, which were experimentally validated. Notably, intronic variant (rs11631591) is located in a cell type-specific enhancer sequence, where its risk allele binds to the hnRNP-K protein and modulates RASGRP1 expression in Jurkat and primary T-cells. As risk allele dosage of rs11631591 correlates with increased RASGRP1 expression and ERK activity, we suggest that this SNP may underlie SLE risk at this locus

Geografie bariér

Title in English: Geography of barriers: Examples of good barrier-free implementations The book Geography of Barriers: Examples of Good Barrier-free Practice offers a collection of texts that are interested in making space, services, and information accessible. Thus, the collection is primarily about barriers, their nature, localization, and possible effects. Under barriers, most people imagine material barriers for wheelchair users in the form of steps or sidewalk curbs. Only a few would think that barriers can be represented by loosely placed rugs, unfit lighting, large glass surface, a doorbell without visual output, unwanted attention, frequent asking and offering help, lack of language knowledge, pity, etc. Thus, the book broadens awareness of what can be considered a barrier. The texts are divided into three parts – theoretical, methodic, and empirical – and their arrangement follows the logic of thematic focusing from the most general to the most concrete types of barriers. While the theoretical part places the policies of accessibility into the wider context of scientific disciplines and their development – such as disability studies, disability geography or service design, the methodic part discusses the introduction of accessibility policies in the city of Brno, describing how it tried to make its space, services, and information more accessible. Finally, the empirical part offers 18 examples of relatively good barrier-free implementations that have been recently realized in Brno. This division reflects an effort to target several groups of readers. The first part thus addresses mainly students interested in accessibility issues, the second, methodic part is intended for politicians and municipalities searching for inspiration to implement their own accessibility measures and policies. The last part stating concrete examples of good barrier-free implementations is aimed at general public, at people who like to think about a whole range of topics related to accessibility of space, services, and information