Book Reviews

Review of the following books: Chez Nous: The St. John Valley by Guy F. Dubay; Stagecoach East: Stagecoach Days in the East from the Colonial Period to the Civil War by Oliver W. Holmes and Peter Rohrbach; Coastal New England by William F. Robinson

Book Reviews

Reviews of the following books: Sanford and Springvale, Maine in the Days of Fred Philpot; Alfred Maine: The Shakes and the Village; Sanford and Springvale, Maine: A Backward Glance; A Cluster of Maine Villages: Sanford and Springvale, Acton, Shapleigh and Alfred; Village on the Mousam: Sanford and Springvale, Maine; by Harland H. Eastman. Ties of Common Blood: History of Maine\u27s Northeastern Boundary Dispute with Great Britain by Geraldine Tidd Scott

Book Reviews

Anchor of the Soul (a documentary video about black life in Maine) produced by Shoshana Hoose and Karen Odlin; Headstrong: The Biography of Amy Morris Bradley, 1823-1904, A Life of Nobel Usefulness by Diane Cobb Cashman; Fifty year of Fortitude: The Maritime Career of Captain Jotham Blaisdell of Kennebunk, Maine 1820-1860 by Kendrick Price Daggett; The Civil War Letters of Capt. John Franklin Godfrey edited by Candace Sawyer and Laura Orcut; Dearest Father: The Civil War Letters of Lt. Frank Dickerson, A Son of Belfast, Maine edited by Draper Hunt; Dear Friend Anna: The Civil War Letters of a Common Soldier from Maine edited by Beverly Hayes Kallgren and James L. Crouthamel; William E. Barry\u27s Sketch of an Old River: Shipbuilding on the Kennebunk edited by Joyce Butler; Maine Politics and Government by Kenneth T. Palmer, G. Thomas Taylor and Marcus A. Librizzi

Book Reviews

Reviews of the following books: Bootleggers, Lobstermen & Lumberjacks: Fifty of the Grittiest Moments in the History of Harscrabble New England by Matthew P. Mayo; Remarkable Americans: The Washburn Family by Kerck Kelsey; Historic Photos of Maine by Francis Pollitt; On Pownal Time: One Hundred Years in a Rural Maine Town by Donna Fulton Boyles, James G. Boyles, Craig Dietrich, Sherilyn R. Dietrich, Jennifer Blackstone Kaplan and Joseph R. Raymond; Frontier to Industrial City: Lewiston Town Politics, 1768-1863 by Douglas I. Hodgkin; In the Shadow of the Eagle by Donna Loring; The Land In Between: the Upper St. John Valley from Prehistory to World War One by Beatrice Craig & Maxime Dagenais with the collaboration of Lisa Ornstein and Guy Dubay; Maine in the World: Stories of Some of Those from Here Who Went Away by Neil Rolde

Book Reviews

Review of the following books: Nearby History: Exploring the Past Around You by David E. Kyvig and Myron A. Marty; The Forerunners: The Tragic Story of 156 Down-East Americans Led to Jaffa in 1866 by Charismatic G.J. Adams to Plant the Seeds of Modern Israel by Reed M. Holmes; Islands of Maine: Where America Really Began by Bill Caldwell; Foundations of Northeast Archaeology edited by Dean R. Snow; A Short History of the American Locomotive Builders in the Steam Era by John H. Whit

Re-Gendering the Libertine; or, The Taming of the Rake: Lucy Vestris as Don Giovanni on the Early Nineteenth-Century London Stage

When Luigi Bassi entered the stage of the Prague National Theatre in 1787 to create the title role of Mozart and Da Ponte's Don Giovanni, he could have drawn inspiration from a rich tradition of theatrical, pantomimic and marionette representations of the legendary Don Juan, to which this new opera was the latest contribution. Previous incarnations had been shaped by the likes of Tirso de Molina, Molière, Shadwell, Purcell and Gluck; yet it is Mozart and Da Ponte's version that has for us become the definitive: the Don as paradox; an uncomfortable blend of the despicable and the admirable, hero and anti-hero. Lecher, rapist, liar, cheat, murderer, he is the brutal epitome of macho striving for power and domination, yet clothed with a seductive panache, conviction and bravado — the reckless-heroic libertine phallocrat who would rather face the fires of eternal damnation than curb his appetites

Book Reviews

Reviews of the following books: Mainers in the Civil War by Harry Gratwick; The 22nd Maine Volunteer Infantry in the Civil War: A History and Roster by Ned Smith; Write Quick: War and a Woman\u27s Life in Letters 1835-1867 Edited by Ann Fox Chandonnet and Robert Gibson Pevear; Civil War Senator: William Pitt Fessenden and the Fight to Save the American Republic by Robert J. Cook; Lincoln\u27s Friend: Leonard Swett by Robert S. Eckley; We Are in His Hands Whether We Live or Die: The Letters of Brevet Brigadier General Charles Henry Howard edited by David K. Thomson; Fanny & Joshua: The Enigmatic Lives of Frances Caroline Adams and Joshua Lawrence Chamberlain by Diane Monroe Smith; This Birth Place of Souls:The Civil War Nursing Diary of Harriet Eaton edited with an Introduction by Jane E. Schultz; Army at Home: Women and the Civil War on the Northern Home Front by Judith Giesberg; A Visitation of God: Northern Civilians Interpret the Civil War by Sean A. Scott; Freedom National: The Destruction of Slavery in the United States, 1861-1865 by James Oakes; War Upon the Land: Military Strategy and the Transformation of Southern Landscapes during the American Civil War by Lisa M. Brady; Remembering the Civil War: Reunion and the Limits of Reconciliation by Caroline E. Janne

Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study

A41 Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study In: Addiction Science & Clinical Practice 2017, 12(Suppl 1): A4

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference