Use of complementary and alternative medicine in Hawaii cancer patients.

This research investigated complementary and alternative medicine (CAM) use by Hawaii cancer patients. Thirty-six percent of patients used CAM, most commonly religious/spiritual therapy and herbal treatments. CAM use was linked with younger age, female gender, Catholic religion, and more education. More research is needed to inform decision-making.R01 CA 61711/CA/NCI NIH HHS/United StatesR01 CA 64045/CA/NCI NIH HHS/United State

Tratamiento y aplicación de la teoría del levantamiento del velo societario en grupos empresariales para garantizar el pago de beneficios sociales en el derecho peruano

La presente investigación está relacionada con la teoría del levantamiento del velo societario en grupos empresariales en caso de incumplimiento de obligaciones laborales, garantizándose el efectivo cumplimiento del pago de los beneficios sociales del trabajador que labora para un grupo empresarial y además podrá servir para incentivar a los empresarios a cumplir con sus obligaciones laborales para evitar perjuicios a nivel económico- empresarial. Uno de los objetivos del presente estudio es demostrar que la aplicación de la teoría del levantamiento del velo societario resulta eficiente para los intereses del trabajador de un grupo empresarial así como resulta necesario que los empleadores promuevan mecanismos de prevención de riesgos, para evitar estas situaciones. Se puede decir que la teoría del levantamiento del velo societario es el mecanismo para prescindir de la personalidad jurídica o de la forma externa de una sociedad, para ingresar en el interior de un grupo empresarial y tener la capacidad de poder identificar a cada uno de los accionistas y consecuentemente conocer su patrimonio personal con el que se harán responsables en caso de que exista incumplimiento en el pago de beneficios sociales será aplicada es caso de abuso de derecho, fraude a la ley, es decir de manera excepcional siempre que exista las condiciones antes mencionadas. El juez laboral a través de sus facultades de independencia será quien aplique la teoría en un caso particular de cobro de beneficios sociales en un grupo empresarial debidamente fundamentado. Con todo lo expuesto se llegó a la conclusión de que sí puede aplicarse la Teoría del Levantamiento del Velo Societario, siempre y cuando se cumplan ciertas condiciones que le permitan al juzgador ejercer su labor de impartir justicia, siendo necesario invocarla en un proceso laboral, de igual forma será importante que exista una pretensión concreta, en el presente caso, incumplimiento de beneficios sociales, en un determinado grupo empresarial así se delimita la aplicación de manera específica.Trabajo de investigació

Antitumor Effect of Malaria Parasite Infection in a Murine Lewis Lung Cancer Model through Induction of Innate and Adaptive Immunity

BACKGROUND: Lung cancer is the most common malignancy in humans and its high fatality means that no effective treatment is available. Developing new therapeutic strategies for lung cancer is urgently needed. Malaria has been reported to stimulate host immune responses, which are believed to be efficacious for combating some clinical cancers. This study is aimed to provide evidence that malaria parasite infection is therapeutic for lung cancer. METHODOLOGY/PRINCIPAL FINDINGS: Antitumor effect of malaria infection was examined in both subcutaneously and intravenously implanted murine Lewis lung cancer (LLC) model. The results showed that malaria infection inhibited LLC growth and metastasis and prolonged the survival of tumor-bearing mice. Histological analysis of tumors from mice infected with malaria revealed that angiogenesis was inhibited, which correlated with increased terminal deoxynucleotidyl transferase-mediated (TUNEL) staining and decreased Ki-67 expression in tumors. Through natural killer (NK) cell cytotoxicity activity, cytokine assays, enzyme-linked immunospot assay, lymphocyte proliferation, and flow cytometry, we demonstrated that malaria infection provided anti-tumor effects by inducing both a potent anti-tumor innate immune response, including the secretion of IFN-γ and TNF-α and the activation of NK cells as well as adaptive anti-tumor immunity with increasing tumor-specific T-cell proliferation and cytolytic activity of CD8(+) T cells. Notably, tumor-bearing mice infected with the parasite developed long-lasting and effective tumor-specific immunity. Consequently, we found that malaria parasite infection could enhance the immune response of lung cancer DNA vaccine pcDNA3.1-hMUC1 and the combination produced a synergistic antitumor effect. CONCLUSIONS/SIGNIFICANCE: Malaria infection significantly suppresses LLC growth via induction of innate and adaptive antitumor responses in a mouse model. These data suggest that the malaria parasite may provide a novel strategy or therapeutic vaccine vector for anti-lung cancer immune-based therapy

Immunotoxins and Anticancer Drug Conjugate Assemblies: The Role of the Linkage between Components

Immunotoxins and antibody-drug conjugates are protein-based drugs combining a target-specific binding domain with a cytotoxic domain. Such compounds are potentially therapeutic against diseases including cancer, and several clinical trials have shown encouraging results. Although the targeted elimination of malignant cells is an elegant concept, there are numerous practical challenges that limit conjugates’ therapeutic use, including inefficient cellular uptake, low cytotoxicity, and off-target effects. During the preparation of immunoconjugates by chemical synthesis, the choice of the hinge component joining the two building blocks is of paramount importance: the conjugate must remain stable in vivo but must afford efficient release of the toxic moiety when the target is reached. Vast efforts have been made, and the present article reviews strategies employed in developing immunoconjugates, focusing on the evolution of chemical linkers

Ethnic Related Selection for an ADH Class I Variant within East Asia

The alcohol dehydrogenases (ADH) are widely studied enzymes and the evolution of the mammalian gene cluster encoding these enzymes is also well studied. Previous studies have shown that the ADH1B*47His allele at one of the seven genes in humans is associated with a decrease in the risk of alcoholism and the core molecular region with this allele has been selected for in some East Asian populations. As the frequency of ADH1B*47His is highest in East Asia, and very low in most of the rest of the world, we have undertaken more detailed investigation in this geographic region.Here we report new data on 30 SNPs in the ADH7 and Class I ADH region in samples of 24 populations from China and Laos. These populations cover a wide geographic region and diverse ethnicities. Combined with our previously published East Asian data for these SNPs in 8 populations, we have typed populations from all of the 6 major linguistic phyla (Altaic including Korean-Japanese and inland Altaic, Sino-Tibetan, Hmong-Mien, Austro-Asiatic, Daic, and Austronesian). The ADH1B genotyping data are strongly related to ethnicity. Only some eastern ethnic phyla or subphyla (Korean-Japanese, Han Chinese, Hmong-Mien, Daic, and Austronesian) have a high frequency of ADH1B*47His. ADH1B haplotype data clustered the populations into linguistic subphyla, and divided the subphyla into eastern and western parts. In the Hmong-Mien and Altaic populations, the extended haplotype homozygosity (EHH) and relative EHH (REHH) tests for the ADH1B core were consistent with selection for the haplotype with derived SNP alleles. In the other ethnic phyla, the core showed only a weak signal of selection at best.The selection distribution is more significantly correlated with the frequency of the derived ADH1B regulatory region polymorphism than the derived amino-acid altering allele ADH1B*47His. Thus, the real focus of selection may be the regulatory region. The obvious ethnicity-related distributions of ADH1B diversities suggest the existence of some culture-related selective forces that have acted on the ADH1B region

Barriers to mammography in a low income, multiethnic clinic population.

Breast cancer-related knowledge, attitudes, behaviors and barriers to obtaining a mammogram were assessed in women attending a primary care clinic serving a low-income minority population. Although most women believed in the value of mammograms, fewer than one in six was compliant with guidelines, and there were considerable deficits in knowledge about breast cancer risk. Ethnic and age differences in responses have implications for health program planning.KO7CAO1642/CA/NCI NIH HHS/United State

Síntesis por vía microbiana de nanopartículas de sulfuro de cadmio a partir de un residuo industrial

Tesis (Doctorado en Tecnología Avanzada), Instituto Politécnico Nacional, CICATA, Unidad Querétaro, 2017, 1 archivo PDF, (191 páginas). tesis.ipn.m