1,754 research outputs found
Matrices permutable to ∗ matrices
AbstractA (0, 1) matrix (aij) is said to be a ∗ matrix iff aij = 1 implies ai′j′ = 1 for all (i′, j′) satisfying 1 ⩽ i′ ⩽ i, 1 ⩽ j′ ⩽ j. (0, 1) matrices permutable to ∗ matrices are characterized and counted. Commutivity of matrices which permute to ∗ matrices is also discussed
The genetic structure of Nautilus pompilius populations surrounding Australia and the Philippines.
Understanding the distribution of genetic diversity in exploited species is fundamental to successful conservation. Genetic structure and the degree of gene flow among populations must be assessed to design appropriate strategies to prevent the loss of distinct populations. The cephalopod Nautilus pompilius is fished unsustainably in the Philippines for the ornamental shell trade and has limited legislative protection, despite the species' recent dramatic decline in the region. Here, we use 14 microsatellite markers to evaluate the population structure of N. pompilius around Australia and the Philippines. Despite their relative geographical proximity, Great Barrier Reef individuals are genetically isolated from Osprey Reef and Shark Reef in the Coral Sea (FST =0.312, 0.229, respectively). Conversely, despite the larger geographical distances between the Philippines and west Australian reefs, samples display a small degree of genetic structure (FST =0.015). Demographic scenarios modelled using approximate Bayesian computation analysis indicate that this limited divergence is not due to contemporary gene flow between the Philippines and west Australia. Instead, present-day genetic similarity can be explained by very limited genetic drift that has occurred due to large average effective population sizes that persisted at both locations following their separation. The lack of connectivity among populations suggests that immigrants from west Australia would not facilitate natural recolonization if Philippine populations were fished to extinction. These data help to rectify the paucity of information on the species' biology currently inhibiting their conservation classification. Understanding population structure can allow us to facilitate sustainable harvesting, thereby preserving the diversity of genetically distinct stocks. This article is protected by copyright. All rights reserved
“Enriching Lives within Sedimentary Geology”: Actionable Recommendations for Making SEPM a Diverse, Equitable and Inclusive Society for All Sedimentary Geologists
Innovative science benefits from diversity of thought and influence at all waypoints along the scientific journey, from early education to career-length contributions in research and mentorship. Scientific societies, like the Society for Sedimentary Geology (SEPM), steward their innovators and the direction of the science, thereby defining the societal impact and evolution of a discipline. They are uniquely positioned to promote the representation and success of all scientists, including those from minoritized populations, through proactive advocacy, and inclusive mentorship, awards, and leadership. We introspectively review available records of SEPM membership, leadership, awardees, and editorial boards to identify areas for growth and begin a dialogue about how the society and its members can work together to better reflect our community. In the last decade, SEPM has seen a decline in membership, while representation and recognition of scientists from minoritized groups has remained low. Awards and honors have overwhelmingly gone to men, even in the last ten years, and very few women or people of color are in leadership roles. SEPM has recently taken positive steps towards becoming more inclusive (e.g., the Code of Professional Conduct); however, much more work is needed. We provide recommendations for swift actions that SEPM and its members should undertake for the society to become a diverse, inclusive, and equitable environment where all scientists thrive. The systemic changes needed will take continuous effort, which must be shared by all of us, to build an enduring legacy that we can be proud of
Role of DNA sequences outside the cores of DNase hypersensitive sites (HSs) in functions of the β-globin locus control region. Domain opening and synergism between HS2 and HS3
The roles of each DNase hypersensitive site (HS), and the DNA sequences between them, in the activity of the locus control region of the mammalian β-globin gene domain were examined by placing human and rabbit restriction fragments containing the cores of HS2, HS3, HS4, and HS5, along with varying amounts of flanking DNA, upstream of a hybrid ε-globin-luciferase reporter gene and testing for effects on expression both prior to and after integration into the chromosomes of K562 cells, a human erythroid cell line. Prior to integration, fragments containing HS2 enhanced expression to the greatest extent, and the modest enhancement by some fragments containing HS3 correlated with the presence of a well-conserved binding site for AP1/NFE2. The stronger effects of larger locus control region DNA fragments in clones of stably transfected cells indicates a role for sequences outside the HS cores after integration into the genome. The strong effect of a 1.9-kilobase HindIII fragment containing HS3 after, but not prior to, integration argues for the presence of a chromatin domain-opening activity. Use of a rabbit DNA fragment containing both HS2 and HS3 demonstrated a synergistic interaction between the two HSs when their natural context and spacing are preserved
Methods for the recognition of geological weakness zones and other surface discontinuities caused by underground mining in Carboniferous terrain
Since March 1992 the British Geological Survey (BGS) has collaborated in a CEC part-funded project under the leadership of Dr Clasen of Saarberg, Saarbrueken, Germany. The aim of this project was to determine the most efficient combination of surface geophysical techniques to be used in combination with airborne optical scanning data for the routine detection of shallow faults. Such features, when reactivated following undermining, may become the locii of damaging subsidence, but where they can be traced in advance of mining operations then remedial measures (such as underpinning etc) may be undertaken. This final report outlines the geophysical methods applied and describes our most significant results. Conclusions are drawn concerning the relative efficiencies of each technique and possible
complementary applications
Triple oxygen isotopic composition of the high-<sup>3</sup>He/<sup>4</sup>He mantle
Measurements of Xe isotope ratios in ocean island basalts (OIB) suggest that Earth’s mantle accreted heterogeneously, and that compositional remnants of accretion are sampled by modern, high-3He/4He OIB associated with the Icelandic and Samoan plumes. If so, the high-3He/4He source may also have a distinct oxygen isotopic composition from the rest of the mantle. Here, we test if the major elements of the high-3He/4He source preserve any evidence of heterogeneous accretion using measurements of three oxygen isotopes on olivine from a variety of high-3He/4He OIB locations. To high precision, the Δ17O value of high-3He/4He olivines from Hawaii, Pitcairn, Baffin Island and Samoa, are indistinguishable from bulk mantle olivine (Δ17OBulk Mantle − Δ17OHigh 3He/4He olivine = −0.002 ± 0.004 (2 × SEM)‰). Thus, there is no resolvable oxygen isotope evidence for heterogeneous accretion in the high-3He/4He source. Modelling of mixing processes indicates that if an early-forming, oxygen-isotope distinct mantle did exist, either the anomaly was extremely small, or the anomaly was homogenised away by later mantle convection.
The δ18O values of olivine with the highest 3He/4He ratios from a variety of OIB locations have a relatively uniform composition (∼5‰). This composition is intermediate to values associated with the depleted MORB mantle and the average mantle. Similarly, δ18O values of olivine from high-3He/4He OIB correlate with radiogenic isotope ratios of He, Sr, and Nd. Combined, this suggests that magmatic oxygen is sourced from the same mantle as other, more incompatible elements and that the intermediate δ18O value is a feature of the high-3He/4He mantle source. The processes responsible for the δ18O signature of high-3He/4He mantle are not certain, but δ18O–87Sr/86Sr correlations indicate that it may be connected to a predominance of a HIMU-like (high U/Pb) component or other moderate δ18O components recycled into the high-3He/4He source
Rapid non-contacting resistivity logging of core
We demonstrate a non-contact approach to whole-core and split-core resistivity measurements, imaging a 15 mm-thick, dipping, conductive layer, producing a continuous log of the whole core and enabling the development of a framework to allow representative plugs to be taken, for example. Applications include mapping subtle changes in grain fabric (e.g. grain shape) caused by variable sedimentation rates, for example, as well as the well-known dependencies on porosity and water saturation.
The method operates at relatively low frequencies (i.e. low induction numbers), needing highly sensitive coil pairs to provide resistivity measurements at the desired resolution. A four-coil arrangement of two pairs of transmitter and receiver coils is used to stabilize the measurement. One ‘coil pair’ acts as a control, enabling the effects of local environmental variations, which can be considerable, to be removed from the measurement at source.
Comparing our non-contact approach and independent traditional ‘galvanic’ resistivity measurements indicates that the non-contact measurements are directly proportional to the reciprocal of the sample resistivity (i.e. conductivity). The depth of investigation is discussed in terms of both theory and practical measurements, and the response of the technique to a variety of synthetic ‘structures’ is presented.
We demonstrate the potential of the technique for rapid electrical imaging of core and present a whole-core image of a dipping layer with azimuthal discrimination at a resolution of the order of 10 mm. Consequently, the technique could be used to investigate different depths within the core, in agreement with theoretical predictions
Coherent photon bremsstrahlung and dynamics of heavy-ion collisions: comparison of different models
Differential spectra of coherent photon bremsstrahlung in relativistic heavy
ion collisions are calculated within various schematic models of the
projectile-target stopping. Two versions of the degradation length model, based
on a phenomenological deceleration law, are considered. The simple shock wave
model is studied analytically. The predictions of these models agree in the
soft photon limit, where the spectrum is determined only by the final velocity
distribution of charged particles. The results of these models in the case of
central Au+Au collisions at various bombarding energies are compared with the
predictions of the microscopic transport model UrQMD. It is shown that at the
AGS energy the coherent photon bremsstrahlung exceeds the photon yield from
-decays at photon energies \omega\loo 50 MeV.Comment: 23 pages RevTeX, 9 eps Figure
A Quantum Mechanical Model of Spherical Supermembranes
We present a quantum mechanical model of spherical supermembranes. Using
superfields to represent the cartesian coordinates of the membrane, we are able
to exactly determine its supersymmetric vacua. We find there are two classical
vacua, one corresponding to an extended membrane and one corresponding to a
point-like membrane. For the case, instanton effects then
lift these vacua to massive states. For the case, there is
no instanton tunneling, and the vacua remain massless. Similarities to
spherical supermembranes as giant gravitons and in Matrix theory on pp-waves is
discussed.Comment: 9 page
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness
BACKGROUND:
There are conflicting data on the effects of antipsychotic medications on delirium in patients in the intensive care unit (ICU).
METHODS:
In a randomized, double-blind, placebo-controlled trial, we assigned patients with acute respiratory failure or shock and hypoactive or hyperactive delirium to receive intravenous boluses of haloperidol (maximum dose, 20 mg daily), ziprasidone (maximum dose, 40 mg daily), or placebo. The volume and dose of a trial drug or placebo was halved or doubled at 12-hour intervals on the basis of the presence or absence of delirium, as detected with the use of the Confusion Assessment Method for the ICU, and of side effects of the intervention. The primary end point was the number of days alive without delirium or coma during the 14-day intervention period. Secondary end points included 30-day and 90-day survival, time to freedom from mechanical ventilation, and time to ICU and hospital discharge. Safety end points included extrapyramidal symptoms and excessive sedation.
RESULTS:
Written informed consent was obtained from 1183 patients or their authorized representatives. Delirium developed in 566 patients (48%), of whom 89% had hypoactive delirium and 11% had hyperactive delirium. Of the 566 patients, 184 were randomly assigned to receive placebo, 192 to receive haloperidol, and 190 to receive ziprasidone. The median duration of exposure to a trial drug or placebo was 4 days (interquartile range, 3 to 7). The median number of days alive without delirium or coma was 8.5 (95% confidence interval [CI], 5.6 to 9.9) in the placebo group, 7.9 (95% CI, 4.4 to 9.6) in the haloperidol group, and 8.7 (95% CI, 5.9 to 10.0) in the ziprasidone group (P=0.26 for overall effect across trial groups). The use of haloperidol or ziprasidone, as compared with placebo, had no significant effect on the primary end point (odds ratios, 0.88 [95% CI, 0.64 to 1.21] and 1.04 [95% CI, 0.73 to 1.48], respectively). There were no significant between-group differences with respect to the secondary end points or the frequency of extrapyramidal symptoms.
CONCLUSIONS:
The use of haloperidol or ziprasidone, as compared with placebo, in patients with acute respiratory failure or shock and hypoactive or hyperactive delirium in the ICU did not significantly alter the duration of delirium. (Funded by the National Institutes of Health and the VA Geriatric Research Education and Clinical Center; MIND-USA ClinicalTrials.gov number, NCT01211522 .)
- …