Identification and evaluation of land use vulnerability in a coal mining area under the coupled human-environment

Based on the coupled human–environment, and taking the Hegang coal mining area (Heilongjiang Province, China) as a research area, combined with RS and GIS technologies, from the perspectives of environmental exposure, sensitivity, and adaptive capacity, the analytic hierarchy process and expert consultation methods were used to establish the evaluation index system and weight. Then the mathematical model of vulnerability assessment was constructed, and the spatial analysis method was used to dynamically identify and evaluate the vulnerability of land use in the study areas in 1994, 2006, 2010, and 2014. The results show that: 1) the vulnerability of land use shows an increasing trend from 1994-2014, and most of the landscape types show a strong dominant vulnerability; 2) the adaptive capacity of land use gradually became unstable under the influence of human–land coupling, and the land-use environment showed the trend of transformation from potential vulnerability to extreme vulnerability under the dual action of sensitivity and exposure; 3) from the type of land use, the vulnerability of coal mine land and unutilized land was relatively prominent. The two landscape types were mostly distributed in severe or extremely vulnerable areas over the past 20 years, indicating a greater degree of interference. The results provide the decision-making basis for the scientific planning and management of the land, and provide guidance for ecological restoration and environmental protection

Haze Control by Industrialization: A Win-win Mode of Ecological Civilization and Economic Development

Haze control is a difficult and arduous battle, and it is a major decision concerning the people's livelihood and national ecological civilization construction. Taking Heilongjiang Province as an example, this paper introduced a new idea for haze control. Haze in Heilongjiang Province was mainly resulted from straw burning. Market-oriented, large-scale, and industrialized haze control relying on science and technology is new opportunity and challenge for realizing ecological civilization and revitalizing the economy of Heilongjiang Province

Poly (I:C)-Induced microRNA-30b-5p Negatively Regulates the JAK/STAT Signaling Pathway to Mediate the Antiviral Immune Response in Silver Carp (<i>Hypophthalmichthys molitrix</i>) via Targeting CRFB5

In aquaculture, viral diseases pose a significant threat and can lead to substantial economic losses. The primary defense against viral invasion is the innate immune system, with interferons (IFNs) playing a crucial role in mediating the immune response. With advancements in molecular biology, the role of non-coding RNA (ncRNA), particularly microRNAs (miRNAs), in gene expression has gained increasing attention. While the function of miRNAs in regulating the host immune response has been extensively studied, research on their immunomodulatory effects in teleost fish, including silver carp (Hyphthalmichthys molitrix), is limited. Therefore, this research aimed to investigate the immunomodulatory role of microRNA-30b-5p (miR-30b-5p) in the antiviral immune response of silver carp (Hypophthalmichthys molitrix) by targeting cytokine receptor family B5 (CRFB5) via the JAK/STAT signaling pathway. In this study, silver carp were stimulated with polyinosinic-polycytidylic acid (poly (I:C)), resulting in the identification of an up-regulated miRNA (miR-30b-5p). Through a dual luciferase assay, it was demonstrated that CRFB5, a receptor shared by fish type I interferon, is a novel target of miR-30b-5p. Furthermore, it was found that miR-30b-5p can suppress post-transcriptional CRFB5 expression. Importantly, this study revealed for the first time that miR-30b-5p negatively regulates the JAK/STAT signaling pathway, thereby mediating the antiviral immune response in silver carp by targeting CRFB5 and maintaining immune system stability. These findings not only contribute to the understanding of how miRNAs act as negative feedback regulators in teleost fish antiviral immunity but also suggest their potential therapeutic measures to prevent an excessive immune response

A Novel Peroxisome Proliferator-activated Receptor (PPAR)γ Agonist 2-Hydroxyethyl 5-chloro-4,5-didehydrojasmonate Exerts Anti-Inflammatory Effects in Colitis.

Inflammatory bowel disease (IBD) is a chronic inflammatory disease with increasing incidence and prevalence worldwide. Here we investigated the newly synthesized jasmonate analogue 2-hydroxyethyl 5-chloro-4,5-didehydrojasmonate (J11-Cl) for its anti-inflammatory effects on intestinal inflammation. First, to test whether J11-Cl can activate peroxisome proliferator-activated receptors (PPARs), we performed docking simulations because J11-Cl has a structural similarity with anti-inflammatory 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2), one of the endogenous ligands of PPARγ. J11-Cl bound to the ligand binding domain of PPARγ in the same manner as 15d-PGJ2 and rosiglitazone, and significantly increased transcriptional activity of PPARγ. In animal experiments, colitis was significantly reduced in mice with J11-Cl treatment, determined by analyses of survival rate, body weight changes, clinical symptoms, and histological evaluation. Moreover, J11-Cl decreased production of pro-inflammatory cytokines including IL-6, IL-8, and G-CSF as well as chemokines including chemokine (C-C motif) ligand (CCL)20, chemokine (C-X-C motif) ligand (CXCL)2, CXCL3, and chemokine (C-X3-C motif) ligand 1 (CX3CL1) in colon tissues, and LPS or TNF-α-stimulated macrophages and epithelial cells. In contrast, production of anti-inflammatory cytokines including IL-2 and IL-4 as well as the proliferative factor, GM-CSF, was increased by J11-Cl. Furthermore, inhibition of MAPKs and NF-κB activation by J11-Cl was also observed. J11-Cl reduced intestinal inflammation by increasing the transcriptional activity of PPARγ and modulating inflammatory signaling pathways. Therefore, our study suggests that J11-Cl may serve as a novel therapeutic agent against IBD

The information of the SSR markers and SNP markers on the linkage map.

<p>The information of the SSR markers and SNP markers on the linkage map.</p