Analisis Capital Budgeting Sebagai Alat Untuk Pengambilan Keputusan Investasi Asset Tetap (Studi Pada Pt.pandawa Sakti Lintas Nusa Jasa Tour Dan Travel Malang)

Fixed asset investment in common need a lot of money and one of the critical decision for the company success. In that case, every single company need to allocate their capital or usually we called capital budgeting. PT. Pandawa Sakti Lintas Nusa MJ Tour & Travel Malang need to do the fixed asset investment, in this case an addition of Gran Max BV 1.3 AC, and we used the capital budgeting to calculate it. After several point of view used capital budgeting technique, We can conclude that the company can used that investment. One of the technique we used is Average Rate of Return we got the value 11,6% >10,8%, Payback Period show that the investment return period is 5 years 8 months, and the calculation NPV > 0, and the precise value is Rp 1.525.986,36. The Benefit Cost Ratio value is 1,014. and Internal Rate of Return value is 11,2% >10,8%. From the conclusion I suggest that the company must do the addition fixed asset Gran Max BV 1.3 AC because the investment plan can produce a lot of profit for the company and the capital budgeting can reduce the risk of failure that can impact the company life

Creative Confidence

This project is about increasing creative confidence. Creative confidence is the natural human ability to come up with breakthrough ideas and the courage to act on them. In this project the focus is on using your body as an instrument in order to develop a larger confidence. The foundation of this idea comes from improv theater. Improv theater is the process and product of creativity occurring simultaneously. I order to do so you have to have a large creative confidence. There is a proved correlation between creative thinking skills and improv theater. This project provides information on this topic, provides a database with activities and a YouTube channel with short videos

A retrospective study of smoker types and optimal cessation procedures.

Thesis (M.S.

Adaptasi Organisasi Pelayanan Manusia selama Pandemi Covid-19 (Studi pada Yayasan Kampus Diakoneia Modern)

Organisasi Pelayanan Manusia memiliki peran penting dalam sektor kesejahteraan sosial. Melihat peran penting ini, maka organisasi pelayanan manusia harus memiliki kemampuan untuk beradaptasi pada situasi dan perubahan yang terjadi di lingkungan eksternal. Adaptasi dilakukan bukan hanya untuk menjawab kebutuhan klien, tetapi juga untuk keberlanjutan organisasi. Pandemi Covid-19 yang menimbulkan banyak dampak pada aspek ekonomi, kesehatan, pendidikan, lingkungan, teknologi, dan sosial, juga berimbas pada dinamika organisasi pelayanan manusia. Yayasan KDM sebagai organisasi penyedia layanan kesejahteraan anak, perlu melakukan proses adaptasi agar dapat tetap menjangkau klien dan memenuhi hak mereka, meskipun akan menemukan tantangan sekaligus pembelajaran di tengah situasi yang sulit. Sejumlah adaptasi dilakukan pada program, kegiatan, dan prosedur agar tetap dapat memenuhi permintaan karena meningkatnya kebutuhan klien di tengah pandemi. Keberhasilan proses adaptasi sebuah organisasi dipengaruhi oleh budaya organisasi dan tipe kepemimpinan.   

Strategic Alliances Of Small And Medium Entrepreneurs A Challenge For The Colective Modernization Of Transport In The City Of Bogota

The public collective transportation of the city of Bogotá is facing a new reality, caused by a significant advance in the urban development, as well as, making progress of the mobility which expressed by the implementation of in a new system of massive transport for the city called TRANSMILENIO. In response to the challenge that this new urban dynamics has generated, the entrepreneurs of the collective transport of the city of Bogotá have made them aware of the urgent need to modernize their sector, in order to, succeed in being competitive within the new concept of public transport. This complex process of modernization of the collective transport has raised the need to create new paradigms of business management which include the construction of strategic alliances of small and medium entrepreneurs of the collective transportation of the city. This process has relied on the participation of the academy, local authorities and the support of programs that Inter American Development Bank has been implementing in the area of managerial partnership. The article on consideration shows the process of modernization that is given inside the collective companies of transports in the city of Bogotá, taking as a main referring the experience of “ Alliance Tránsfer” which considers the construction of new paradigms of business management, quality of the service, social managerial responsibility and the construction of citizenship. The principles on which the “Alliance Tránsfer” is getting built are based on a new conception of the urban collective public transport of passengers. “ALIANZA TRANSFER” not only includes the implementation of high standards of planning, operation, management, and quality in the service, but also the commitment in rebuilding values and the managerial social responsibility. At the same time, “Alliance Tránsfer” attempts to contribute trough the development of the collective public service of transport in the process of the social inclusion using it as a tool to fortify processes of construction and formation of the civilian population. Finally, “Alliance Tránsfer” seeks to agglutinate entrepreneurs through the sum of synergies of the transporters of the collective public sector to constitute themselves in to authentic agents of the social and economic development.Institute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne

Early propranolol treatment induces lung heme-oxygenase-1, attenuates metabolic dysfunction, and improves survival following experimental sepsis

INTRODUCTION: Pharmacological agents that block beta-adrenergic receptors have been associated with improved outcome in burn injury. It has been hypothesized that injuries leading to a hypermetabolic state, such as septic shock, may also benefit from beta-blockade; however, outcome data in experimental models have been contradictory. Thus, we investigated the effect of beta-blockade with propranolol on survival, hemodynamics, lung heat shock protein (HSP) expression, metabolism and inflammatory markers in a rat cecal ligation and puncture (CLP) model of sepsis. METHODS: Sprague-Dawley rats receiving either repeated doses (30 minutes pre-CLP and every 8 hours for 24 hours postoperatively) of propranolol or control (normal saline), underwent CLP and were monitored for survival. Additionally, lung and blood samples were collected at 6 and 24 hours for analysis. Animals also underwent monitoring to evaluate global hemodynamics. RESULTS: Seven days following CLP, propranolol improved survival versus control (P < 0.01). Heart rates in the propranolol-treated rats were approximately 23% lower than control rats (P < 0.05) over the first 24 hours, but the mean arterial blood pressure was not different between groups. Metabolic analysis of lung tissue demonstrated an increase in lung ATP/ADP ratio and NAD+ content and a decreased ratio of polyunsaturated fatty acids to monounsaturated fatty acids (PUFA/MUFA). Cytokine analysis of the inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) demonstrated decreased expression of TNF-alpha in both lung and plasma at 24 hours post CLP induced sepsis. Finally, propranolol led to a significant increase in lung hemeoxygenase-1 expression, a key cellular protective heat shock protein (HSP) in the lung. Other lung HSP expression was unchanged. CONCLUSIONS: These results suggest that propranolol treatment may decrease mortality during sepsis potentially via a combination of improving metabolism, suppressing aspects of the inflammatory response and enhancing tissue protection

A modern way to teach and practice manual therapy

Background: Musculoskeletal conditions are the leading contributor to global disability and health burden. Manual therapy (MT) interventions are commonly recommended in clinical guidelines and used in the management of musculoskeletal conditions. Traditional systems of manual therapy (TMT), including physiotherapy, osteopathy, chiropractic, and soft tissue therapy have been built on principles such as clinician-centred assessment, patho-anatomical reasoning, and technique specificity. These historical principles are not supported by current evidence. However, data from clinical trials support the clinical and cost effectiveness of manual therapy as an intervention for musculoskeletal conditions, when used as part of a package of care. Purpose: The purpose of this paper is to propose a modern evidence-guided framework for the teaching and practice of MT which avoids reference to and reliance on the outdated principles of TMT. This framework is based on three fundamental humanistic dimensions common in all aspects of healthcare: safety, comfort, and efficiency. These practical elements are contextualised by positive communication, a collaborative context, and person-centred care. The framework facilitates best-practice, reasoning, and communication and is exemplified here with two case studies. Methods: A literature review stimulated by a new method of teaching manual therapy, reflecting contemporary evidence, being trialled at a United Kingdom education institute. A group of experienced, internationally-based academics, clinicians, and researchers from across the spectrum of manual therapy was convened. Perspectives were elicited through reviews of contemporary literature and discussions in an iterative process. Public presentations were made to multidisciplinary groups and feedback was incorporated. Consensus was achieved through repeated discussion of relevant elements. Conclusions: Manual therapy interventions should include both passive and active, person-empowering interventions such as exercise, education, and lifestyle adaptations. These should be delivered in a contextualised healing environment with a well-developed person-practitioner therapeutic alliance. Teaching manual therapy should follow this model

Surgical Treatment of Diabetic Foot Ulcers Complicated by Osteomyelitis with Gentamicin-Loaded Calcium Sulphate-Hydroxyapatite Biocomposite

Diabetic foot ulcers, complicated by osteomyelitis, can be treated by surgical resection, dead space filling with gentamicin-loaded calcium sulphate-hydroxyapatite (CaS-HA) biocomposite, and closure of soft tissues and skin. To assess the feasibility of this treatment regimen, we conducted a multicenter retrospective cohort study of patients after failed conventional treatments. From 13 hospitals we included 64 patients with forefoot (n = 41 (64%)), midfoot (n = 14 (22%)), or hindfoot (n = 9 (14%)) ulcers complicated by osteomyelitis. Median follow-up was 43 (interquartile range, 20-61) weeks. We observed wound healing in 54 patients (84%) and treatment success (wound healing without ulcer recurrence) in 42 patients (66%). Treatment failures (no wound healing or ulcer recurrence) led to minor amputations in four patients (6%) and major amputations in seven patients (11%). Factors associated with treatment failures in univariable Cox regression analysis were gentamicin-resistant osteomyelitis (hazard ratio (HR), 3.847; 95%-confidence interval (CI), 1.065-13.899), hindfoot ulcers (HR, 3.624; 95%-CI, 1.187-11.060) and surgical procedures with gentamicin-loaded CaS-HA biocomposite that involved minor amputations (HR, 3.965; 95%-CI, 1.608-9.777). In this study of patients with diabetic foot ulcers, complicated by osteomyelitis, surgical treatment with gentamicin-loaded CaS-HA biocomposite was feasible and successful in 66% of patients. A prospective trial of this treatment regimen, based on a uniform treatment protocol, is required