3,655 research outputs found
High salt diet impairs cerebral blood flow regulation via saltâinduced angiotensin II suppression
ObjectivesThis study sought to determine whether saltâinduced ANG II suppression contributes to impaired CBF autoregulation.MethodsCerebral autoregulation was evaluated with LDF during graded reductions of blood pressure. Autoregulatory responses in rats fed HS (4% NaCl) diet vs LS (0.4% NaCl) diet were analyzed using linear regression analysis, modelâfree analysis, and a mechanistic theoretical model of blood flow through cerebral arterioles.ResultsAutoregulation was intact in LSâfed animals as MAP was reduced via graded hemorrhage to approximately 50Â mm Hg. Shortâterm (3Â days) and chronic (4Â weeks) HS diet impaired CBF autoregulation, as evidenced by progressive reductions of laser Doppler flux with arterial pressure reduction. Chronic low dose ANG II infusion (5Â mg/kg/min, i.v.) restored CBF autoregulation between the preâhemorrhage MAP and 50Â mm Hg in rats fed shortâterm HS diet. Mechanisticâbased model analysis showed a reduced myogenic response and reduced baseline VSM tone with shortâterm HS diet, which was restored by ANG II infusion.ConclusionsShortâterm and chronic HS diet lead to impaired autoregulation in the cerebral circulation, with saltâinduced ANG II suppression as a major factor in the initiation of impaired CBF regulation.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149286/1/micc12518_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149286/2/micc12518.pd
The spectra of lifted digraphs
We present a method to derive the complete spectrum of the lift \mathrm{\Gamma\alpha} of a base digraph \mathrm{\Gamma}, with voltage assignment α on a (finite) group . The method is based on assigning to \mathrm{\Gamma} a quotient-like matrix whose entries are elements of the group algebra \mathds{C}[], which fully represents \mathrm{\Gamma\alpha}. This allows us to derive the eigenvectors and eigenvalues of the lift in terms of those of the base digraph and the irreducible characters of G. Thus, our main theorem generalizes some previous results of Lovåsz and Babai concerning the spectra of Cayley digraphs
Recognition of Face Identity and Emotion in Expressive Specific Language Impairment
Objective: To study face and emotion recognition in children with mostly expressive specific language impairment (SLI-E). Subjects and Methods: A test movie to study perception and recognition of faces and mimic-gestural expression was applied to 24 children diagnosed as suffering from SLI-E and an age-matched control group of normally developing children. Results: Compared to a normal control group, the SLI-E children scored significantly worse in both the face and expression recognition tasks with a preponderant effect on emotion recognition. The performance of the SLI-E group could not be explained by reduced attention during the test session. Conclusion: We conclude that SLI-E is associated with a deficiency in decoding non-verbal emotional facial and gestural information, which might lead to profound and persistent problems in social interaction and development. Copyright (C) 2012 S. Karger AG, Base
A topological classification of convex bodies
The shape of homogeneous, generic, smooth convex bodies as described by the
Euclidean distance with nondegenerate critical points, measured from the center
of mass represents a rather restricted class M_C of Morse-Smale functions on
S^2. Here we show that even M_C exhibits the complexity known for general
Morse-Smale functions on S^2 by exhausting all combinatorial possibilities:
every 2-colored quadrangulation of the sphere is isomorphic to a suitably
represented Morse-Smale complex associated with a function in M_C (and vice
versa). We prove our claim by an inductive algorithm, starting from the path
graph P_2 and generating convex bodies corresponding to quadrangulations with
increasing number of vertices by performing each combinatorially possible
vertex splitting by a convexity-preserving local manipulation of the surface.
Since convex bodies carrying Morse-Smale complexes isomorphic to P_2 exist,
this algorithm not only proves our claim but also generalizes the known
classification scheme in [36]. Our expansion algorithm is essentially the dual
procedure to the algorithm presented by Edelsbrunner et al. in [21], producing
a hierarchy of increasingly coarse Morse-Smale complexes. We point out
applications to pebble shapes.Comment: 25 pages, 10 figure
The order of the quantum chromodynamics transition predicted by the standard model of particle physics
We determine the nature of the QCD transition using lattice calculations for
physical quark masses. Susceptibilities are extrapolated to vanishing lattice
spacing for three physical volumes, the smallest and largest of which differ by
a factor of five. This ensures that a true transition should result in a
dramatic increase of the susceptibilities.No such behaviour is observed: our
finite-size scaling analysis shows that the finite-temperature QCD transition
in the hot early Universe was not a real phase transition, but an analytic
crossover (involving a rapid change, as opposed to a jump, as the temperature
varied). As such, it will be difficult to find experimental evidence of this
transition from astronomical observations.Comment: 7 pages, 4 figure
Revisiting the S-matrix approach to the open superstring low energy effective lagrangian
The conventional S-matrix approach to the (tree level) open string low energy
effective lagrangian assumes that, in order to obtain all its bosonic
order terms, it is necessary to know the open string (tree level)
-point amplitude of massless bosons, at least expanded at that order in
. In this work we clarify that the previous claim is indeed valid for
the bosonic open string, but for the supersymmetric one the situation is much
more better than that: there are constraints in the kinematical bosonic terms
of the amplitude (probably due to Spacetime Supersymmetry) such that a much
lower open superstring -point amplitude is needed to find all the
order terms. In this `revisited' S-matrix approach we have
checked that, at least up to order, using these kinematical
constraints and only the known open superstring 4-point amplitude, it is
possible to determine all the bosonic terms of the low energy effective
lagrangian. The sort of results that we obtain seem to agree completely with
the ones achieved by the method of BPS configurations, proposed about ten years
ago. By means of the KLT relations, our results can be mapped to the NS-NS
sector of the low energy effective lagrangian of the type II string theories
implying that there one can also find kinematical constraints in the -point
amplitudes and that important informations can be inferred, at least up to
order, by only using the (tree level) 4-point amplitude.Comment: 34 pages, 3 figure, Submitted on Aug 4, 2012, Published on Oct 15,
201
Genetic Modifiers of Mendelian Monogenic Collagen IV Nephropathies in Humans and Mice
Familial hematuria is a clinical sign of a genetically heterogeneous group of conditions, accompanied by broad inter- and intrafamilial variable expressivity. The most frequent condition is caused by pathogenic (or likely pathogenic) variants in the collagen-IV genes, COL4A3/A4/A5. Pathogenic variants in COL4A5 are responsible for the severe X-linked glomerulopathy, Alport syndrome (AS), while homozygous or compound heterozygous variants in the COL4A3 or the COL4A4 gene cause autosomal recessive AS. AS usually leads to progressive kidney failure before the age of 40-years when left untreated. People who inherit heterozygous COL4A3/A4 variants are at-risk of a slowly progressive form of the disease, starting with microscopic hematuria in early childhood, developing Alport spectrum nephropathy. Sometimes, they are diagnosed with benign familial hematuria, and sometimes with autosomal dominant AS. At diagnosis, they often show thin basement membrane nephropathy, reflecting the uniform thin glomerular basement membrane lesion, inherited as an autosomal dominant condition. On a long follow-up, most patients will retain normal or mildly affected kidney function, while a substantial proportion will develop chronic kidney disease (CKD), even kidney failure at an average age of 55-years. A question that remains unanswered is how to distinguish those patients with AS or with heterozygous COL4A3/A4 variants who will manifest a more aggressive kidney function decline, requiring prompt medical intervention. The hypothesis that a subgroup of patients coinherit additional genetic modifiers that exacerbate their clinical course has been investigated by several researchers. Here, we review all publications that describe the potential role of candidate genetic modifiers in patients and include a summary of studies in AS mouse models
Direct observation of incommensurate magnetism in Hubbard chains
The interplay between magnetism and doping is at the origin of exotic
strongly correlated electronic phases and can lead to novel forms of magnetic
ordering. One example is the emergence of incommensurate spin-density waves
with a wave vector that does not match the reciprocal lattice. In one dimension
this effect is a hallmark of Luttinger liquid theory, which also describes the
low energy physics of the Hubbard model. Here we use a quantum simulator based
on ultracold fermions in an optical lattice to directly observe such
incommensurate spin correlations in doped and spin-imbalanced Hubbard chains
using fully spin and density resolved quantum gas microscopy. Doping is found
to induce a linear change of the spin-density wave vector in excellent
agreement with Luttinger theory predictions. For non-zero polarization we
observe a decrease of the wave vector with magnetization as expected from the
Heisenberg model in a magnetic field. We trace the microscopic origin of these
incommensurate correlations to holes, doublons and excess spins which act as
delocalized domain walls for the antiferromagnetic order. Finally, when
inducing interchain coupling we observe fundamentally different spin
correlations around doublons indicating the formation of a magnetic polaron
Early Warning Signals for Critical Transitions: A Generalized Modeling Approach
Critical transitions are sudden, often irreversible, changes that can occur in a large variety of complex systems; signals that warn of critical transitions are therefore highly desirable. We propose a new method for early warning signals that integrates multiple sources of information and data about the system through the framework of a generalized model. We demonstrate our proposed approach through several examples, including a previously published fisheries model. We regard our method as complementary to existing early warning signals, taking an approach of intermediate complexity between model-free approaches and fully parameterized simulations. One potential advantage of our approach is that, under appropriate conditions, it may reduce the amount of time series data required for a robust early warning signal
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